Clinical trials: Antibiotic
Antibiotic Stewardship, Overactive Bladder
Antibiotic Usage Prior to OnabotulinumtoxinA Injection
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is…
- Conditions
- Antibiotic Stewardship, Overactive Bladder, Onabotulinumtoxin A, UTI
- Trial name
- NCT04754737
- Testing
- No antibiotic, Prophylactic antibiotic, cystoscopic injection of onabotulinumtoxinA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Chronic Rhinosinusitis (Diagnosis)
Comparison of Topical Therapies in Post op Endoscopic Sinus Surgery Patients
The goal of the study is to compare postoperative symptom scores and endoscopy findings between in patients who receive either nasal saline rinses, saline + budesonide, and saline + topical antibiotics and budesonide following…
- Trial name
- NCT03303677
- Testing
- Saline Nasal, Budesonide Nasal, Topical Antibacterial (Product)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
ATC/DDD, Antibiotic Utilization
Using the ATC/DDD to Monitor Antibiotic Use at Lower Primary Care Facilities in Southwestern Uganda
This is a non blinded two arm cluster randomized control trial, aimed at assessing the feasibility of using the Anatomical Therapeutic Chemical Classification/define Daily Doses system tool to monitor antibiotic use at lower…
- Trial name
- NCT04782011
- Testing
- ATC/DDD
- Where
- Uganda
- Volunteers
- 1,406 people, healthy volunteers welcome
- Sponsor
- Makerere University
Diarrhea., Pneumonia.
The Effectiveness of Co-packaging With Zinc to Improve Treatment of Diarrhea and Pneumonia in Guatemala
This project applies a randomized community design to test the effectiveness of health center level co-packaging and counseling messages to improve provider and caregiver behavior in the treatment of diarrhea with zinc \& oral…
- Trial name
- Zinc10 (NCT02044107)
- Testing
- Co-packaging and counseling messages
- Where
- Guatemala
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Center for Studies of Sensory Impairment, Aging and Metabolism
Diarrhea
Impact of Bismuth Subsalicylate on Antimicrobial Use Among Adult Diarrhea Outpatients--Pakistan
The purpose of this study is to learn whether bismuth subsalicylate can reduce use of antibiotics among adults with diarrhea in Pakistan.
- Trial name
- NCT02047162
- Testing
- Bismuth subsalicylate
- Where
- Pakistan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Vaccination Failure
EXTENSION OF THE EUROPEAN E-BUG PROJECT
Bacterial resistance to antibiotics is a growing concern in Europe, vaccination coverage is inadequate, and young adults, who are the highest antibiotic consumers, have the lowest level of knowledge.
- Trial name
- Ext EBUG (NCT03683732)
- Testing
- Individual semi-structured interviews
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Psoriasis
Characterization of Cutaneous Microbiota in the Psoriasis Pathogenesis
The skin harbors a complex and dynamic microbiota constituted by numerous microorganisms that live in symbiosis with the host. The specific etiology of psoriasis is still not-well understood; nonetheless several studies…
- Trial name
- MICROBIOTA (NCT03475914)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Plaque Induced Gingivitis, Plaque, Dental
Antibacterial Effect of Paradontax Toothpaste
The purpose of the study is to test the antibacterial effect of Parodontax toothpaste on plaque formation, and thus gingivitis compared to placebo toothpaste.
- Trial name
- NCT05441371
- Testing
- Toothpaste; Paradontax
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Sting
Trial to Test if Antibiotic Ointments & Cream Will Sting After Application on a Minor Wound After Tape Stripping Injury
The purpose of this study is to have subjects report whether or not several antibiotic products sting when they are applied to minor wounds created on the inner arms.
- Trial name
- NCT02320695
- Testing
- Saline, Isopropyl Alcohol, Pain Relieving Cream
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Neonatal Sepsis
Use of Probiotics to Reduce Infections, Death and ESBL Colonisation
This study examines the effect of oral probiotic treatment to newborns on preventing hospitalizations, death and colonization with Extended-spectrum beta-lactamase-producing Gram negative bacteria.
- Trial name
- ProRIDE (NCT04172012)
- Testing
- Labinic (R) probiotic mixture
- Where
- Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Haydom Lutheran Hospital
Resorption of Tooth or Root
Clinical & Radiographic Evaluation of LSTR in Non-vital Primary Molars Using Two Different Vehicles
LSTR will be done for primary teeth with significant root resorption needing non-vital pulp therapy to save such teeth for up to 12 months.
- Trial name
- LSTR (NCT05079802)
- Testing
- Double antibiotic paste mixed with chitosan nanoparticles, Double antibiotic paste mixed with propylene glycol
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Lyme Disease, Lyme Neuroborreliosis
PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics
Overview PEMF Therapy for relief or reduction of lingering symptoms after antibiotic treatment of Lyme disease of participants in the UK.
- Conditions
- Lyme Disease, Lyme Neuroborreliosis, Lyme Arthritis, Unknown Origin Fever
- Trial name
- PEMF (NCT04577053)
- Testing
- Scientific Consciousness Interface Operations (SCIO) Class II FDA approved medical device
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kasey Phifer
Rhinosinusitis
Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents
Chronic rhinosinusitis (CRS) is common disorder which affects up to 13% of the US population. CRS affects numerous Quality of Life (QOL) factors including smell, sleep and communication.
- Trial name
- NCT00948519
- Testing
- Laser + ICG, Laser only
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York Head & Neck Institute
Pregnancy Preterm, Pregnancy Prom
Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age
A randomized, controlled, non-placebo trial to primarily assess the effect of oral, outpatient antibiotics (i.e., azithromycin and amoxicillin) on latency (i.e., proportion of patients that deliver within 28 days from membrane…
- Conditions
- Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy), PROM (Pregnancy)
- Trial name
- NCT05345457
- Testing
- Azithromycin Pill, Amoxicillin Pill
- Where
- 3 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Healthy
To Demonstrate the Relative Bioequivalence of Cefdinir and Omnicef 300 mg Capsule Fasting Conditions
To demonstrate the relative bioequivalence of Cefdinir and Omnicel 300 mg capsule fasting conditions.
- Trial name
- NCT00882700
- Testing
- Cefdinir 300 mg Capsule (Sandoz, Austria), Omnicef Cefdinir 300 mg Capsule (Abbott Laboratories, USA)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sandoz
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
The study proposes to assess the effect of multiple applications of antimicrobial Photodynamic Therapy (aPDT) as an adjunct to non-surgical periodontal treatment (nsPT) in smokers without use of antibiotics.
- Trial name
- NCT03039244
- Testing
- Photodynamic therapy, Control Group, Diode Laser
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cholecystitis; Acute, With Cholelithiasis
Is an Antibiotic Prescription Required After Laparoscopic Cholecystectomy
The need for antibiotics to reduce surgical site infection after cholecystectomy for acute calculous cholecystitis is still controversial.
- Trial name
- NCT04290104
- Testing
- 1gr oral ampicillin/sulbactam group
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Gingival Diseases, Caries
Short- and Long Term Antibacterial Effects of a Single Rinse With Different Mouthwashes: a Randomized Clinical Trial
Objectives: To reduce the microbial level in the aerosol created during dental procedures is essential in avoiding infections. The aim of this study was to examine the change of Streptococcus mutans (S.
- Trial name
- NCT05178823
- Testing
- Chlorhexidine mouthwash
- Where
- Hungary
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Antimicrobial Prescribing Practices, Antimicrobial Resistance (AMR)
Development and Implementation of Mobile Antibiograms to Optimize Empirical Antibiotic Prescriptions Among Prescribers in Tertiary Hospitals in Tanzania
Antimicrobial resistance (AMR) is a critical issue, especially in Africa, with resistance to common antibiotics reaching 100% in some areas.
- Trial name
- AMR; AMU; DDD (NCT07393308)
- Testing
- Mobile antibiogram application, standard of care
- Where
- 2 sites in Tanzania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Muhimbili University of Health and Allied Sciences
Joint Infection
Or v IV Antibiotics for Infection
Management of periprosthetic joint infection (PJI) commonly includes 6 weeks of intravenous (IV) antibiotics after surgical treatment. However, there is little evidence to suggest that oral (PO) therapy results in worse outcomes.
- Trial name
- NCT04723940
- Testing
- Bactrim, Cefadroxil, Doxycycline Hcl
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics