Clinical trials: Appropriateness
Adverse Drug Reaction (ADR)
The INTEGRATE Study: Integrated Pharmacogenetics, TDM and Active Pharmacovigilance as Innovative Tools for the Optimisation and Appropriateness of Drug Therapy
The primary goal of this observational study is to evaluate the feasibility of implementing a multidisciplinary approach based on pharmacogenetics, TDM (Therapeutic Drug Monitoring) and MedReview into the clinical practice in…
- Trial name
- INTEGRATE (NCT06822959)
- Testing
- Pharmacogenetics, TDM and MedReview
- Where
- 2 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Direzione centrale salute, politiche sociali e disabilità
Feasibility Studies, Physical Activity
AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study
The purpose of this research is to investigate the feasibility, acceptability, appropriateness, and preliminary efficacy of a wearable and artificial intelligence-driven mobile application-based exercise prescription grounded in…
- Conditions
- Feasibility Studies, Physical Activity, Mental Health (Depression), Anxiety
- Trial name
- NCT07768670
- Testing
- Fitness app powered by AI and wearable device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Coronary Artery Disease, Angina Pectoris
Appropriateness of Angioplasty in Patients With Chronic Coronary Syndromes
Percutaneous coronary intervention (PCI) has dramatically changed the treatment of obstructive coronary artery disease patients.
- Trial name
- RIGHT-PCI (NCT06545448)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- Brazil
- Volunteers
- 1,875 people
- Sponsor
- University of Sao Paulo General Hospital
Polypharmacy, General Surgery
Polypharmacy and Associated Risk Factors and Clinical Outcomes for Surgical Patients Discharged From Hospital
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue.
- Trial name
- NCT04805151
- Testing
- No intervention
- Where
- Iceland
- Volunteers
- 56,000 people
- Sponsor
- University of Iceland
Lung Cancer, Cancer of the Lung
Implementation and Effectiveness of the BJC-Pink and Pearl Project on Lung Cancer Screening
The investigators proposal is ripe for executing as the investigators seek to leverage this "natural experiment" initiated by the BJC health system to evaluate the effectiveness of the Pink \& Pearl Campaign as an implementation…
- Trial name
- NCT06898333
- Where
- United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Renal Artery Stenosis Atherosclerotic, Secondary Hypertension Renal Arterial
Fractional Flow Reserve to Determine Atherosclerosis Renovascular Hypertension Stenting
Although randomized trials have demonstrated there is no benefit of renal-artery stenting in addition to medical therapy for patients with atherosclerosis renal artery stenosis, many patients indeed gained benefit in daily…
- Trial name
- FAIR-Pilot (NCT05732077)
- Testing
- Dopamine, Fractional Flow Reserve, Renal, Renal artery stenting
- Where
- 13 sites in China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Quality of Care, Evaluation
Evaluation of the Quality of Care in the Emergency Department by Studying the Appropriateness of Admissions of Patients Accessing the Emergency Department (ASST Papa Giovanni XXIII)
The aim of this study is to develop, study and validate a rigorous and sustainable method for assessing the clinical appropriateness of the decision taken in the Emergency Department to admit or not to admit patients.
- Conditions
- Quality of Care, Evaluation, Emergency Departments, Appropriateness
- Trial name
- NCT06345378
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Skin Diseases, Skin Condition
Pilot Study: AI Algorithm for Dermatology Referral Optimization
The goal of this observational prospective and analytical study is to validate that the device is a valid tool for improving the adequacy of referrals to dermatology.
- Trial name
- DAO_DERIVATION (NCT06228014)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- AI Labs Group S.L
Inappropriate Prescribing
Ensuring Clinical Appropriateness and Safety of Pharmacological Therapies in Nursing Home Residents
The goal of this clinical study is to evaluate whether a structured, clinical pharmacology team-led medication review improves the appropriateness and safety of medication prescribing in elderly nursing home (NH) residents.
- Trial name
- NCT07407387
- Testing
- Multi-Component Intervention on Medication Prescribing
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- Lugano Istituti Sociali
Syntax Score, Appropriateness
Real-time Feedback of SYNTAX Score Category During Coronary Angiographies to Improve Appropriateness of Coronary Revascularization for Patients With Stable Coronary Artery Diseases: a Before-and-after Controlled Study
The SYNTAX score (SS) has been recommended by clinical guideline and appropriate use criteria for coronary revascularization (CR) to provide guidance on optimal treatment strategies for patients with stable coronary artery…
- Conditions
- Syntax Score, Appropriateness, Coronary Revascularization
- Trial name
- NCT03068858
- Testing
- real-time feedback of SYNTAX score category
- Where
- China
- Volunteers
- 3,245 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart Failure, Atrial Fibrillation (AF)
Assessment of Medication Adherence in Ccu Admitted Patients
This study aims to assess medication adherence and the appropriateness of prescribed medications among patients admitted to the Coronary Care Unit (CCU).
