Clinical trials: Arterial Occlusive Diseases
Carotid Artery Stenosis, Aortic Calcification
Aortic Calcification - is it a Marker for Carotid Artery Stenosis?
Atherosclerosis is the major contributor for the morbidity and mortality for the variety of cardiovascular diseases. Aortic calcification on x-ray is a marker for arterial atherosclerosis and an independent prognostic factor for…
- Trial name
- NCT01458860
- Volunteers
- 200 people
- Sponsor
- Ziv Hospital
Heart Failure, Resistance Training
The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation
The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.
- Conditions
- Heart Failure, Resistance Training, Coronary Artery Disease
- Trial name
- NCT05391620
- Testing
- Cardiac rehabilitation with 3/7 method, Cardiac rehabilitation with 3X9 method
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Université Libre de Bruxelles
Peripheral Arterial Disease
The Isthmus Logic Post Market Clinical Follow-up Study
Isthmus Logic Carbostent™ is a CE-marked cobalt chromium stent with a bio inducer surface for the treatment of peripheral iliac artery disease.
- Trial name
- NCT05616143
- Testing
- Isthmus Logic
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- CID S.p.A.
Peripheral Arterial Disease
Egg Study With Peripheral Arterial Disease
The current research study has the potential to generate data that would provide solid clinical endpoints as to the impact of including eggs in a regular diet in individuals with peripheral arterial disease.
- Trial name
- NCT01256320
- Testing
- Classic Egg Group, Omega 3 Egg Group
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Atherosclerosis, Prediction Model
Metabolomics Characterization of Biomarkers of ASCVD and Prediction Model
1. Describe the risk factors and metabonomics characteristics of atherosclerotic cardiovascular disease in Chinese patients. 2. Establish accurate prediction model of atherosclerotic heart disease.
- Trial name
- MEAL (NCT05148182)
- Where
- 2 sites in China
- Volunteers
- 1,869 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Diabetes Mellitus Type 2, Coronary Artery Diseases
Comparison of Effects of Buffered and Enteric-coated Forms of Aspirin on Platelet Aggregation in Patients With Diabetes Mellitus and Chronic Coronary Syndrome
Patients with diabetes mellitus are characterized by "hyperreactive" platelets and a reduced response to ASA compared to individuals without diabetes.
- Conditions
- Diabetes Mellitus Type 2, Coronary Artery Diseases, Aspirin Resistance
- Trial name
- CASCADE (NCT06716255)
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Nizhpharm
Cardiovascular Diseases, Coronary Artery Disease
Using the Visualization for Lifestyle Change in Patients At Risk of Cardiovascular Diseases
In the framework of PhD research, the investigators will present a visualization of estimation of CVDs risk and the possibility of monitoring blood glucose levels in real-time.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Heart Diseases, Coronary Heart Disease
- Trial name
- NCT06226948
- Testing
- CGM, Visualization
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Maribor
SLE, Cardiovascular Diseases
Flow Mediated Dilation in Association With Hyperuricemia
Assess cardiovascular affection and subclinical atherosclerosis in patients with systemic lupus using the non invasive flow mediated dilation.
- Conditions
- SLE, Cardiovascular Diseases, Atherosclerosis
- Trial name
- NCT05342285
- Testing
- Flow mediated dilation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiovascular Disease (CVD), Stroke
A Genomic Approach for Clopidogrel in Caribbean Hispanics
Clopidogrel is a prescription medicine used to minimize blood clot formation in patients with cardiovascular disease, particularly those undergoing heart catheterization and stroke.
- Conditions
- Cardiovascular Disease (CVD), Stroke, Acute Coronary Syndrome, Peripheral Arterial Disease
- Trial name
- NCT03419325
- Testing
- CYP2C19 test, P2RY12 assay
- Where
- 2 sites in Puerto Rico
- Volunteers
- 150 people
- Sponsor
- University of Puerto Rico
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Arterial Disease
The Impact of Branched-Chain Amino Acid Metabolism on Limb Dysfunction in PAD
Test the theory that abnormalities in the large blood vessels that deliver blood to your leg and the very small blood vessels in your leg's muscles (invisible to the eye) work together to worsen your leg function and walking.
- Trial name
- NCT03490968
- Testing
- Supervised Exercise, Vascular Assessment
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes Mellitus, Coronary Artery Disease
Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease
Type 2 diabetes is associated with a markedly increased risk for atherosclerotic coronary arteries and cerebrovascular diseases.
- Trial name
- NCT01038050
- Testing
- Ginkgo Biloba Extract (GBE)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Peripheral Artery Disease
Microvascular Reactivity in Peripheral Artery Disease
Peripheral Artery Disease (PAD) is a major risk factor for lower limb amputation. Microvascular reactivity assessed with near-infrared spectrometry has been studied in people with PAD but not in people with limb loss (PLL) who…
- Trial name
- NCT05063474
- Testing
- No Intervention-Clinical Assessments only
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Columbia University
Heart Valve Diseases, Coronary Artery Disease
coRonary assEssment of Preoperative vaLvulopathy pAtients Using ComputEd Tomographic Angiography (REPLACE)
Preoperative detection of combined coronary artery disease by invasive coronary angiography (ICA) is recommended in American Heart Association (AHA)/American College of Cardiology (ACC) guidelines for most patients (>40 yrs male…
- Trial name
- REPLACE (NCT02632617)
- Testing
- Computed tomographic angiography
- Where
- 5 sites in China
- Volunteers
- 2,644 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Intermittent Claudication, Peripheral Vascular Disease
Efficacy and Safety of NM-702 Tablets for the Treatment of Intermittent Claudication
NM-702 oral tablets are being developed for the treatment of Intermittent Claudication, a primary early stage indication of peripheral arterial disease (PAD).
- Trial name
- NCT00102050
- Testing
- NM-702 (phosphodiesterase inhibitor)
- Where
- 17 sites in United States
- Volunteers
- 390 people
- Sponsor
- Nissan Chemical Industries
Atherosclerosis, Hypercholesterolemia
Rosuvastatin Affecting Aortic Valve Endothelium
Recent studies support the hypothesis that aortic stenosis (AS) develops due to atherosclerosis affecting the aortic valve endothelium.
- Trial name
- NCT00114491
- Testing
- Rosuvastatin
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital Pedro Hispano
Coronary Artery Disease, Coronary Artery Stenosis
Sirolimus-coated Balloon Versus Drug-eluting Stent in Native Coronary Vessels - TRANSFORM II
International, multicentric, prospective, investigator-driven, open-label, randomized (1:1) clinical trial to observe and evaluate the efficacy, of Magic Touch Sirolimus Coated Balloon (SCB) compared to one of the gold standard…
- Trial name
- TRANSFORM II (NCT04893291)
- Testing
- Everolimus Eluting Stent, Sirolimus Coated Balloon
- Where
- 53 sites in Bangladesh, Brazil and 9 more
- Volunteers
- 1,820 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Fibromuscular Dysplasia, Renal Artery Stenosis
Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study
Fibromuscular dysplasia (FMD) is localized structural defects in the arterial wall, whose innate or acquired character is still unknown.
- Trial name
- NCT02528149
- Testing
- tissue of adjacent part and aneurysm of renal aneurysm, blood sample
- Where
- 17 sites in France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atherosclerotic Cardiovascular Disease
A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE)
The purpose of this study was to assess the effectiveness of an "inclisiran first" implementation strategy (addition of inclisiran to maximally tolerated statin therapy immediately upon failure to achieve acceptable LDL-C with…
- Trial name
- V-INITIATE (NCT04929249)
- Testing
- Inclisiran
- Where
- 43 sites in United States
- Volunteers
- 450 people
- Sponsor
- Novartis Pharmaceuticals
Femoral Artery Occlusion
Remote Endarterectomy vs Remote Endarterectomy + Drug Coated Balloon (DCB) Angioplasty in Patients With the Femoral Artery Occlusive Disease
Comparison effectiveness two methods revascularization of the superficial femoral artery: remote endarterectomy vs. remote endarterectomy supplemented DCB angioplasty in patients with steno-occlusive lesion of the…
- Trial name
- NCT03142347
- Testing
- Remote endarterectomy, Remote endarterectomy + DCB balloon
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
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