Clinical trials: Antimicrobial
Antimicrobial Resistance
Surveillance of Healthcare-associated Infections & Antimicrobial Resistance
The aims of this project, called "Surveillance of Healthcare-associated infections \& Antimicrobial Resistance", or "SHARE", are to 1) enhance laboratory capacity to detect emerging AMR patterns; 2) strengthen hospital…
- Trial name
- NCT05734391
- Testing
- Routine Infection control
- Where
- 2 sites in United States, Botswana
- Volunteers
- 642 people
- Sponsor
- University of Pennsylvania
Peri Implant Mucositis, Dental Implant Rehabilitation
Home-Use Dual-Light Antibacterial Photodynamic Therapy for Peri-Implant Mucositis in Full-Arch Implant Prostheses
The goal of this clinical trial is to learn whether a home-use light device helps control gum inflammation around dental implants in adults who have a full set of fixed teeth attached to implants.
- Conditions
- Peri Implant Mucositis, Dental Implant Rehabilitation, Prosthesis and Implant Dentistry, Implant Supported Prosthesis
- Trial name
- NCT07763431
- Testing
- Dual-light antibacterial photodynamic therapy, Supportive peri-implant care
- Volunteers
- 24 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection
Optimizing Antibiotic Prescription in STI Clinics Using Rapid POCT
Sexually transmitted infections (STIs) caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are increasing in France, with a significant proportion of asymptomatic infections.
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Sexually Transmitted Infections, Antimicrobial Resistance / Antibiotic Overuse
- Trial name
- OPTIMISE (NCT07884656)
- Testing
- cobas® Liat® CT/NG Point-of-Care Test
- Where
- 2 sites in France
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Antimicrobial Resistance (AMR)
A Digital Escape Room to Teach Medical Students About Antimicrobial Resistance Using the One Health Approach
The goal of this clinical trial is to evaluate the effectiveness of a One Health-based educational intervention in final-year medical students from two universities in Norway and Zambia. The main question it aims to answer is: 1.
- Trial name
- NCT07848217
- Testing
- AMRageddon
- Where
- 2 sites in Norway, Zambia
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Plaque, Dental, Antimicrobial
Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash
Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their…
- Conditions
- Plaque, Dental, Antimicrobial, Mouthwash, Cytotoxicity
- Trial name
- NCT04575948
- Testing
- Moringa Oleifera, Chlorhexidine mouthwash, Base formula
- Volunteers
- 90 people
- Sponsor
- Misr International University
Antimicrobial Stewardship
Evidence Based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU)
The goal of this observational study is to learn about the implementation of a process to review antimicrobial prescriptions for adult patients in Intensive Care Unit (ICU).
- Trial name
- EQUIPS-ICU (NCT06666738)
- Testing
- Structured antimicrobial review
- Where
- Vietnam
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Antimicrobial Stewardship, Antimicrobial Resistance (AMR)
A Digital Escape Room to Teach Veterinary Students About Antimicrobial Resistance Using the One Health Approach
The goal of this study is to evaluate the effectiveness of a One Health-based educational intervention in second-year medical students from the veterinary university in Norway The main question it aims to answer is: 1.
- Trial name
- NCT07864077
- Testing
- AMRageddon
- Where
- Norway
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Evaluation of Postoperative Pain and Antimicrobial Efficacy
Evaluation of Postoperative Pain and the Antimicrobial Effect of Super Oxidized Water (Microcyn) and Chlorhexidine When Compared With Sodium Hypochlorite in Teeth With Asymptomatic Necrotic Pulps. A Randomized Clinical Trial
The objective of this study is to evaluate the postoperative pain and antimicrobial efficacy when using super-oxidized water (Microcyn) and 2% Chlorhexidine as irrigating solutions in comparison to 2.5% Sodium hypochlorite in…
- Trial name
- NRS (NCT07852260)
- Testing
- super-oxidized water (Microcyn) irrigating solution, 2% chlorhexidine irrigating solution, 2.5% sodium hypochlorite
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Infectious Diseases, Antimicrobial Drug Resistance
A Phase 1 Study of the Safety and Tolerability of Single and Multiple Ascending Doses of BWC0977 in Healthy Volunteers
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of single and multiple intravenous doses of BWC0977 when administered to healthy adult volunteers.
- Trial name
- NCT07029932
- Testing
- BWC0977
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bugworks Research Inc.
