Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis
A Study in Participants With Rheumatoid Arthritis
The primary purpose of this study is to help answer if LY2127399 is safe and effective in the treatment of rheumatoid arthritis in participants with an inadequate response to one or more tumor necrosis factor-alpha (TNF-α)…
- Trial name
- FLEX V (NCT01202773)
- Testing
- LY2127399
- Where
- 201 sites in United States, Argentina and 17 more
- Volunteers
- 456 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
To Evaluate the Immunogenicity and Safety of Sarilumab Administered as Monotherapy in Patients With Rheumatoid Arthritis (RA)
Primary Objective: To evaluate the immunogenicity of sarilumab administered as monotherapy. Secondary Objectives: To evaluate the other safety aspects of sarilumab administered as monotherapy.
- Trial name
- SARIL-RA-ONE (NCT02121210)
- Testing
- sarilumab SAR153191 (REGN88)
- Where
- 28 sites in United States, Chile and 5 more
- Volunteers
- 132 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis (RA) Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDs
This is a randomized, double-blind study comparing ABT-494 to placebo in Japanese participants with moderately to severely active rheumatoid arthritis who are on a stable dose of conventional synthetic disease-modifying…
- Trial name
- SELECTSUNRISE (NCT02720523)
- Testing
- Upadacitinib
- Where
- 50 sites in Japan
- Volunteers
- 197 people
- Sponsor
- AbbVie
Rheumatoid Arthritis
Difference in GC-induced Adrenal Insufficiency in RA Related to Polymorphisms in the Glucocorticoid Receptor Gene
Development of glucocorticoid (GC)-induced adrenal insufficiency is a serious adverse effect of GC treatment. It is today not possible to predict this adverse effect.
- Trial name
- NCT01411046
- Testing
- Synacthen test
- Where
- Denmark
- Volunteers
- 106 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Rheumatoid Arthritis
A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid Arthritis
This randomized, double-blind, placebo-controlled study will compare the efficacy with regard to sustained remission and safety of tocilizumab and methotrexate, in combination or as monotherapy, in treatment-naïve patients with…
- Trial name
- NCT01034137
- Testing
- methotrexate, tocilizumab [RoActemra/Actemra]
- Where
- 21 sites in Netherlands
- Volunteers
- 317 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Study to Evaluate Efficacy, Safety and Tolerability of JTE-051 in Subjects With Active Rheumatoid Arthritis
This study will evaluate the efficacy, safety, tolerability and pharmacokinetics (PK) of JTE-051 administered for 12 weeks in subjects with active rheumatoid arthritis who are receiving background non-biologic disease-modifying…
- Trial name
- MOVE-RA (NCT02919475)
- Testing
- JTE-051
- Where
- 39 sites in United States, Argentina and 8 more
- Volunteers
- 260 people
- Sponsor
- Shionogi Inc.
Temporomandibular Disorders, Rheumatoid Arthritis
Biomarkers Associated With Temporomandibular Disorders in Patients With Rheumatoid Arthritis
The goal of this observational study is to determinate temeporomandibular disorders (TMDs) and levels of biomarkers in 30 rheumatoid arthritis patients and 30 healthy controls.
- Trial name
- NCT06488937
- Where
- Croatia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Rheumatoid Arthritis (RA)
Safety, Tolerability, and PK/PD of CIGB-814 in Chinese Health Participants
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of CIGB-814 for injection after single and multiple administrations in healthy participants.
- Trial name
- NCT07182656
- Testing
- CIGB-814 (single-dose group), CIGB-814 (multiple-dose group)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yi Fang
Rheumatoid Arthritis (RA)
Nutrition in Rheumatoid Arthritis
Background: Individuals with Rheumatoid Arthritis (RA) often experience persistent symptoms such as pain and stiffness despite modern pharmacological treatments. They also have an increased risk of cardiovascular disease.
- Trial name
- NUTRA (NCT06831331)
- Testing
- Healthy diet based on NNR2023, Control/waiting-list
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Vastra Gotaland Region
Rheumatoid Arthritis (RA)
Medical Device for Sustained Remission in Rheumatoid Arthritis Treated With Biological Therapy
This study aims to evaluate a new tool designed to help doctors decide whether it is safe to reduce medication in patients with rheumatoid arthritis (RA) who are in remission.
- Trial name
- REMRABIT-Plus (NCT07678112)
- Testing
- Predictive Model-Guided Decision Strategy
- Where
- 9 sites in Spain
- Volunteers
- 184 people
- Sponsor
- Francisco J. Blanco
Rheumatoid Arthritis (RA)
Phase IIIB Subcutaneous Abatacept Monotherapy Study
To evaluate safety and immunogenicity of abatacept when used with or without methotrexate in the absence of an IV loading dose of abatacept
- Trial name
- NCT00547521
- Testing
- abatacept, Methotrexate (MTX)
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 119 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis (RA)
L-carnitine Supplementation in Rheumatoid Arthritis Patients
This study aims to evaluate the effect of l-carnitine as add- on therapy for improving the outcome in rheumatoid arthritis patients.
- Trial name
- NCT06753565
- Testing
- Carnitine, Disease-modifying anti-rheumatic drugs
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Rheumatic Diseases
Disease Activity in RA and SLE Patients and Its Relation to Muscle Performance,Fatigue and Blood Parameters
Assessment of disease activity in Rheumatoid Arthritis and Systemic lupus patients related to muscle performance, fatigue and blood parameters
- Trial name
- NCT03728231
- Testing
- Complete blood count
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pancreatitis, Inflammatory Bowel Diseases
Thiopurine Induced Pancreatitis in IBD Patients
Azathioprine (AZA) and its metabolite 6-mercaptopurine (6-MP) were developed over 50 years ago by Gertrude Elion and George Hitchings and were initially used clinically in the management of childhood leukemia and organ…
- Trial name
- NCT02281799
- Testing
- Azathioprine
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Rheumatoid Arthritis (RA), Crohn's Disease (CD)
Ketogenic and Carnivore (Lion) Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis
This study is a randomized controlled clinical trial evaluating whether two therapeutic dietary approaches - a ketogenic diet and a carnivore (lion) diet - can improve quality of life, reduce symptoms, and influence measures of…
- Conditions
- Rheumatoid Arthritis (RA), Crohn's Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07524244
- Testing
- Ketogenic diet, Carnivore (Lion) Diet
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Fuller Research Foundation
Rheumatoid Arthritis
Study Evaluating the Tolerance and Safety of Enbrel (Etanercept) in Adults and Children
This postmarketing surveillance study will evaluate the safety profile of Enbrel (etanercept) in an Indian population. It will provide surveillance on a currently approved indication for Enbrel of reducing symptoms and inhibiting…
- Trial name
- NCT00484809
- Testing
- Enbrel (Etanercept)
- Volunteers
- 100 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
RETRO (REduction of Therapy in RA Patients in Ongoing Remission)
This is a phase 3, multicenter, randomized, open, prospective, controlled, parallel-group intervention study in 318 patients with Rheumatoid Arthritis.
- Trial name
- RETRO (NCT02779114)
- Testing
- Control group, Reduction group 1, Reduction group 2
- Where
- 12 sites in Germany
- Volunteers
- 318 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Rheumatoid Arthritis (RA
Dysphagia in Rheumatoid Arthritis
The primary goal of this cross-sectional study is to assess risk factors/predictors for dysphagia in RA. The secondary goals include demonstrating whether flexible fiberoptic pharyngolaryngoscopy can detect…
- Trial name
- NCT07401732
- Testing
- flexible fiberoptic pharyngolaryngoscopy
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Rheumatoid Arthritis
Assessment of 14-3-3 η (Eta) Protein Antibodies in the Serum of Rheumatoid Arthritis Patients and Its Relation to Atherosclerosis.
The aims of this study are: • To assess 14-3-3 η (eta) protein antibodies in the serum of rheumatoid arthritis patients and its relation to disease activity and severity.
- Trial name
- NCT04937140
- Testing
- 14-3-3 η (eta) protein antibodies in the serum of rheumatoid arthritis patients
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sohag University
Rheumatoid Arthritis
Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)
The purpose of this study is to 1)to determine if it is better to treat all early RA patients with methotrexate in combination with hydroxychloroquine plus sulfasalazine or in combination with etanercept or reserve this treatment…
- Trial name
- TEAR (NCT00259610)
- Testing
- methotrexate, sulfasalazine, hydroxychloroquine
- Where
- United States
- Volunteers
- 755 people
- Sponsor
- University of Alabama at Birmingham