Clinical trials: Apneic Oxygenation
Sleep-disordered Breathing (SDB)
Sleep-disordered Breathing and Neurocognitive Assessment in Children and Young Adults
One of main problems in the management of sleep-disordered breathing (SDB) in children and young adults is their screening, and the absence or the weak correlation between clinical symptoms and polysomnography (PSG).
- Trial name
- TRSPed (NCT04971850)
- Testing
- Sleep study
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia
Evaluation of Lung Atelectasis During Apneic Oxygenation Using THRIVE in Adults During Laryngeal Surgery.
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing.
- Trial name
- A-THRIVE (NCT03458091)
- Testing
- THRIVE, Endotracheal intubation
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Obesity, Morbid
EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
The risk of complication associated with airway in obese patient is important. The result of pre-oxygenation gives the clinician a prolonged non-hypoxic apnea time.
- Trial name
- EPO2-A (NCT02590406)
- Testing
- Beach chair (BC) and ZEEP, Reverse Trendelenburg and NIPPV
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Apnea of Prematurity, Preterm Birth
Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants
Intermittent episodes of hypoxemia and/or bradycardia, also defined as cardio-respiratory events (CRE) are very frequent in preterm infants and may result in transient hypoxia and hypoperfusion of target organs, with possible…
- Conditions
- Apnea of Prematurity, Preterm Birth, Patent Ductus Arteriosus, Hypoxia, Brain
- Trial name
- NCT04184245
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Obstructive Sleep Apnea Syndrome (OSAS)
The Effect of Inspiratory Muscle Training on Cognitive Functions, Cerebral Oxygenation, and Neurotrophic Factor Level in Patients With Obstructive Sleep Apnea Syndrome
The aim of this clinical study is to examine the effect of an 8-week training program applied to the respiratory muscles that enable breathing in individuals with obstructive sleep apnea syndrome on cognitive functions…
- Trial name
- NCT07329049
- Testing
- inspiratory muscle training, Usual Care
- Volunteers
- 42 people
- Sponsor
- Istinye University
Apnea
Different Flow Rates on Gas Exchange in Children During Apnea
Background: Children desaturate rapidly during apnea following anesthetic induction. The optimal apneic oxygenation flow rate and its effect on CO2 accumulation remain unclear.
- Trial name
- NCT06659887
- Testing
- nasal cannula
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Yasser S Mostafa, MD
Hypoxemia
Pre-oxygenation in Sitting Position and Oxygen Reserve Index
This prospective, controlled and randomized study aims at comparing the effect of position on the oxygen reserve index alarm time which is considered as predictor of hypoxemia in prolonged apnea which might be faced during…
- Trial name
- NCT05964309
- Testing
- supine group, sitting group
- Where
- Saudi Arabia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Airway Obstruction
Effectiveness Of Apneic Oxygenation During Induction Of General Anesthesia In Children
During general anesthesia, the administration of anesthetics and muscle relaxants induces apnea, wherein spontaneous breathing ceases .
- Trial name
- NCT06742476
- Testing
- nasal cannula
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Fayoum University Hospital
Obstructive Sleep Apnea Syndrome
Brain Oxygenation and Hemodynamics During Sleep in Obstructive Sleep Apnea Sufferers
The goal of this trial is to assess the performance of the OxiplexTS-an absolute near-infrared oximeter-as an instrument to measure brain oxygenation and hemodynamics in sleep medicine as well as in the broader field of…
- Trial name
- NIRS-OSAS (NCT00591591)
- Testing
- OxiplexTS
- Where
- 4 sites in United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- ISS, Inc.
Difficult Airway, Difficult Airway Intubation
SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation
Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety.
- Conditions
- Difficult Airway, Difficult Airway Intubation, Neonate
- Trial name
- SEALION (NCT06683599)
- Testing
- Apneic oxygenation
- Where
- 4 sites in Australia, Brazil and 2 more
- Volunteers
- 240 people
- Sponsor
- Vinícius C Quintão, MD, MSc, PhD
Apnoeic Oxygenation
Physiology Regarding Apnoeic Oxygenation During Nasal Cannula Therapy at Different Flow Rates
This study compares under controlled conditions if different flow rates affect apnoea time after induction of anaesthesia and how CO2 clearance is influenced.
- Trial name
- PHARAO (NCT03478774)
- Testing
- Oxygen 70l/min, Oxygen 10 l/min, Oxygen 2l/min
- Where
- Switzerland
- Volunteers
- 125 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diffuse Apneic Oxygenation
EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
To determine the impact, if any the application of oxygen during the apnea period of rapid sequence intubation has on patients being intubated in the emergency department.
- Trial name
- ENDAO (NCT02737917)
- Testing
- Oxygen, Standard of care
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- New York City Health and Hospitals Corporation
Intubation
Utah Study Evaluating Apneic Oxygenation for Emergency Department Intubation
This study will determine rates of first pass success without hypoxemia in emergency department intubations with and without the use of apneic oxygenation by nasal cannula.
- Trial name
- USE AP OX (NCT02961933)
- Testing
- Apneic oxygenation, Pre-oxgenation with NRB, NIPPV, BVM
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Intermountain Health Care, Inc.
Intubation of Pediatric Dental Surgery Patients
The Use of Apneic Oxygenation During Prolonged Intubation in Pediatric Patients: a Randomized Clinical Trial
Patient demographics (age, height and weight) will be collected for 546 consecutive patients presenting for dental restoration under general anesthesia. The baseline saturation will be recorded.
- Trial name
- NCT01886807
- Testing
- TrueView PCD Video Laryngoscope
- Where
- United States
- Volunteers
- 482 people
- Sponsor
- University of Texas Southwestern Medical Center
Intubation, Oxygen Inhalation Therapy
Pre- and Apnoeic Oxygenation for RSI in ED
Critically ill patients may need support for breathing by means of intubation, which is placement of a breathing tube into the windpipe.
- Trial name
- Pre-AeRATE (NCT03396094)
- Testing
- High-flow nasal cannulae (HFNC) oxygenation, Non-rebreather mask and standard nasal cannula
- Where
- Singapore
- Volunteers
- 192 people
- Sponsor
- National University Hospital, Singapore
Obstructive Sleep Apnea, Cognitive Impairment
12-week Tele-exercise Program in Patients With OSA
Obstructive sleep apnea (OSA) contributes to a number of adverse health effects, particularly on brain health. Chronic sleep disturbances caused by OSA could adversely affect cognitive health.
- Trial name
- NCT06467682
- Testing
- tele-exercise
- Volunteers
- 60 people
- Sponsor
- University of Cyprus
Coronary Artery Disease
Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease
Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care.
- Trial name
- CADOS-CMR (NCT02233634)
- Testing
- Oxygen, Hyperventilation Breath-hold (HVBH), HVBH with Oxygen
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anesthesia
High Flow Nasal Cannula in Comparison to Apneic Oxygenation During Foreign Body Removal by Rigid Bronchoscope
To compare the effect of HFNC with standard apneic oxygenation on patient oxygenation and airway protection during foreign body removal by rigid bronchoscope.
- Trial name
- NCT04885673
- Testing
- Vapotherm, Apneic oxygenation
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Apnea, Respiration; Arrest
Pre-oxygenation With Facemask Oxygen vs High-flow Nasal Oxygen vs High-flow Nasal Oxygen Plus Mouthpiece Oxygen
Pre-oxygenation increases oxygen reserves in the body to reduce the likelihood of oxygen desaturation on induction of general anaesthesia. Pre-oxygenation with facemask is the commonest method method of pre-oxygenation.
- Conditions
- Apnea, Respiration; Arrest, Anesthesia
- Trial name
- PREOX (NCT04767867)
- Testing
- Pre-oxygenation
- Where
- Ireland
- Volunteers
- 84 people
- Sponsor
- University College Hospital Galway
Preoxygenation
Improvement of Oxygenation During Apnoea by i-THRIVE
Improvement of oxygenation during apnoea by i-THRIVE Infant Transnasal Humidified Rapid Insufflation Ventilatory Exchange A single-centre prospective randomized controlled trial.
- Trial name
- i-Thrive (NCT02979067)
- Testing
- Nasal oxygen flow
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern