Clinical trials: Antimicrobial Drug Resistance
Polio
Environmental Surveillance (ES) for Polio and AMR Using the TaqMan Array Card
This study will be used to develop a tool to streamline poliovirus environmental surveillance for the polio endgame and to provide a tool for detecting polio in places where there is no capacity to carry out the gold standard…
- Trial name
- NCT03818477
- Where
- Bangladesh
- Volunteers
- 8,500 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Bacterial Resistance to Antimicrobial
Prevalence of Digestive Carriage of Integrons
Bacterial resistance to antimicrobials is an increasing problem. Doctors occasionally face genuine therapeutic dead-ends, when attempting to cure nosocomial infections and, more and more frequently, community-acquired infections.
- Trial name
- APIHA (NCT01985217)
- Where
- France
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis
STI Prophylaxis and Emergence of Antimicrobial Resistance
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted…
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Antibiotic Prophylaxis, Antibiotic Resistance, Bacterial, Microbiome
- Trial name
- SPEAR (NCT06778083)
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University College, London
Neisseria Gonorrhoeae Infection
SpeeDx Ciprofloxacin gyrA Assay for N. Gonorrhoeae Gonococcal Infection
This study aims to test the effectiveness of using of SpeeDx Resistance Plus assay to guide treatment of Neisseria gonorrhoeae (Ng) in a sexual health clinic setting.
- Trial name
- NCT05286931
- Testing
- Ciprofloxacin 500 mg
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Washington
Helicobacter Pylori Infection, Helicobacter Pylori Gastritis
Helicobacter Pylori Local Prevalence and Antibiotic Resistance
The clinical management of H. pylori infection depends essentially on two factors, prevalence and local resistance. In Germany, only limited data from rather small cohorts currently exist regarding both factors.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Gastritis, Drug Resistant Bacterial Infection, Antibiotic Resistant Infection
- Trial name
- HelicoPTER (NCT05561504)
- Where
- Germany
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Mortality, Resistance Bacterial
Azithromycin for Child Survival in Niger: Mortality and Resistance Trial
The MORDOR trial found that biannual distribution of azithromycin to children 1-59 months old reduced child mortality. The World Health Organization (WHO) released conditional guidelines for this intervention, which include…
- Conditions
- Mortality, Resistance Bacterial, Child, Only
- Trial name
- AVENIR (NCT04224987)
- Testing
- Azithromycin
- Where
- Niger
- Volunteers
- 864,493 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Rotavirus Gastroenteritis, Rotavirus Vaccines
ROTA-biotic: Measuring the Impact of Rotavirus Vaccines on Paediatric Antibiotic Usage
Rotavirus is the most common aetiology of serious diarrhoea in young children. Despite antibiotics not being indicated in its treatment, diarrhoea remains a very common cause for antibiotic prescribing in low-income settings.
- Conditions
- Rotavirus Gastroenteritis, Rotavirus Vaccines, Antimicrobial Resistance (AMR), Antibiotic
- Trial name
- NCT06882070
- Testing
- Vaccine
- Where
- 2 sites in Ghana, Zambia
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Knowledge, Perception and Behaviour of Resistance to Antimicrobial Among HCW
Knowledge and Perception of Resistance to Antimicrobials Among Healthcare Workers in France
The objectives of this survey are to determine the level of antimicrobial resistance knowledge and perception of health care workers (HCW) in France, to measure the impact of health care facilities (HCF) and to identify the…
- Trial name
- PerceptR (NCT02265471)
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy Subjects
Safety, Tolerability, Pharmacokinetics and Food Effects Study of PBTZ169
Open-label prospective non-comparative ascending dose randomized cohort study of single and multiple oral administration of PBTZ169 (capsules 80 mg) in healthy volunteers
- Trial name
- NCT04150224
- Testing
- PBTZ169 640 mg OD, PBTZ169 640 mg BiD, PBTZ169 960 mg SD
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nearmedic Plus LLC
Antimicrobial Agent, Cephalosporins
Effect of Ceftobiprole on Human Intestinal Microflora
The purpose of the study is to investigate the effect of ceftobiprole treatment on intestinal microflora in healthy volunteers.
