Clinical trials: Aspiration, Respiratory
Liver Function After Partial Liver Resection
Xenon-anesthesia on Patients Undergoing Major Liver-resection
The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.
- Trial name
- XeLiv (NCT03504033)
- Testing
- Xenon, Desflurane
- Where
- Germany
- Sponsor
- RWTH Aachen University
Anesthesia Intubation Complication, Mechanical Ventilation Complication
Endotracheal Tube Audible Leak Test
The endotracheal tube (ETT) leak test (LT), or audible leak test is a widely performed assessment to verify appropriate tube size in neonates, infants and children.
- Trial name
- NCT02461017
- Testing
- Assess for Audible Endotracheal Leak, Assess for Endotracheal Leak with direct visualization under rigid bronchoscope
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Mississippi Medical Center
Hyponatraemia, Hypernatraemia
Do Changes in Plasma Osmolality Influence Ventilation?
Primary hypothesis: osmolality changes influence the sensitivity of the respiratory center to carbon dioxide, hyponatraemia causing hyperventilation, and hypernatraemia depressing ventilation.
- Trial name
- OSM (NCT01008644)
- Testing
- Water, Saline 3%
- Where
- Sweden
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vibeke Moen
Mechanical Ventilation Complication, Respiratory Failure
Effect of PEEP on Lung Regional Ventilation and Perfusion
Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT
- Conditions
- Mechanical Ventilation Complication, Respiratory Failure, Hypoxia
- Trial name
- PEEP (NCT04081155)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Yun Long
Chronic Obstructive Pulmonary Disease
Respiratory Muscle Activations During Stable Threshold Load and Increasing Threshold Load Endurance Tests in COPD
In the literature, it has been observed that there is an increase in respiratory muscle activity in individuals with COPD due to the increase in respiratory workload and in response to the loads given by respiratory muscle…
- Trial name
- NCT04983485
- Testing
- Observational
- Volunteers
- 21 people
- Sponsor
- Abant Izzet Baysal University
Stress, Stress, Psychological
The Effect of SKY Breath Meditation on Health and Well-being
The goal of this pilot SKY (Sudarshan Kriya Yoga) Breath Meditation study is to establish feasibility and acceptability of the intervention; and investigate preliminary effectiveness of the intervention at the DNA methylation…
- Conditions
- Stress, Stress, Psychological, Stress, Physiological, Anxiety
- Trial name
- NCT05523414
- Testing
- SKY
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Graft-Versus-Host Disease
Measurements of Resting Energy Expenditure in Patients With or at Risk of Developing Graft Versus Host Disease
This study aims to show that the MedGem indirect calorimetry measurement device will be feasible to use in children with GVHD. Also, it aims to show that children with chronic GVHD will have elevated REE that is not adequately…
- Trial name
- NCT00600314
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pediatric Cancer, Inspiratory Muscle Training
The Effect of Inspiratory Muscle Training on Pediatric Cancer Patient
The aim of this study is to examine the effects of inspiratory muscle training on respiratory functions, functional capacity, fatigue and quality of life in pediatric cancer patients who have recently completed treatment.
- Trial name
- NCT06597552
- Testing
- Training Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people
- Sponsor
- Medipol University
Respiratory Insufficiency, Fasting
Non-inferiority of Continuing Oral Intake Versus Fasting in Patients With Acute Respiratory Failure
Fasting in intensive care is mainly studied in mechanically ventilated patients or those in the weaning phase. Recent research challenge the common assumption of fasting and suggests that continuing enteral nutrition before…
- Conditions
- Respiratory Insufficiency, Fasting, Dysphagia, Swallowing Disorder
- Trial name
- JEUN-TUBE (NCT06510972)
- Testing
- Oral intake continuation strategy, Fasting strategy
- Where
- 14 sites in France
- Volunteers
- 754 people
- Sponsor
- University Hospital, Tours
Nitrous Oxide, Electroencephalography
Effect of Nitrous Oxide on EEG
Our recent preclinical observations suggest that monitoring of slow electroencephalogram (EEG) oscillations may be used to predict the efficacy of rapid-acting antidepressants such as ketamine or nitrous oxide.
