Clinical trials: Arthritis, Rheumatoid (RA)
Chronic Widespread Pain
A Prevalence Study of Chronic Widespread Pain (CWP) Among Patients With Rheumatoid Arthritis (RA) and Control Population in Tallinn and Harjumaa County
The chronic widespread pain (CWP) and fibromyalgia (FM) cause serious discomfort, but at the same time they are not life threatening and they cannot be detected by any laboratory tests.
- Trial name
- NCT00721318
- Where
- Estonia
- Volunteers
- 6,000 people
- Sponsor
- Estonian Society for Rheumatology
Rheumatoid Arthritis
A Study of Tocilizumab in Participants With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Non-Biological Disease-modifying Anti-rheumatic Drugs (DMARDs)
This observational study will evaluate the safety and efficacy of tocilizumab in participants with active moderate to severe RA and an inadequate response to non-biologic DMARDs.
- Trial name
- NCT01617005
- Testing
- Tocilizumab
- Where
- Montenegro
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Success of Tocilizumab in RA Patients With Remission Induction and Sustained Efficacy After Discontinuation
The objective of this study is to investigate the efficacy and safety of the humanized anti-human IL-6 receptor monoclonal antibody tocilizumab (TCZ) either in monotherapy or in combination therapy with methotrexate (MTX) in…
- Trial name
- SURPRISE (NCT01120366)
- Testing
- Tocilizumab plus methotrexate, Tocilizumab
- Where
- 30 sites in Japan
- Volunteers
- 233 people
- Sponsor
- SURPRISE Study Group
Rheumatoid Arthritis
The Durability of Early RA Disease Control After Tocilizumab Withdrawal: A Canadian Experience
Patients who participated in the FUNCTION Study (Protocol WA19926) will be enrolled in this study. The investigators want to learn how long it takes Early Rheumatoid Arthritis patients who were treated with Tocilizumab to require…
- Trial name
- NCT03109470
- Sponsor
- Pope Research Corporation
Rheumatoid Arthritis
Prediction of Response to Certolizumab Pegol Treatment by Functional MRI of the Brain
By using functional MRI the investigators have recently shown that TNFi elicit rapid changes in brain function linked to the perception of RA [5].
- Trial name
- PreCePRA (NCT01864265)
- Testing
- Certolizumab Pegol
- Where
- 6 sites in Germany, Portugal and 1 more
- Volunteers
- 156 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Rheumatoid Arthritis, Axial Spondyloarthritis
Observational Study to Evaluate the Real-Life Effectiveness of Benepali Following Transition From Enbrel
The primary objective is to evaluate the effectiveness of Benepali in participants with Rheumatoid Arthritis (RA) and axial spondyloarthritis (axSpA), including participants with Ankylosing Spondylitis (AS) and non-radiographic…
- Trial name
- BENEFIT (NCT03100734)
- Testing
- Benepali, Enbrel
- Where
- Germany
- Volunteers
- 585 people
- Sponsor
- Biogen
Rheumatoid Arthritis, Arthritis, Rheumatoid
A Study of JHL1101 Versus MabThera® in Subjects With Severe Rheumatoid Arthritis
This is a multicentre, randomised, double-blind, parallel group study to compare the pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, safety, tolerability and efficacy of JHL1101 versus MabThera in subjects with…
- Trial name
- NCT03161457
- Testing
- JHL1101, MabThera
- Where
- 32 sites in Bosnia and Herzegovina, Bulgaria and 9 more
- Volunteers
- 153 people
- Sponsor
- JHL Biotech, Inc.
Rheumatoid Arthritis
Safety and Efficacy of the Combination of Diacerein 100 mg Daily and MTX Versus MTX Alone in the Treatment of Early Rheumatoid Arthritis (RA)
To evaluate the efficacy of Diacerein 100 mg daily versus placebo in reducing rheumatoid arthritis symptoms, when added to stable oral MTX therapy in patients with active early RA.
- Trial name
- NCT01264211
- Testing
- Diacerein
- Where
- 2 sites in Thailand
- Volunteers
- 40 people
- Sponsor
- TRB Chemedica
Rheumatoid Arthritis
Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification
The main aim of the study is to determine the clinical utility of naive T-cell stratification for rationalising treatment with methotrexate (MTX), for DMARD-naive early RA patients.
- Trial name
- TEEMS (NCT03813771)
- Testing
- Benepali, Sulfasalazine, Methotrexate
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Leeds
Arthritis, Rheumatoid, Biological Therapy
Assessment of the Clinical and Medico-economic Impact of SinnoTest® in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is one of the main chronic inflammatory rheumatic diseases (RCI), with a prevalence of about 0.4% of the population.