- Conditions
- Antimicrobial Agent, Cephalosporins, Drug Resistance
- Trial name
- NCT00965042
- Testing
- Ceftobiprole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Mortality
Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali
The LAKANA trial will assess the impact on mortality and other health outcomes of quarterly and biannual azithromycin mass drug administration (MDA) when delivered to 1-11-month (29-364 days) old infants in a high-mortality…
- Trial name
- LAKANA (NCT04424511)
- Testing
- Azithromycin
- Where
- Mali
- Volunteers
- 149,201 people, healthy volunteers welcome
- Sponsor
- Tampere University
Health-Related Quality-of-Life, Social Capital
Cocreating Action to Improve Rationality in the Health System
Despite widespread recognition of social, economic, or environmental health determinants, health action remains heavily dominated by individual-level solutions (e.g., medication, patient counselling, vaccination).
- Conditions
- Health-Related Quality-of-Life, Social Capital, Health Literacy, Community Based Participatory Research
- Trial name
- CAIR (NCT07237971)
- Testing
- Cocreation process
- Where
- 2 sites in Spain
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Methicillin Resistance in Staphylococcus Aureus (MRSA)
Farm-originated Antimicrobial Resistance Modeling: Exploring Humans-to-Animal Dissemination
Antimicrobial resistance is a major public health issue. Methicillin resistance in Staphylococcus aureus (MRSA) is one of the indicators that is monitored particularly closely.
- Trial name
- FARMHAND (NCT07898930)
- Testing
- Sample collection
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Atopic Dermatitis (AD), Scabies
Secondary Bacterial Infections and Nasal Colonization in Scabies and Atopic Dermatitis
This prospective observational study will evaluate the microbiological profile of secondary bacterial infection and nasal colonization in participants with scabies or atopic dermatitis.
- Conditions
- Atopic Dermatitis (AD), Scabies, Impetigo
- Trial name
- NCT07813611
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Antimicrobial Resistance, Colonization
Fecal Microbiota Transplantation for CRE/VRE
Multidrug-resistant organisms (MDRO) present an increasingly serious public health threat to the global community.The prevalence of various MDRO, including carbapenem-resistant Enterobacteriaceae (CRE) and vancomycin-resistant…
- Trial name
- NCT03479710
- Testing
- FMT infusion
- Where
- Hong Kong
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Antimicrobial Resistance (AMR), Oral Microbiota
Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial…
- Conditions
- Antimicrobial Resistance (AMR), Oral Microbiota, Oral Microbiome Health, Chlorhexidine
- Trial name
- SMARCH (NCT07570927)
- Testing
- 0.06% Chlorhexidine Digluconate Toothpaste
- Where
- 2 sites in Czechia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Recurrent Urinary Tract Infection
Faecal Microbiota Transplantation as Means of Preventing Recurrent Urinary Tract Infections
This study investigates Faecal microbiota transplantation (FMT) in prevention of recurrent urinary tract infections (UTIs) caused either by sensitive E. coli or ESBL-E. coli.
- Trial name
- FMT-UTI (NCT06050148)
- Testing
- Feacal microbial transplantation (FMT)
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Antimicrobial Resistance (AMR)
A Digital Escape Room to Teach Medical Students About Antimicrobial Resistance Using the One Health Approach
The goal of this clinical trial is to evaluate the effectiveness of a One Health-based educational intervention in final-year medical students from two universities in Norway and Zambia. The main question it aims to answer is: 1.
- Trial name
- NCT07848217
- Testing
- AMRageddon
- Where
- 2 sites in Norway, Zambia
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Community Members
Using Social Influencers for Public Health Education on Antibiotic Use and Antimicrobial Resistance
This study aims to compare the effectiveness of health education facilitated by neighborhood food and beauty establishments with that facilitated by clinics in increasing the public's knowledge of antibiotic use and antimicrobial…
- Trial name
- NCT06998576
- Testing
- Animated educational video on antibiotic use
- Where
- Singapore
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital