Clinical trials: Antimicrobial Stewardship
Sepsis, Procalcitonin
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU).
- Conditions
- Sepsis, Procalcitonin, Antimicrobial Stewardship
- Trial name
- ProPICU (NCT03440918)
- Testing
- Procalcitonin-Guided Antimicrobial Stewardship, Baseline Antimicrobial Stewardship
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis, Sepsis Mrsa
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU).
- Conditions
- Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy
- Trial name
- REVAMP (NCT05975671)
- Testing
- Multifaceted de-implementation strategy to reduce vancomycin overuse
- Where
- 4 sites in United States
- Volunteers
- 52,500 people
- Sponsor
- Children's Hospital of Philadelphia
Bacteremia, Antimicrobial Stewardship
Knowledge Attitude and Practice Regarding Bloodstream Bacterial Infections and Antibiotics Usage Among Doctors.
This study is designed to use a questionnaire to assess doctors' knowledge, attitudes, and practices regarding bloodstream bacterial infections and antibiotic use in Tawam and Al Ain tertiary Hospitals (both hospitals have the…
- Conditions
- Bacteremia, Antimicrobial Stewardship, Antibiotic Use, Antibiotic Abuse
- Trial name
- NCT06605677
- Testing
- Questionnaire
- Where
- United Arab Emirates
- Volunteers
- 100 people
- Sponsor
- Abu Dhabi Health Services Company
Systemic Infection
Efficacy and Safety of a Protocol Using C-reactive Protein to Guide Antibiotic Therapy
The growing resistance of microorganisms to antimicrobials is a major threat to public health nowadays. Reducing the consumption of antibiotics is one of the main strategies to control this issue.
- Trial name
- NCT05841875
- Testing
- C reactive protein algorithm
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Minas Gerais
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Pneumonia, Pneumonia, Viral
Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients
The goal of this prospective randomized study is to improve antibiotic use among hospitalized patients with suspected pneumonia.
- Conditions
- Pneumonia, Pneumonia, Viral, Pneumonia, Bacterial
- Trial name
- UP-CAPTAIn (NCT05976581)
- Testing
- Electronic alert, Structured communication of test results
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- Jonathan Baghdadi
Antimicrobial Stewardship Program, Resistance Bacterial
Antimicrobial Stewardship Program Implementation in Brazilian Public Hospitals (PeGASUS)
Antimicrobial resistance is a major global public health challenge, leading to increased morbidity, mortality, and healthcare costs.
- Trial name
- PeGASUS (NCT07514884)
- Testing
- ASP implementation
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Carbapenemase-Producing Enterobacteriaceae (CPE), Healthcare-Associated Infections (HAIs)
Effect of Daily Chlorhexidine Bathing and Antibiotic/PPI Stewardship on Prevention of CPE Transmission and Infection
This multicenter, cluster-randomized crossover trial aims to evaluate the effectiveness and safety of a bundled intervention-including daily chlorhexidine bathing and targeted antimicrobial and proton pump inhibitor (PPI)…
- Trial name
- NCT07039955
- Testing
- Daily Chlorhexidine Bathing, Antimicrobial and PPI Stewardship Program, Standard Bathing
- Where
- 3 sites in South Korea
- Volunteers
- 5,760 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Hospital Infection, Standardized Antibiotic Prescribing Ratio (SAR)
InPART RX - Epicenters
InPART Rx is a collaborative research study to measure the impact of a planned quality improvement initiative to reduce unnecessary antibiotic prescribing by the Hospital Medicine Service through a process of receiving…
- Trial name
- InPART RX (NCT07368660)
- Testing
- Messaging Hospitalists, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Emory University
Pneumonia, Critically Ill
Impact of Rapid Pathogen Detection in ICU Patients With Suspected Pneumonia on Antimicrobial Therapy
The goal of this intervention trial is to determine the feasibility, safety, and potential impact of rapid respiratory pathogen detection by FA Pneumonia Panel on antibiotic therapy in mechanically ventilated critically ill…
- Trial name
- IRISPAT-1 (NCT06478953)
- Testing
- FA Pneumonia Panel
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
CDI
Precision Antimicrobial STewardship for Clostridioides DIfficile Prevention
To decrease CDI incidence by implementing an electronic health record-integrated CDI-risk classification tool for Clostridioides difficile infection (CDI) to focus a bundle of antimicrobial stewardship (AMS) CDI prevention…
- Trial name
- PASTCDI (NCT05508607)
- Testing
- CDI-risk Classification Tool
- Where
- United States
- Volunteers
- 13,319 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Sinusitis, Streptococcal Pharyngitis
Antimicrobial Stewardship for Primary Care Pediatricians
The purpose of the study is to determine if physician education coupled with audit and feedback of antibiotic prescribing can improve antibiotic prescribing by primary care clinicians.
