Clinical trials: Arthroplasty
Total Hip Arthroplasty
Does Virtual Reality Rehabilitation Improve Mobility, Balance, and Walking in Patients With Total Hip Arthroplasty?
This study aims to assess the efficacy of virtual reality through the Virtual Reality Rehabilitation System (VRRS) added to conventional rehabilitation versus conventional rehabilitation alone, for improving mobility, balance…
- Trial name
- NCT05173480
- Testing
- Conventional rehabilitation, Virtual Reality Rehabilitation System (VRRS)
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mauro Crestani
Diabetes Mellitus, Type 2, Arthroplasty, Replacement, Hip
CGM Monitoring in T2DM Patients Undergoing Orthopaedic Replacement Surgery
The purpose of this study is to analyze the efficacy and accuracy of real-time continuous glucose monitoring devices (rtCGM) in patients with Type 2 diabetes undergoing inpatient elective hip or knee surgery in the pre-, peri…
- Conditions
- Diabetes Mellitus, Type 2, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT05666479
- Testing
- Dexcom G6 Pro Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stony Brook University
Allergic Reaction, Wound Complication
Prineo Sensitivity Dressing Study
Wound complications can be devastating following total joint arthroplasty, resulting in an increased practice burden in the form of more frequent follow ups, increased clinic visits potential for wound dehiscence, superficial…
- Trial name
- NCT06011603
- Testing
- Prineo dressing
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis
Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation
The general hypothesis is that in older adults muscle regrowth after an acute musculoskeletal stress will be positively influenced by traditional physical rehabilitation, and further enhanced by nutritional supplementation.
- Trial name
- NCT00760383
- Testing
- Essential amino acids, Alanine
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Post-operative Pain, Osteoarthritis
Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty
The purpose of this study is to determine the contribution of spinal epimorph to patient's perioperative pain management in Total Knee Arthroplasty (TKA).
- Trial name
- NCT01667445
- Testing
- Epimorph, Spinal analgesia
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Total Knee Arthroplasty
Low-Load Blood Flow Restriction Training With Patients Who Underwent a Total Knee Arthroplasty: a Feasibility Trial
This project aims to investigate the feasibility of a low load (LL) isokinetic knee flexor and extensor strength training (ST) protocol under blood flow restriction (BFR) conditions in early postoperative total knee arthroplasty…
- Trial name
- NCT05843773
- Testing
- Low Load Strength Training under Blood Flow Restriction
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- HES-SO Valais-Wallis
Anxiety
Melatonin vs Pregabalin for Anxiolysis and Sedation
preoperative melatonin, pregabalin or both will be given to all patients preoperative
- Trial name
- NCT05221151
- Testing
- Melatonin, Pregabalin, Ondansetron 4 MG
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Quadro-Iliac Plane Block, Pericapsular Nerve Group Block (PENG Block)
PENG+LFCN Block vs QIPB for Total Hip Arthroplasty
This randomized clinical trial aims to evaluate and compare the analgesic efficacy and functional outcomes of the quadro-iliac plane block (QIPB) and the pericapsular nerve group (PENG) block combined with lateral femoral…
- Conditions
- Quadro-Iliac Plane Block, Pericapsular Nerve Group Block (PENG Block), Hip Arthroplasty, Total, Pain Management
- Trial name
- NCT07667231
- Testing
- Quadro iliac Plane Block(QİPB), PENG Block and LFCN Blok, Lateral femoral cutaneous nerve block(LFCN)
- Volunteers
- 60 people
- Sponsor
- Antalya City Hospital
Total Hip Arthroplasty, Osteoarthritis, Hip
Migration in Total Hip Arthroplasty with a Cemented BiMobile Cup: Better Stability with More Cement?
Objective: The main objective of this study is to compare the (early) migration of the cemented BiMobile cup at two year post-surgery between two different cup sizes after standard optimal reaming, and consequently adjusting the…
- Trial name
- Be-Mobile (NCT04049279)
- Testing
- BiMobile standard cement, BiMobile larger cement, Avantage standard cement
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- JointResearch
Degenerative Arthritis
Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty
This prospective randomized controlled trial was conducted To compare the efficacy of TNA in terms of total blood loss and the allogenic transfusion rate among the three study groups; intravenous alone, combined intravenous and…
- Trial name
- NCT02286973
- Testing
- Tranexamic Acid
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Knee Instability in Total Knee Artrhroplasty
Knee Arthroplasty Instability Study
Total knee replacement (TKR) instability is a poorly defined entity. The diagnosis is based on symptoms and clinical tests of knee laxity.
- Trial name
- KISS (NCT05676437)
- Testing
- Stress radiography
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Diakonhjemmet Hospital
Femoral Neck Disease
A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty
Total hip arthroplasty is currently the most effective method for treating hip joint lesions and improving quality of life, but postoperative severe pain is not conducive to rapid recovery of patients.
- Trial name
- NCT06284941
- Testing
- Ropivacaine combined with methylene blue for iliac fascia block
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Wang wanxia
Pain Management, Arthroplasty Total Hip Replacement
QLESP Block Versus PENG+LFCN Block for Total Hip Arthroplasty
Total hip arthroplasty (THA) is a common surgery to replace damaged hip joints, but many patients experience significant pain after surgery, which can delay recovery and increase the need for strong pain medications (opioids).
- Trial name
- QLESP (NCT07771829)
- Testing
- QLESP Block, PENG+LFCN Block, ropivacaine
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Huazhong University of Science and Technology
Hip Arthroplasty, Total
Analysis of Biomechanical Parameters and Return to Sport After Total Hip Replacement
This prospective study aims to evaluate the dynamic biomechanical parameters of gait in active patients who have undergone total hip replacement (THR), focusing on movements critical for return to sport.
- Trial name
- NCT06803914
- Testing
- Biomechanical analysis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Clinique du Sport, Bordeaux Mérignac
Prosthetic Joint Infection (PJI)
A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 2b, randomized, controlled, open-label clinical study evaluating the efficacy, safety, and local PK profiles of TNP-2092 administered via IA injection on a background of antibiotic treatment in participants with…
- Trial name
- NCT07858916
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics
- Where
- China
- Volunteers
- 40 people
- Sponsor
- TenNor Therapeutics (Zhongshan) Limited
Total Knee Replacement
Patellar Resurfacing Versus Patellar Retention in Total Knee Arthroplasty - A Randomized Clinical Trial
Background: Despite the excellent results of total knee replacement, also known as total knee arthroplasty (TKA) there is persistent controversy over whether or not to replace the surface of the kneecap.
- Trial name
- PROFIX (NCT01500252)
- Testing
- Patellar Replacement Prosthesis, Profix TKR with Patellar Retention
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Hemi Knee Arthroplasty, Patello-femoral Osteoarthritis
Evaluation of Orthopedic Knee Measurement Using Lunar iDXA
This study is to compare scans of the knee performed using new software designed specifically to look at the knee joint with those performed using approved software designed for scans of the hip.
- Trial name
- NCT01348958
- Testing
- iDXA knee software
- Where
- New Zealand
- Volunteers
- 36 people
- Sponsor
- GE Healthcare
Knee Osteoarthritis
Gait Analysis in Patients Underwent Total Knee Arthroplasty With a Medial Pivot Design.
The purpose of the present pilot study is to evaluate, through gait analysis and rating scales, the functional outcome during the execution of motor tasks with high functional demand such as walking on an unstable surface, stair…
- Trial name
- NCT04244838
- Testing
- Gait Analysis
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Ortopedico Rizzoli
Total Ankle Replacement, Total Ankle Arthroplasty
The UK ADAPTIS Study
An ankle replacement procedure consists of replacing the worn-out joint surfaces of the ankle with metal and plastic components that are shaped to allow continued movement of the ankle.
- Trial name
- UK ADAPTIS (NCT06941558)
- Testing
- INFINITY™ with ADAPTIS™ and EVERLAST™
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Prehabilitation, Knee Osteoarthritis
Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.
We live in an increasingly aging society in which the incidence of osteoarticular diseases increases, among which osteoarthritis (OA) stands out.
- Conditions
- Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities
- Trial name
- Preoperative (NCT06721897)
- Testing
- Prehabilitation Program, Non prehabilitation Program
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Jaén
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