Clinical trials: Appetite, open to volunteers
Obesity/Therapy
Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity
Glucagon-like peptide 1 receptor agonists (GLP-1RA), such as Ozempic and Wegovy, have been rapidly adopted for the treatment of obesity in both youth and adults.
- Trial name
- PLASTIC (NCT07021937)
- Testing
- Semaglutide 1.7mg subcutaneous
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Hematologic Neoplasms, Nausea
The Effect of a Protective Oral Care Protocol Using Peppermint Oil Mouthwash
Hematologic malignancies are the fifth most common type of cancer in the world. Patients with hematologic malignancies receive long-term and exhausting treatments such as chemotherapy, radiotherapy, hematopoietic stem cell…
- Conditions
- Hematologic Neoplasms, Nausea, Vomiting, Anorexia
- Trial name
- NCT07179094
- Testing
- Routine Protective Oral Care, Protective Oral Care Using Peppermint Oil Mouthwash
- Volunteers
- 72 people
- Sponsor
- Şule Güzle
Healthy Adult, Appetite
Interaction Between White Potato Consumption and Meal Timing on Glycemic Response and Appetite in Adults [Experiment 2]
The purpose of this study is to evaluate the interaction between white potato consumption and meal timing on glycemic response, subjective appetite, and energy intake in adults.
- Conditions
- Healthy Adult, Appetite, Mealtiming, Glycemic Response
- Trial name
- NCT07854938
- Testing
- Oven-baked Home Fries, Oven-baked White Russet Potato, Oven-baked Fries
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Obesity (Disorder), Morbid Obesity
Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients
This randomized controlled trial will evaluate the impact of chrono-nutrition, a dietary approach that aligns meal timing with the body's circadian rhythms, on weight change, metabolic outcomes, appetite, and gut microbiota in…
- Conditions
- Obesity (Disorder), Morbid Obesity, Bariatric Sleeve Gastrectomy, Meal Time
- Trial name
- Chrono-ALIGN (NCT07324044)
- Testing
- Standard Post-Bariatric Care (Control), Early Time-Restricted Eating (eTRE), Chronotype-Based Chrono-Nutrition (CB-CN)
- Where
- Saudi Arabia
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- King Saud University
Malnutrition Elderly, Protein Malnutrition
The Effect of a Plant-based, Protein-dense Sauce on Essential Amino Acid Concentrations and Gut Fullness in Older Adults
The goal of this clinical trial is to determine whether meals fortified with plant-based high protein sauce (ProSauce) provide better metabolic availability of essential amino acids compared to meals with standard lower-protein…
- Trial name
- ProSauce (NCT06965699)
- Testing
- ProSauce, low-protein sauce
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Type 2 Diabetes, Appetite Regulation
GLycaemic Outcomes With Whey Protein in ageING
The goal of this placebo-controlled, partial crossover design study is to identify the impact of consuming whey protein before meals on free-living glucose control in older adults living with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Appetite Regulation, Whey Protein, Ageing and Geriatric Health
- Trial name
- GLOWING (NCT07285811)
- Testing
- Glycaemic control with whey protein, Glycaemic control with different doses of whey protein
- Where
- 2 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
T1D, T1DM
Pre-Exercise Whey and Pea Protein in Adolescents With Type 1 Diabetes
The goal of this clinical trial is to learn whether drinking whey protein or pea protein before exercise affects blood sugar levels and appetite in adolescents with type 1 diabetes.
- Trial name
- NCT07836673
- Testing
- low whey protein, moderate whey protein, low Pea protein
- Volunteers
- 30 people
- Sponsor
- University of Jordan
Advanced Malignant Solid Neoplasm, Advanced Biliary Tract Carcinoma
Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer
This phase II trial tests how well olanzapine works in managing cancer cachexia in patients experiencing esophagogastric, hepatopancreaticobiliary, colorectal, or lung cancer that may have spread from where it first started to…
- Conditions
- Advanced Malignant Solid Neoplasm, Advanced Biliary Tract Carcinoma, Advanced Esophageal Carcinoma, Metastatic Esophageal Carcinoma
- Trial name
- NCT05705492
- Testing
- Olanzapine, Questionnaire Administration
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- OHSU Knight Cancer Institute
Healthy Adults
Evaluation of RSB11-HI Postbiotic Supplementation for Supporting Weight Management, Metabolic Wellness, and Quality of Life in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial will evaluate the safety, tolerability, and efficacy of RSB11-HI, a heat-inactivated postbiotic, in healthy adults over an 8-week intervention period.
