Clinical trials: Aspiration, Respiratory
Liver Function After Partial Liver Resection
Xenon-anesthesia on Patients Undergoing Major Liver-resection
The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.
- Trial name
- XeLiv (NCT03504033)
- Testing
- Xenon, Desflurane
- Where
- Germany
- Sponsor
- RWTH Aachen University
Ventilation and Oxygenation, Obese; Positioning
Reverse Trendelenburg Position Versus Semi-recumbent Position in Obese Critically Ill Patients
The aim of this study is to assess the effect of reverse Trendelenburg position versus semi-recumbent position on ventilation and oxygenation parameters of obese critically ill patients
- Conditions
- Ventilation and Oxygenation, Obese; Positioning, Critically Ill
- Trial name
- NCT04376047
- Testing
- Reverse Trendelenburg position, Semi-recumbent position
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Alexandria University
Pulmonary Embolism, Pulmonary Hypertension
Ventilation and Perfusion Scan in Pulmonary Embolism Following Catheter Directed Thrombectomy Versus Anticoagulation Alone
Clinical presentation of acute pulmonary embolism (PE) is complex and varied and not uncommonly involves respiratory failure with dyspnea or hypoxia.
- Conditions
- Pulmonary Embolism, Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- VQPE (NCT05133713)
- Testing
- Catheter directed therapy, Systemic anticoagulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Aspiration, Aspiration Pneumonia
Early Antibiotics After Aspiration in ICU Patients
The purpose of this study is to evaluate the use of early antibiotics in ICU patients who appear to have aspirated, to help determine whether this improves outcomes by reducing the later incidence of pneumonia and other negative…
- Trial name
- NCT05079620
- Testing
- Ceftriaxone, Amoxicillin clavulanic acid, Cefepime
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UConn Health
Lung Cancer
Endobronchial Ultrasound-transbronchial Needle Aspiration (EBUS-TBNA) Sample Division
EBUS-TBNA specimen are used for lung cancer diagnosing and staging, as well for molecular analysis. The purpose of this study is to evaluate if samples from on lymph node site can be divided for diagnosis and molecular analysis.
- Trial name
- NCT02157194
- Where
- Germany
- Volunteers
- 88 people
- Sponsor
- University Hospital, Essen
Healthy
Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With Two Reference Products
The purpose of this study is to compare the absorption of three different inhalation products with the reference products in healthy volunteers.
- Trial name
- NCT02627625
- Testing
- Tiotropium
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Lung Cancer
Comparison of 22-gauge and 19-gauge Aspiration Needle During EBUS-TBNA
Investigators intend to compare the 19-gauge needle and the 22-gauge-needle during EBUS-TBNA concerning the diagnostic yield, the quality and quantity of each biopsy needle without raising the rate of complications.
- Trial name
- NCT02813603
- Testing
- EBUS
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Essen
Asthma
Comparing the Efficacy of Bricanyl M2 and Bricanyl M3 at 0.5 and 1.5 mg Dose Levels, to Allow for a Switch From Bricanyl Turbuhaler M2 to Bricanyl Turbuhaler M3
A randomised, double-blind, double-dummy, multi-site, phase III, single dose, 4-way cross-over pharmacodynamic study evaluating the efficacy of Bricanyl Turbuhaler M3 compared to Bricanyl Turbuhaler M2 by studying the protective…
- Trial name
- NCT02322788
- Testing
- Terbutaline sulphate
- Where
- 4 sites in Canada, Netherlands and 1 more
- Volunteers
- 95 people
- Sponsor
- AstraZeneca
Respiration, Artificial, Pleural Effusion
Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation
Patients with acute respiratory failure (ARF) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated.
