Clinical trials: Antibiotics Resistance
Resistance Bacterial
Impact of Antimicrobial Stewardship Programs in the Global Setting
Antimicrobial resistance is one of the greatest threats to human health, and is driven by inappropriate antimicrobial use. Antimicrobial stewardship programs (ASPs) improve the use of antimicrobials in hospitals.
- Trial name
- PEARL (NCT03382470)
- Testing
- Antimicrobial stewardship advice
- Where
- Sri Lanka
- Volunteers
- 3,115 people
- Sponsor
- Duke University
Antibiotic Side Effect, Antibiotic Resistant Infection
Antibiotic Use and Resistance KAP Among Dental Interns
The study is designed as a cross-sectional online-based questionnaire, and it will be distributed among dental interns. Assess the following among dental interns (1) The knowledge, attitude, and practices (KAP) towards…
- Trial name
- NCT06383637
- Volunteers
- 343 people
- Sponsor
- Cairo University
Antimicrobial Resistance, Neonatal Sepsis
Microbiology, Antimicrobial Resistance and Outcomes of Neonatal Sepsis in China
Neonatal sepsis remains one of the most important cause of mortality and morbidities in China. This study will establish a prospective registral cohort of all infants with culture-proven neonatal sepsis in Chinese NICUs…
- Trial name
- NCT05089760
- Testing
- No intervention
- Volunteers
- 1,200 people
- Sponsor
- Children's Hospital of Fudan University
Infection Resistant to Drugs, Gram-Negative Bacterial Infection
Burden of Antibiotic Resistance in Gram-Negative Infections in Dutch Hospitals
This study aims to assess how large an additional disease burden and what extra costs are generated by antibiotic resistance in patients suffering from infections caused by gram-negative bacteria, such as Escherichia coli and…
- Trial name
- GRAND-ABC (NCT02007343)
- Where
- 8 sites in Netherlands
- Volunteers
- 3,895 people
- Sponsor
- UMC Utrecht
NSCLC (Advanced Non-small Cell Lung Cancer)
Oral Pooled Fecal Microbiotherapy (MaaT033) Concomitant to Cemiplimab Versus Best Investigator's Choice in Patients With Resistance to Treatment Due to Antibiotics Uptake With Advanced Non-small Cell Lung Cancer
The goal of IMMUNOLIFE2 is to overcome primary resistance to immune checkpoint inhibitors (ICIs), such as pembrolizumab or nivolumab used alone or in combination with chemotherapy, observed in patients with advanced non-small…
- Trial name
- IMMUNOLIFE2 (NCT07001618)
- Testing
- MaaT033 capsule, Cemiplimab, Cisplatin
- Where
- 6 sites in France
- Volunteers
- 162 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Increased Drug Resistance, Infectious Diseases
Reducing Inappropriate Antibiotic Prescribing by Primary Care Clinicians
Hypotheses and Specific Aims: The continued emergence of antibiotic-resistance in the outpatient setting underlines the need to responsibly manage antimicrobial prescribing.
- Trial name
- NCT01099943
- Testing
- Intervention: Education, Decision Support Tools
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Helicobacter Pylori Infection
Study of Levofloxacin-based Concomitant Therapy for H. Pylori Eradication in Diabetic Patients
The study aims to evaluate H. pylori eradication rate in diabetic patients by using novel 10-day levofloxacin-based concomitant therapy compared with conventional 10-day sequential therapy.
- Trial name
- NCT02466919
- Testing
- Pantoprazole, Amoxicillin, Metronidazole
- Volunteers
- 114 people
- Sponsor
- Chung-Tai Wu
Antibiotic Resistance, Bacterial
Antibiotic Resistance in Danish EDs.
The spread of multiresistant bacteria is an increasing problem which will mean increased costs, morbidity and mortality in the coming years.
- Trial name
- AB-RED (NCT03352167)
- Where
- 8 sites in Denmark
- Volunteers
- 5,117 people
- Sponsor
- University of Southern Denmark
Acute Pyelonephritis Without Severity Symptoms Due to ESBL-producing E.Coli
Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli
Escherichia coli is the primary cause of urinary tract infections and Gram-negative bacteremia worldwide. Since the early years of the 21st century, E.coli has acquired a new mechanism of resistance to antibiotics: extended…
- Trial name
- FOXICOLI (NCT01820793)
- Testing
- Cefoxitin
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Vascular Surgical Antibiotic Prophylaxis Study (VSAPS 2)
The current recommended antibiotic, Cefazolin, treatment for vascular surgery, provides coverage only for Methicillin-Sensitive Staphylococcus Aureaus (MSSA), other gram-positive bacteria, and some gram-negative bacteria which…
- Trial name
- NCT01612052
- Testing
- Antibiotic Prophylaxis
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Acute Uncomplicated Diverticulitis
APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)
The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice.
- Trial name
- NCT07492134
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, Metronidazole, Cefuroxime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Bacterial Pneumonia
Comparative Study of Ceftaroline vs. Ceftriaxone in Adult Subjects With Community-Acquired Pneumonia
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of Community-Acquired Pneumonia
- Trial name
- CAP (NCT00621504)
- Testing
- Ceftaroline fosamil for Injection, IV Ceftriaxone, Clarithromycin
- Where
- 168 sites in United States, Argentina and 21 more
- Volunteers
- 606 people
- Sponsor
- Forest Laboratories
Keratitis, Ulcerative, Antibiotic Resistance, Microbial
Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis
This clinical study was conducted to evaluate the efficacy and safety of gold-silver cuprous oxide composite nanogels combined with photothermal therapy system in the treatment of severe drug-resistant bacterial keratitis…
- Conditions
- Keratitis, Ulcerative, Antibiotic Resistance, Microbial, Photothermal Therapy
- Trial name
- NCT05268718
- Testing
- Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel, Voriconazole eye drops, Normal saline
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection.
Clarithromycin (CLA)、amoxicillin (AMO)、metronidazole (MET)、levofloxacin (LEV) and tetracycline (TET) are commonly used antibiotics for Helicobacter pylori (Hp) therapy.
- Trial name
- NCT03583476
- Testing
- Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole
- Where
- Taiwan
- Volunteers
- 1,821 people
- Sponsor
- National Taiwan University Hospital
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Respiratory Tract Infections, Corona Virus Infection
Inhaled Gaseous Nitric Oxide (gNO) Antimicrobial Treatment of Difficult Bacterial and Viral Lung (COVID-19) Infections
Non tuberculous mycobacteria (NTM), Burkholdria spp, Aspergillus in the lung are almost impossible to eradicate with conventional antibiotics. In addition COVID-19 has know current treatment.
- Trial name
- NCT03331445
- Testing
- Nitric Oxide 0.5 % / Nitrogen 99.5 % Gas for Inhalation
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Chris Miller
Mortality, Antimicrobial Resistance
Azithromycin for Child Survival in Niger II
Several randomized controlled trials have demonstrated that azithromycin mass drug administration (MDA) reduces child mortality, but increases antimicrobial resistance (AMR).
- Trial name
- AVENIR II (NCT06358872)
- Testing
- Azithromycin for Oral Suspension
- Where
- Niger
- Volunteers
- 3,300,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gram-Negative Bacterial Infections
Quantifying Gram-negative Resistance to Empiric Therapy in the Intensive Care Unit
Antimicrobial resistance is a global health emergency estimated to be responsible for 700,000 deaths per year worldwide, and it is well known that previous antibiotic exposure is the single most contributing factor.
- Trial name
- RESTART (NCT05171257)
- Testing
- IV antibiotic treatment from prior, differing IV antibiotic treatment
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- Methodist Health System
Urinary Tract Infection Complicated, Kidney Stones
Resistance Characteristics and Development of Diagnostic Model for Postoperative UTI in Patients With Kidney Stones
The combined detection of HBP, ADPN, NGAL, and hs-CRP enables the construction of a highly efficient diagnostic model, offering a novel strategy for early infection identification and risk stratification after surgery.
- Conditions
- Urinary Tract Infection Complicated, Kidney Stones, Antimicrobial Resistance
- Trial name
- NCT06946667
- Testing
- the UTI group, the Non-UTI group
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Xingxin Jiang
Bloodstream Infection Multidrug-resistant Gram-negative Bacteria
Combating Multidrug-resistant Gram-negative Bacteria in Africa Through Diagnostic and Antimicrobial Stewardship
Antimicrobial resistance (AMR) is a major threat to public health and the well-being of humans, with high mortality rates of infections caused by MDR GNB.
- Trial name
- ComBac (NCT07820332)
- Testing
- Treatment according to AMR algorithm
- Volunteers
- 1,320 people
- Sponsor
- Universität des Saarlandes