Clinical trials: Arthritis, Unspecified
Dry Eye
Tear Proteins, Conjunctival Cells and Imaging Eyes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients
Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are chronic systemic autoimmune diseases that have been reported to affect the ocular surface of patients [1,2].
- Trial name
- NCT02217137
- Where
- Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Ankle Arthropathy, Anesthesia; Functional
The Impact of a Preoperative Nerve Block in Foot and Ankle Surgery on the Consumption of Sevoflurane
Reconstructive foot and ankle surgery is performed under general anesthesia. Included in this spectrum of surgery are ankle arthroplasties, various fusions, corrective arthrodesis, and more.
- Conditions
- Ankle Arthropathy, Anesthesia; Functional, Ankle Arthritis
- Trial name
- NCT04022057
- Testing
- Ropivacaine injection, Dextrose 5
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Psoriasis
Use of Serum M2BP and MSUS to Predict Arthritis in Psoriatic Patients
Aims of the study: 1. Measurement of serum level of Mac 2 binding protein among patients with psoriasis, psoriatic arthritis and subclinical psoriatic arthritis compared with healthy individuals. 2.
- Trial name
- NCT04435730
- Testing
- serum level of Mac 2 binding protein, musculoskeletal ultrasound
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assiut University
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Osteoarthritis, Knee
A Single Intra-articular Injection of aMAT vs PRP in Patients With OA of the Knee
The study proposes to compare performances and safety of intra-articular injections of aMAT with those of a control group (PRP injections) for the treatment of symptomatic OA of the knee.
- Trial name
- LIPOJOINT (NCT03117608)
- Testing
- injection of autologous micro-fragmented adipose tissue (aMAT), injection of Platelet-rich Plasma (PRP)
- Where
- Italy
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Lipogems International spa
Arthritis, Diabetes Mellitus
Use of Complementary and Alternative Medicine Among Older Mexican Americans
The purpose of this study is to examine complementary and alternative medicine use among older Mexican Americans and to determine how this use influences physical, functional, and mental health.
- Conditions
- Arthritis, Diabetes Mellitus, Fractures, Hypertension
- Trial name
- NCT00084110
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Osteoarthritis, Intraoperative Bleeding
Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Applying a fibrin spray, after knee device implantation, will help in reducing patient blood loss and decrease the drop in both hemoglobin and hematocrit levels.
- Trial name
- NCT01656759
- Testing
- Evicel Fibrin Spray
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Hyperuricemia, Gout
Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
This is a Phase 1, single-center, randomized, partially double-blind, placebo- and positive controlled, 4-way crossover study to evaluate the effect of a therapeutic and a supratherapeutic dose of LC350189 on the QTcF in healthy…
- Conditions
- Hyperuricemia, Gout, Qt Interval, Variation in
- Trial name
- NCT04966325
- Testing
- LC350189 200mg, Moxifloxacin 400mg, LC350189 600mg
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- LG Chem
Primary Generalized (Osteo)Arthritis, Post-traumatic Arthrosis of Other Joints, Upper Arm
Simpliciti IDE Trial; Replacing the Humeral Head in Total Shoulder Arthroplasty
The purpose of this study is to demonstrate safety and efficacy of the Simpliciti Shoulder System in total shoulder arthroplasty.
- Trial name
- NCT01390038
- Testing
- Simpliciti™ Shoulder System
- Where
- 14 sites in United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis
Feasibility Study: Effect of Patient Decision Aids for Total Joint Replacement on Surgical Referrals
Ministries of Health consider wait lists for total joint replacement a top priority. Research priorities to manage wait lists indicate the need to establish benchmarks that consider patient preferences.
- Trial name
- NCT00743951
- Testing
- 1 Patient decision aid, 2 Usual care
- Where
- Canada
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Septic Arthritis, Inflammatory Arthritis
Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis
The purpose is to found new biomarker that differentiate septic arthritis and Juvenile Idiopathic Arthritis in children. Synovial liquid and blood samples with proteomic, MiRNA searching, multiplex cytokine analysis and cellular…
- Conditions
- Septic Arthritis, Inflammatory Arthritis, Children
- Trial name
- DIANE (NCT03827759)
- Where
- 5 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sjogren's Syndrome, Dry Eye
Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease
This project will examine the similarities and differences of the ocular surface and tear film in patients with Sjogren's syndrome related to dry eye, severe dry eye and those who do not have dry eye.
- Trial name
- JADE (NCT00809003)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Osteoporosis, Postmenopausal, Osteoarthritis, Knee
The Effect of High Impact Exercise on Bone and Articular Cartilage in Post-menopausal Women
Osteoarthritis (OA) and osteoporosis (OP) affect large numbers of the population. Around 8 million people in the UK are affected by OA and over 300,000 people present with fragility fractures in the UK each year.
- Conditions
- Osteoporosis, Postmenopausal, Osteoarthritis, Knee, BMD
- Trial name
- NCT03225703
- Testing
- Hopping
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Rheumatoid Arthritis
ALX-0061 Phase I Bioavailability Study in Healthy Volunteers
The overall aims of the study are: To assess the bioavailability of single doses of ALX-0061, administered s.c. at three dose levels, using 2 corresponding single i.v. dose levels as reference.
- Trial name
- NCT02101073
- Testing
- ALX-0061
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ablynx, a Sanofi company
Fibromyalgia, Secondary
Fibromyalgia in Rheumatiod and Psoriatic Patients
the study based on investigate for fibromyalgia among rheumatiod arthritis patient and psoriatic arthritis.....and to what extent gibromyalgia affect disease activity indices ....and its relation to serum Vitamin D level in those…
- Trial name
- NCT04892602
- Testing
- Serum vitaminDlevel
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sohag University
Arthritis, Rheumatoid
Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
The purpose of this feasibility study is to determine if a new emerging technology called photoacoustic tomography (PAT) can be adapted for use in humans for the detection of chronic rheumatoid arthritis.
- Trial name
- NCT00748254
- Testing
- Laser Based Photoacoustic Tomography, MRI, Ultrasound
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Knee Osteoarthritis (Knee OA)
Muscle Isometric Contraction for the Treatment of Knee Osteoarthritis
This study compares the effects of three different intensities of Muscle Isometric Contraction (MIC) on balance ability, proprioception, muscle strength, KOA symptoms, and inflammatory factors in synovial fluid among elderly…
- Trial name
- KOA (NCT06870656)
- Testing
- Low-intensity group, Medium-intensity group, High-intensity group
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chengdu Sport University
Osteoarthritis
A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis
This is a retrospective, single-site observational study, designed to assess the clinical outcomes and collect safety data of GMK Revision knee system used for primary or revision total knee arthroplasty at minimum two years…
- Trial name
- NCT02912351
- Testing
- Patient record review, Radiographs, and questionaires.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Umbilical Cord Bleeding, Knee Osteoarthritis
Evaluating Safety and Efficacy of Mesenchymal Stem Cells From Umbilical Cord
This study was to evaluate the safety and efficacy of Mesenchymal Stem Cells (MSCs) from umbilical cord in the treatment of 7 knee OA patients by assessing unexplained local and systemic symptoms or death before and at 1, 2, 3, 6…
- Trial name
- NCT03358654
- Testing
- mesenchymal stem cells from umbilical cord
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Adult Onset Still Disease
Multi-center Registration Study of Adult Onset Still's Disease in Chinese Population
This multi-center registration study will investigate the clinical characteristics of AOSD population in China , identify possible factors inducing the onset and active condition of AOSD in Chinese population , and identify the…
- Trial name
- MAOSDC (NCT03651193)
- Testing
- Exon sequencing and Methylated sequencing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
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