Clinical trials: Arthritis Knee
Knee Arthropathy
Effect of Pre-op Patient Education on Functional Outcomes After TKA
This study aims to evaluate the effect of preoperative patient education program on functional mobility, gait, postural control, and kinesiophobia level in subjects with TKA.
- Trial name
- NCT03230942
- Testing
- Pre-operative education, Pos-operative rehabilitation
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of the State of Santa Catarina
Osteoarthritis, Knee, Knee Osteoarthritis
Baseline Predictors of Response to Radial Pressure Wave Therapy in Knee Osteoarthritis
This observational study aims to identify baseline factors that predict clinical response at six months in patients with knee osteoarthritis treated with radial pressure wave therapy (rESWT).
- Trial name
- PRE-RPWT-OA (NCT07531160)
- Testing
- Radial Pressure Wave Therapy
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Hospital Civil de Guadalajara
Osteoarthritis, Knee
Is Botox Effective in Relieving Pain From Knee Osteoarthritis?
Patients with painful knee osteoarthritis will be randomly allocated to one of three groups. Each group will receive a knee injection of: 1) cortisone, 2) low dose Botox, or 3) high dose Botox.
- Trial name
- NCT00279903
- Testing
- Botulinum toxin type A (Btx-A), Cortisone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Mayo Clinic
Knee Arthroplasty, Total, Knee Osteoarthritis
Cementless Triathlon 5YR Follow-Up
All artificial joint implants need to be solidly held (fixed) within the bone. Cementless fixation has become a popular method to achieve fixation for total knee replacements where the bone grows directly onto the implanted…
- Conditions
- Knee Arthroplasty, Total, Knee Osteoarthritis, Radiostereometric Analysis
- Trial name
- NCT05877261
- Testing
- Cementless Total Knee Replacement
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
Comparison of Functional Recovery After Total Knee Arthroplasty Between Low Phase Angle and High Phase Angle Group
The goal of this observational study is to compare the functional outcome of patients with end-stage knee osteoarthritis (OA) before and after total knee arthroplasty based on the phase angle level.
- Trial name
- NCT06701474
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Osteo Arthritis Knee, Joint Diseases
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection).
- Conditions
- Osteo Arthritis Knee, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
- Trial name
- SURE (NCT06550024)
- Testing
- SakuraBead Resorbable Microspheres, Corticosteroid Injection
- Where
- 8 sites in United States, Georgia and 2 more
- Volunteers
- 89 people
- Sponsor
- CrannMed
Knee Osteoarthritis
Wearable Sensors in Knee OA
This is a single-arm clinical trial to investigate the outcome of exercise-based physical therapy in people with knee osteoarthritis through the use of wearable sensors.
- Trial name
- WESENS-OA (NCT04243096)
- Testing
- Exercise-based Physical Therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Boston University Charles River Campus
Knee Osteoarthritis
Phase II Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis
In recent years, the incidence rate and disability rate of osteoarthritis have continued to grow, and it has become a common chronic disease of elderly patients, second only to the "three highs", and poses a continuous threat to…
- Trial name
- NCT07547735
- Testing
- UC-MSCs
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Osteoarthritis, Knee, Osteoarthritis, Hip
Improving Resilience and Longevity for Workers Through Exercise
The purpose of this study is to examine the impact of an OA-specific aerobic and strengthening exercise program, delivered within the workplace, on mobility, pain, physical capacity, and resilience among workers with knee or hip…
- Trial name
- NCT03050320
- Testing
- Exercise, No Exercise
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Knee Osteoarthritis
Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.
The goal of this observational, non-interventional cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis.
- Trial name
- KNEE (NCT07833488)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Osteoarthritis
Effect of Cutting Blades for Total Knee Arthroplasty on Implant Migration
There have been considerable efforts to control rising health care costs. One of the more recent developments is the practice of reprocessing single use medical devices.
- Trial name
- NCT01772589
- Testing
- New saw blade, Reprocessed saw blade
- Where
- Canada
- Sponsor
- Glen Richardson
Osteoarthritis, Knee
An Acupuncture Functional Magnetic Resonance Imaging (fMRI) Study on Chronic Pain: Response Reliability and Dose Effect
In this proposal, we plan to dynamically investigate brain response to verum acupuncture (of two different "doses") and placebo acupuncture, using a paradigm that approximates clinical acupuncture practice across multiple…
- Trial name
- NCT01079390
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital
Osteo Arthritis Knee
The Need for Compression Bandage Following Total Knee Arthroplasty A Prospective Randomized Controlled Trial Conducted in Simultaneous Bilateral Total Knee Replacements
The purpose of this study is to evaluate if applying a compression bandage on the leg alters early outcome following TKA. The primary objective of this study is to evaluate leg swelling by measuring leg circumference following…
- Trial name
- NCT03521869
- Testing
- Compression bandage, Gauze dressing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rothman Institute Orthopaedics
Radiofrequency, Arthroplasty
Phenol Neurolysis and Radiofrequency Thermocoagulation in Knee Arthroplasty Surgery
Patients who presented to the Department of Neurology, Algology, and underwent knee arthroplasty surgery for chronic knee osteoarthritis between 2025 and 2026 and underwent radiofrequency or chemical neurolysis of the geniculate…
- Conditions
- Radiofrequency, Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT07381335
- Testing
- genicular nerve radiofrequency thermocoagulation and fenole neurolysis
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Osteoarthritis of the Knee
Efficacy and Safety of 3 Different Dosage Regimens of Hyaluronic Acid in Patients With Knee Osteoarthritis (OA)
The main objective is the comparison of three different dosage regimens of hyaluronic acid in the treatment of osteoarthritis of the knee.
- Trial name
- NCT01290497
- Testing
- Hyaluronic acid 5 x 2.5 ml, Hyaluronic acid 1 x 5 ml, Hyaluronic acid 2 x 5 ml
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement
Brief Summary The goal of this clinical trial is to learn if nurse-led telehealth consultations can help detect complications and support recovery after total knee replacement surgery.
- Trial name
- NCT07058623
- Testing
- Nurse-Led Telehealth Consultation, Traditional In-Person Nursing Consultation
- Where
- Hong Kong
- Volunteers
- 98 people
- Sponsor
- Hospital Authority, Hong Kong
Osteoarthritis, Knee
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels.
- Trial name
- NCT02570503
- Testing
- Ropivacaine, Ketorolac, Clonidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Knee Osteoarthritis, Bone; Deformity, Congenital
COREV 2.0 PMCF-Study on Manual and Navigated Revision Knee Patients
The Columbus® Revision endoprosthetic system is bearing the CE-mark. This means that within the scope of this observational study the patient will not be subjected to any additional stressful, study-related medical examinations…
- Conditions
- Knee Osteoarthritis, Bone; Deformity, Congenital, Prosthesis Failure, Prosthesis-Related Infections
- Trial name
- COREV (NCT05113303)
- Testing
- Navigated Revision Total Knee Arthroplasty, Manual Revision Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Knee Osteoarthritis, Arthropathy of Knee
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients
This research is being done to see if the amount of an enzyme in blood (called serum mast cell tryptase) changes before and after surgery.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
- Trial name
- NCT03598829
- Testing
- Tryptase, Serum test
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
Magnesium Sulfate Combined With Intraarticular Cocktail Injection for Analgesia After Simultaneous Bilateral Total Knee Arthroplasty
Total knee arthroplasty is a safe procedure with excellent outcome. In recent years, simultaneous bilateral total knee arthroplasty has become more popular.
- Trial name
- NCT06445829
- Testing
- Magnesium sulfate
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital