Clinical trials: Ascorbic Acid
Systemic Lupus Erythematosus (SLE)
Efficacy of Vitamin C Supplementation on Malondialdehid Levels and Disease Activity in SLE Patients
The study aimed to evaluate the efficacy of vitamin C supplementation compared to placebo towards malondialdehid levels and disease activity with the MEX-SLEDAI score in Systemic Lupus Erythematosus (SLE) patients.
- Trial name
- NCT07083622
- Testing
- Vitamin C
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Sriwijaya
Bowel Cleansing in Preparation for Colonoscopy
PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation
The colonoscopy accuracy and safety depend on the quality of colon cleansing. An inadequately prepped bowel will increase the risk of missing a lesion, prolong procedure, increase patient discomfort, and eventually increase…
- Trial name
- NCT01788709
- Testing
- preparation cleaning solution
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- American University of Beirut Medical Center
Occluded Totally Implanted Central Venous Catheter
Determining the Safe Dosage of Ascorbic Acid Used in the Treatment of Occluded Totally Implanted Central Venous Catheter
The hypothesis of the study is to evaluate whether ascorbic acid is able to clear totally implanted central venous catheter
- Trial name
- NCT01270152
- Testing
- Ascorbic Acid
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- University of Sao Paulo
Gingival Recession, Localized, Gingival Diseases
How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?
Periodontal diseases are a prevalent issue, often leading to gingival recession, where the gingival margin recedes, exposing the tooth root and causing various problems.
- Conditions
- Gingival Recession, Localized, Gingival Diseases, Recession, Gingival
- Trial name
- recession (NCT06936592)
- Testing
- Ascorbic acid
- Volunteers
- 30 people
- Sponsor
- Minia University
Colonoscopy Preparation
Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid.
The purpose of the study is to assess whether a low volume polyethylene glycol (PEG) plus ascorbic acid based bowel preparation for colonoscopy is not inferior to a large volume polyethylene glycol preparation in subjects with…
- Trial name
- REPREP1 (NCT02073552)
- Testing
- Polyethylene glycol 4000, Macrogol 3350 plus ascorbic acid
- Where
- Spain
- Volunteers
- 472 people
- Sponsor
- Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Iron, Cerebral Blood Flow
16 Weeks' Dietary Supplementation With Iron and Iron + Vitamin C on Cerebral Blood Flow and Energy Expenditure in Women of Reproductive Age
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Conditions
- Iron, Cerebral Blood Flow, Energy Metabolism, Cognitive Function
- Trial name
- NCT04477018
- Testing
- Iron bis-glycinate chelate and vitamin C, Iron bis-glycinate chelate
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Tooth Whitening, Tooth Discoloration
Clinical Research Study to Evaluate Stain Removal and Whitening Improvement
The objective of this clinical research study is to evaluate the stain removal and whitening improvement of a toothpaste containing Vitamin C and 1100 ppm F as sodium fluoride as compared to a matching placebo toothpaste…
- Trial name
- NCT07870018
- Testing
- Vitamin C toothpaste
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Coronary Artery Disease
Noninferiority Trial Of Sirolimus With Ascorbic Acid Versus Everolimus in All-comers
The objective of this study is to demonstrate the primary hypothesis that, in patients with chronic and acute coronary syndromes requiring percutaneous coronary intervention (PCI), the novel sirolimus-ascorbic acid eluting stent…
- Trial name
- NOVA (NCT07566091)
- Testing
- Sirolimus-Ascorbic Acid Eluting Stent, Everolimus-Eluting Stent
- Where
- South Korea
- Volunteers
- 2,034 people
- Sponsor
- Jung-min Ahn
Shock, Septic, Critically Ill
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial
Sepsis has been characterised as a dysregulated host response to infection. Adjunctive therapies targeting the inflammatory cascade are being increasingly explored, although to date, have failed to demonstrate consistent benefit…
- Conditions
- Shock, Septic, Critically Ill, Vasoplegic Syndrome, Sepsis
- Trial name
- VITAMINS (NCT03333278)
- Testing
- Vitamin C, Thiamine, Hydrocortisone,
- Where
- 8 sites in Australia, Brazil and 1 more
- Volunteers
- 216 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Carcinoma, Non-Small-Cell Lung
Pharmacological Ascorbate for Lung Cancer
This clinical trial evaluates adding high-dose ascorbate (vitamin C) to standard of care treatment of non-small cell lung cancer (NSCLC) in adults.
- Trial name
- NCT02420314
- Testing
- Paclitaxel, Carboplatin, Ascorbic Acid
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Joseph J. Cullen, MD, FACS
Vitamin C Deficiency
The Effect of Vitamin C on GCF Total Oxidant Capacity in Smoker Patients With Periodontitis
The effect of vitamin C supplementation on GCF total oxidant capacity in smoker patients with periodontitis following non-surgical periodontal therapy.
- Trial name
- NCT05009355
- Testing
- Vitamin C
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain
Analgesic Effect of Melatonin and Vitamin C Administration, Alone or In Combination in Major Abdominal Surgery.
The goal of this clinical trial is to compare the analgesic effect of melatonin, and vitamin C and their combination in patients aged 18-60 years old who will undergo major abdominal surgery with mid-line incision within an…
- Trial name
- NCT06374771
- Testing
- Melatonin 10 MG, Vitamin C
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Multiple Myeloma, Stem Cell Transplantation
Arsenic Trioxide With Ascorbic Acid and Melphalan for Myeloma Patients
1. To evaluate the toxicity and safety of a combination of arsenic trioxide with ascorbic acid and high-dose Melphalan in patients with multiple myeloma 2.
- Trial name
- NCT00661544
- Testing
- Arsenic Trioxide, Melphalan, Ascorbic Acid
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- M.D. Anderson Cancer Center
Blood Pressure
Effects of Dietary Nitrate and Vitamin C Co-supplementation on Blood Pressure and Endothelial Function in Overweight Individuals
The investigators have shown in two short-term studies in healthy, young participants that the combined supplementation of inorganic nitrate with vitamin C has beneficial effects on blood pressure and blood vessel wall stiffness.
- Trial name
- NCT07242066
- Testing
- Beetroot juice plus vitamin C tablet
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Nitrite Infusion Studies
This study will examine 1) how nitrite (a natural blood substance that relaxes blood vessels) increases blood flow and lowers blood pressure, and 2) how to increase the effects of nitrite on blood pressure.
- Trial name
- NCT00102271
- Testing
- Oxypurinol, Sodium Nitrite
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Kidney Injury
Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicty
A Randomized controlled trial aiming to investigate whether ascorbic acid has a role in preventing vancomycin induced nephrotoxicity or not in critically ill patients.
- Trial name
- NCT03921099
- Testing
- Ascorbic Acid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Myeloma
Velcade, Trisenox, Vitamin C and Melphalan for Myeloma Patients
Primary Objectives: 1. To evaluate the toxicity and safety of a combination of bortezomib with arsenic trioxide, ascorbic acid and high-dose melphalan in patients with multiple myeloma 2.
- Trial name
- NCT00469209
- Testing
- Trisenox (Arsenic Trioxide), Velcade (Bortezomib), Melphalan
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Haematopoiesis
A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.
Iron deficiency anaemia (Haemoglobin, Hb < 12gm/dl) is one of India's major public health problems particularly in women. Effective control of iron deficiency anaemia decreases the incidence of fatigue, bodyache, headache, lack…
- Trial name
- NCT01160198
- Testing
- ferrous ascorbate, ferrous bisglycinate chelate 1 OD, ferrous bisglycinate chelate 2 OD
- Where
- 7 sites in India
- Volunteers
- 271 people
- Sponsor
- GlaxoSmithKline
Elevated Blood Lead Levels
Lead Detoxifying Effects of Ascorbic Acid Among School Going Adolescents of Karachi- A Cluster Randomized Control Trial
The toxic nature of lead has been recognized ubiquitous for than 2,000 years and today it is a persistent and common environmental contaminant in most parts of the world.
- Trial name
- LDVC (NCT02745873)
- Testing
- Ascorbic Acid
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Scurvy
"Vitamin C Deficiency in Hospitalized Adults: Systematic Screening Vs. Traditional Judgment - a Before-and-After Observational Study"
Brief Summary of the Study The goal of this observational study is to assess the incidence of vitamin C deficiency among hospitalized adults presenting with hemorrhagic signs.
- Trial name
- NCT06876545
- Testing
- systematical screening of at risk patients based on predefined hemorrhagic criteria
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Internist.Ro