Clinical trials: Ascending Aortic Dilatation
Hypertension, Aortic Aneurysm
Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)
Aortic stiffness is an important imaging biomarker of vascular aging. The ascending aorta is the most elastic segment, and it is excluded by reference non-invasive method carotid to femoral pulse wave velocity (PWV).
- Conditions
- Hypertension, Aortic Aneurysm, Bicuspid Aortic Valve, Marfan Syndrome
- Trial name
- InSide-CC (NCT05711693)
- Testing
- Laser doppler vibrometry (LDV), heart(cordium) carotid pulse wave velocity (ccPWV), Blood pressure and heart rate measurement, carotid to femoral PWW measurement
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aortic Aneurysm, Athlete
Prevalence of Ascending Aortic Dilation in Sports Medicine
This study aims to assess the prevalence of ascending aortic dilation in athletes from the general population undergoing routine sports medicine evaluation.
- Trial name
- PRAADS (NCT07050953)
- Testing
- focused cardiac ultrasound
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Aortic Stenosis, Ascending Aortic Dilatation
Comparison of Self- and Balloon-expandable Valves in Patients With Ascending Aortic Dilation Undergoing Transcatheter Aortic Valve Replacement: The AAD-CHOICE
This study aimed at comparing the performance of self-expandable valves versus balloon-expandable valves in patients with ascending aortic dilation undergoing transcatheter aortic valve replacement.
- Trial name
- NCT06009588
- Testing
- self-expandable valves, balloon-expandable valves
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Marfan Syndrome
Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome
Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities.
- Trial name
- NCT00429364
- Testing
- Losartan Potassium, Atenolol
- Where
- 26 sites in United States, Belgium and 1 more
- Volunteers
- 608 people
- Sponsor
- Carelon Research
Congenital Heart Disease, Bicuspid Aortic Valve
Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve
Bicuspid aortic valve (BAV) is a form of congenital heart disease (the person is born with it). With BAV, the heart valves in the aorta (the blood vessel that takes blood away from the heart to the body) are not formed right.
- Trial name
- NCT00412386
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Type A Aortic Dissection, Ascending Aortic Dissection
Outcomes of Aortic Dissection Repair
Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity.
- Conditions
- Type A Aortic Dissection, Ascending Aortic Dissection, Aortic Diseases, Aortic Arch
- Trial name
- STAAD (NCT05927090)
- Testing
- Conservative Root- Sparing Aortic Valve Resuspension with or without Hemiarch Repair, Extensive Ascending Aorta Replacement (AAR) with Aortic Root Replacement (ARR), Extensive Ascending Aorta Replacement (AAR) with Total Arch Replacement (TARP)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Centre Cardiologique du Nord
Aortic Stenosis, Ascending Aortic Dilatation
Efficacy of Self-expandable and Balloon-expandable Valves in Patients With Ascending Aortic Dilation
This study evaluated the efficacy of self-expandable valves and balloon-expandable valves in patients with ascending aortic dilation who undergo transcatheter aortic valve replacement.
- Trial name
- NCT06743568
- Testing
- Transcatheter aortic valve replacement
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Aortic Disease
Dosing of Amicar and Measure of Fibrinolysis by TEG During Cardiac Surgery
This study hopes to determine the optimal antifibrinolytic dosing to decrease bleeding and blood transfusion after cardiac surgery without increasing adverse events
- Trial name
- EACA (NCT01965730)
- Testing
- epsilon-aminocaproic acid (EACA)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Ascending Aortic Aneurysm, Aortic Adventitial Pathology
Prospective Evaluation of Adventitial Histopathology in Borderline Ascending Aortic Dilatatio
This prospective study investigates microscopic changes in the outer layer (adventitia) of the ascending aorta in patients undergoing coronary artery bypass grafting (CABG) surgery.
- Conditions
- Ascending Aortic Aneurysm, Aortic Adventitial Pathology, Coronary Artery Bypass Grafting (CABG), Borderline Aortic Dilatation
- Trial name
- NCT07034586
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Samsun University
Aortic Diseases, Aortic Dissection
Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes
The aorta is the principal arterial vessel arising from the left heart that transfers blood to the body. Certain genetic and familial disease processes are known to weaken the aortic wall resulting in dilation and potential…
- Conditions
- Aortic Diseases, Aortic Dissection, Aortic Aneurysm, Thoracic, Aortic Ectasia
- Trial name
- NCT05389865
- Testing
- Surgery on the proximal aorta (aortic root +/- ascending aorta), Patients diagnosed with thoracic aortopathy but not operated upon
- Where
- United Kingdom
- Volunteers
- 1,662 people
- Sponsor
- Golden Jubilee National Hospital
Aortic Dissection, Aortic Arch
Repair Versus Non-repair of the Aortic Arch in Type A Aortic Dissection
Acute Stanford type A aortic dissection (TAAD) is a life-threatening clinical status requiring surgery that is usually performed as a salvage procedure.We planned a multicenter study to evaluate the balance between the patient's…
- Conditions
- Aortic Dissection, Aortic Arch, Aortic Dissection Rupture, Aortic Dilatation
- Trial name
- AoArch (NCT05912634)
- Testing
- Conservative TAAD-R, Extensive TAAD- R
- Where
- France
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Centre Cardiologique du Nord
Aortic Rupture
In Vivo Evaluation of Growth and Risk of Rupture of Dilated Ascending Aorta Using 4D Cardiac Magnetic Resonance
Ascending aorta aneurysmal disease is common and can be complicated by dissection or rupture. There is substantial variation in individual aneurysm progression: established risk factors for an accelerated aneurysm growth rate…
- Trial name
- NCT03172390
- Testing
- 4D Cardiac Magnetic Resonance
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ascending Aorta Aneurysm, Dilation of the Ascending Aorta
Study of Treatment of Thoracic Aortic Aneurysms and Dilatation in Combination With Tricuspid and Bicuspid Aortic Valves.
Clarification of indications for surgical correction in patients with borderline expansion of the ascending aorta
- Trial name
- NCT04372563
- Testing
- aortic prosthetics
- Where
- 2 sites in Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Aortic Aneurysm, Thoracic
Impact of Anesthesia on the Dimension of the Ascending Aorta
The aim of this study is to evaluate the accuracy and reliability of intra-operative TEE after the induction of anesthesia when assessing proximal thoracic aorta diameters in a cohort of aortic aneurysm patients.
- Trial name
- NCT03431870
- Testing
- Trans-esophageal echocardiography
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Transcatheter Aortic Valve Replacement (TAVR), Ascending Aortic Dilation
Outcomes for Patients With Ascending Aortic Dilation Who Underwent TAVR
The present study was designed to evaluate the safety of TAVR with a preoperative ascending aortic (AA) diameter ≥ 40 mm. This study also aimed to explore the procedural outcomes and clinical prognoses of patients with AAD…
- Trial name
- NCT07148973
- Testing
- Transcatheter Aortic Valve Replacement
- Where
- China
- Volunteers
- 101 people
- Sponsor
- zjq
Aortic Valve Stenosis
Ascending Aortic Dilation in BiAV After TAVR
This study sought to evaluate changes in ascending aorta size after transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve (BiAV) compared with patients with tricuspid aortic valve (TAV).
- Trial name
- NCT03051334
- Testing
- diagnosed as bicuspid aortic valve
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Bicuspid Aortic Valve (BAV)
A Study of Chinese Congenital Bicuspid Aortic Valve
Pervious studies indicated that the prevalence of bicuspid aortic valve（BAV） might be higher in China. There is a familial predisposition to the development of BAV.
- Trial name
- NCT06802016
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Aortic Stenosis, Ascending Aortic Dilatation
Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement
The goal of this observational study is to assess the changes of ascending aortic diameter in patients undergoing transcatheter aortic valve replacement. The main questions it aims to answer are: 1.
- Conditions
- Aortic Stenosis, Ascending Aortic Dilatation, Bicuspid Aortic Valve
- Trial name
- NCT05739253
- Testing
- Transcatheter aortic valve replacement
- Where
- China
- Volunteers
- 480 people
- Sponsor
- China National Center for Cardiovascular Diseases
Ascending Aortic Dilatation, Aortic Aneurysm, Thoracic
Aortic Dilatation Under 5 cm: Genetic Risk Mapping
This retrospective study investigates the prevalence of genetic mutations in patients with ascending aortic dilatation measuring between 4.0 and 5.0 cm-below the standard surgical threshold.
- Conditions
- Ascending Aortic Dilatation, Aortic Aneurysm, Thoracic, Aortic Diseases
- Trial name
- NCT07034430
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Samsun University