Clinical trials: Arginine
Dentine Hypersensitivity
Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes
Dentin hypersensitivity is a common problem in society. Untreated hypersensitivity affects the patient's quality of life, complicates plaque control and increases the risk of caries and periodontal disease.
- Trial name
- NCT06197555
- Testing
- Sodium Monofluorophosphate, Stannous Fluoride, Nano-Hydroxyapatite
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Altinbas University
Prevention of White Spot Lesions
the Remineralizing Self-Assembling Peptide P11-4, 2% Arginine Enriched Sodium Fluoride and Functionalized Tri Calcium Phosphate Fluoride White Spot Lesions
The aim of the current study is to compare the remineralizing ability of Self-assembling peptide P11-4, 2% Arginine Enriched Sodium Fluoride and Functionalized Tri Calcium Phosphate Fluoride varnishes in treatment of white spot…
- Trial name
- NCT05127889
- Testing
- curodont
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Anemia, Sickle Cell
Effectiveness of Arginine as a Treatment for Sickle Cell Anemia
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited genetic disease that can cause intense pain episodes.
- Trial name
- Arginine (NCT00513617)
- Testing
- Arginine
- Where
- 17 sites in United States
- Volunteers
- 128 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Hypersensitivity
Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity
The objective of this study is to assess clinical efficacy of a toothpaste containing 8% arginine (Colgate-Palmolive Company, New York, NY, USA) to provide dental hypersensitivity relief (tactile and air blast) in comparison to…
- Trial name
- NCT07257042
- Testing
- Toothpaste containing 8% Arginine, Colgate Cavity Protection Toothpaste
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Healthy Adult
L-arginine Supplementation and Resistance Exercise
The purpose of this study was to examine the acute endothelial, cardiovascular, and performance responses to L-arginine by assessing flow-mediated dilation (FMD) and heart rate variability (HRV) both before and after resistance…
- Trial name
- NCT03827005
- Testing
- L-arginine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Healthy
Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Experimental Increase of Intraocular Pressure in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00914394
- Testing
- NG-monomethyl-L-arginine (L-NMMA), Phenylephrine, Laser Doppler Flowmetry
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Periodontitis
Supplementation With L-ornithine But Not L-arginine Increases Density of CD68+ and CD163+ Macrophages in Periodontitis
The aim of the study was to investigate whether oral administration of L-arginine or L-ornithine could modulate local representation density and ratio of macrophages in periodontitis-affected gingiva by using immunohistochemical…
- Trial name
- NCT05042024
- Testing
- Scaling and root planing, Oral L-arginine aspartate administration, Oral L-ornithine aspartate administration
- Where
- Ukraine
- Volunteers
- 75 people
- Sponsor
- Ukrainian Medical Stomatological Academy
Placebo Analgesia
Oxytocin and Arginine Vasopressin in Pain Relief
Background: Oxytocin, a substance produced mostly in the brain, plays a role in influencing social interactions and reactions to stress, and may be related to pain.
- Trial name
- NCT01328561
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Dentin Sensitivity, Dentin Hypersensitivity
Efficacy of a Sonic Toothbrush and 8% Arginine Toothpaste in Reducing Dentinal Hypersensitivity
This clinical study evaluates the efficacy of an oral hygiene regimen consisting of an electric sonic toothbrush used in combination with an 8.0% arginine and calcium carbonate toothpaste in reducing dentinal hypersensitivity…
- Trial name
- NCT07871786
- Testing
- 8.0% Arginine Dentifrice, Electric Sonic Toothbrush, Adult Soft Bristle Manual Toothbrush
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Colgate Palmolive
Arginine Vasopressin Deficiency, Central Diabetes Insipidus
Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls
The study aims to investigate whether intranasal oxytocin (OXT) improves sexual well-being in patients with Arginine Vasopressin Deficiency (AVP-D).
- Conditions
- Arginine Vasopressin Deficiency, Central Diabetes Insipidus, Oxytocin Deficiency
- Trial name
- OxyPLEASURE (NCT06808516)
- Testing
- Oxytocin nasal spray
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pre-diabetes, Type 2 Diabetes
Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass
This study evaluates exenatide, sitagliptin, and glimepiride for the treatment of high blood sugar in patients with impaired fasting glucose or early type 2 diabetes.