- Trial name
- NCT07788833
- Testing
- RSB11-HI Heat-Inactivated Postbiotic
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Able Biolabs, LLC
Prediabetes
Effects of Dihydroberberine (DHB) on GLP-1, Glycemic Control, Appetite, and Mood in Adults With Pre-Diabetes
The goal of this clinical trial is to learn if Dihydroberberine (DHB) supplementation affects adults with pre-diabetes. The main questions it aims to answer are: Does DHB supplementation increase the concentration of GLP-1 in the…
- Trial name
- DHB (NCT07210684)
- Testing
- Dihydroberberine（DHB）400 mg
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Nanjing Nutrabuilding Bio-tech Co., Ltd.
Appetite, Binge Eating Behaviour
Effects of Home-Based Transcranial Direct Current Stimulation on Appetite
This randomized, placebo-controlled, double-blind, parallel-design study aims to evaluate the neurophysiological effects of home-based transcranial direct current stimulation (tDCS) on appetite in adults with binge eating…
- Conditions
- Appetite, Binge Eating Behaviour, Food Cravings
- Trial name
- NCT07757438
- Testing
- Active Home-Based tDCS
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Glycemic Response to Feeding in Healthy Participants, Postprandial Amino Acid Concentrations
Comparison of Dairy and Plant-based Alternatives in Adolescents and Older Adults
The purpose of the Dairy vs Plant study is to compare the effects of dairy and plant-based alternative products on blood sugar regulation and nutrient quality in adolescents and older adults.
- Conditions
- Glycemic Response to Feeding in Healthy Participants, Postprandial Amino Acid Concentrations, Appetite Regulation
- Trial name
- NCT06874400
- Testing
- Dairy, Plant-based alternative
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity and Overweight
Brain and Behavior Influences on Obesity Development From Infancy Through Childhood
The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function.
- Trial name
- RESONATE (NCT06861868)
- Testing
- fMRI cue reactivity task, fMRI go no go task, Ad libitum meal test
- Where
- 4 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy, Adult
Interaction Between White Potato Consumption and Meal Timing on Glycemic Response and Appetite in Adults
The purpose of this study is to evaluate the interaction between white potato consumption and meal timing on glycemic response, subjective appetite, and energy intake in adults.
- Conditions
- Healthy, Adult, Appetite, Glycemic Response
- Trial name
- NCT07230951
- Testing
- Oven-baked Home Fries, Oven-baked White Russet Potato, Oven-baked Fries
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Healthy
Effect of Exercise on Appetite in Response to Meals
This clinical trial's primary aim is to investigate the acute effect of two exercise bouts (short [10 minutes] and long [30 minutes]) on appetite and appetite-regulatory hormone responses to a standard meal test.
- Trial name
- NCT06096233
- Testing
- Bouts of Exercise
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Overweight or Obesity
Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes
This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing…
- Trial name
- NCT07685808
- Testing
- Olatorepatide
- Where
- 21 sites in United States
- Volunteers
- 360 people
- Sponsor
- Regeneron Pharmaceuticals
Healthy
cGMP: Metabolism and Appetite Modulation
Phenylketonuria is an inborn error of phenylalanine metabolism. Although the phenylalanine-restricted diet is recognized as the mainstay of therapy, little is known about the impact of protein substitutes on the metabolism of…
- Trial name
- NCT06794515
- Testing
- cGMP-AAs alone (20 g of protein equivalent), cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 160 g of unpeeled apple, cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 10 g of olive oil
- Where
- Portugal
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Overweight
Physical Inactivity and Appetite Regulation
The goal of this parallel-group, two-arm, assessor-blinded, randomised clinical trial is to investigate the effects of reducing physical activity on food intake and satiety in physically active and healthy males, 40-55 years of…
- Trial name
- NCT06240208
- Testing
- Inactivity
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy Overweight/Obese
The Metabolic Effects of Oral Tributyrin Administration
The goal of this double-blinded randomized clinical cross-over trial is to investigate the metabolic and appetite regulating effects of oral tributyrin (a butyrate pro-drug) administration vs placebo.
- Trial name
- TRIMET (NCT07463495)
- Testing
- tributyrin, Control
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Overweight (BMI > 25), Appetite
An Open Label Pilot Study Assessing the Impact of Chromium Picolinate Supplementation on Appetite and Cravings in Overweight Individuals
This open-label, decentralized pilot study evaluates the effects of daily chromium picolinate supplementation (8 mg providing 1,000 mcg chromium) for 8 weeks on appetite, food cravings, and food-related intrusive thoughts ("food…
- Conditions
- Overweight (BMI > 25), Appetite, Craving
- Trial name
- NCT07909109
- Testing
- Study Product
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Nutrition 21, Inc.