- Trial name
- NCT07504406
- Testing
- No intervention (observational study)
- Where
- 2 sites in Iraq
- Volunteers
- 250 people
- Sponsor
- AlFayhaa General Hospital
Fever, Acute Pain
Using a Decision-making System to Support the Management of Fever and Acute Pain in Children
FEVER is a single-center, prospective, open-label, pre-market, pivotal, single-arm study aimed at demonstrating how the use of an algorithm integrated with a Class I Medical Device (Puntofarma®), which is made available through a…
- Trial name
- FEVER (NCT07344090)
- Testing
- Puntofarma® FEVER
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Qwince Innovation S.r.l.
Multimorbidity, Polypharmacy
Multi-PAP: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy
This study assesses the effectiveness of a complex intervention in young-old patients with multimorbidity and polypharmacy aimed at improving physician drug prescription in primary care, measured by means of the Medication…
- Conditions
- Multimorbidity, Polypharmacy, Other Diagnoses, Comorbidities, and Complications
- Trial name
- Multi-PAP (NCT02866799)
- Testing
- Multi-PAP, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 593 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud
Hemostasis, Perioperative Bleeding
Appropriateness of Hemostatic Agent Use in Cardiovascular Surgery (HAEMOVAX)
Hemostatic agents are widely used in cardiac and vascular surgery to support intraoperative bleeding control. Despite their clinical relevance and substantial economic impact, little is known about real-world patterns of use…
- Conditions
- Hemostasis, Perioperative Bleeding, Cardiovascular Surgery, Cardiac Surgery
- Trial name
- HAEMOVAX (NCT07699016)
- Testing
- observational study
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Milan
Severe Community-acquired Pneumonia (sCAP)
Appropriateness of Antibiotic Combination Therapy for Severe Community-acquired Pneumonia in South Korea
This study aims to provide high-level evidence for appropriate empirical antibiotic use tailored to the clinical reality in Korea by conducting a randomized controlled trial comparing monotherapy with piperacillin/tazobactam and…
- Trial name
- ACTSCAP (NCT06977347)
- Testing
- Piperacillin/Tazobactam, Piperacillin/tazobactam + Levofloxacin
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- CHOSEOK YOON
Any Conditions
Health Care Appropriateness Assessment and Support Programme at a University Hospital Centre (CHU) in Bordeaux
Non-appropriateness of care is a common and serious phenomenon that affects healthcare institutions in France. Appropriateness in health care is about adequacy of any type of health care with patient's needs.
- Trial name
- sPREAdPerti (NCT04908501)
- Testing
- Intervention
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Bordeaux
Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes
Appropriateness of Coronary Angioplasty in PAtients With isCHEmic Heart Disease
An observational, retrospective, multicenter, blinded adjudication study to evaluate the clinical appropriateness of Percutaneous Coronary Intervention (PCI) indication and execution in patients with stable Coronary Artery…
- Conditions
- Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes, NSTEMI, Unstable Angina
- Trial name
- APACHE (NCT02748603)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Italian Society of Invasive Cardiology
Diarrhea
Study to Determine the Best Way to Measure How Quickly the Drug Can Give Relief From Sudden Diarrhea
For six hours following drug administration, subjects will rate the severity of specific symptoms. At the end of the six hour study, subjects will rate the overall effectiveness of the product.
- Trial name
- NCT00685607
- Testing
- loperamide-simethicone
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Rheumatic Diseases, Inflammatory Arthritis
The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions
The goal of this prospective observational quality improvement study is to determine if a physician tool, MedSafer, combined with educational brochures for patients, can help to reduce the use of 'potentially inappropriate…
- Conditions
- Rheumatic Diseases, Inflammatory Arthritis, Systemic Lupus Erthematosus (SLE), Vasculitis
- Trial name
- NCT07278609
- Testing
- MedSafer deprescribing opportunity reports, EMPOWER brochures
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Quality of Care, Evaluation
Evaluation of the Quality of Care in the Emergency Department by Studying the Appropriateness of Admissions of Patients Accessing the Emergency Department (Fondazione IRCCS Ca' Granda Ospedale Maggione Policlinico)
The aim of this study is to develop, study and validate a rigorous and sustainable method for assessing the clinical appropriateness of the decision taken in the Emergency Department to admit or not to admit patients.
- Conditions
- Quality of Care, Evaluation, Emergency Department, Appropriateness
- Trial name
- NCT06345352
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Mario Negri Institute for Pharmacological Research