Clinical trials: Arthropathy of Knee
Osteoarthritis of Knee, Arthroplasties, Knee Replacement
Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?
The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery.
- Conditions
- Osteoarthritis of Knee, Arthroplasties, Knee Replacement, Sleeve Gastrectomy
- Trial name
- NCT06767787
- Testing
- laparoscopic sleeve gastrectomy, total knee arthroplasty
- Where
- 2 sites in Canada
- Volunteers
- 142 people
- Sponsor
- Memorial University of Newfoundland
Knee Osteoarthritis, PRP Injection
Comparing the Efficacy of Lyophilized Self Growth Factor Versus PRP Injection for Knee OA
Knee osteoarthritis(OA) is a common degenerative joint disease that often leads to knee pain, stiffness, and a decline in quality of life among middle-aged and elderly individuals.
- Trial name
- NCT06932614
- Testing
- Lyophilized self growth factor, Platelet-Rich Plasma(PRP)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Osteoarthritis, Knee
lIfestyle iNterventionS for PaIn ReliEf (INSPIRE)
This is a 2x2 factorial design randomised controlled trial in which participants with knee pain will be grouped into the diet intervention, exercise intervention, diet and exercise intervention or placebo arm.
- Trial name
- INSPIRE (NCT05670314)
- Testing
- Inulin Fibre supplement, Exercise
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteo Arthritis of the Knee
Home-Based Leg Dexterity Trainer for Management of Knee Osteoarthritis
Rationale: Roughly 14 million adults aged 60 or older (10% male/13% female) in the United States experience symptoms of knee osteoarthritis (OA).
- Trial name
- NCT07397806
- Testing
- Lex Dexterity Trainer, Wobble Board
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Steadman Philippon Research Institute
Symptomatic Knee Osteoarthritis
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
This was a double-blinded, two-arm, phase 2a study to assess efficacy, safety and tolerability of DFV890 in participants with symptomatic knee osteoarthritis.
- Trial name
- NCT04886258
- Testing
- DFV890
- Where
- 31 sites in United States, Argentina and 6 more
- Volunteers
- 115 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee, Degenerative Joint Disease of Knee
Post Marketing Clinical Follow up Study to Evaluate the Performance and Safety of ORTHIX PLUS
This trial is a post marketing clinical follow up study, aiming to evaluate the performance and safety of ORTHIX PLUS for pain relief in patients suffering from osteoarthritis or degenerative joint diseases.
- Trial name
- NCT05348525
- Volunteers
- 54 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Lower-limb Orthoses, Osteoarthritic Knee Pain
Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal
The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations.
- Conditions
- Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
- Trial name
- NCT07673328
- Testing
- Modular powered orthosis
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Knee Osteoarthritis
Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT
Each year, approximately 75,000 Canadians undergo knee replacement surgery, and up to 25% develop persistent post-surgical pain.
- Trial name
- NCT03825965
- Testing
- MPL-001 (CBD: THC 25:1)
- Where
- 2 sites in Canada
- Volunteers
- 39 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Randomized Trial of Regenexx Stem Cell Support Formula
Regenexx, LLC developed a nutritional supplement formula containing many components related to supporting healthy joints This oral, liquid supplement is intended to help improve joint and cartilage health while also increasing…
- Trial name
- NCT04661267
- Testing
- Stem Cell Support Formula
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Regenexx, LLC
Knee Osteoarthritis
Gait Pattern Comparison of Cruciate-retaining and Posterior-stabilized Arthroplasties
In total knee arthroplasty (TKA), the posterior-cruciate ligament-retaining (CR) and posterior-cruciate-ligament stabilized (PS) techniques are widely used depending on the individual preference of the surgeon.
- Trial name
- NCT04968600
- Testing
- total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Gulhane Training and Research Hospital
Knee Osteoarthritis
Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study
The goal of this study was to perform pulsed radiofrequency ablation with a modified target suggested in the cadaver study by Park et al.
- Trial name
- NCT05202847
- Testing
- pulsed radiofrequency ablation to modifined points group, pulsed radiofrequency ablation to conventional points group
- Sponsor
- Gangnam Severance Hospital
Diabetes Mellitus, Steroid Diabetes
Effect of Corticosteroid Injections on Blood Glucose
The purpose of this study is to measure the effect of various corticosteroids administered to the shoulder, knee and hip joints in diabetic patients on resultant blood glucose readings.
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Shoulder Osteoarthritis, Knee Osteoarthritis
- Trial name
- CSI (NCT05048264)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Osteoarthritis
Study of Association of Anti-inflammatory and Anti-rheumatic
Phase III Study, double-blind, comparing association of anti-inflammatory and anti-rheumatic in 375 subjects with knee osteoarthritis.
- Trial name
- ZDPC00213 (NCT02448199)
- Testing
- Meloxicam and Glucosamine, Meloxicam, Glucosamine
- Volunteers
- 375 people
- Sponsor
- Zodiac Produtos Farmaceuticos S.A.
Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis)
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
The purpose of this study is to assess the long-term safety and performance of the LEGION Medial Stabilized insert and to generate clinical evidence to support and maintain product registration in global markets.
- Conditions
- Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
- Trial name
- NCT07199738
- Testing
- Cemented CoCr, Cemented Oxinium, Cementless
- Where
- 4 sites in United States
- Volunteers
- 144 people
- Sponsor
- Smith & Nephew, Inc.
Osteo Arthritis Knee, Knee Arthroplasty
Effects of Motor Imagery Intervention on Functional Recovery Following Total Knee Arthroplasty
The knee osteoarthritis becoming a leading cause of disability among older adults' population. When conventional treatments fail, a total knee arthroplasty (TKA) is suggested.
- Trial name
- KSV2017 (NCT03684148)
- Testing
- Motor imagery practice
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- Science and Research Centre Koper
Patellofemoral Pain Syndrome
Utilizing the Trunk as a Proximal Lever to Strengthen the Hip Musculature and Alter Lower Extremity Function
Does a rotary based triplanar exercise intervention that utilizes the trunk as a proximal lever, strengthen the hip and alter dynamic LE alignment in running females?
- Trial name
- NCT03285464
- Testing
- Triplanar Rotary Resistance
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- High Point University
Osteoarthritis,Knee
Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)
The purpose of this study is to compare different medication combinations used in a periarticular injection after total knee replacement surgery(TKR).
- Trial name
- NCT01042093
- Testing
- Ropivacaine, Toradol, Clonidine
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Towson Orthopaedic Associates
Knee Osteoarthritis, Pain
Effectiveness of the Transitional Care Model in Total Knee Arthroplasty Patients
The aim of this study was to determine the effectiveness of transitional care in patients with total knee arthroplasty on patients' functional status, perceived self-efficacy, and health care use.
- Conditions
- Knee Osteoarthritis, Pain, Self Efficacy, Health Care Utilization
- Trial name
- NCT05525793
- Testing
- Transitional care model
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hasan Kalyoncu University
Knee Osteoarthritis
Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
Knee replacement surgery for osteoarthritis is a commonly performed procedure in Canada with 75,000 of these surgeries performed each year.
- Trial name
- RELIFE (NCT06423716)
- Testing
- Duloxetine
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Sunnybrook Health Sciences Centre
Osteoarthritis, Knee
Standing Computed Tomography (SCT) Imaging of the Knee Joint
This study will help us decide the best way to image the knee for diagnostic purposes: Knee computed tomography vs knee x-ray. The computed tomography will provide a weight bearing 3D view.
- Trial name
- NCT03446404
- Testing
- Standing Computed Tomography
- Where
- United States
- Volunteers
- 826 people, healthy volunteers welcome
- Sponsor
- Neil A Segal
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