Clinical trials: Artificial Pancreas
Pancreatic Cancer
A Multi-center Study on the Efficacy and Safety of AI-assisted Navigation System for Biliopancreatic EUS
Pancreatic cancer is one of the most lethal cancers. Survival rates vary largely depending on the stage at which it is diagnosed. EUS is considered one of the most sensitive modalities for pancreatic cancer detection.
- Trial name
- NCT04892329
- Testing
- Artificial intelligence assistant system
- Where
- 2 sites in China
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Type1 Diabetes Mellitus
Effect of SGLT2i in Conjunction With the Artificial Pancreas on Improving the Glycemia in T1DM in the Outpatient Setting
The most advanced configurations of the Artificial Pancreas (AP) have not yet been demonstrated to sufficiently maximize time in target glycemia.
- Trial name
- CLASS17 (NCT03979352)
- Testing
- empagliflozin, artificial pancreas
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Type 1 Diabetes Mellitus
Feasibility Study of Closed Loop Control in Type 1 Diabetes Using Heart Rate Monitoring as an Exercise Marker
The purpose of this study is to see if the Artificial Pancreas Platform (AP Platform = Cell Phone + Closed Loop Control) can successfully control blood sugar in people with type 1 diabetes mellitus on insulin pump therapy in a…
- Trial name
- NCT01582139
- Testing
- Heart rate informed SSM+HMM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format
In previous studies, we tested the feasibility of a bi-hormonal closed loop system. This system for automated control of blood glucose in patients with type 1 diabetes was tested in the clinical research center as well as at the…
- Trial name
- APPEL4 (NCT02160275)
- Testing
- Artificial Pancreas (Inreda Diabetic BV), Insulin pump therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 16 people
- Sponsor
- J.H. DeVries
Type-1-Diabetes
Early Feasibility Evaluation of the UniBE Hybrid Closed-loop Insulin Delivery System in Type 1 Diabetes: UBLoop-Genesis
The study is investigating the early feasibility of a novel algorithm for a hybrid closed-loop (HCL) insulin delivery system in adult patients with Type 1 diabetes.
- Trial name
- UBLoop-Gen (NCT07087340)
- Testing
- UBLoop System
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Bern
Type 1 Diabetes Mellitus With Artificial Pancreas Device
OCT and OCT-A Deep Learning in Diabetic Patients Wiht Artificial Pancreas Device
This study evaluates the ability of deep learning to improve the knowledge about structural and vascular retinal changes in diabetic patients undergoing artificial pancreas device, using optical coherence tomography angiography.
- Trial name
- NCT05809843
- Testing
- hybrid artificial pancreas systems (CSII)
- Where
- Italy
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federico II University
Type 1 Diabetes, Gastroparesis Due to Diabetes Mellitus Type I
To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.
The goal of this clinical trial is to evaluate the efficacy and safety of Medtronic 780G automated insulin delivery system in adult persons with type 1 diabetes and gastroparesis.
- Trial name
- NCT07287943
- Testing
- Medtronic 780G AID
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Viral N. Shah
Secondary Pancreatic Diabetes
Closed-loop Insulin Delivery Systems in Pancreatic Diabetes
The purpose of this study is to evaluate the metabolic and the safety outcomes in people living with pancreatic diabetes (pancreatitis or pancreatectomy-induced diabetes) and using a closed-loop insulin delivery systems…
- Trial name
- IADIASP (NCT06227650)
- Testing
- hybrid closed loop insulin delivery system
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Sud Francilien
Diabetes Mellitus, Type 1
Android Artificial Pancreas System (Android APS) Versus Control-IQ
The aim of the investigator's study is to compare two different closed loop hybrid systems - certified Control-IQ and noncertified AndroidAPS in adult patients with Type 1 Diabetes (T1D), who had been using AndroidAPS previously…
- Trial name
- CODIAC (NCT05165615)
- Testing
- Insulin Pump t:slim X2 with Control-IQ technology
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
Type 1 Diabetes Mellitus
At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation
This clinical trial is a study to assess the performance of an automated glucose control system (Artificial Pancreas, AP) device in home settings for subjects with type 1 diabetes.
- Trial name
- NCT02705053
- Testing
- CGM and Insulin Pump, Closed-Loop Control System
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes Mellitus
Crossover Feasibility Study of Portable AP Device With Zone-MPC and HMS and Adapted I:C and Basal Insulin
The purpose of this trial is to assess the performance of an Artificial Pancreas (AP) device using the Portable Artificial Pancreas System (pAPS) platform for subjects with type 1 diabetes using an insulin pump and rapid acting…
- Trial name
- DP3 (NCT01929798)
- Testing
- portable Artificial Pancreas
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Sansum Diabetes Research Institute
Type1 Diabetes
Neural-net Artificial Pancreas (NAP)
This study is intended to assess a Neural-net Artificial Pancreas (NAP) implementation of an established AP controller - the University of Virginia Model Predictive Control Algorithm (UMPC).
- Trial name
- NAP (NCT05876273)
- Testing
- Neural-net Artificial Pancreas, University of Virginia Model Predictive Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Insulin-plus-pramlintide Closed-loop Strategy to Regulate Glucose Levels Without Carbohydrate Counting
Closed-loop system systems that are shown to alleviate the burden of carbohydrate counting without degrading glucose control are still lacking.
- Trial name
- Dual (NCT03800875)
- Testing
- 27-hour inpatient intervention
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Pancreatic Cystic Lesion (PCL)
An Artificial Intelligence System for Multimodal, Multi-class Diagnosis of Pancreatic Cystic Lesions Based on Endoscopic Ultrasonography
The aim of this study is to develop and validate an artificial intelligence system named iEUS-PCL (intelligent endoscopic ultrasound system-pancreatic cystic lesions） for detecting and multimodal, multi-class diagnosing…
- Trial name
- NCT07543263
- Testing
- iEUS-PCL(intelligent endoscopic ultrasound system- pancreatic cystic lesion)
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Qilu Hospital of Shandong University
Type 1 Diabetes Mellitus
A Study of an Automated Insulin Delivery System in Adult Participants With Type 1 Diabetes Mellitus During Meal Challenges
The Automated Insulin Delivery (AID) System is an investigational insulin delivery device being developed for use for participants with diabetes.
- Trial name
- NCT03848767
- Testing
- AID System, Insulin Lispro
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Diabetes Mellitus, Type 1
Automated Closed-loop in Children and Adolescents With Type 1 Diabetes
People with type 1 diabetes need regular insulin injections or continuous delivery of insulin using a pump. Keeping blood sugars in the normal range is known to reduce long term complications.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam09 (NCT02129868)
- Testing
- Closed-loop (Android Closed-Loop platform)
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1
Switch of AndroidAPS to Commercially Available AID Systems
The aim of the study was to investigate the switch between open-source automated insulin delivery system (OS-AID) - AndroidAPS (AAPS) and commercially available AID systems - Control-IQ (CIQ) and MiniMed 780G (780G) in extended…
- Trial name
- NCT06709729
- Testing
- Insulin pump with closed-loop system
- Where
- Czechia
- Volunteers
- 41 people
- Sponsor
- Charles University, Czech Republic
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 5 Days in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02488616
- Testing
- 5-day intervention with single-hormone closed-loop strategy, 5-day intervention with sensor-augmented pump therapy, Insulin pump
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Pancreatic Cancer, Diabetes
Artificial Intelligence-based Early Screening of Pancreatic Cancer and High Risk Tracing (ESPRIT-AI)
Pancreatic cancer is one of the most fatal malignancies with a 5-year survival rate of only ~6%[1]. The reasons for this high mortality rate can be attributed to several factors, of which perhaps the most important is delayed…
- Conditions
- Pancreatic Cancer, Diabetes, Familial Pancreatic Cancer, Pancreatic Cystic Neoplasm
- Trial name
- ESPRIT-AI (NCT04743479)
- Testing
- high-resolution MRI/CT examinations
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Changhai Hospital
Type 1 Diabetes Mellitus, Hypoglycemia
Exercise-Induced Hypoglycemia Prevention in Adults With Type 1 Diabetes Using an Artificial Pancreas
This is a randomized crossover trial with 1:1 randomization to the admission sequence of using the Control AP system (rMPC - Naïve Model Predictive Control) vs.
- Trial name
- NCT03859401
- Testing
- EnMPC (Ensemble Model Predictive Control) AP Controller, rMPC (Naïve Model Predictive Control) AP Controller
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marc Breton