Clinical trials: Arthroplasties, Replacement
- Condition Arthroplasties, Replacement
- Funder type Industry (pharma, biotech, devices)
- Has posted results yes
Pain, Perioperative
Study To Investigate The Effectiveness Of Pregabalin For Management Of Patients Undergoing Total Hip Replacement
The purpose of this study is the investigate if pregabalin started a day before surgery and continued for 14 days post-operatively can reduce post-operative pain, relieve pre- and post-operative anxiety and sleep disturbances.
- Trial name
- NCT00905437
- Testing
- Pregabalin
- Where
- 7 sites in India
- Volunteers
- 72 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.
Degenerative Joint Disease, Osteoarthritis
PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during total knee replacement; to monitor and record post-operative pain, activity level, narcotic consumption, adverse…
- Trial name
- PRECISE (NCT01081886)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Medtronic Surgical Technologies
Venous Thromboembolism
A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement (TKR) surgery.
- Trial name
- ROXI-VTE II (NCT06454630)
- Testing
- REGN7508, Enoxaparin
- Where
- 14 sites in Bulgaria, Hungary and 3 more
- Volunteers
- 179 people
- Sponsor
- Regeneron Pharmaceuticals
Deep Vein Thrombosis of Lower Limb, Pulmonary Embolism (PE)
Deep Vein Thrombosis (DVT) Prevention in Total Hip Arthroplasty: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH)
Evaluation of the safety and effectiveness of ActiveCare+ CECT device +/- baby dose aspirin (81 mg QD) for lowering the potential risk for bleeding and of DVT during and after THA surgery in comparison with LMWH.
- Conditions
- Deep Vein Thrombosis of Lower Limb, Pulmonary Embolism (PE), Bleeding
- Trial name
- SAFE (NCT00358735)
- Testing
- ActiveCare CECT device, Enoxaparin
- Where
- 9 sites in United States
- Volunteers
- 411 people
- Sponsor
- Medical Compression Systems
Postoperative Pain
Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement
The objectives in this study are to evaluate: (1) efficacy of buprenorphine transdermal system (BTDS, Butrans™) on postoperative pain following total knee replacement surgery; (2) the impact of BTDS on functional rehabilitative…
- Trial name
- NCT00403234
- Testing
- Buprenorphine transdermal patch
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Purdue Pharma LP
Arthroplasty, Replacement, Knee
Scorpio Posterior Stabilised (PS) vs Scorpio NRG ("Energize") PS - Total Knee Arthroplasty
Single-centre, prospective, randomized comparative study to compare the maximum flexion and Chair Raise achievement ratios of the Scorpio PS and and the Scorpio NRG PS. Documentation of all complications.
- Trial name
- ScorpioNRGPS (NCT02520531)
- Testing
- Scorpio PS (posterior stable), Scorpio NRG PS
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- Stryker Orthopaedics
Pain, Postoperative
Evaluation of Preoperative N1539 in Total Knee Arthroplasty
The primary objective of this study is to assess the effect of preoperative administration of N1539 on opioid consumption in subjects undergoing open unilateral total knee arthroplasty compared to placebo.
- Trial name
- NCT03434275
- Testing
- N1539
- Where
- 6 sites in United States
- Volunteers
- 194 people
- Sponsor
- Baudax Bio
Osteoarthritis, Knee
A Multicenter Prospective Randomized Control Study on Persona Total Knee System vs NexGen
A multicenter, prospective randomized controlled trial comparing the Persona knee system to the Nexgen knee system in total knee arthroplasty.
- Trial name
- NCT03073941
- Testing
- Persona total knee system, Nexgen total knee system
- Where
- 5 sites in Denmark
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet
Hip Osteoarthritis
A Prospective Multi-center Study on Total Hip Arthroplasty With E1
The primary objectives of this clinical study include: Evaluate E1 Wear including early bedding-in process, clinical outcomes on patients who received Total Hip Arthroplasty with E1 Compare E1 wear used with CoCr and Biolox Delta…
- Trial name
- NCT01883492
- Testing
- Femoral Stem, Acetabular Cup, Acetabular Liner
- Where
- 5 sites in Japan
- Volunteers
- 153 people
- Sponsor
- Zimmer Biomet
Arthroplasty, Replacement, Hip
Restoration® Modular Revision Hip System Post Market Study
The purpose of this study is to demonstrate survivorship of the femoral stem at 5 years.
