Clinical trials: Antimicrobial Treatment
Urinary Tract Infections, Pediatric Disorder
Assessment of the Efficacy on the 5th Day of Antibiotic Therapy for Febrile Urinary Tract Infections Among Children From 3 Months to 18 Years Old
The main objective is to describe the rate of asymptomatic patients after 5 days of effective antibiotic therapy in an uncomplicated febrile urinary tract infection in children between 3 months and 18 years of age.
- Trial name
- PEDIU5 (NCT04667546)
- Testing
- Survey
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cesarean Section, Infection
Trial Comparing the Optimal Timing of Antibiotic Prophylaxis at the Time of Cesarean Delivery
The purpose of this study is to evaluate the rates of maternal and neonatal infectious morbidity in gravid patients undergoing cesarean delivery.
- Trial name
- NCT00811603
- Testing
- Cefazolin (Timing of Antibiotic Prophylaxis)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- MemorialCare
Antimicrobial Agent, Cephalosporins
Effect of Ceftobiprole on Human Intestinal Microflora
The purpose of the study is to investigate the effect of ceftobiprole treatment on intestinal microflora in healthy volunteers.
- Conditions
- Antimicrobial Agent, Cephalosporins, Drug Resistance
- Trial name
- NCT00965042
- Testing
- Ceftobiprole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Colitis, Ulcerative
Antibiotics for the Treatment of Ulcerative Colitis
Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease, whose cause is unknown. However, it is widely accepted that bacteria living in the large bowel are essential for the development of the disease.
- Trial name
- NCT00355602
- Testing
- Cefuroxime, Ciprofloxacin, Clarithromycin
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Dundee
Osteomyelitis
Antibiotic Device for Osteomyelitis of the Extremities Pivotal Trial - Genex With Gentamicin.
The purpose of this trial is to determine if genex with gentamicin (genex G) an antibiotic loaded bone void filler, works to treat and is a safe option as part of the surgical treatment of osteomyelitis in the extremities.
- Trial name
- ADOPT GG (NCT07270380)
- Testing
- genex with gentamicin (genex G)
- Where
- 4 sites in United States
- Volunteers
- 139 people
- Sponsor
- Biocomposites Ltd
Endophthalmitis
Study of Intraocular Concentrations (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis
Endophthalmitis is an intraocular inflammation due to a serious infection of bacterial, fungal or parasitic origin, involving visual prognosis if it is not treated in time and correctly.
- Trial name
- CINEBIOPHTA (NCT03968341)
- Testing
- Pharmacokinetic and pharmacodynamic study of antibiotics used in severe endophthalmitis from samples taken from treated patients
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Infection, Bacterial
Therapeutic Drug Monitoring of Antiinfectives for Patients With Severe Illness = TAPSI
Therapeutic drug monitoring of antiinfectives in intensive care patients is an usual research topic of the last years. Based on research result, which have shown subtherapeutic plasma concentrations of antibiotics, a routines…
- Trial name
- TAPSI (NCT03985605)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Ophthalmopathy , Lacrimal System
Evaluation of Lacrimal Punctal Changes by Anterior Segment Optical Coherence Tomography AS-OCT After Topical Combined Antibiotics and Steroids Treatment in Cases of Inflammatory Punctual Stenosis
Punctal stenosis is an important etiological factor that should be considered when assessing patients with epiphora. Anatomically, acquired punctal stenosis is a condition in which the external opening of the lacrimal canaliculus…
- Trial name
- NCT05028907
- Testing
- 5 mg chloramphenicol, 1 mg dexamethasone sodium phosphate, 0.25 mg tetryzoline hydrochloride, 2 mg Hydroxypropyl Methyl Cellulose, 10 mg α-tocopherol acetate and 8 mg macrogol 400)., sodium hyaluronate, polyethylene and propylene glycol based) three times daily for three months
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Sohag University
Gram-negative Bacterial Infection
A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH)
The purpose of this study is to learn about the safety and effects of ATM-AVI for the possible treatment of infections caused by a type of bacteria called gram-negative bacteria.
