Clinical trials: Aphasia
Post-stroke Depression, Post-stroke Aphasia
Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
The present parallel-group, single-center, blinded-assessment controlled trial seeks to explore the feasibility - in terms of high completion rates - and potential efficacy of intensive communicative-pragmatic social interaction…
- Trial name
- CONNECT (NCT04318951)
- Testing
- Intensive communicative-pragmatic social interaction., Standard care.
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Medicine Greifswald
Aphasia
Determining Learning Ability in People With Aphasia
Aphasia is an impairment in the expression or comprehension of language that results from stroke, traumatic brain injury or progressive neurological disease.
- Trial name
- NCT05119023
- Testing
- SRT Observational Learning, AGL Observational Learning, AGL Rule-based Learning
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- MGH Institute of Health Professions
Aphasia, Apraxia of Speech
Treatments of Acquired Apraxia of Speech
This study was designed to examine the effects of speech therapy on ability to produce speech sounds in persons with acquired apraxia of speech.
- Conditions
- Aphasia, Apraxia of Speech, Stroke
- Trial name
- Apraxia (NCT01483807)
- Testing
- Sound Production Treatment - Blocked, Sound Production Treatment - Random
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Aphasia
Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia
We hypothesize patients who have difficulty with word recall (naming pictures) due to a stroke will experience greater benefit in word recall after receiving a combination of transcranial direct current stimulation (tDCS) and…
- Trial name
- NCT02226796
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Aphasia
Transcranial Direct Current Stimulation (tDCS) and Intensive Therapy in Aphasia
Intensive therapy for aphasia has been demonstrated to improve language functioning after stroke or other neurological injury. However, recovery is generally not complete and new therapies are needed to improve outcomes.
- Trial name
- NCT03510182
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Michigan
Apraxia of Speech, Aphasia
A Novel Treatment for Aphasia and Apraxia of Speech : Measurement of Outcomes
In order to determine if speech-language therapy has positive effect, reliable measurement tools are required to document outcomes.
- Trial name
- NCT01979159
- Testing
- Combined Aphasia and Apraxia of Speech Treatment (CAAST)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Ischemic Stroke
Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study
The primary study objective is to assess the feasibility of using the MindFrame System to safely and effectively restore blood flow in a thrombotic neurovascular occlusion in patients experiencing an ischemic stroke.
- Trial name
- PRIISM (NCT00810095)
- Testing
- MindFrame System
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MindFrame, Inc.
To Healthy Volunteer, Virtual Lesions for Aphasia
Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types
Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.
- Trial name
- NCT01877161
- Testing
- Repetitive magnetic stimulation to superior temporal gyrus, Repetitive magnetic stimulation to middle temporal gyrus
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Subcortical Aphasia, Ischemic Stroke
The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study
Previous studies have demonstrated that venlafaxine significantly improves the language function of healthy subjects and increase of fMRI activation in cortical language area.
- Trial name
- NCT03588572
- Testing
- Venlafaxine hydrochloride capsules
- Where
- 2 sites in China
- Volunteers
- 43 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Stroke, Aphasia
Adapting Acceptance and Commitment Therapy for Stroke Survivors With Aphasia
The proposed study is a Stage I successive cohort trial intended to adapt Acceptance and Commitment Therapy (ACT) to meet the specific needs of stroke survivors with aphasia ("ACT for Aphasia").
- Trial name
- NCT04984239
- Testing
- Acceptance and Commitment Therapy for aphasia
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Aphasia, Stroke
Dosage and Predictors of Naming Treatment Response in Aphasia
This study examines aphasia treatment response among Veterans and non-Veterans living with aphasia. It seeks to identify cognitive and neural factors which are predictive of positive response to treatment targeting naming…
- Trial name
- NCT02005016
- Testing
- Naming therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
Stroke, Acute, Aphasia
Yes/No Questionnaire for Aphasic Patients (YNQ)
Quality of care depends strongly on oral communication with patients. Stroke patients, who have language disorders, have understanding difficulties, but also have difficulties in expressing their needs and in being understood.
- Trial name
- YNQ (NCT03257696)
- Testing
- Close-ended questionnaire
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Mild Cognitive Impairment, Primary Progressive Aphasia
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild…
- Conditions
- Mild Cognitive Impairment, Primary Progressive Aphasia, Dementia
- Trial name
- NCT05978804
- Testing
- Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Aphasia, Acquired
Effects of rTMS on Brain Activation in Aphasia
This study will investigate the use of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation method, to improve word-finding abilities in Veterans and non-Veterans with chronic language problems…
- Trial name
- NCT03292471
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Stroke
Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment
People with post-stroke aphasia are left with some degree of chronic deficit for which current rehabilitative treatments are variably effective.
- Trial name
- NCT02901574
- Testing
- Anodal or Cathodal tDCS, Computerized naming therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
Primary Progressive Aphasia
Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)
The purpose of this study is to establish the feasibility of a program of remotely supervised transcranial direct current stimulation (RS-tDCS) paired with language skills practice for people living with the semantic or logopenic…
- Trial name
- NCT05615922
- Testing
- Transcranial Direct Current Stimulation (tDCS), Word-Naming Activity
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Primary Progressive Aphasia, MCI
tDCS Intervention in Primary Progressive Aphasia
Primary progressive aphasia (PPA) is a neurodegenerative disease that affects first and foremost language abilities. Mild cognitive impairment (MCI) is slowly progressive decline in a single domain of cognition (e.g.
- Conditions
- Primary Progressive Aphasia, MCI, FTD
- Trial name
- NCT02606422
- Testing
- Active HD-tDCS plus Speech-Language Therapy
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Aphasia, Stroke
Post-Stroke Aphasia and Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Study
In this study the investigators will examine the efficacy of navigated excitatory repetitive transcranial magnetic stimulation (nerTMS) for the treatment of post stroke aphasia.
- Trial name
- PART (NCT01512264)
- Testing
- Magstim SuperRapid
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
Aphasia, Acquired
Word Retrieval in the Wild in People With Post-Stroke Aphasia
People with post-stroke aphasia (PWA) suffer from anomia, a condition where they know what they want to say but cannot retrieve the words.
- Trial name
- NCT05338216
- Testing
- Traditional EMA, Micro-Interaction EMA
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northeastern University
Primary Progressive Aphasia
Communication Bridge 2
This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA).
- Trial name
- CB2 (NCT03371706)
- Testing
- Communication Bridge™, Evidence-Based Impairment Focused
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Chicago