- Trial name
- NCT00962013
- Testing
- Restoration® Modular Revision Hip System
- Where
- 13 sites in United States
- Volunteers
- 137 people
- Sponsor
- Stryker Orthopaedics
Knee Osteoarthritis
Evaluation of the Safety and Effectiveness of the Kinamed Gem Ceramic Femoral Component for Total Knee Replacement
The aim of this study is to provide evidence that the safety and effectiveness of the ceramic femoral component of the Gem Total Knee System is similar to FDA approved implants used in total knee replacement surgery.
- Trial name
- NCT00743717
- Testing
- zirconia femoral component, cobalt chrome femoral component
- Volunteers
- 4 people
- Sponsor
- Kinamed Incorporated
Osteoarthritis, Knee, Osteoarthritis, Hip
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform
Post-market prospective, multi-center longitudinal study to determine if mobile application-guided education and exercise paired with accurate and sensitive activity monitoring, captured from consumer wearables, can provide a…
- Trial name
- NCT03737149
- Testing
- mymobility with Apple Watch
- Where
- 30 sites in United States, Australia and 2 more
- Volunteers
- 6,559 people
- Sponsor
- Zimmer Biomet
Arthroplasty, Replacement, Hip
A Comparative Study of In-vivo Wear Between 28 mm and 40 mm Metal Heads
Prospective, single centre, randomized clinical study; series of patients with a 5-years patient evaluation period.
- Trial name
- X3largeheads (NCT02525627)
- Testing
- Trident cup, X3 inserts, 28 mm head, Trident cup, X3 inserts, 40 mm head, Symax stem
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Stryker Orthopaedics
Arthroplasty, Replacement, Knee
Stryker NTX Registry Scorpio NRG (Re-"Energize"), Triathlon Total Knee, Triathlon Partial Knee Resurfacing (PKR) With X3 Polyethylene Insert
Provide outcomes information with regard to surgical and implant performance and patient clinical outcomes of the patients who are eligible for either a Total Knee Arthroplasty (TKA) replacement surgery or Partial Knee…
- Trial name
- NTX (NCT02525562)
- Testing
- Triathlon Total Knee System with X3 insert, Scorpio NRG Total Knee System with X3 insert, Triathlon PKR System with X3 insert
- Where
- 3 sites in Germany, Luxembourg and 1 more
- Volunteers
- 237 people
- Sponsor
- Stryker Orthopaedics
Arthroplasty, Replacement, Knee
Triathlon® Partial Knee Replacement (PKR) Outcomes Study
The purpose of this study is to compare the 10-year Knee Society Score (KSS) functional results of the Triathlon PKR Unicondylar Knee to the 10-year Knee Society Score (KSS) functional results of the Triathlon Cruciate Retaining…
- Trial name
- PKR (NCT00966979)
- Testing
- Triathlon PKR
- Where
- 9 sites in United States, Germany and 2 more
- Volunteers
- 111 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis, Rheumatoid Arthritis
A Clinical Investigation of the Discovery™ Elbow System
The purpose of this study is to perform a five-year, multi-center prospective evaluation of the Discovery™ Elbow System for outcome and durability.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis, Humeral Fractures
- Trial name
- NCT00698867
- Where
- 4 sites in United States
- Volunteers
- 118 people
- Sponsor
- Biomet Orthopedics, LLC
Arthroplasty, Replacement, Hip
Trident® X3 Polyethylene Insert Study
The primary objective of the study is to demonstrate the linear wear rates of the Trident® X3 polyethylene insert are superior to a polyethylene control group wear rate at 5 years postoperative.
- Trial name
- NCT00958191
- Testing
- Trident® X3 Polyethylene Insert
- Where
- 9 sites in United States
- Volunteers
- 250 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis, Knee
Alignment Comparison Between TruMatch™ Personalized Solutions and Conventional Total Knee Replacement Instrumentation
This investigation is intended to provide clinical information about alignment using TruMatch™ and to compare the results to a conventional total knee replacement.
- Trial name
- NCT01108237
- Testing
- TruMatch™ Personalized Solutions, Total Knee Arthroplasty with Conventional Instrumentation.
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems
The primary objective of this investigation is to test the hypothesis that the Duofix Tibial component results in a reduction of immediate postoperative pain compared to the LCS Porocoat version.
- Trial name
- NCT00733499
- Testing
- LCS Complete Duofix, LCS Complete Porocoat
- Where
- Ireland
- Volunteers
- 206 people
- Sponsor
- DePuy International