Clinical trials: Antibiotic Side Effect
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Affecting Blood Constituents
Antibiotic Concentrations After MassivE Transfusion Study
Combat and civilian trauma frequently result in open wounds that are at risk for infection. Data from the Department of Defense Trauma Registry demonstrate that 74% of combat trauma casualties have an open wound.
- Trial name
- ACME (NCT06699901)
- Testing
- Massive Transfusion Group, Control Group
- Where
- 2 sites in United States
- Volunteers
- 417 people
- Sponsor
- Brooke Army Medical Center
Surgical Site Infection, Capsular Contracture Associated With Breast Implant
Postoperative Antibiotics Following Primary and Secondary Breast Augmentation
Postoperative antibiotics are routinely used for implant-based breast augmentation at the investigators' institution. From 2017-2019, the investigators' institution has conducted approximately 270 primary and secondary breast…
- Conditions
- Surgical Site Infection, Capsular Contracture Associated With Breast Implant, Antibiotic Resistant Infection, Antibiotic Side Effect
- Trial name
- NCT04834310
- Testing
- Cefazolin, Cephalexin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Antibiotic Side Effect
Probiotics in Primary Care
Antibiotics are lifesaving medicines and generally safe, yet unwanted side effects are common. While destroying illness-causing 'bad' bacteria, antibiotics can upset the protective 'good' bacteria in the body.
- Trial name
- NCT01254097
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Milton S. Hershey Medical Center
Antibiotic Side Effect
Prevention of Cefoperazone-induced Coagulopathy
Evaluating the effect of prophylactic doses of vitamin K in preventing the adverse effect of cefoperazone/sulbactam induced coagulopathy in critically ill patients.
- Trial name
- NCT05742295
- Testing
- Vitamin K
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Helwan University
Sepsis, Sepsis Bacterial
Molecular Culture for the Diagnosis of Pediatric Sepsis
Babies and children have an increased risk of getting an infection with a bacteria in the bloodstream (sepsis). It is often difficult for the doctor to determine whether a child has an infection of the bloodstream, because the…
- Conditions
- Sepsis, Sepsis Bacterial, Sepsis, Neonatal, Infection, Bacterial
- Trial name
- CHAMPIONS (NCT06018792)
- Testing
- Molecular Culture
- Where
- 2 sites in Netherlands
- Volunteers
- 1,835 people
- Sponsor
- Jip Groen
Early-Onset Neonatal Sepsis, Antibiotic Side Effect
Individualized Duration of Antibiotic Treatment in Early Onset Infection in Newborns.
A nationwide multicenter open label randomized controlled non-inferiority trial, including 18 departments. The study aims to compare an individualized antibiotic treatment duration with standard seven days of antibiotic treatment…
- Trial name
- DurATi-n (NCT05329701)
- Testing
- Individualized treatment duration strategy
- Where
- Denmark
- Volunteers
- 488 people
- Sponsor
- Ulrikka Nygaard
Chronic Rhinosinusitis (Diagnosis), Antibiotic Side Effect
Effect of Topical Sinonasal Antibiotics
In this study, patients who have had previous endoscopic sinus surgery and present with an acute exacerbation of chronic rhinosinusitis will be offered endoscopic-guided, culture-directed antibiotic therapy.
- Trial name
- NCT03935828
- Testing
- Oral versus topical antibioitics
- Sponsor
- United States Naval Medical Center, San Diego
Antibiotic Side Effect
The Effect of Probiotic Supplement on Urinary D-lactic Acid Level in Newborns
It is thought that prophylactic enteral probiotics in newborns may play a role in the prevention of infection and NEC-related morbidity by preventing bacterial migration in the mucosa, reducing their number by competing with…
- Trial name
- NCT04620629
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- H. Tolga Çelik
Gut Microbiome, Antibiotic Side Effect
Endoscopic Assessment and Prediction of Microbiome-modifying Interventions
The investigators would like to examine the extent of gut microbiome rehabilitation in healthy people after the consumption of antibiotics. Outcomes of probiotic treatment versus bacteriotherapy will be compared.
- Trial name
- microbiome (NCT03218579)
- Testing
- Probiotic treatment, Bacteriotherapy
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Postoperative Complications, Antibiotic Reaction
Complications After Lower Third Molar Surgery
Surgical removal of impacted mandibular wisdom teeth is a frequent intervention, usually accompanied by unpleasant sequelae (pain, swelling and trismus) in the postoperative period, sometimes even with possibly serious…
- Conditions
- Postoperative Complications, Antibiotic Reaction, Antibiotic Side Effect, Antibiotic Resistant Infection
- Trial name
- NCT05027893
- Testing
- Moxifloxacin 400 mg Oral Tablet, Cefixime 400 mg Oral Tablet
- Where
- Serbia
- Volunteers
- 157 people
- Sponsor
- University of Novi Sad
Drug-Related Side Effects and Adverse Reactions, Treatment Adherence and Compliance
Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)
Bone and joint infections (BJI) are most often bacterial infections that can occur after surgery or de novo. They are rarely fatal in the short term, but are associated with significant morbidity, impaired quality of life and…
- Trial name
- OTABIO (NCT05202964)
- Testing
- Tolerance and adherence to oral antibiotics in patients managed for BJI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Antimicrobial Stewardship, Antibiotics Causing Adverse Effects in Therapeutic Use
A Multimodal Intervention to Optimise Antimicrobial Use in Residential Aged Care Facilities (ENGAGEMENT Study)
The antimicrobial stewardship ENGAGEMENT study aims to deliver a bundle of interventions, including education of GPs and nursing staff, guideline implementation and telehealth support for 18 residential aged care facilities…
- Trial name
- ENGAGEMENT (NCT04705259)
- Testing
- Antimicrobial Stewardship ENGAGEMENT bundle
- Where
- 4 sites in Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Side-effect of Antibiotic
Penetration of Moxifloxacin Into Liver Tissue of Patients Undergoing Liver Resection.
The aim of the study is to provide data on the pharmacokinetics (PK) of moxifloxacin (MXF) in serum and liver tissue of patients undergoing liver resection due to primary or secondary tumor of the liver.
- Trial name
- MOXI (NCT01302951)
- Testing
- Moxifloxacin 400 mg
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University Hospital, Saarland
Antibiotic Side Effect
The Impact of Probiotic Supplementation on Antibiotic Induced Changes in Gastrointestinal Function And/or Faecal Microbiota Composition
To investigate whether probiotic supplementation during the consumption of oral antibiotics can impact gastrointestinal responses and/or the regrowth of the gut microbiota.
- Trial name
- FANTIB (NCT05355571)
- Testing
- LAB4 + Saccharomyces boulardii
- Where
- Bulgaria
- Volunteers
- 50 people
- Sponsor
- Cultech Ltd
Ear Infection Bacterial, Surgical Site Infection
Use of Preoperative and Postoperative Antimicrobial Treatment
In this study, patients undergoing ear surgery (cochlear implantation, stapedotomy, tympanoplasty) will be randomized to one of two antibiotic treatment groups.
- Conditions
- Ear Infection Bacterial, Surgical Site Infection, Antibiotic Side Effect
- Trial name
- NCT04707092
- Testing
- Antibiotic
- Where
- Canada
- Volunteers
- 304 people
- Sponsor
- Sunnybrook Health Sciences Centre
Orthopedic Devices Associated With Misadventures, Infection, Surgical Site
Short Against Long Antibiotic Therapy for Infected Orthopedic Sites
The investigators will perform two concomitant RCTs, depending on the presence of infected osteosynthesis material at enrolment: SALATIO 1. Infected implant not removed (or new material inserted): Randomization 6 vs.
- Conditions
- Orthopedic Devices Associated With Misadventures, Infection, Surgical Site, Antibiotic Side Effect
- Trial name
- SALATIO (NCT05499481)
- Testing
- Antibiotic
- Where
- Switzerland
- Volunteers
- 495 people
- Sponsor
- Balgrist University Hospital
Antibiotics Causing Adverse Effects in Therapeutic Use
De-Implementation of Inappropriate Antimicrobial Use After Cardiac Device Procedures
This project will use automated audit and feedback to improve compliance with antimicrobial prophylaxis guidelines for CIED procedures that we anticipate will translate into better outcomes for our patients.
- Trial name
- CIED (NCT05020418)
- Testing
- Chart Review
- Where
- United States
- Volunteers
- 5,469 people
- Sponsor
- VA Office of Research and Development
Urinary Tract Infection
Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder
Although clean intermittent catheterization (CIC) remains the mainstay to ensure complete low-pressure bladder emptying in neurogenic bladder (NB) patients, this forms a vehicle for bacterial entry and colonization of the urinary…
- Trial name
- NCT02044965
- Testing
- Antibiotic, Probiotic
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- London Health Sciences Centre
Antibiotics Causing Adverse Effects in Therapeutic Use
To Investigate the Multiple Dose Safety, Tolerability and Pharmacokinetics of WCK 4282 (FEP-TAZ)
To evaluate the safety, tolerability and pharmacokinetics (PK) of multiple IV doses of FEP-TAZ 4 g (2 g cefepime + 2 g tazobactam) administered every 8 hours (q8h) in healthy adult volunteers for 10 days.
- Trial name
- NCT03622008
- Testing
- FEP-TAZ 4 g
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wockhardt
Antibiotic Side Effect, Probiotics
Effectiveness and Safety of Lactobacillus Acidophilus LA85 in Preventing Antibiotic-Associated Diarrhea
This randomized, placebo-controlled, double-blind clinical trial aims to evaluate the efficacy and safety of probiotics as food supplements in preventing antibiotic-associated diarrhea.
- Conditions
- Antibiotic Side Effect, Probiotics, Diarrhea
- Trial name
- NCT05974657
- Testing
- Probiotic Lactobacillus acidophilus LA85
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Wecare Probiotics Co., Ltd.