Clinical trials: Aphasia
Aphasia, Stroke
Stepped Care for Aphasia
This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not…
- Trial name
- NCT05851573
- Testing
- Psychosocial intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Primary Progressive Aphasia, MCI
tDCS Intervention in Primary Progressive Aphasia
Primary progressive aphasia (PPA) is a neurodegenerative disease that affects first and foremost language abilities. Mild cognitive impairment (MCI) is slowly progressive decline in a single domain of cognition (e.g.
- Conditions
- Primary Progressive Aphasia, MCI, FTD
- Trial name
- NCT02606422
- Testing
- Active HD-tDCS plus Speech-Language Therapy
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Primary Progressive Aphasia
Communication Bridge 2
This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA).
- Trial name
- CB2 (NCT03371706)
- Testing
- Communication Bridge™, Evidence-Based Impairment Focused
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Chicago
Aphasia, Primary Progressive Aphasia
CB3 Pilot (Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia)
This study will evaluate evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA). The aim of the study is to help identify efficacious communication and quality of life interventions for those with PPA…
- Conditions
- Aphasia, Primary Progressive Aphasia, Dementia, Communication
- Trial name
- CB3 Pilot (NCT05697380)
- Testing
- Communication Bridge™
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Chicago
Primary Progressive Aphasia
Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)
The purpose of this study is to establish the feasibility of a program of remotely supervised transcranial direct current stimulation (RS-tDCS) paired with language skills practice for people living with the semantic or logopenic…
- Trial name
- NCT05615922
- Testing
- Transcranial Direct Current Stimulation (tDCS), Word-Naming Activity
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Post-stroke Depression, Post-stroke Aphasia
Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
The present parallel-group, single-center, blinded-assessment controlled trial seeks to explore the feasibility - in terms of high completion rates - and potential efficacy of intensive communicative-pragmatic social interaction…
- Trial name
- CONNECT (NCT04318951)
- Testing
- Intensive communicative-pragmatic social interaction., Standard care.
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Medicine Greifswald
Primary Progressive Aphasia
HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms
This study aims to evaluate the effectiveness of a therapy called High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for the treatment of the language deficits experienced by people with a type of Primary…
- Trial name
- NCT03805659
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
Primary Progressive Aphasia, PPA
Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy
People with Primary Progressive Aphasia (PPA) are is a debilitating disorder characterized by the gradual loss of language functioning, even though cognitive functioning is relatively well preserved until the advanced stages of…
- Trial name
- NCT03728582
- Testing
- Active tDCS plus Speech-Language Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Stroke
Stimulating Language in Subacute StrokE
The investigators will study the effects of transcranial direct current (tDCS) stimulation during language therapy for naming in individuals with aphasia in the acute and subacute post stroke period.
- Trial name
- SLISSE (NCT02674490)
- Testing
- A-tDCS (1 mA), SALT
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Aphasia, Acquired
Effects of rTMS on Brain Activation in Aphasia
This study will investigate the use of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation method, to improve word-finding abilities in Veterans and non-Veterans with chronic language problems…
- Trial name
- NCT03292471
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Aphasia
Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia
We hypothesize patients who have difficulty with word recall (naming pictures) due to a stroke will experience greater benefit in word recall after receiving a combination of transcranial direct current stimulation (tDCS) and…
- Trial name
- NCT02226796
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Aphasia, CVA
Treatment Intensity - Apraxia of Speech
A growing neurorehabilitation literature suggests that intense treatment may be desired to maximize the effects of therapy following neurologic injury.
- Conditions
- Aphasia, CVA, Apraxia of Speech
- Trial name
- NCT02332915
- Testing
- Sound Production Treatment (SPT)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Stroke, Acute, Aphasia
Yes/No Questionnaire for Aphasic Patients (YNQ)
Quality of care depends strongly on oral communication with patients. Stroke patients, who have language disorders, have understanding difficulties, but also have difficulties in expressing their needs and in being understood.
- Trial name
- YNQ (NCT03257696)
- Testing
- Close-ended questionnaire
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Broca Aphasia
Speech Hero Home Therapy for Aphasia
The investigators will run an at-home usability study of a newly developed speech therapy app called Speech Hero with 10 individuals with Broca's aphasia in the chronic stage of stroke.
- Trial name
- NCT04471935
- Testing
- At home Speech Hero therapy app
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Flint Rehabilitation Devices, LLC
Aphasia
TMS in Aphasia Recovery
Stroke often causes substantial problems in speaking or understanding speech. Treatments for these problems are currently very limited.
- Trial name
- NCT04777214
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pennsylvania
Apraxia of Speech, Aphasia, Acquired
Apraxia of Speech: Comparison of EPG Treatment (Tx) and Sound Production Treatment (SPT)
The purpose of the proposed research is to examine the effects of two treatment approaches on speech production involving speakers with chronic apraxia of speech (AOS) and aphasia.
- Conditions
- Apraxia of Speech, Aphasia, Acquired, Speech Disorders
- Trial name
- EPG&SPT (NCT02554513)
- Testing
- EPG Tx, SPT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Subcortical Aphasia, Ischemic Stroke
The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study
Previous studies have demonstrated that venlafaxine significantly improves the language function of healthy subjects and increase of fMRI activation in cortical language area.
- Trial name
- NCT03588572
- Testing
- Venlafaxine hydrochloride capsules
- Where
- 2 sites in China
- Volunteers
- 43 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Strategy Training
Strategy Training for People With Aphasia After Stroke
One-third to one-half of acute strokes result in newly acquired cognitive impairments. Approximately 30 to 40% of people in the acute phase of stroke also sustain communication impairments.
- Trial name
- NCT03593876
- Testing
- Strategy Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pittsburgh
Aphasia
Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia
Intensive therapy for aphasia has been demonstrated to improve language functioning after stroke or other neurological injury. However, recovery is generally not complete and new therapies are needed to improve outcomes.
- Trial name
- NCT03510182
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Aging, Aphasia
Exercise Effects on Word Learning
The aging Veteran population will substantially increase over the next 10 years, as the 24.9% of Veterans who are currently between 55-64 years of age join the 38.5% who are already over age 65.
- Trial name
- NCT03370471
- Testing
- Retrieval Practice + Moderate Intensity Exercise, Retrieval Practice + Gentle Stretching, Study Only + Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development