Clinical trials: Anti-bacterial Agents
Pyelonephritis Acute, Kidney Transplant Infection
Efficacy of 7 Days Versus 14 Days of Antibiotic Therapy for Acute Pyelonephritis in Kidney Transplant Recipients, a Multicentre Randomized Non-inferiority Trial.
Infections are a major cause of morbidity and mortality in solid organ transplant recipients. In kidney transplant recipients (KTR) urinary tract infection (UTI) represent 45-72% of all infections, and 30% of all hospitalizations…
- Trial name
- SHORTCUT (NCT05597540)
- Testing
- Short antibiotic treatment, Usual antibiotic treatment
- Where
- 9 sites in France
- Volunteers
- 470 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Unexplained Infertility, Endometriosis
Probiotic and Antibiotic Therapies in Women With Unexplained Infertility
The study is designed as a proof of concept pilot study with 3 study arms to evaluate the safety and feasibility of the use of oral probiotics and/or antibiotics in women with unexplained infertility/endometriosis.
- Trial name
- NCT04955574
- Testing
- SH-DS01 + Metronidazole
- Sponsor
- McMaster University
Urinary Tract Infections, Antiobiotic Stewardship
Post-Emergency Optimization of Antibiotic Therapy for Urinary Tract Infection (UTI)
Prospective, multicenter, non-interventional study conducted over 6 months, including patients presenting to the emergency department with suspected urinary tract infection managed as outpatients and discharged with or without…
- Conditions
- Urinary Tract Infections, Antiobiotic Stewardship, Emerging Infectious Disease
- Trial name
- REVIU48 (NCT07559318)
- Testing
- Adaptation of antibiotics therapy for outpatient urinary infection following emergency care
- Where
- 3 sites in France
- Volunteers
- 330 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Infection Secondary to Surgical Procedure
Antibiotic Prophylaxis in Gynecologic Laparoscopy
Laparoscopy is a surgical procedure indicated for most gynecological pathologies and presents numerous advantages over laparotomy, among them lower rates of surgical site infection and less comorbidity feverish.
- Trial name
- NCT01991834
- Testing
- gynecologic laparoscopy, Cefazolin
- Where
- 2 sites in Brazil
- Volunteers
- 114 people
- Sponsor
- Universidade do Vale do Sapucai
Microbial Colonization, Antibiotic Side Effect
Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome
In this study, investigators seek to determine whether the timing of antibiotics given to mothers during an elective C-section affects the composition of their infant's gut microbiome.
- Conditions
- Microbial Colonization, Antibiotic Side Effect, Cesarean Section Complications
- Trial name
- CSBabyBiome (NCT06030713)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Telemedicine
Systematic Quality Improvement With Realtime Event Support
The goal of this study is to improve perioperative quality metric performance in patients receiving anesthesia care provided by Washington University Department of Anesthesiology.
- Trial name
- SQUIRES (NCT04983329)
- Testing
- Telemedicine intervention
- Where
- United States
- Volunteers
- 25,506 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis, Hip, Total Hip Arthroplasty
Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA
Aim: To compare the effect of one single dose versus multiple doses of prophylactic antibiotics administered within 24 hours, on the development of PJI in patients with osteoarthritis undergoing primary THA.
- Conditions
- Osteoarthritis, Hip, Total Hip Arthroplasty, Prosthetic-joint Infection
- Trial name
- ProHipQ-OA (NCT05530551)
- Testing
- Antibiotic dosage practice
- Where
- 36 sites in Denmark
- Volunteers
- 20,000 people
- Sponsor
- Soren Overgaard
Infection
Antimicrobial PK in Infants With Suspected or Confirmed Infection
The purpose of this protocol is to provide a mechanism for the ongoing collection of blood and urine samples in newborns that will be used to measure levels of antimicrobial products used in the newborn population where there are…
- Trial name
- NCT00491426
- Testing
- Ampicillin, Metronidazole, Piperacillin/Tazobactam
- Where
- 6 sites in United States
- Volunteers
- 450 people
- Sponsor
- Duke University
Asthma, Lung Diseases
Antibiotics in Infancy--Risk Factor for Childhood Asthma
To examine possible relationships between antibiotic use, as determined by prescriptions filled, and asthma in children ages 6 to 7.
- Trial name
- NCT00037726
- Sponsor
- Augusta University
Typhoid Fever
Typhoid Fever: Combined vs. Single Antibiotic Therapy
The current study goal is to examine the effect of Cephalosporins, Azithromycin and the combination of both on typhoid fever therapy in endemic population.
- Trial name
- NCT02224040
- Testing
- ceftriaxone, ceftriaxone and azithromycin, azithromycin
- Where
- Nepal
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Oral Bacterial Colonization, Oral Hygiene
Effects of Three Oral Hygiene Protocols on Oral Bacteria in Intensive Care Patients
Patients in intensive care may develop changes in the bacteria found in their mouths. Some of these bacteria can cause infections, and patients who cannot clean their own teeth depend on staff to provide oral care.
- Trial name
- NCT07868549
- Testing
- Mechanical Oral Hygiene, Chlorhexidine, Hexetidine
- Where
- Croatia
- Volunteers
- 86 people
- Sponsor
- University of Zagreb
Recurrent Uti
A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections
Patients with recurrent UTI were randomized to receive either the probiotic Sacchromyces Boulardii at enrollment, and the intracellularly active Ciprofloxacin with their first UTI episode after enrollment, or they received…
- Trial name
- NCT06149676
- Testing
- Saccharomyces Boulardii 250 MG [Florastor]
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Bacteremia
Study to Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Participants With Staphylococcus Aureus Bacteremia Receiving Standard-of-Care (SOC) Antibiotics
This is a Phase Ib, randomized double-blind, placebo-controlled multiple-ascending dose study to investigate the safety, tolerability, and pharmacokinetics of multiple doses of DSTA4637S when given in addition to…
- Trial name
- NCT03162250
- Testing
- DSTA4637S, SOC
- Where
- 16 sites in United States, South Korea and 1 more
- Volunteers
- 27 people
- Sponsor
- Genentech, Inc.
Tissue Expander Based Breast Reconstruction
Local Antibiotic Concentrations With Tissue Expanders in Breast Reconstruction
Infections after tissue expander breast reconstruction can lead to pain, additional surgeries, and loss of the reconstruction. This study will compare two types of antibiotic carriers used during surgery to help lower the risk of…
- Trial name
- NCT07339215
- Testing
- Antibiotic loaded calcium sulfate beads, Polymethylmethacrylate antibiotic disc
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Acute Lithiasic Cholecystitis Grade I or II, Symptoms Lasting for Less Than 5 Days
Place of Antibiotics in the Postoperative Acute Lithiasic Cholecystitis
Assess whether postoperative antibiotics after cholecystectomy for acute lithiasic cholecystitis little or moderately severe, is effective and therefore justified.
- Conditions
- Acute Lithiasic Cholecystitis Grade I or II, Symptoms Lasting for Less Than 5 Days, Required Cholecystectomy, Preoperative Amoxicillin Clavulanic Acid for at Most 5 Days
- Trial name
- ABCAL (NCT01015417)
- Testing
- Amoxicillin clavulanic acid, No medication
- Where
- 21 sites in France
- Volunteers
- 414 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Antibiotic Associated Diarrhea
Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children
Recent studies showed that intestinal microbiota consist more than thousand bacteria, and these microorganisms play the role as balance and continuity of the anatomical and functional integrity gastrointestinal tract.
- Trial name
- PEARL (NCT02765217)
- Testing
- Lactobacillus reuteri DSM 17938, Amoxicillin-Clavulanic Acid
- Where
- Turkey (Türkiye)
- Volunteers
- 1,325 people
- Sponsor
- Eskisehir Osmangazi University
Joint Infection
Or v IV Antibiotics for Infection
Management of periprosthetic joint infection (PJI) commonly includes 6 weeks of intravenous (IV) antibiotics after surgical treatment. However, there is little evidence to suggest that oral (PO) therapy results in worse outcomes.
- Trial name
- NCT04723940
- Testing
- Bactrim, Cefadroxil, Doxycycline Hcl
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Community Members
Using Social Influencers for Public Health Education on Antibiotic Use and Antimicrobial Resistance
This study aims to compare the effectiveness of health education facilitated by neighborhood food and beauty establishments with that facilitated by clinics in increasing the public's knowledge of antibiotic use and antimicrobial…
- Trial name
- NCT06998576
- Testing
- Animated educational video on antibiotic use
- Where
- Singapore
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Microbiota, Anti-bacterial Agents
Healthy Patients & Effect of Antibiotics
The objective of this study is to evaluate the impact of antimicrobial (antibiotic) exposures on the microbiome in healthy adults, specifically during and after usual courses of the antimicrobials used to treat community acquired…
- Trial name
- NCT03098485
- Testing
- Levofloxacin, Azithromycin, Cefpodoxime
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Urinary Tract Infections in Children
Oral Antibiotics Alone in Children Aged 4 Weeks to 2 Months With a Urinary Tract Infection
The goal of this prospective study is to investigate whether oral antibiotic therapy alone is feasible and safe in clinically stable children aged 4 weeks to 2 months without any past high-risk medical history with a suspected or…
- Trial name
- NCT05819229
- Testing
- Oral antibiotic therapy
- Where
- 4 sites in Denmark
- Volunteers
- 125 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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