Clinical trials: Antibiotic Usage
Opioid Use Disorder
Determining the Feasibility of Outpatient Parenteral Antibiotic Therapy for Persons Who Inject Opioids
Patients with a history of injection drug use are historically excluded from home outpatient parenteral antibiotic therapy programs.
- Trial name
- NCT05300581
- Testing
- OPAT for PWID
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Increased Drug Resistance, Infection Resistant to Quinolones and Fluoroquinolones
Change in Ocular Flora Resistance From Repeated Topical Antibiotic Use
The purpose of this study is to determine if antibiotic resistance of the ocular surface flora to the 4th generation fluoroquinolones will increase after repeated use of topical antibiotics for three days post intravitreal…
- Trial name
- NCT01181713
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sepsis, Bacteremia
Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture.
The objective of this study is to evaluate the consumption of antimicrobial therapy in patients comparing a rapid molecular test (PCR in Real-Time Multiplex) with blood cultures to identify the etiological agents of sepsis.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NCT01450358
- Testing
- Antibiotic regimen
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto do Coracao
Carbapenem-Resistant Enterobacteriaceae Infection, KPC
Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infections
This is an observation study comparing prospective use of Imipenem/Cilastatin/Relebactam (IMI/REL) to retrospective data using Meropenem/Vabobactam (MVB)and Ceftazidime/Avibactam CZA) in treatment of Klebsiella Producing…
- Conditions
- Carbapenem-Resistant Enterobacteriaceae Infection, KPC, Gram-Negative Bacterial Infections, Antibiotic Resistant Infection
- Trial name
- NCT04785924
- Testing
- Imipenem+Relebactam
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Neonates
Optimizing Antibiotic Use in Neonatal Intensive Care Units in China
This project aims to reduce antibiotic use in Chinese neonatal intensive care units (NICU) by 1) developing an adaptable framework of NICU-targeted antimicrobial stewardship programs (ASP); 2) implementing the NICU-targeted ASP…
- Trial name
- NCT05073549
- Testing
- Collaborative Antimicrobial Stewardship Program (ASP)
- Where
- 26 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Children's Hospital of Fudan University
Peri Implant Mucositis, Dental Implant Rehabilitation
Home-Use Dual-Light Antibacterial Photodynamic Therapy for Peri-Implant Mucositis in Full-Arch Implant Prostheses
The goal of this clinical trial is to learn whether a home-use light device helps control gum inflammation around dental implants in adults who have a full set of fixed teeth attached to implants.
- Conditions
- Peri Implant Mucositis, Dental Implant Rehabilitation, Prosthesis and Implant Dentistry, Implant Supported Prosthesis
- Trial name
- NCT07763431
- Testing
- Dual-light antibacterial photodynamic therapy, Supportive peri-implant care
- Where
- Vietnam
- Volunteers
- 24 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Congenital Malformations
Maternal Use of Antibiotics and the Risk of Congenital Malformations
Antibiotics are widely used during pregnancy to prevent or treat infections, yet concerns remain regarding their fetal safety. Drawing on data from spontaneous reporting databases and cohort studies, this study aims to explore…
- Trial name
- NCT06770465
- Testing
- Different categories of antibiotics
- Where
- China
- Volunteers
- 850,000 people
- Sponsor
- West China Hospital
Hospital Acquired Infection
Effect of Copper Impregnated Textiles on Healthcare Associated Infections and Antibiotic Use
This is a prospective Infection Control study comparing rates of antibiotic usage and infections in the General Intensive Care Unit (GICU) in beds with copper impregnated linens versus regular linens.
- Trial name
- NCT02351895
- Testing
- Copper impregnated linen
- Where
- United States
- Volunteers
- 1,302 people
- Sponsor
- Eastern Virginia Medical School
Bacterial Infections
PROcalcitonin Reduce Antibiotic Treatments in Acute-Ill Patients (PRORATA)
The study is a prospective, randomized, controlled intervention trial conducted in 9 centers, comparing a conventional strategy versus a PCT-guided strategy to start or to discontinue antibiotics, in patients with suspected…
- Trial name
- PRORATA (NCT00472667)
- Testing
- Procalcitonin guided strategy
- Where
- France
- Volunteers
- 630 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Resistance Bacterial, Increased Drug Resistance
Decreasing Irrational Antimicrobial Use in Bangladesh: A Digital Intervention Program
We developed 'SmartAMR', a digital pharmacy system featuring real-time records, symptom checks, telemedicine, counselling, and medication reminders.
- Conditions
- Resistance Bacterial, Increased Drug Resistance, Drug Resistance, Microbial
- Trial name
- SmartAMR (NCT06313619)
- Testing
- SmartAMR
- Where
- Bangladesh
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Supracondylar Humerus Fracture, Post Operative Wound Infection
Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS)
The aim of this study is to determine if antibiotics affect the outcome after percutaneous surgery for pediatric supracondylar humerus fractures.
- Trial name
- NCT03261830
- Testing
- Cefazolin, Clindamycin, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Sumit Gupta
Infection Rate After Fingertip Amputation
Prophylactic Antibiotic in Treatment of Fingertip Amputation
Fingertip amputation is a common injury. Considerable controversy exists as to whether prophylactic antibiotics are necessary for this injury.
- Trial name
- NCT02077400
- Testing
- Cephazolin
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Ulcerative Colitis, Inflammatory Bowel Diseases
Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis
The study is planned as a randomised control trial to study the adjuvant use of antibiotics (ceftriaxone and metronidazole) to achieve a clinical response in hospitalised patients with acute severe ulcerative colitis
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Acute Severe Colitis
- Trial name
- AAASUC (NCT03794765)
- Testing
- Ceftriaxone, Metronidazole
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Respiratory Tract Infection
The Procalcitonin Guided Antibiotics in Respiratory Infections in General Practice
Antimicrobial resistance rates have reached alarming levels and the Worlds Health Organisation (WHO) states it constitutes a serious public health concern by threatening one of the most effective and mortality lowering…
- Trial name
- PARI (NCT04216277)
- Testing
- Procalcitonin
- Where
- 6 sites in Denmark
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Community-acquired Pneumonia
Combined Use of a Respiratory Broad Panel mPCR and Procalcitonin to Reduce Duration of Antibiotics Exposure in Patients With Severe Community-Acquired Pneumonia
To assess the effectiveness of a management strategy combining a broad panel respiratory mPCR and an algorithm of early antibiotic de-escalation and discontinuation based on both the mPCR results and the procalcitonin…
- Trial name
- MULTI-CAP (NCT03452826)
- Testing
- Antibiotic therapy according to the result of mPCR (device)
- Where
- France
- Volunteers
- 411 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polycystic Ovarian Syndrome (PCOS), Irregular Menstrual Cycles
Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome
The purpose of this study is to study the effect of a commonly used antibiotic, doxycycline, on the production of ovarian hormones and menstrual cycles in women with Polycystic Ovarian Syndrome (PCOS).
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Irregular Menstrual Cycles, Androgen Excess
- Trial name
- MI-PCOS (NCT01788215)
- Testing
- doxycycline, Sugar Pill
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Acute Infection
Short-Term Use of Antibiotics and Adherence Level
Objectives: To evaluate the impact of educational intervention on antibiotic short-term adherence . Methods: A prospective randomized controlled study was conducted in a tertiary hospital in Jordan.
- Trial name
- NCT05293977
- Testing
- Routine care by the dispensing pharmacist, Pharmaceutical education/counseling about prescribed antibiotic
- Where
- Jordan
- Volunteers
- 589 people
- Sponsor
- Jordan University of Science and Technology
Cystitis Acute, Antibiotic Resistant Infection
Dipsticks and Microscopy to Reduce Antibiotic Use in Women's Urinary Tract Infections: a Pilot Trial (MicUTI)
With the aim to pilot a full-scaled trial to reduce unnecessary antibiotics in women with suspected uncomplicated urinary tract infections, twenty general practices in Bavaria, Germany, will be randomized to deliver patient…
- Conditions
- Cystitis Acute, Antibiotic Resistant Infection, Medication Adherence, Urinary Tract Infection Bacterial
- Trial name
- MicUTI (NCT05667207)
- Testing
- Point-of-care microscopy and dipstick guided management
- Where
- 2 sites in Germany
- Volunteers
- 154 people
- Sponsor
- Wuerzburg University Hospital
Community Acquired Pneumonia
Bacterial Pneumonia Score (BPS) Guided Antibiotic Use in Children With Pneumonia and Pneumococcal Vaccine
The aim of this study is to test if BPS (Bacterial Pneumonia Score) guided antibiotic use in children with non severe community acquired pneumonia (CAP) and pneumoccocal vaccine will reduce antibiotic use as compared to standard…
- Trial name
- NCT01875731
- Testing
- BPS, Guideline
- Where
- Argentina
- Volunteers
- 66 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde