Clinical trials: Arthroplasty
Venous Thromboembolism
A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement (TKR) surgery.
- Trial name
- ROXI-VTE II (NCT06454630)
- Testing
- REGN7508, Enoxaparin
- Where
- 14 sites in Bulgaria, Hungary and 3 more
- Volunteers
- 179 people
- Sponsor
- Regeneron Pharmaceuticals
Pain, Acute, Hip Arthropathy
Safety of Ibuprofen After Major Orthopaedic Surgeries
Safety of an eight-day treatment with ibuprofen after primary hip and knee arthroplasties.
- Conditions
- Pain, Acute, Hip Arthropathy, Knee Arthropathy, Safety Issues
- Trial name
- PERISAFE (NCT05575700)
- Testing
- Ibuprofen
- Where
- 11 sites in Denmark
- Volunteers
- 2,904 people
- Sponsor
- Naestved Hospital
Arthroplasty, Replacement Material
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when…
- Conditions
- Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- CRYO-TKA (NCT07425457)
- Testing
- CT-guided Cryoneurolysis of the Genicular Nerves
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Knee Osteoarthritis
Staged Versus Simultaneous Bilateral Knee Arthroplasty
The purpose of this study is to assist surgeons and patients in answering the question "Should I have both knees replaced at the same time, or should I just do one and wait to do the second one?"
- Trial name
- NCT03564730
- Testing
- Simultaneous Knee Arthroplasty (UKA), Staged Knee Arthroplasty (UKA)
- Where
- 8 sites in Canada
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Innovation Centre
Knee Pain Chronic, Pes Anserinus Bursitis
Platelet-rich Plasma Injections for Persistent Medial Knee Pain After Total Knee Arthroplasty
This study will investigate the potential effects of platelet rich plasma for the treatment of persistent medial knee pain after total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Pes Anserinus Bursitis, Status-Post Total Knee Arthroplasty
- Trial name
- NCT03225092
- Testing
- Ultrasound-guided platelet rich plasma injection
- Where
- United States
- Sponsor
- Ohio State University
Postsurgical Pain
Study of CA-008 (Vocacapsaicin) in Total Knee Arthroplasty
This is a two-part, Phase 2, multi-center, randomized, double-blind, placebo-controlled, parallel design study of CA-008 (vocacapsaicin) vs. placebo injected/instilled during an elective TKA.
- Trial name
- NCT03731364
- Testing
- CA-008
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Concentric Analgesics
Arthritis
Birmingham Hip Resurfacing (BHR) Study: Implantation of a Hip Resurfacing Endoprosthesis
The purpose of this study is the investigation of the functional and radiological results and subjective patient outcome after the implantation of a hip resurfacing endoprosthesis (Birmingham hip resurfacing).
- Trial name
- NCT00180206
- Testing
- Birmingham Hip Resurfacing
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis
ARVIS TKA vs Conventional TKA
This study is a pilot analysis of a novel augmented reality guidance platform, the augmented reality visualization and information system (ARVIS, Insight Medical), with aims to demonstrate accuracy of bone resection and implant…
- Trial name
- ARVIS (NCT06663384)
- Testing
- Evaluation of Augmented Reality technology in TKA compared to standard TKA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Foundation for Orthopaedic Research and Education
Knee Arthroplasty
Perioperative Analgesia After Knee Arthroplasty
The purpose of this study is to compare two accepted methods of pain control in knee arthroplasty surgery.The first method combines the periarticular injection of ropivacaine with continuous blockade of the femoral nerve.The…
- Trial name
- NCT01225484
- Testing
- Continuous femoral nerve block + periarticular infiltration, Intraarticular and periarticular ropivacaine
- Where
- Austria
- Volunteers
- 123 people
- Sponsor
- Landeskrankenhaus Feldbach
Osteoarthritis
Tourniquet vs. no Tourniquet During Total Knee Arthroplasty
The purpose of this study is to correlate functional outcomes and perioperative complications with tourniquet use during total knee arthroplasty.
- Trial name
- NCT02907047
- Testing
- tourniquet inflated, tourniquet not inflated
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Registries, Quality Improvement
Improving Quality Based on the Joint Registry
Test whether an intervention, consisting of frequently feedback of performance outcomes and education will improve patient care, expressed in better functional outcomes, fewer complications and more quality improving…
- Conditions
- Registries, Quality Improvement, Hip Arthropathy, Knee Arthropathy
- Trial name
- IQ Joint (NCT04055103)
- Testing
- Monthly feedback, education and linking hospitals
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Total Hip Replacement
A Randomized Study of Approaches in Total Hip Arthroplasty
The primary aim of the study is to compare the results of an established, successful procedure, which is total hip arthroplasty through a mini-posterior approach to a less studied - increasingly popular procedure, which is total…
- Trial name
- NCT01613508
- Testing
- Direct Anterior Approach, Mini-Posterior Approach
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Mayo Clinic
Metastatic Bone Disease of the Proximal Femur
Occlusive Skin Closure May Reduce Wound Drainage After Tumor Hip Arthroplasty
Study Type: Investigator initiated, non-significant risk Study Objective(s): To establish the effect of occlusive wound closure with the DERMABONDTM PRINEO skin closure system, compared to routine wound closure with skin staples…
- Trial name
- NCT03746717
- Testing
- occlusive wound closure, conventional wound closure
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Knee Replacement, Manipulation
Efficacy and Safety of Chuna Manual Treatment as an Adjunctive Therapy After Total Knee Arthroplasty: A Study Protocol for a Single-Center, Randomized, Assessor Blind, Parallel-Group Clinical Trial
Evaluate the efficacy and safety of Chuna treatment as an adjunctive therapy in patients with moderate pain following total knee replacement.
- Trial name
- NCT03625050
- Testing
- Chuna + Usual care(Celecoxib and esomeprazole), Usual care(Celecoxib and esomeprazole)
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Gachon University Gil Oriental Medical Hospital
Osteoarthritis, Knee
Outcome Comparison of Two Total Knee Arthroplasty Systems: e.Motion-Pro Versus Genesis II
Recently, E.Motion-PS-Pro (B.Braun-Aesculap, Tuttlingen, Germany), a new mobile bearing knee system with a unique ball and socket post-cam mechanism was developed for use in total knee arthroplasty.
- Trial name
- NCT02276118
- Testing
- device: e.motion PS Pro, device : Genesis II
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Nerve Block; Pain Medication
Obturator Nerve Block With Femoral and Sciatic Block
The purpose of this study is to evaluate how many patients require the addition of the obturator nerve block in the recovery room after the total knee surgery.
- Trial name
- NCT01409460
- Testing
- Oburator Nerve block
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Trinity Health Of New England
Arthritis Knee, Anesthesia
Prediction Model of Acute Postoperative Pain in Bilateral Total Knee Replacement Arthroplasty Patient
This study aims to predict risk factors of acute postoperative pain of the patients undergoing Total Knee Replacement Arthroplasty(TKRA).
- Conditions
- Arthritis Knee, Anesthesia, Arthropathy of Knee
- Trial name
- NCT03765723
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Total Knee Replacement, Virtual Reality Therapy
Effects of Virtual Reality Rehabilitation in Patients With Total Knee Arthroplasty
The aim of this study is to assess the efficacy of virtual rehabilitation through the Virtual Reality Rehabilitation System (VRRS) versus traditional rehabilitation improving the functional outcomes after primary Total Knee…
- Conditions
- Total Knee Replacement, Virtual Reality Therapy, Osteoarthritis, Knee Arthroplasty
- Trial name
- NCT02413996
- Testing
- Kinetec® knee continuous passive motion (CPM ), Functional activities, VRRS rehabilitation
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Arthroplasty
The Effect of the Combined Use of Naloxone and Tramacet on Postoperative Analgesia in the Elderly
Ten patients 70 years and older having elective total hip/knee replacement surgery will be recruited to receive a continuous IV infusion of naloxone and oral tramacet for analgesia.
- Trial name
- NCT00665262
- Testing
- tramacet
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Primary; Coxarthrosis
Gait Initiation and Transition From Double to Single Support in Patients With Unilateral Primary Coxarthrosis
The study consists to evaluate the impact of prosthetic surgery (PTH and RTH) on kinematic and dynamic parameters (joint torques) of the lower limbs during gait initiation in patients with primary coxarthrosis.
- Trial name
- COXAM (NCT06258369)
- Testing
- Patients with primary coxarthrosis (any stage)., Patients with primary coxarthrosis (any stage) and operated with Total Hip Prosthesis (THP)., Patients with primary coxarthrosis (any stage) and operated with RTH (Hip resurfacing).
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Lille Catholic University
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