Clinical trials: Arthritis
Osteoarthritis of the Knee
Nerve Ablation by Cooled Radiofrequency Compared to Corticosteroid Injection for Management of Knee Pain
This study is designed to: Determine the effectiveness (primarily measured by pain relief) of Coolief when used to create radiofrequency lesions of the genicular nerves compared to pain relief following corticosteroid injection…
- Trial name
- NCT02343003
- Testing
- Cooled Radiofrequency, Corticosteroid injection
- Where
- 11 sites in United States
- Volunteers
- 151 people
- Sponsor
- Halyard Health
Rheumatoid Arthritis
Efficacy and Safety Study of MP-435 in Combination With Methotrexate (MTX) in Patients With Rheumatoid Arthritis
The purpose of this study is to determine the Efficacy, Safety, and Pharmacokinetics of MP-435 administered for 12 weeks in subjects with rheumatoid arthritis (RA) on stable doses of Methotrexate.
- Trial name
- NCT01143337
- Testing
- MP-435(dose1) + Methotrexate
- Where
- Japan
- Volunteers
- 112 people
- Sponsor
- Tanabe Pharma Corporation
Rheumatoid Arthritis
An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate
Primary Objective: To demonstrate the treatment effect of sarilumab and methotrexate (MTX) compared to etanercept and MTX in participants with rheumatoid arthritis (RA) and an inadequate response to adalimumab and MTX by…
- Trial name
- RA-COMPARE (NCT01764997)
- Testing
- Sarilumab, Etanercept, Methotrexate
- Where
- 257 sites in United States, Argentina and 29 more
- Volunteers
- 776 people
- Sponsor
- Sanofi
Chronic Low Back Pain, Osteoarthritis
Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee
The primary objective of the study is to evaluate the efficacy of fasinumab in relieving Chronic low back pain (CLBP) as compared to placebo in participants with a clinical diagnosis of moderate-to-severe non-radicular CLBP and…
- Trial name
- FACT CLBP 1 (NCT03285646)
- Testing
- Fasinumab
- Where
- 56 sites in United States
- Volunteers
- 63 people
- Sponsor
- Regeneron Pharmaceuticals
Rheumatoid Arthritis
A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis (RA)
The main purpose of this study is to evaluate the safety and effectiveness of the study drug known as baricitinib in participants with moderately to severely active rheumatoid arthritis who have had an inadequate response to…
- Trial name
- NCT02265705
- Testing
- Baricitinib
- Where
- 30 sites in Argentina, Brazil and 1 more
- Volunteers
- 290 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
Efficacy, Pharmacokinetics, Safety, and Immunogenicity Study of Abatacept Administered Subcutaneously to Treat Rheumatoid Arthritis in Japanese Patients
The purpose of this study is to assess the efficacy, pharmacokinetics, safety, and immunogenicity of abatacept after subcutaneous and intravenous administration in Japanese participants with active rheumatoid arthritis and…
- Trial name
- NCT01001832
- Testing
- Intravenous (IV) abatacept, Subcutaneous (SC) abatacept
- Where
- 33 sites in Japan
- Volunteers
- 118 people
- Sponsor
- Bristol-Myers Squibb
Ankylosing Spondylitis, Axial Spondyloarthritis
Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis
This is a 6-week randomized, double-blind trial of 4 different non-steroidal anti-inflammatory drugs in patients with axial spondyloarthritis to compare the change of pain score from baseline at 4 weeks to the change of pain…
- Trial name
- NCT03473665
- Testing
- Indomethacin, Diclofenac, Meloxicam
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Columbia University
Juvenile Idiopathic Arthritis
A Long-Term Extension Study of RoActemra/Actemra (Tocilizumab) in Patients With Juvenile Idiopathic Arthritis From France Who Completed WA19977 Core Study
This long-term, open-label extension study will evaluate the safety of RoActemra/Actemra (tocilizumab) in patients with polyarticular-course juvenile idiopathic arthritis who completed the WA19977 core study.
- Trial name
- NCT01673919
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 4 sites in France
- Volunteers
- 7 people
- Sponsor
- Hoffmann-La Roche
Noninflammatory Degenerative Joint Disease, Rheumatoid Arthritis
A Multicentre Observational Study to Evaluate Clinical Outcomes of the G7 Acetabular System
This is a prospective observational multi-center non-controlled study. The primary purpose of this study is to evaluate the clinical and radiographic performance of the G7 Acetabular Cup System.
- Trial name
- NCT02036931
- Testing
- Metal on Polyethylene articulation, Ceramic on Polyethylene articulation, Ceramic on Ceramic articulation
- Where
- 6 sites in United States, France and 4 more
- Volunteers
- 162 people
- Sponsor
- Zimmer Biomet
Obesity, Osteoarthritis
Walking Aids in the Management of Knee Osteoarthritis
The purpose of this study is to assess whether the single point cane will relieve pain and disability in overweight or obese people with knee OA through altered joint biomechanics and what factors influence acceptance of cane use.