- Trial name
- SINNO-RA (NCT04117165)
- Testing
- Biotherapy Prescription with SinnoTest® software, Patient Current Care
- Where
- 16 sites in France
- Sponsor
- University Hospital, Grenoble
Rheumatoid Arthritis, Insulin Resistance
Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA)
Muscle strength helps determine a person's quality of life and functional independence. Patients with rheumatoid arthritis often suffer from muscle weakness and a pre-diabetic condition called insulin resistance.
- Trial name
- NCT02535832
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Rheumatoid Arthritis
Efficacy and Safety of Sarilumab and Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (SARIL-RA-MONARCH)
Primary Objective: To demonstrate that sarilumab monotherapy was superior to adalimumab monotherapy with respect to signs and symptoms as assessed by disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) in…
- Trial name
- NCT02332590
- Testing
- Sarilumab, Adalimumab
- Where
- 86 sites in United States, Chile and 13 more
- Volunteers
- 369 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
Rheumatoid Arthritis Patients and Porphyromonas Gingivalis
Rheumatoid arthritis (RA) is the most frequent joint inflammatory disease inducing joint destruction strongly correlated with anti-citrullinated protein antibodies citrullinated anti-peptide (ACPA).
- Trial name
- NCT02905175
- Testing
- blood sample, synovial tissue
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Rheumatoid Arthritis, Osteoarthritis
Patient Education in Rheumatoid Arthritis and Osteoarthritis
This project will evaluate the effectiveness and general usefulness of two arthritis patient education programs. The first, the Arthritis Self-Management Program, is a 6-week, community-based program taught in small groups by…
- Trial name
- NCT00000414
- Testing
- Arthritis Self-Management Program, SMART Program
- Where
- 5 sites in United States, Canada
- Volunteers
- 1,200 people
- Sponsor
- Stanford University
Rheumatoid Arthritis (RA)
Integrated Care Approach for Rheumatoid Arthritis Patients
The goal of this study is to learn about the long-term effects of integrated care approach in persons over the age of 20 who take part in integrated care approach to treat their rheumatoid arthritis (RA).
- Trial name
- NCT06791980
- Testing
- ETLA
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Dalin Tzu Chi General Hospital
Rheumatoid Arthritis, Polyarthritis
The Use of Anti-CD4 Monoclonal Antibody (mAb)-Fragment for the Imaging of Chronic Inflammation in Patients With Active Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a disease with a large economic impact due to the long lasting disabling nature of the disease. Furthermore, diagnosis of the disease is difficult and only a scheme with different symptoms is used to…
- Conditions
- Rheumatoid Arthritis, Polyarthritis, Rheumatism, Autoimmune Disease
- Trial name
- NCT00372177
- Testing
- Fab-fragment of Anti-human CD4
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- Biotectid GmbH
Arthritis, Rheumatoid
A Study to Compare Meloxicam IM Once Daily Versus Meloxicam Orally Once Daily in Patients With Rheumatoid Arthritis
The objective of this trial was to assess the efficacy and safety of 15 mg meloxicam i.m. once daily compared with 15 mg meloxicam tablets once daily p.o. in patients with Rheumatoid arthritis over a time period of 7 days.
- Trial name
- NCT00239382
- Testing
- Meloxicam ampoule, Meloxicam tablet
- Where
- 8 sites in China
- Volunteers
- 150 people
- Sponsor
- Boehringer Ingelheim
Rheumatoid Arthritis
Real Life Evaluation of Rheumatoid Arthritis Patients in Israel Treated With HUMIRA
In Israel, data is lacking regarding the long-term effectiveness of Adalimumab in outpatient real life setting. Moreover, the association between long-term effectiveness of Adalimumab and patients' functional status as well as…
- Trial name
- ORIENT (NCT02322723)
- Sponsor
- AbbVie
Rheumatoid Arthritis
Quantification of GADD34 Expression in RA
GADD34 is an inducible cofactor of protein phosphatase 1, which has an important role in the Unfolded Protein Response (UPR). UPR is a cellular response to ER stress which is implicated in several autoimmune diseases.
- Trial name
- GADD34-RA (NCT02401165)
- Testing
- Blood test
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Rheumatoid Arthritis
A Study of KD6005 in Healthy Participants and Participants With Rheumatoid Arthritis (RA)
This phase 1 study will consist of two parts: Phase 1a is a single-dose study, and will evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary pharmacodynamics (PD) in healthy participants.
- Trial name
- NCT06213259
- Testing
- KD6005
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Shanghai Kanda Biotechnology Co., Ltd.