Clinical trials: Antimicrobial
Surgical Site Infections, Venous Thromboembolism
Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection
The principal aim of the present research is to compare two methods of antibiotic delivery: concomitant tumescent antibiotic delivery (TAD) and intravenous antibiotic delivery (IVAD) versus IVAD alone, (TAD+IVAD vs IVAD), with…
- Trial name
- NCT02503904
- Testing
- Concomitant Tumescent Antibiotic Delivery & IV Delivery, Subcutaneous Tumescent Infiltration, cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline)
- Volunteers
- 400 people
- Sponsor
- Klein, Jeffrey A., M.D.
Infected Total Hip or Knee Arthroplasty
Assessing Renal Function in Patients With an Antibiotic Laden Spacer
The purpose of this study is to monitor the renal function of patients who have an antibiotic laden spacer in place to treat an infected hip or knee arthroplasty.
- Trial name
- NCT01683734
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Central DuPage Hospital
Antibiotic Resistance, Bacterial
Antibiotic Resistance in Danish EDs.
The spread of multiresistant bacteria is an increasing problem which will mean increased costs, morbidity and mortality in the coming years.
- Trial name
- AB-RED (NCT03352167)
- Where
- 8 sites in Denmark
- Volunteers
- 5,117 people
- Sponsor
- University of Southern Denmark
Rhinosinusitis
Topical Antibiotic Use In Chronic Rhinosinusitis A Double-Blinded, Randomized, Placebo Controlled Study
Chronic rhinosinusitis is a pervasive and costly disease. Recent estimates describe over 20 million Americans suffering from this diagnosis at a cost of over $4.3 billion per year.
- Trial name
- NCT00669799
- Testing
- gentamyacin
- Where
- United States
- Sponsor
- University of South Florida
Acute Appendicitis
Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE)
The ALACARTE study evaluates a strategy in which patients with acute uncomplicated appendicitis are given the choice between appendectomy and antibiotic therapy alone.
- Trial name
- ALACARTE (NCT07857252)
- Testing
- Shared decision-making, amoxicillin-clavulanate, Appendectomy
- Where
- France
- Volunteers
- 560 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nosocomial Infections
Effect of Metallic Nanoparticles on Nosocomial Bacteria
This research aims to study the properties of metallic nanoparticles"MNPs" (silver nanoparticles "AgNps" and copper nanoparticles "CuNps") on the 2 most common nosocomial bacteria which are highly resistant to antibiotics…
- Trial name
- NCT04775238
- Testing
- Silver nanoparticles, Copper nanoparticles
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Early Stage Breast Cancer
Granulocyte-colony Stimulating Factors or Antibiotics for Primary Prophylaxis for Febrile Neutropenia
Taxotere-cyclophosphamide (TC) chemotherapy is commonly used as an adjuvant chemotherapy regimen in patients with resected early stage breast cancer.
- Trial name
- REaCT-TC2 (NCT02816112)
- Testing
- Ciprofloxacin, Neupogen
- Where
- Canada
- Volunteers
- 458 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Periodontitis Complex
Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.
Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics.
- Trial name
- NCT03692819
- Testing
- Amoxicillin 500 Mg, Lactobacillus reuteri Oral Drops
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Pain, Postoperative, Irreversible Pulpitis
Comparison of Nitrofurantoin and Calcium Hydroxide as Intracanal Medicaments in Alleviating Post-operative Pain
Intracanal medicaments have been frequently used in patients with endodontic and periradicular infection for the elimination of microorganisms.
- Trial name
- NCT04900571
- Testing
- Nitrofurantoin 100 MG
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Hand Infections
The Role of Antibiotics After Surgical Treatment of Simple Hand Infections: A Prospective Study
Three patient groups with simple hand infections are tested regarding the necessity of antibiotics after surgical treatment.
- Trial name
- NCT01429571
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- BG Trauma Center Tuebingen
Crohn's Disease
Study of Antibiotics in the Treatment of Colonic Crohn's Disease
Crohn's disease (CD) is a form of inflammatory bowel disease that can affect any part of the digestive system. Symptoms of this chronic illness include abdominal pain, bloating, nausea, vomiting, and diarrhea.
- Trial name
- NCT00257699
- Testing
- ciprofloxacin, metronidazole
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Mount Sinai Hospital, Canada
Bacterial Infection, Anti-infective Agents
Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction
Antibiotics are used routinely in postoperative tissue expander based breast reconstruction (TE) and autologous flap (AF) breast reconstruction procedures.
- Conditions
- Bacterial Infection, Anti-infective Agents, Breast Implantation
- Trial name
- NCT01244698
- Testing
- Cefadroxil discontinued early, Cefadroxil until drain removal
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Obstetric Complication, Postpartum Hemorrhage
Antibiotics During Intrauterine Balloon Tamponade Placement
The goal of this study is to identify whether antibiotics given at the time of placement of an intrauterine balloon tamponade (IBT) will result in reduction of the risk of endometritis.
- Conditions
- Obstetric Complication, Postpartum Hemorrhage, Postpartum Endometritis
- Trial name
- NCT03478163
- Testing
- CeFAZolin 1000 MG, Clindamycin 900 MG in 6 ML Injection
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Frenectomy, Erbium YAG Laser
Retrospective Frenectomy Analysis: Techniques and Adjunctive Antimicrobials
The frenulum is a mucosal fold that connects the lips and cheeks to the alveolar mucosa or gingiva, with abnormal attachments-particularly papillary and papillary-penetrating types-linked to clinical issues such as gingival…
- Conditions
- Frenectomy, Erbium YAG Laser, Antimicrobial Agent
- Trial name
- NCT07054021
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Urinary Tract Infection (cUTI), Intra-abdominal Infection (cIAI) and
Reporting Patterns and Results of Initial Antibiotic Treatment in Patients With cUTI, cIAI,NP Including VAP
Reporting patterns and results of initial antibiotic treatment in patients with complicated urinary tract infection (cUTI), complicated intra-abdominal infection (cIAI) and nosocomial pneumonia (NP) including…
- Conditions
- Urinary Tract Infection (cUTI), Intra-abdominal Infection (cIAI) and, Nosocomial Pneumonia (NP)
- Trial name
- RECOMMEND (NCT02364284)
- Where
- 27 sites in Brazil, France and 4 more
- Volunteers
- 1,322 people
- Sponsor
- Pfizer
Wound Infection
Prevention of Gastrostomy-Related Wound Infection by Vancomycin in Carriers of Methicillin-Resistant Staphylococcus Aureus.
The aim of this study is to determine whether vancomycin with cefazoline is superior to vancomycin with placebo in preventing gastrostomy-related wound infection in carriers of methicillin-resistant staphylococcus aureus (MRSA).
- Trial name
- NCT00150852
- Testing
- Vancomycin
- Where
- 3 sites in France, Switzerland
- Volunteers
- 96 people
- Sponsor
- University Hospital, Geneva
Chronic Periodontitis
Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
The objective of this study is to evaluate the anti-inflammatory and anti-infective properties of amniotic membrane (AM) when used for guided tissue regeneration (GTR) in periodontal bone defects.
- Trial name
- NCT02033226
- Testing
- Amniotic Membrane, Control group (Hydroxyapatite only)
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Sepsis, Bacterial Infections
Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis
As antibiotic resistance increases globally, it becomes more difficult to select empiric antibiotic therapy, particularly in patients with sepsis who stand to benefit from early adequate treatment.
- Conditions
- Sepsis, Bacterial Infections, Community-Acquired Infections, Hospital Infection
- Trial name
- IDEAS-CRXO (NCT06103500)
- Testing
- Clinical Decision Support Algorithm for Empiric Antibiotics in Sepsis
- Where
- 3 sites in Canada
- Volunteers
- 1,478 people
- Sponsor
- Ottawa Hospital Research Institute
Endodontic Disease, Root Canal Infection
Comparison of Antibacterial Efficacy of Three Final Irrigants
This study was conducted to determine the antibacterial affect of three different solutions used as final irrigant during endodontic therapy.
- Trial name
- NCT03853200
- Testing
- QMix Root Canal Irrigant, 17%EDTA+2%Chlorhexidine, EDTA
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Antibiotic Toxicity, Liver Cirrhosis
A Study to Determine Pharmacokinetic Changes of Ceftriaxone in Patients With Liver Cirrhosis
The investigators designed an observational multicenter explorative in vivo study to investigate the changes in ceftriaxone pharmacokinetics in blood and ascites.
- Conditions
- Antibiotic Toxicity, Liver Cirrhosis, Renal Insufficiency, Ceftriaxone Overdose
- Trial name
- TACTILE (NCT05960006)
- Testing
- No intervention (observational study)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)