Clinical trials: Artificial Respiration
Heart Defects, Congenital, Intensive Care Units, Pediatric
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery
- Conditions
- Heart Defects, Congenital, Intensive Care Units, Pediatric, Respiration, Artificial, Extubation
- Trial name
- NCT07059689
- Testing
- High Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Indonesia
- Volunteers
- 114 people
- Sponsor
- Universitas Indonesia
Respiration, Artificial, Noninvasive Ventilation
Epidemiology of Non- Invasive Mechanical Ventilation in Argentina: a Multicenter Observational Study
Introduction Non-invasive mechanical ventilation (NIMV) is a fundamental strategy in the management of acute respiratory failure, preventing intubation and reducing complications.
- Conditions
- Respiration, Artificial, Noninvasive Ventilation, Intensive Care Units
- Trial name
- EpVAr-VMNI (NCT06837402)
- Where
- Argentina
- Volunteers
- 246 people
- Sponsor
- Argentinian Intensive Care Society
Respiration, Artificial, Reverse Triggering
Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study
Background: Reverse triggering (RT) is a frequent phenomenon observed in sedated patients under a mechanical ventilation mode called assist-control ventilation.
- Trial name
- SEVERE (NCT06293976)
- Testing
- Changes in the ventilator respiratory rate and tidal volume
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Respiration, Artificial
Association Between Tidal Volume and Mortality in Pressure Support in Adults Under Invasive Mechanical Ventilation
The goal of this Multicenter retrospective cohort study is to assessing the association between the development of a tidal volume magnitude > 8 ml/kg of predicted body weight during the first transition to partial support phase…
- Trial name
- SAFE-VT (NCT06195475)
- Testing
- high vs low tidal volume
- Where
- Argentina
- Volunteers
- 2,607 people
- Sponsor
- Sanatorio Anchorena San Martin
Respiratory Muscles, Respiration, Artificial
Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation
This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm.
- Conditions
- Respiratory Muscles, Respiration, Artificial, Respiratory Function Tests
- Trial name
- VIREM (NCT05459116)
- Testing
- Placement of nasogastric balloon
- Where
- 3 sites in Belgium, Canada
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Ventilator Weaning, Respiration, Artificial
Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training
The TONES trial aims to evaluate the neuroventilatory efficiency (NVE = tidal volume / peak voltage of diaphragm contraction) measured during a zero-assist manoeuvre (ZAM, i.e. with PEEP but without pressure support).
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Muscles, Respiratory Failure
- Trial name
- TONES (NCT05380687)
- Testing
- Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Antwerp
Mechanical Ventilation, Artificial Respiration
Dead Space in Mechanical Ventilation With Constant Expiratory Flow
Conventional continuous mandatory mechanical ventilation relies on the passive recoil of the chest wall for expiration. This results in an exponentially decreasing expiratory flow.
- Trial name
- DeXFLoW (NCT06024993)
- Testing
- Flow-controlled ventilation (FCV), Conventional volume-controlled ventilation (VCV)
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Antwerp
Acute Respiratory Distress Syndrome, Respiration, Artificial
Impact of Decreasing Respiratory Rate on Lung Injury Biomarkers in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a form of acute lung injury of inflammatory origin, which represents a public health problem worldwide due to its prevalence, and its high mortality rate, close to 40%.
- Conditions
- Acute Respiratory Distress Syndrome, Respiration, Artificial, Ventilator-Induced Lung Injury
- Trial name
- NCT04641897
- Testing
- Respiratory rate modification
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiratory Insufficiency, Ventilation Therapy; Complications
KAP Asynchrony Survey
The investigators developed a web-based survey to assess knowledge, attitudes and practice of health care professionals about patient-ventilator asynchrony.
- Conditions
- Respiratory Insufficiency, Ventilation Therapy; Complications, Ventilators, Mechanical, Respiration, Artificial
- Trial name
- KAPA (NCT03439683)
- Testing
- Survey about patient-ventilator asynchrony
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Respiratory Mechanics, Respiration, Artificial
Ventilatory Variables in Subjects With Acute Respiratory Distress Syndrome Due to COVID-19
Research question: Are the ventilatory variables related to mechanical power associated with the outcome of subjects who received mechanical ventilation (MV) for Acute Respiratory Distress Syndrome (ARDS) secondary to pneumonia…
- Conditions
- Respiratory Mechanics, Respiration, Artificial, Respiratory Distress Syndrome
- Trial name
- NCT05946525
- Where
- Argentina
- Volunteers
- 110 people
- Sponsor
- Hospital Donación Francisco Santojanni
Respiration, Artificial
Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm
The aim of this study is to study the combined impact of mechanical ventilation and sepsis on the human diaphragm in order to establish the neutral, protective or destructive character of mechanical ventilation by studying the…
- Trial name
- SEPTIC (NCT03371602)
- Testing
- surgery, multi-organ sampling
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Hospices Civils de Lyon
Respiration, Artificial
Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)
The purpose of this trial is to evaluate if augmenting a usual audit and feedback implementation approach with telehealth-enabled support improves coordinated spontaneous awakening/breathing trials and patient outcomes for…
- Trial name
- TEACH (NCT05141396)
- Testing
- Telehealth- enabled support for SAT/SBT adherence, Usual audit and feedback for SAT/SBT adherence
- Where
- 11 sites in United States
- Volunteers
- 13,400 people
- Sponsor
- Intermountain Health Care, Inc.
Thoracic Surgery, One-lung Ventilation
Individualized PEEP in Thoracic Surgery
Intraoperative protective ventilation with low tidal volumes (TV), positive end-expiratory pressure (PEEP) and possibly lung recruitment maneuvers (RMs) reduces postoperative pulmonary complications.
- Conditions
- Thoracic Surgery, One-lung Ventilation, Respiratory Mechanics, Artificial Respiration
- Trial name
- NCT04740151
- Testing
- Best PEEP, Standard PEEP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Trieste
Respiration, Artificial, Ventilator Weaning
Pediatric Ventilation Weaning
The hypothesis of the present study is that the use of Continuous Positive Airway Pressure (CPAP) plus PS can accelerate the weaning process and, consequently, shorten the MV.
- Trial name
- PROVENTUS (NCT04023643)
- Testing
- Ventilation Weaning
- Where
- 5 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- São Paulo State University
Respiratory Distress Syndrome, Adult, Respiration, Artificial
PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury
The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. Many parameters have been described as influential on the values of renal RI.
- Conditions
- Respiratory Distress Syndrome, Adult, Respiration, Artificial, Acute Kidney Injury
- Trial name
- PRE-VIKI (NCT03969914)
- Testing
- PEEP changes
- Where
- 2 sites in Italy
- Volunteers
- 105 people
- Sponsor
- Università degli Studi di Ferrara
Pediatric Respiratory Diseases, Ventilator Weaning
WOB and Paediatric Mechanical Ventilation
Rationale: The most common approach to weaning infants and children is gradual reduction of ventilatory support ("traditional approach").
- Conditions
- Pediatric Respiratory Diseases, Ventilator Weaning, Respiration, Artificial, Respiratory Failure
- Trial name
- PedWOB (NCT05254691)
- Testing
- Sprinting
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Neuromuscular Diseases, Respiration, Artificial
Quality of Life in Ventilator-dependant Neuromuscular Patients
This study aims at evaluating the quality of life of patients with slowly progressive neuromuscular disorders who are dependant on mechanical ventilation (daily usage ≥ 16h).
- Conditions
- Neuromuscular Diseases, Respiration, Artificial, Tracheostomy, Noninvasive Ventilation
- Trial name
- EqualVENT (NCT04652401)
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
COVID-19 Acute Respiratory Distress Syndrome, Respiration, Artificial
Flow-controlled Ventilation (FCV) in Moderate Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19
Flow controlled ventilation (FCV) is a fairly new mode of mechanical ventilation, consisting of a constant inspiratory and expiratory flow. Inspiration is thus comparable to volume controlled ventilation (VCV).
- Trial name
- VICAR (NCT04894214)
- Testing
- Arterial blood gas (ABG), Recording of hemodynamic monitoring, Recording of respiratory monitoring
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- University Hospital, Antwerp
Weaning, Respiration, Artificial
Effectiveness of Musicotherapy in Weaning From Mechanical Ventilation
1. OBJECTIVES: General objective: Assess the effects of a music therapy intervention during the weaning from the mechanical ventilation in a group of patients, and compare it to the usual clinical practice.
- Conditions
- Weaning, Respiration, Artificial, Music Therapy
- Trial name
- NCT04602182
- Testing
- music therapy intervention
- Where
- 2 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Basque Health Service
Electric Stimulation, Respiration, Artificial
Breath Synchronized Abdominal Muscle Stimulation to Facilitate Ventilator Weaning: a Pilot Study
The primary objective of this study is to determine whether neuromuscular electrical stimulation applied to the abdominal wall muscles in synchrony with exhalation can increase the strength of the respiratory muscles in prolonged…
- Conditions
- Electric Stimulation, Respiration, Artificial, Ventilator Weaning
- Trial name
- NCT03019107
- Testing
- Breath synchronized abdominal NMES
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Liberate Medical