Clinical trials: Arthritis,Rheumatoid
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Safety and Pharmacokinetics of LPX-TI641 in Rheumatoid Arthritis and Psoriatic Arthritis
The goal of this clinical trial is to study the drug LPX-TI641 in patients with rheumatoid arthritis and psoriatic arthritis. We will compare the safety and tolerability of LPX-TI641 to placebo that contains no drug.
- Trial name
- NCT06628206
- Testing
- LPX-TI641
- Where
- 6 sites in United States, Jordan
- Volunteers
- 48 people
- Sponsor
- LAPIX Therapeutics Inc.
Rheumatoid Arthritis
A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA)
This study will evaluate the efficacy and safety of various treatment and retreatment regimens of MabThera. All patients will receive concomitant methotrexate, 10-25mg once weekly either orally or parenterally.
- Trial name
- NCT00422383
- Testing
- rituximab [MabThera/Rituxan]
- Where
- 91 sites in Australia, Belgium and 16 more
- Volunteers
- 378 people
- Sponsor
- Hoffmann-La Roche
Arthritis, Rheumatoid
Efficacy and Safety of CDP870 and Methotrexate Compared to Methotrexate Alone in Subjects With Rheumatoid Arthritis
The main purpose of the study was to determine the efficacy of CDP870 in treating RA signs/symptoms in patients who were partial responders to MTX.
- Trial name
- NCT00544154
- Testing
- CDP870
- Volunteers
- 247 people
- Sponsor
- UCB Pharma
Rheumatoid Arthritis, Osteoarthritis
A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Pinnacle™ Cup with a polyethylene-on-metal bearing combination in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00208429
- Testing
- Pinnacle Acetabular System
- Sponsor
- DePuy International
Rheumatoid Arthritis, Osteoarthritis
An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the DePuy PROXIMA™ hip in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT01134445
- Testing
- DePuy Proxima™ Hip
- Where
- 4 sites in France, Portugal and 2 more
- Volunteers
- 42 people
- Sponsor
- DePuy International
Rheumatoid Arthritis
104RA204 Assessment of the Safety and Efficacy of BG9924 in Rheumatoid Arthritis (RA) Participants
To observe the long-term treatment with BG9924 when administered to participants with RA who previously participated in a Biogen Idec Study.
- Trial name
- RESPOND-EXT (NCT00664573)
- Testing
- Baminercept alfa (BG9924)
- Where
- 8 sites in Argentina, Brazil and 6 more
- Volunteers
- 339 people
- Sponsor
- Biogen
Rheumatoid Arthritis
Dose-Escalating Study of BG9924 in Combination With Methotrexate in Active Rheumatoid Arthritis
This Phase 2a study is designed to evaluate the safety and tolerability of multiple subcutaneous (SC) doses of BG9924, administered in a cohort dose-escalation fashion, in patients with active rheumatoid arthritis (RA) who have…
- Trial name
- NCT00292422
- Testing
- BG9924
- Where
- 10 sites in United States, Poland
- Volunteers
- 50 people
- Sponsor
- Biogen
Rheumatoid Arthritis
Comparison of the Safety and Pharmacokinetics of Two SAR153191 (REGN88) Drug Products in Rheumatoid Arthritis Patients
Primary Objective: Assess the comparative safety and tolerability of two SAR153191 (REGN88) drug products after a single dose administration in rheumatoid arthritis patients.
- Trial name
- NCT01328522
- Testing
- SAR153191 (REGN88)
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
Observational Trial With Enbrel
The diagnosis, evaluation and treatment of rheumatoid arthritis (RA) continue to undergo rapid change. Randomized controlled trials such as the TEMPO study have demonstrated the efficacy and safety of the combination of…
- Trial name
- NCT00488475
- Testing
- etanercept
- Where
- Germany
- Volunteers
- 4,945 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Safety and Efficacy Study of Adalimumab in Adult Chinese Rheumatoid Arthritis Subjects Treated With Methotrexate
A study to assess the safety and efficacy of adalimumab administered as a subcutaneous injection in adult Chinese subjects with rheumatoid arthritis and treated with methotrexate
- Trial name
- NCT00538902
- Testing
- Adalimumab 80 mg, Adalimumab 40 mg
- Where
- 11 sites in China
- Volunteers
- 302 people
- Sponsor
- Abbott
Rheumatoid Arthritis
A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent
This open-label study will evaluate the efficacy and safety of tocilizumab as monotherapy or in combination with methotrexate or other non-biologic disease modifying anti-rheumatic drugs (DMARDs) in participants with active…
- Trial name
- ACT-MOVE (NCT02046603)
- Testing
- Tocilizumab, DMARDs, Oral Corticosteroids
- Where
- 38 sites in United Kingdom
- Volunteers
- 162 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
An Extension to Study MA21573, Evaluating Tocilizumab in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biological DMARDs and/or Anti-tumor Necrosis Factor (TNF) Therapy
This study was an extension to study MA21573 [NCT00750880], which was an open label single arm study to investigate the safety, tolerability and efficacy of tocilizumab monotherapy, or combination therapy with non-biological…
- Trial name
- NCT00883753
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 171 sites in Australia, Canada and 12 more
- Volunteers
- 934 people
- Sponsor
- Hoffmann-La Roche
Arthritis, Rheumatoid
A Trial of Anti-TNF Chimeric Monoclonal Antibody (cA2) in Korean Patients With Active Rheumatoid Arthritis Despite Methorexate (Extension Part)(Study P05645)(COMPLETED)
This trial is extension part of the P04280 (placebo-controlled, double-blind, randomized study of chronic treatment with infliximab in approximately 140 patients, NCT00202852).
- Trial name
- NCT00732875
- Testing
- Infliximab + methotrexate (MTX)
- Volunteers
- 92 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
Efficacy, Pharmacokinetics, Safety, and Immunogenicity Study of Abatacept Administered Subcutaneously to Treat Rheumatoid Arthritis in Japanese Patients
The purpose of this study is to assess the efficacy, pharmacokinetics, safety, and immunogenicity of abatacept after subcutaneous and intravenous administration in Japanese participants with active rheumatoid arthritis and…
- Trial name
- NCT01001832
- Testing
- Intravenous (IV) abatacept, Subcutaneous (SC) abatacept
- Where
- 33 sites in Japan
- Volunteers
- 118 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Open-label Study to Assess the Safety and Efficacy of CDP6038 (Olokizumab) in Patients Who Completed RA0056
The purpose of this study is to evaluate the long term safety and tolerability of CDP6038 (olokizumab) treatment in adult subjects with active rheumatoid arthritis who completed study RA0056 (NCT01242488).
- Trial name
- NCT01296711
- Testing
- CDP6038 (olokizumab)
- Where
- 55 sites in United States, Belgium and 1 more
- Volunteers
- 190 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Xerostomia, Sjogren's Syndrome
Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome
The purpose of this study is to evaluate the effectiveness of NGX267 in the improvement of decreased salivary flow associated with primary or secondary Sjögren's syndrome.
- Trial name
- NCT00637793
- Testing
- NGX267
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- TorreyPines Therapeutics
Rheumatoid Arthritis
A Study Assessing the Safety and Efficacy of Subcutaneous RoActemra/Actemra Alone or in Combination With Non-biologic Antirheumatics in Rhuematoid Arthritis Patients in Latin America With Inadequate Response to Non-biologic Antirheumatic Drugs.
This multi-center, open-label, single-arm, Phase IIIb study will evaluate the safety and efficacy of subcutaneous RoActemra/Actemra alone or in combination with non-biologic disease modifying antirheumatic drugs (DMARDs) in…
- Trial name
- NCT02011334
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 25 sites in Argentina, Brazil and 4 more
- Volunteers
- 285 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
The Efficacy and Safety of Fang yi Qing Feng Shi Granules in Subjects With Rheumatoid Arthritis
The aim of this study is to evaluate the efficacy and safety of Fang yi qing Feng shi granules in subjects with Rheumatoid Arthritis.
- Trial name
- NCT02029599
- Testing
- Fang yi qing feng shi granule, Methotrexate, Acetaminophen tablets
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Maoxiang Group Jilin Pharmaceutical Co., Ltd.
Active Rheumatoid Arthritis
A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate
The only trial in participants who are methotrexate-inadequate responders and have active Rheumatoid Arthritis, in which gadolinium-enhanced Magnetic Resonance Imaging; Bone Mineral Density; and biochemical markers of bone…
- Trial name
- NCT00420199
- Testing
- Abatacept
- Where
- 10 sites in Belgium, Germany and 4 more
- Volunteers
- 50 people
- Sponsor
- Bristol-Myers Squibb
Joint Disease
Post Market Clinical Follow-Up Study Protocol for PROFEMUR® L Revision Femoral Stems
MicroPort Orthopedics (MPO) is conducting this PMCF study to evaluate the safety and efficacy of its THA and resurfacing components marketed in the EU.
- Trial name
- NCT02314702
- Testing
- PROFEMUR® L Revision Femoral Stem
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- MicroPort Orthopedics Inc.
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