- Trial name
- CHERISH (NCT06462235)
- Testing
- Part A: ATM-AVI Single Dose, Cohorts 1-4, Part B: Multiple-dose ATM-AVI, Cohorts 1-4
- Where
- 32 sites in United States, Argentina and 7 more
- Volunteers
- 48 people
- Sponsor
- Pfizer
Escherichia Coli Bacteremia, Klebsiella Bacteraemia
Switch to Oral Antibiotics in Gram-negative Bacteremia
Eligible subjects will be those age 18 years or more with mono-microbial blood stream infection caused by E. coli, Klebsiella species, Enterobacter species, Serratia species, Citrobacter species, or Proteus species, who have…
- Conditions
- Escherichia Coli Bacteremia, Klebsiella Bacteraemia, Enterobacter Bacteraemia, Serratia Bacteraemia
- Trial name
- SOAB (NCT04146922)
- Testing
- Step down to oral antimicrobial therapy, IV antimicrobial therapy
- Where
- 7 sites in Bahrain, Kuwait and 2 more
- Volunteers
- 176 people
- Sponsor
- Hamad Medical Corporation
Sinusitis
Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
The investigators objective is to compare short course (5 days) to long course (14 days)antibiotics for the treatment of acute bacterial sinusitis in children.
- Trial name
- NCT01166945
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- University of Wisconsin, Madison
Drug Resistance, Carbapenem-Resistant Enterobacteriaceae Infection
Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae
The purpose of this study is to evaluate the treatment outcomes in patients with CRE infections.
- Conditions
- Drug Resistance, Carbapenem-Resistant Enterobacteriaceae Infection, Sepsis, Septic Shock
- Trial name
- NCT04516395
- Testing
- Combined antibiotic regimens, Standard antibiotic regimens
- Where
- Thailand
- Volunteers
- 102 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Periprosthetic Joint Infection, Anti-Bacterial Agents
Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.
This is a multicenter prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before phase II revision surgery.
- Trial name
- PACER-PJI (NCT05284318)
- Testing
- Antibiotics treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Bacterial Infections
Compliance With AntibIotic TherapY Guidelines in French PICUs
This observational, prospective, multicenter study, conducted in nine French Pediatric and Neonatal Intensive Care Units (ICUs), will assess the antibiotic therapy for a child hospitalized in ICU and receiving systemic…
- Trial name
- COMITY (NCT04642560)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Toulouse
Febrile Neutropenia
Procalcitonin Protocol to Shorten the Antibiotic Therapy in Febrile Neutropenia
In this study the investigators aim to test if a procalcitonin (PCT) - guided strategy allows to reduce the antibiotic use in patients with febrile neutropenia hospitalized in a Brazilian tertiary university hospital, causing no…
- Trial name
- NCT00928291
- Testing
- procalcitonin, antibiotic therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
Pneumonia, Probiotics
Impact of Probiotics on Antibiotic-associated Diarrhea in Community-acquired Pneumonia
The study goal is to determine whether oral administration of a probiotic mixture can reduce the incidence of antibiotic-associated diarrhea in patients with community-acquired pneumonia.
- Conditions
- Pneumonia, Probiotics, Diarrhea
- Trial name
- PROBIO (NCT06990568)
- Testing
- Lacidofil
- Volunteers
- 100 people
- Sponsor
- National Health Insurance Service Ilsan Hospital
Recurrent Acute Otitis Media
Effect of Ventilation Tubes in Otitis-prone Children
The purpose of this study is to investigate the effects of ventilation tubes in children with recurrent ear infections. By drawing lots, young children with recurrent ear infections will be assigned to one of two groups…
- Trial name
- NCT05348291
- Testing
- ventilation tubes
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Bronchiectasis, Inflammation
Bronchiectasis and Long Term Azithromycin Treatment
1. SUMMARY Rationale: Patients with bronchiectasis often experience lower respiratory tract infections with progression of symptoms and decline in quality of life.
- Trial name
- BAT (NCT00415350)
- Testing
- Azithromycin
- Where
- 16 sites in Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- W.G.Boersma
HIV Infections, Gonorrhea
Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection
The objective of the study is to determine the efficacy and safety of 0.5% and 2% PRO 2000/5 gels compared to placebo in preventing vaginally acquired HIV infection.
- Conditions
- HIV Infections, Gonorrhea, Chlamydial Infections, Genital Herpes
- Trial name
- NCT00262106
- Testing
- PRO 2000/5
- Where
- 6 sites in South Africa, Tanzania and 2 more
- Volunteers
- 9,404 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
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