- Trial name
- NCT00223795
- Testing
- Single point cane
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis
ROBODOC® Clinical Trials: Long-Term Follow-Up
This is a follow-up study looking at the and long-term results of two methods of preparing the thigh bone to receive an implant during hip replacement surgery.
- Trial name
- NCT01831219
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Curexo Technology Corporation
Arthritis, Rheumatoid
A Study Comparing Sirukumab (CNTO 136) Monotherapy With Adalimumab (HUMIRA®) Monotherapy in the Treatment of Active Rheumatoid Arthritis
The primary objective is to investigate the efficacy of sirukumab monotherapy compared with adalimumab monotherapy in biologic naïve subjects with active rheumatoid arthritis who are intolerant to methotrexate, who are considered…
- Trial name
- SIRROUND-H (NCT02019472)
- Testing
- adalimumab 40 mg, sirukumab 100 mg, sirukumab 50 mg
- Where
- 107 sites in United States, Bulgaria and 14 more
- Volunteers
- 559 people
- Sponsor
- Janssen Research & Development, LLC
Vitamin B12 Deficiency
Autoantibodies to Gastric Parietal Cells in Rheumatoid Arthritis Patients
A review of the literature reveals that very few studies have assessed the potential co-existence of vitamin B12 deficiency due to gastric parietal cell autoantibodies. While Segal et al.
- Trial name
- NCT01876329
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Keesler Air Force Base Medical Center
Spondylitis, Ankylosing
A Two-Part 26-Week Study of Etoricoxib as Treatment for Ankylosing Spondylitis (AS) (MK-0663-108)
The purpose of the study is to evaluate the efficacy and tolerability of two doses of etoricoxib compared to naproxen in the treatment of ankylosing spondylitis (AS).
- Trial name
- NCT01208207
- Testing
- Part I - etoricoxib 60 mg, Part I - etoricoxib 90 mg, Part I- naproxen 1000 mg
- Volunteers
- 1,015 people
- Sponsor
- Organon and Co
Osteoarthritis
A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb
Hyaluronan is a man-made preparation of a protein complex that occurs naturally in joints and that is often low in people with osteoarthritis.
- Trial name
- NCT00398866
- Testing
- Synvisc (Hylan G-F20; hyaluronan injection), Bupivicaine (local anesthesia injection), Kenalog (triamcinolone; corticosteroid injection)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hospital for Special Surgery, New York
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a TNF-Blocker.
This single arm study will evaluate the efficacy and safety of MabThera in patients with active rheumatoid arthritis whose current treatment with one or more TNF blocker had produced an inadequate response.
- Trial name
- NCT00424502
- Testing
- rituximab [MabThera/Rituxan], Methotrexate
- Where
- 3 sites in Hungary
- Volunteers
- 20 people
- Sponsor
- Hoffmann-La Roche
Axial Spondyloarthritis, Nonradiographic Axial Spondyloarthritis
Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS
Patients with active Axial Spondyloarthritis without x-ray evidence of Ankylosing Spondylitis and with signs of inflammation will be randomly assigned to receive certolizumab pegol (CZP) 200 mg every two weeks or placebo.
- Conditions
- Axial Spondyloarthritis, Nonradiographic Axial Spondyloarthritis, Nr-axSpA
- Trial name
- C-AXSPAND (NCT02552212)
- Testing
- Certolizumab Pegol
- Where
- 105 sites in United States, Australia and 7 more
- Volunteers
- 317 people
- Sponsor
- UCB BIOSCIENCES GmbH
Obesity
Obesity and the Initiation of Knee Osteoarthritis
Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120.
- Trial name
- NCT00856739
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Rheumatoid Arthritis
A Study in Patients With Rheumatoid Arthritis
The primary purpose of the study is to help answer the following research questions, and not to provide treatment for Rheumatoid Arthritis (RA): The safety of LY2439821 and any side effects that might be associated with it.
- Trial name
- NCT00966875
- Testing
- LY2439821
- Where
- 75 sites in United States, Argentina and 9 more
- Volunteers
- 448 people
- Sponsor
- Eli Lilly and Company
Gout
Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout
The overall objective of the study is to assess the efficacy, safety, tolerability, and pharmacokinetics (PK) of the concomitant use of pegloticase with methotrexate (MTX) to enhance the response rate seen with pegloticase alone…
- Trial name
- MIRROR OL (NCT03635957)
- Testing
- Pegloticase, Methotrexate (MTX), Standard Gout Flare Prophylaxis
- Where
- 6 sites in United States
- Volunteers
- 14 people
- Sponsor
- Amgen