- Conditions
- Nitrous Oxide, Electroencephalography, Anesthetic, Inhalation
- Trial name
- HUMANOID (NCT04884893)
- Testing
- Nitrous Oxide
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
ARDS
Electrical Impedance Tomography-Derived Dorsal Recruitment-to-Inflation Ratio Identifies PEEP Responsiveness and Risk Phenotypes in ARDS
In the treatment of critically ill patients, mechanical ventilation is a key link, and appropriate mechanical ventilation strategies can open the alveoli and improve oxygenation, while inappropriate mechanical ventilation can…
- Trial name
- NCT06823804
- Testing
- Electrical Impedance tomography Monitoring
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ruijin Hospital
Dysphagia, Respiratory Tract Infections
Using Plain Water With Oral Care to Increase Hydration for Long Term Care Residents With Disordered Swallowing
The Frazier Free Water Protocol (FFWP) using plain, thin (unmodified) water is an accepted method to increase fluid intake and hydration in older adults with disordered swallowing and dementia.This study aims to take an…
- Trial name
- FFWP (NCT03672552)
- Testing
- FFWP and Improved Oral Care
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Memorial University of Newfoundland
Spinal Cord Injuries
Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury
This study will examine if acute intermittent hypoxia (brief episodes of breathing lower oxygen), which has been shown to enhance plasticity and motor output, can enhance functional outcomes and muscle activation in individuals…
- Trial name
- NCT03071393
- Testing
- Hypoxia via Hypoxico Hyp-123
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Florida
Respiration, Artificial
Weaning From Mechanical Ventilation Comparison of Open-loop Decision Support System and Routine Care
The purpose of this study is to compare mechanical ventilation following advice from the Beacon Caresystem to that of routine care in patients from the state of requiring invasive mechanical ventilation until successful…
- Trial name
- BEACON (NCT02842944)
- Testing
- open loop weaning group (Beacon), Routine care
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Respiration, Artificial
Effects of Sternal Wall Pressure in Children
This protocol is a prospective, pilot, observational study in the Pediatric Intensive Care Unit (PICU), Progressive Care Unit (PCU) and the Operating Room (OR) settings at the Children's Hospital of Philadelphia (CHOP).
- Trial name
- SWP (NCT00628407)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Depression, Anxiety
HRV Biofeedback for Brain Tumour Survivors
This study is designed to take a first step toward testing the efficacy and acceptability of heart rate variability biofeedback (HRVB) as a means of ameliorating psychological distress in survivors of Primary Brain Tumour (PBT).
- Conditions
- Depression, Anxiety, Sleep Impairment
- Trial name
- NCT01772498
- Testing
- heart rate variability biofeedback
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- British Columbia Cancer Agency
Severe Pneumonia
The Effect of Prone Position Drainage on the Efficacy of Severe Pneumonia，a Multicenter Randomized Controlled Trial
Enrollment criteria and clinical data collection: follow the principles of medical ethics, the development of inclusion and exclusion criteria, Select all eligible patients with severe pneumonia(SP) who were admitted to the…
- Trial name
- NCT03891212
- Testing
- Placed in prone position for at least 16 consecutive hours a day.
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangya Hospital of Central South University
COPD (Chronic Obstructive Pulmonary Disease)
Phase 1 PK Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients
This is a phase 1, single-dose, 2-period crossover study in healthy volunteers to compare the systemic pharmacokinetic (PK) profile of inhaled AERO-002 versus inhaled active comparator product.
- Trial name
- NCT07802730
- Testing
- AERO-002 (60 mcg), Glycopyrrolate (18 mcg)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AeroRx Therapeutics Inc.
İntensive Care Patients
The Effect of Kinesiology Tape Application on Functional Level and Respiratory Function in Intensive Care Unit Patients
Investigation of the effects of respiratory muscles on the early functional system and respiratory function in the kinesiological period in intensive care patients.
- Trial name
- NCT06597136
- Testing
- Diaphragmatic kinesiology taping, Accessory respiratory muscle kinesiology taping
- Volunteers
- 48 people
- Sponsor
- Istinye University
Dental Pain, Muscle Sensitivity to Pressure
Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children
To assess the analgetic effect of nitrousoxide-oxygen inhalation on pain perception in 12-15 years old children from 1) the dental pulp; 2) the masseter muscle; 3) the skin on the upper lip
- Conditions
- Dental Pain, Muscle Sensitivity to Pressure, Skin Sensitivity to Electric Stimulation
- Trial name
- NCT01022294
- Testing
- Nitrousoxide-oxygen and atmospheric air, Atmospheric air; nitrousoxide-oxygen
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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