- Trial name
- NCT00775684
- Testing
- Exenatide, Sitagliptin, Glimepiride
- Where
- 3 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Pennsylvania
Dental Caries, Oral Bacterial Infection
Ecological Effect of Arginine Dentifrice on Oral Microbiota
caries-free (CF) individuals caries-active (CA) individuals (DMFT ≥ 6) will be recruited. Subjects will be instructed to brush their teeth twice daily for 3 min using Colgate® Sensitive Pro-Relief® toothpaste (containing 8%…
- Conditions
- Dental Caries, Oral Bacterial Infection, Microbiota
- Trial name
- NCT02988349
- Testing
- Colgate® Sensitive Pro-Relief® toothpaste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Severe Falciparum Malaria
Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria
Background: Mortality from severe malaria remains ~15% despite the use of the most rapidly parasiticidal antimalarial therapy, artesunate. Adjunctive treatments may improve outcome.
- Trial name
- ARGISM (NCT00616304)
- Testing
- L-arginine hydrochloride, Normal saline
- Where
- Indonesia
- Volunteers
- 8 people
- Sponsor
- Menzies School of Health Research
Adipose Tissue, Brown, Glucose Intolerance
L-arginine and Brown Adipose Tissue
The South Asian population is facing an epidemic of type 2 diabetes, of which the underlying cause is still unknown. It is currently hypothesized that an ethnic susceptibility towards a disturbed energy metabolism may underlie…
- Conditions
- Adipose Tissue, Brown, Glucose Intolerance, Nitric Oxide
- Trial name
- ArgMB (NCT02291458)
- Testing
- L-arginine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Physiologically Healthy Adult Male Participants
Lysine Oxidation in Response to Arginine Supplementation
This research study is investigating if consuming more of one amino acid (arginine) influences the digestion and absorption of another amino acid (lysine) due to competition in digestion, in a healthy adult population.
- Trial name
- NCT02499926
- Testing
- Arginine
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dental Caries, Dental Plaque
The Effect of Arginine on Biofilm Composition, Architecture and Metabolism
Arginine is an adjunct to oral health care that has the potential to modulate the composition and activity of the microbial community of dental biofilms towards a health-related status without harmful effects for the resident…
- Conditions
- Dental Caries, Dental Plaque, Microbial Colonization
- Trial name
- NCT06135792
- Testing
- Arginine
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Diabetes (DM), Diabetic Ketoacidosis
Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes
Diabetic ketoacidosis (DKA) is increasingly recognized in adults with "ketone-prone" type 2 diabetes. In many of these patients, the pancreas can still make insulin but becomes temporarily "stunned" during severe, prolonged high…
- Conditions
- Diabetes (DM), Diabetic Ketoacidosis, Ketosis Prone Diabetes, Hyperglycaemia (Diabetic)
- Trial name
- NCT07167693
- Testing
- Arginine hydrochloride, Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David K Carroll
Lymphoma, Non-Hodgkin Lymphoma
AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.
This study is designed to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy following oral administration of AZD3470 as a monotherapy, and in combination with other anticancer agents in…
- Conditions
- Lymphoma, Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Peripheral T-cell Lymphoma (PTCL)
- Trial name
- PRIMAVERA (NCT06137144)
- Testing
- AZD3470, Pembrolizumab
- Where
- 38 sites in United States, Australia and 9 more
- Volunteers
- 161 people
- Sponsor
- AstraZeneca
End Stage Renal Disease, Hemodialysis
L-Arginine and Spironolactone Trial in Dialysis-Dependent ESRD
Cardiovascular disease is the primary cause of death in patients with end stage renal disease (ESRD). New research suggests that the high risk of death may be partly due to high levels of fibrosis and a loss of small blood…
- Trial name
- LAST-D (NCT01855334)
- Testing
- Spironolactone, L-arginine
- Where
- 3 sites in United States
- Sponsor
- Brigham and Women's Hospital