- Conditions
- Acute Sinusitis, Streptococcal Pharyngitis, Pneumonia, Viral Infection
- Trial name
- PARTI (NCT01806103)
- Testing
- Antimicrobial Stewardship Bundle
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Children's Hospital of Philadelphia
Pneumonia, Urinary Tract Infection
Reducing Overuse of Antibiotics at Discharge Home
The goal of this two-arm parallel cluster-randomized trial of 40 hospitals is to test the effectiveness of the ROAD Home Intervention on days of antibiotic overuse at discharge in patients hospitalized with community-acquired…
- Conditions
- Pneumonia, Urinary Tract Infection, Antibiotic Stewardship, Care Transition
- Trial name
- ROAD Home (NCT06106204)
- Testing
- ROAD Home Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Pneumonia - Bacterial, Urinary Tract Infection Bacterial
Clinical Impact of a Machine Learning Decision Support System for Empirical Antibiotic Therapy
The goal of this quasi-experimental study is to analyze if a Machine Learning Clinical Decision Support System can improve the empirical antibiotic treatment in patients with pneumonia, urinary tract infection and / or sepsis.
- Conditions
- Pneumonia - Bacterial, Urinary Tract Infection Bacterial, Bloodstream Infection
- Trial name
- NCT07762378
- Testing
- Machine Learning Decision Support System
- Volunteers
- 486 people
- Sponsor
- Instituto de Investigación Sanitaria Gregorio Marañón
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Antibiotic Stewardship in Community Hospitals
Antimicrobial Stewardship in Community Hospitals
The Infectious Diseases Society of America (IDSA) guidelines recommend two "core" strategies for Antibiotic Stewardship (AS): 1) antimicrobial restriction and preauthorization and 2) prospective audit with intervention and…
- Trial name
- NCT02212808
- Testing
- Antimicrobial restriction, Post-antimicrobial prescription review
- Volunteers
- 3,972 people
- Sponsor
- Duke University
Neonatal Infection
Antibiotic Use in a Neonatal Intensive Care Unit Practicing Integrative Medicine
The goal of this study is to describe the antibiotic use in a neonatal intensive care unit (NICU) in Germany that is practising integrative medicine.
- Trial name
- NCT04893343
- Testing
- Antibiotic treatment, No antibiotic treatment
- Where
- Germany
- Volunteers
- 246 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Catheter-Related Infections
Controlling Antimicrobial Use Through Reducing Unnecessary Treatment of Catheter Associated Urinary Tract Infections
Hypothesis: A short course (3-5 days) of antibiotic therapy (experimental arm) is as safe and effective as a long course of antibiotic therapy for the treatment of catheter-associated urinary tract infections.
- Trial name
- CARCUTI (NCT02650518)
- Testing
- Short-course Antibiotics, Catheter Change
- Where
- 3 sites in Singapore
- Volunteers
- 500 people
- Sponsor
- National University Hospital, Singapore
Upper Respiratory Infection, Acute Bacterial Sinusitis
Improving Antibiotic Prescribing for Pediatric Respiratory Infections by Family Physicians With Peer Comparison
Findings from an ongoing improvement project to improve antibiotic prescribing for children and adolescents for three acute respiratory tract infections (ARTIs: upper respiratory tract infection, acute bacterial sinusitis, and…
- Conditions
- Upper Respiratory Infection, Acute Bacterial Sinusitis, Acute Otitis Media
- Trial name
- NCT04588376
- Testing
- Peer comparison feedback monthly
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Herb Clegg
Urinary Tract Infections, Antiobiotic Stewardship
Post-Emergency Optimization of Antibiotic Therapy for Urinary Tract Infection (UTI)
Prospective, multicenter, non-interventional study conducted over 6 months, including patients presenting to the emergency department with suspected urinary tract infection managed as outpatients and discharged with or without…
- Conditions
- Urinary Tract Infections, Antiobiotic Stewardship, Emerging Infectious Disease
- Trial name
- REVIU48 (NCT07559318)
- Testing
- Adaptation of antibiotics therapy for outpatient urinary infection following emergency care
- Where
- 3 sites in France
- Volunteers
- 330 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil