Clinical trials: Anti-bacterial Agents
Antibiotic Resistant Infection
Merck IISP Stewardship Grant for Antibiotic Best Practices
The purpose of this study is to pilot the use of best practices alerts to enhance an antimicrobial stewardship program using the electronic medical record, EPIC.
- Trial name
- NCT01573195
- Where
- United States
- Volunteers
- 1,285 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Sepsis, Critical Illness
Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill
The purpose of the study is to characterize various healthcare practitioners' perspectives on implementation of beta-lactam therapeutic drug monitoring in critical care practice.
- Trial name
- NCT04755777
- Where
- 3 sites in United States, Australia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ventilator-associated Pneumonia
Empiric Antibiotic Therapy for Ventilator-acquired Pneumonia With Gram-negative Bacilli in Intensive Care
this study aims to verify the adequacy of doses of antibiotics prescribed in clinical practice for the treatment of ventilated acquired pneumonia (VAP) in the intensive care unit (ICU) with the pharmacodynamic efficacy criteria…
- Trial name
- TARGET-REA (NCT02127528)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontal Diseases
Antimicrobial Photodynamic Therapy Mediated by PapaMBlue® on Chronic Periodontal Disease
The elimination of the pathogenic microorganisms of the periodontal pocket is one of the main points for success in periodontal treatment.
- Trial name
- NCT03855345
- Testing
- Conventional treatment, aPDT
- Volunteers
- 20 people
- Sponsor
- University of Nove de Julho
Skin Lesion
The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions
The incidence of surgical site infection (SSI) infection in clean dermatologic surgery is very low, between 1-3%. Studies have demonstrated a much higher infection rate in skin excision surgeries in the lower limbs, up to 10% in…
- Trial name
- NCT03357419
- Testing
- Cephalexin
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Respiratory Failure
Vitamin D in Ventilated ICU Patients
The increasing rate of hospital-acquired infection and antibiotic resistance are major causes of prolonged ICU stay and death in hospitalized patients.
- Trial name
- R21 HL-110044 (NCT01372995)
- Testing
- Enteral Vitamin D3 50,000 IU, Enteral Vitamin D3 100,000IU, Inactive substance
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Muscle-Invasive Bladder Carcinoma, Radical Cystectomy
Prophylactic Antibiotics in Cystectomy With Diversion
Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of…
- Conditions
- Muscle-Invasive Bladder Carcinoma, Radical Cystectomy, Ileal Conduit, Neobladder Diversion
- Trial name
- NCT06190197
- Testing
- Prophylactic antibiotics postoperatively.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Minnesota
Skin Flora Infection
Antimicrobial Activity of IV Clear™ Dressing - Prevention of Antimicrobial Regrowth
The purpose of this study is to assess the surface cutaneous antimicrobial activity of IV Clear™ Dressing, Tegaderm CHG™ Dressing and a Silicone Vehicle Control Dressing.
- Trial name
- NCT01368120
- Testing
- IV Clear™ Dressing, Tegaderm CHG™, Silicone Vehicle Control Dressing
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Covalon Technologies Inc.
Schizophrenia
Once Weekly D-cycloserine for Schizophrenia
This is a parallel-group, placebo-controlled trial examining the cognitive effects at weeks 1, 4, \& 8 of once-weekly oral D-cycloserine 50 mg added to a stable dose of antipsychotic for 8 weeks in adult outpatients with…
- Trial name
- NCT00964041
- Testing
- D-cycloserine
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis
Phase 3 Study of Aztreonam for Inhalation Solution (AZLI) in a Continuous Alternating Therapy Regimen for the Treatment of Chronic Pseudomonas Aeruginosa Infection in Patients With CF
The primary objective of this study is to evaluate the safety and efficacy of a CAT regimen with aztreonam for inhalation solution (AZLI) and tobramycin inhalation solution (TIS) in adult and pediatric subjects with cystic…
- Trial name
- AZLI CAT (NCT01641822)
- Testing
- AZLI, Tobramycin inhalation solution
- Where
- 71 sites in United States
- Volunteers
- 107 people
- Sponsor
- Gilead Sciences
Antimicrobial Susceptibility Testing, Triple Therapy
Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer.
- Trial name
- NCT03139253
- Testing
- amoxicillin, clarithromycin, tinidazole
- Volunteers
- 120 people
- Sponsor
- Yanqing Li
Tonsillitis Acute, Pneumonia - Bacterial
Comparative Study of Adherence to Antibiotic Therapy Among Pediatric Patients: Hospital Emergency Department vs. Primary Care Center
This study was initiated because of the limited litterature available on this topic. The objective was to compare adherence to antibiotic therapy among a pediatric population treated in two healthcare settings in France: the…
- Conditions
- Tonsillitis Acute, Pneumonia - Bacterial, Otitis Media Acute, Cystitis Acute
- Trial name
- ObsATBGignaUrg (NCT07711756)
- Volunteers
- 191 people
- Sponsor
- University Hospital, Montpellier
Bacterial Keratitis
Antibiotic Susceptibility of Conjunctival Bacterial Isolates From Refractive Surgery Patients
The purpose of this study is to determine the in vitro antibiotic susceptibility patterns of conjunctival bacterial flora isolated preoperatively from patients undergoing refractive surgery.
- Trial name
- NCT00707005
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Yonsei University
Pseudomonas Aeruginosa in Cystic Fibrosis
Observational Study in Cystic Fibrosis Patients Using TOBI® PODHALER® or Other FDA Approved Inhaled Antipseudomonal Antibacterial Drugs
This is a multicenter, prospective, two cohort, observational study over a 5-year period in Cystic Fibrosis (CF) patients with chronic Pseudomonas aeruginosa infection.The study will collect data over 1 year on respiratory…
- Trial name
- NCT02449031
- Testing
- TOBI® PODHALER®, TOBI®, Bethkis®
- Where
- 47 sites in United States
- Volunteers
- 409 people
- Sponsor
- Mylan Inc.
Chronic Bronchitis
A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis (AECB)
This trial is a research drug study to compare the effects of two antibiotics for the treatment of acute exacerbation of chronic bronchitis
- Trial name
- NCT00254566
- Testing
- Moxifloxacin, Azithromycin SR
- Where
- 34 sites in China, Malaysia and 4 more
- Volunteers
- 398 people
- Sponsor
- Pfizer
Antibiotic Pharmacokinetics
Pharmacokinetics of Piperacillin and Meropenem in ICU Patients
The purpose of the study is to characterize the pharmacokinetics of meropenem and piperacillin in ICU-patients at the time of the first dose administration and to contrast that with the same measurements obtained in the same…
- Trial name
- NCT05134298
- Testing
- Piperacillin/tazobactam, Meropenem
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska University Hospital
Bacterial Infections
ANti-infective Stewardship Using the Wisca Tool in the Electronic Medical Record
Beginning in the mid-to late 1980s and accelerating through the 1990s and 2000s the shield of antibiotic invincibility began to crack sufficiently so that it was apparent to everyone we faced a serious problem.
- Trial name
- ANSWER (NCT03397433)
- Testing
- Information Technology physician assist
- Where
- United States
- Volunteers
- 9,673 people
- Sponsor
- Endeavor Health
Bloodstream Infection, Antibiotic Resistant Strain
Bloodstram Infections in ICU. Single Centre Observational Study.
Hospital-acquired bloodstream infection (BSI) is serious care problem worldwide associated with significant morbidity and mortality.
- Conditions
- Bloodstream Infection, Antibiotic Resistant Strain, Intensive Care Unit
- Trial name
- NCT04926935
- Testing
- Microbiological analysis of blood samples.
- Where
- Poland
- Volunteers
- 3,502 people
- Sponsor
- Military Institute od Medicine National Research Institute
Non-Tuberculous Mycobacterial Pneumonia
Prolonged-Use of Inhaled Gaseous Nitric Oxide (gNO) for Adult With Non-Tuberculous Mycobacteria Infection
An open labeled Study (NCT03331445) is demonstrating encouraging safety and efficacy results for most subjects receiving 160ppm nitric oxide gas (gNO) for treatment of non-tuberculous mycobacteria (NTM) over a 15 day treatment…
- Trial name
- NCT03473314
- Testing
- Nitric Oxide gas at 160ppm
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.