Clinical trials: Antimicrobial Treatment
Sepsis, Procalcitonin
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU).
- Conditions
- Sepsis, Procalcitonin, Antimicrobial Stewardship
- Trial name
- ProPICU (NCT03440918)
- Testing
- Procalcitonin-Guided Antimicrobial Stewardship, Baseline Antimicrobial Stewardship
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Vanderbilt University Medical Center
Overactive Bladder (OAB), Urinary Tract Infection (Diagnosis)
Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection
The goal of this clinical trial is to compare methenamine hippurate prophylaxis to routine antibiotic prophylaxis following onabotulinumtoxinA (BOTOX-A) injections in women with overactive bladder (OAB).
- Trial name
- META (NCT06953271)
- Testing
- Methenamine Hippurate, Typically prescribed oral antibiotic prophylaxis
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections
Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the…
- Conditions
- Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection, Severe Infection, Pseudomonas Aeruginosa
- Trial name
- OPTIMISE (NCT05210387)
- Testing
- Duration of therapy
- Where
- 29 sites in Brazil
- Volunteers
- 107 people
- Sponsor
- Hospital Moinhos de Vento
Preterm Premature Rupture of Membrane
Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane
The purpose of this study is to compare the neonatal outcome and infant neurologic outcome whose mother were treated with cefazolin plus clarithromycin for one week or until delivery after preterm premature rupture of membrane.
- Trial name
- NCT01503606
- Testing
- Cefazolin, Clarithromycin
- Where
- South Korea
- Volunteers
- 151 people
- Sponsor
- Samsung Medical Center
Vaccination Reaction
Early Antibiotic Therapy and Vaccination
Neonatal Sepsis is one of the most common causes of death in preterm infants. Therefore, up to 80% of very low birth weight infants receive antibiotic therapy in their first week of life.
- Trial name
- NCT04109833
- Testing
- ABT
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Urinary Tract Infections, Enterobacteriaceae Infections
Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae
This study evaluates the efficacy in achieving clinical cure in non-bacteremic urinary tract infections (UTI) caused by Escherichia coli or Klebsiella pneumoniae producers of extended-spectrum β-lactamases (ESBL) in adult…
- Conditions
- Urinary Tract Infections, Enterobacteriaceae Infections, Infection Due to ESBL Bacteria, Carbapenem
- Trial name
- CAPITIS (NCT03891433)
- Testing
- Meropenem, Ertapenem 1000 MG, Piperacillin, Tazobactam 4-0.5G Solution for Injection
- Where
- Colombia
- Volunteers
- 198 people
- Sponsor
- Universidad del Norte
Methicillin-resistant Staphylococcal Infections
Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children
Vancomycin is the standard first-line treatment for MRSA infections and a first-line empiric therapy. The relationship between exposure to vancomycin and efficacy is admitted but because of an important intersubject variability…
- Trial name
- OPTIBAYE (NCT02694458)
- Testing
- Early vancomycin monitoring and bayesian dosage adjustment, usual vancomycin dose and monitoring strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients.
This study will directly compare meropenem with standard first line antibiotic therapies in subjects entering an ICU with secondary nosocomial sepsis, or who contract sepsis while resident in an ICU.
- Trial name
- NCT00318552
- Testing
- Meropenem
- Where
- 12 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Pfizer
Febrile Neutropenia, Fever
Time From Onset of Fever to Administration of Antibiotics in Neutropenic Fever Patients
This trial uses an interview and a survey to gather information from cancer patients about the onset of their fever and the administration of antibiotics.
- Trial name
- NCT03968328
- Testing
- Interview, Survey Administration
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- M.D. Anderson Cancer Center
Vertebral Osteomyelitis
Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis
Duration of antimicrobial therapy for spondylodiscitis is not standardized; it could vary from 6 weeks to several months depending on the medical habits.
- Trial name
- DTS (NCT00764114)
- Testing
- antibiotic
- Where
- France
- Volunteers
- 351 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bronchiectasis
Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis
Chronic airways infection with Pseudomonas aeruginosa (PA) is associated with increased frequency of exacerbations, deterioration in quality of life and increased mortality in adult patients with bronchiectasis.
- Trial name
- ANTEIPA (NCT06368804)
- Testing
- Antibiotic monotherapy treatment and follow-up, Antibiotic bitherapy treatment and follow-up
- Where
- 18 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Osteoarticular Material Infection
Impact of Three Probabilistic Antibiotic Therapy on Digestive Microbiota and Colonization With Multi-resistant Bacteria
In the event of suspected osteoarticular material infection (OAMI), broad-spectrum probabilistic antibiotic therapy is recommended immediately after revision surgery.
- Trial name
- HOPE (NCT07058415)
- Testing
- Stool sample 1, Stool sample 2, Stool sample 3
- Where
- 4 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Inflammation Following Cataract Surgery
Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Postoperative Inflammation in Cataract Surgery
efficacy of antibiotic steroid combination compared with individual administration in prevention of postoperative inflammation in patients having cataract surgery
- Trial name
- NCT00331084
- Testing
- antibiotic/steroid combination, moxifloxacin / dexamethasone
- Where
- Brazil
- Volunteers
- 132 people
- Sponsor
- Federal University of São Paulo
Febrile Neutropenia, Hematological Malignancy
Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO
A multicenter open-label non-inferiority randomized clinical trial comparing the safety (non-inferiority) of short antibiotic treatment (72 hours) with an anti-pseudomonal carbapenem with regard to treatment failure in comparison…
- Trial name
- SHORT (NCT02149329)
- Testing
- Discontinuation of imipenem-cilastatin or meropenem
- Where
- 2 sites in Netherlands
- Volunteers
- 276 people
- Sponsor
- Amsterdam UMC, location VUmc
Acquired Immune Deficiency Syndrome, AIDS
Pilot Study of a Raltegravir Based NRTI Sparing Regimen
This pilot study will provide data on the safety and efficacy of the combination of Raltegravir (RAL) 400mg BID + Atazanavir (ATV) 300 mg BID in Antiretroviral (ARV)-experienced subjects that have a suppressed HIV viral load on a…
- Conditions
- Acquired Immune Deficiency Syndrome, AIDS, Human Immunodeficiency Virus, HIV Infections
- Trial name
- NCT00814879
- Testing
- Raltegravir, Atazanavir, Standard treatment regimen
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Enterobacteriaceae Infections
Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers.
Antimicrobial resistance is a major threat worldwide and now concerns last-ressource antibiotics such as carbapenems. As the resistance to carbapenems is directly due to their use, their spare has become a public health…
- Trial name
- PROBATAZO (NCT04276480)
- Testing
- Piperacillin-tazobactam
- Where
- 2 sites in France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Bordeaux
Cellulitis
High-dose Cephalexin for Cellulitis (HI-DOCC)
Cellulitis is a common condition diagnosed and managed in the ED that carries significant burden on healthcare systems globally. Cellulitis is the 8th most common reason patients present to an ED in Canada.
- Trial name
- HI-DOCC (NCT05852262)
- Testing
- Cephalexin
- Where
- 10 sites in Canada
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Efficacy of Preoperative Microbial Reduction in the Nasal Cavity Using Antimicrobial Photodynamic Therapy (aPDT)
Preoperative Microbial Reduction of the Nasal Cavity With Antimicrobial Photodynamic Therapy (aPDT).
The goal of this clinical trial is to investigate the preoperative microbial reduction of the nasal cavity using Photodynamic Therapy (aPDT) in adult patients undergoing surgical intervention at the Department for…
- Trial name
- NCT06570252
- Testing
- activated Light Source (aPDT), non activated Light Source (Control)
- Volunteers
- 208 people
- Sponsor
- University of Zurich
Urinary Tract Infections, Recurrent
Antibiotic Prophylaxis for Clean Intermittent Catheterisation
This research project is designed to find out whether people who suffer repeated urinary tract infections (UTI) related to the need to empty their bladders intermittently with a fine plastic tube (catheter); a process called…
- Trial name
- AnTIC (NCT02145338)
- Testing
- Nitrofurantoin or Trimethoprim or Cefalexin, No prophylaxis
- Where
- United Kingdom
- Volunteers
- 404 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Infection, Skin and Subcutaneous Tissue Bacterial Infections
Study of Accuracy of New Diagnostic Technology to Determine Guide Rapid Antibiotic Treatment for Serious Infections
Military service members and the U.S. veteran population face a growing and serious health threat: widespread antibiotic resistance resulting from resistant bacteria and a dwindling pipe-line of sufficiently potent antibiotics.
- Conditions
- Infection, Skin and Subcutaneous Tissue Bacterial Infections, Healthcare-associated Infection, Infection Due to Resistant Bacteria
- Trial name
- RAMPED (NCT02060513)
- Where
- 3 sites in United States
- Volunteers
- 2,298 people
- Sponsor
- Connie Price
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