Sepsis, Antimicrobial Resistance (AMR)
Implementation of a Sepsis Chart and Its Effects on Mortality Rate in Indonesian Primary Referral Hospitals
The goal of this observational study is to evaluate the effectiveness of implementing Koran Sepsis, or sepsis chart, a paper-based order set designed to guide the implementation of the One-hour Sepsis Bundle, in improving…
- Trial name
- NCT07843277
- Testing
- Sepsis chart (koran sepsis), Usual care
- Where
- 2 sites in Indonesia
- Volunteers
- 304 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Sepsis, Antimicrobial Resistance (AMR)
Molecular-based Optimization of Pathogen Identification in Sepsis Patients in the Indonesian National Referral Hospital
This study aims to compare the diagnostic performance of conventional blood culture with two molecular-based diagnostic approaches, Hybrispot DNA Flow and metagenomic next-generation sequencing (mNGS), for the identification of…
- Trial name
- INA-MOSAIC (NCT07841535)
- Testing
- Standard-of-care blood culture, Hybrispot DNA Flow, Metagenomic 16s RNA
- Where
- Indonesia
- Volunteers
- 415 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Antimicrobial Resistance (AMR), ESBL
One Health Determinants of Rectal Colonization by ESBL-Producing Enterobacterales in the Community
This multicenter cross-sectional observational study aims to determine the prevalence of rectal colonization by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales among community-dwelling adults in Argentina and…
- Conditions
- Antimicrobial Resistance (AMR), ESBL, Gut Microbiota Dysbiosis, Environmental Exposure
- Trial name
- NCT07818109
- Where
- Argentina
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Antimicrobial Resistance
Metaphors to Enhance Antibiotic Appropriate Use Knowledge and Behaviours to Reduce Educational Disparities
A randomized controlled survey experiment was conducted from October to November 2024 to assess the effectiveness of metaphor-based health education in improving Chinese parents' knowledge and behavioural intentions regarding…
- Trial name
- NCT07352371
- Testing
- metaphorical messages, conventional messages
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Bo Yan
Multidrug-Resistant Organism Infection, Healthcare-Associated Infections (HAIs)
Prevalence of Multidrug-Resistant Organism Infections in General Adult Wards in Argentina (PREV-AR 2 - IGA)
This study measures how common infections caused by multidrug-resistant organisms (MDROs) are among adult patients hospitalized in general medical and surgical wards in Argentina, and how these infections relate to in-hospital…
- Conditions
- Multidrug-Resistant Organism Infection, Healthcare-Associated Infections (HAIs), Antimicrobial Resistance (AMR)
- Trial name
- PREVAR 2-IGA (NCT07797569)
- Testing
- Observational data collection (chart review / point-prevalence survey)
- Where
- Argentina
- Volunteers
- 2,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
Surgery Complications, Surgery
SurgWeek-2: Identifying the Global Burden of Post Operative Complications: an International Prospective Cohort Study Protocol
This study aims to assess and improve the global outcomes following surgery. Every year approximately 313 million operations are performed, with 50 million people experiencing a complication and unfortunately 3.5 million people…
- Conditions
- Surgery Complications, Surgery, Global Surgery, Robotic
- Trial name
- SurgWeek-2 (NCT07785076)
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Ocular Rosacea, Antimicrobial Resistance
Ocular Rosacea Biome Study
Ocular rosacea is an inflammatory disease of the eyelids and ocular surface. Like the facial disease, the ocular condition is chronic and recurrent. Sequelae of ocular rosacea vary from mild to severe.
- Trial name
- ORBS (NCT05296837)
- Testing
- Doxycycline 40 MG ( 20mg twice daily), Doxycycline 200 MG ( 100 mg twice daily)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, San Francisco
Mortality, Antimicrobial Resistance
Azithromycin for Child Survival in Niger II
Several randomized controlled trials have demonstrated that azithromycin mass drug administration (MDA) reduces child mortality, but increases antimicrobial resistance (AMR).
- Trial name
- AVENIR II (NCT06358872)
- Testing
- Azithromycin for Oral Suspension
- Where
- Niger
- Volunteers
- 3,300,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Antimicrobial Resistance
Optimizing Antibiotics Prescription
Interventions that are low-cost, do not add substantially to the physician workload, are consistent with good physician practices and WHO guidelines, and serve as a reminder on the risks of overprescribing antibiotics are…
- Trial name
- NCT06436690
- Testing
- Diagnosis Mandate, Individualized Feedback
- Where
- 2 sites in United States, Nepal
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Penn State University
Empirical Antimicrobial Therapy, Critically Ill
Empirical Meropenem Dosing in Critically Ill Patients: Early Assessment of Plasma Exposure and Minimum Inhibitory Concentration Targets
The goal of this prospective cohort study is to characterize meropenem exposure in critically ill adult patients receiving empiric antibiotic treatment in the intensive care unit (ICU).
- Conditions
- Empirical Antimicrobial Therapy, Critically Ill, Meropenem, Pharmacokinetics and Pharmacodynamics
- Trial name
- NCT07681544
- Testing
- Blood extraction
- Where
- Argentina
- Volunteers
- 26 people
- Sponsor
- Hospital Italiano de Buenos Aires
Infection, Antimicrobial Stewardship Program
Molecular Microbiology- Guided Antimicrobial Stewardship Versus Standard Stewardship in Hospitalized Patients
The goal of this clinical trial is to learn whether integrating rapid multiplex molecular microbiology results with predefined clinical and laboratory criteria into an antimicrobial stewardship program improves antimicrobial use…
- Conditions
- Infection, Antimicrobial Stewardship Program, Antimicrobial Resistance, Multiplex PCR
- Trial name
- PROACT (NCT07684300)
- Testing
- Protocolized Antimicrobial Stewardship Strategy, Standard Antimicrobial Stewardship
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Maria Espinosa Perez