- Conditions
- Respiration, Artificial, Pleural Effusion, Ultrasonography
- Trial name
- NCT03394872
- Testing
- Drainage of the pleural effusion
- Volunteers
- 27 people
- Sponsor
- Dokuz Eylul University
Oropharyngeal Dysphagia, Pneumonia
Health Education to Caregivers to Reduce Aspiration Pneumonia
Randomized clinical study with a control group for assessing the decrease in the incidence of pneumonia, in a 12-month follow-up, in older people with cognitive impairment, risk of bronchial aspiration, risk of malnutrition and…
- Conditions
- Oropharyngeal Dysphagia, Pneumonia, Malnutrition
- Trial name
- HECGPN (NCT05405829)
- Testing
- Health education
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Universitat Internacional de Catalunya
Airway Deadspace
Airway Deadspace in Children: Air-Q Versus Endotracheal Tube
The objective of this study will be to measure the airway deadspace associated with use of appropriately sized an AirQ, a commonly used supraglottic airway in young children weighing between 5 and 20 kg and compare that to the…
- Trial name
- NCT03785977
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Dental Pain, Muscle Sensitivity to Pressure
Analgetic Effect of Nitrousoxide-oxygen Inhalation for Dental Treatment of Children
To assess the analgetic effect of nitrousoxide-oxygen inhalation on pain perception in 12-15 years old children from 1) the dental pulp; 2) the masseter muscle; 3) the skin on the upper lip
- Conditions
- Dental Pain, Muscle Sensitivity to Pressure, Skin Sensitivity to Electric Stimulation
- Trial name
- NCT01022294
- Testing
- Nitrousoxide-oxygen and atmospheric air, Atmospheric air; nitrousoxide-oxygen
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Solid Tumor (Excluding CNS)
Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology
Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance.
- Trial name
- Pulmojet 3 (NCT07408375)
- Testing
- High-Frequency Jet Ventilation (HFJV)
- Where
- 7 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
COPD
Phase 1/Phase 2a Study of AERO-007 Inhalation Solution, a Nebulized LABA/LAMA Combination for Maintenance Treatment of COPD
This is a phase 1/phase 2a, single dose, crossover study conducted in two parts. Part 1: Phase 1, open-label, 4-period crossover study in 8 healthy subjects to determine the optimal dose of AERO-001 and AERO-002, the active…
- Trial name
- NCT06841640
- Testing
- AERO-001, AERO-002, AERO-007
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AeroRx Therapeutics Inc.
Heart Failure, Cardiomyopathy
Nebulized Inhaled Milrinone in a Hospitalized Advanced Heart Failure Population
Patients with end stage heart failure have significant symptoms (including fatigue and shortness of breath) which prevent them from being able to perform most activities of daily living.
- Trial name
- iMilrinone (NCT02077010)
- Testing
- Inhaled nebulized milrinone
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Nosocomial Pneumonia, Healthcare-Associated Pneumonia
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open…
- Conditions
- Nosocomial Pneumonia, Healthcare-Associated Pneumonia, Aspiration Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- NCT00610324
- Testing
- Chlorhexidine gluconate, Potassium permanganate
- Where
- India
- Volunteers
- 512 people
- Sponsor
- King Edward Memorial Hospital
Acute Stroke, Aspiration Pneumonia
Metoclopramide vs Placebo for Prevention of Pneumonia in Acute Stroke
Pneumonia is a major cause of mortality and morbidity in patients with acute stroke fed via nasogastric tubes and may be because of vomiting and gastro-esophageal regurgitation.
- Trial name
- NCT04873297
- Testing
- Metoclopramide 10mg
- Where
- Pakistan
- Volunteers
- 106 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Asthma
NIS for Patients Using Symbicort Turbuhaler for Maintenance and Reliever Therapy in a Single Inhaler
The aim of this non-interventional study is to ensure that patients in routine clinical practice follow given treatment instructions and to evaluate the number of reliever inhalations as well as the number of patient/days with…
- Trial name
- SYMCO (NCT00557297)
- Where
- 22 sites in Latvia
- Volunteers
- 250 people
- Sponsor
- AstraZeneca
Breathing
Diagnostic Accuracy of the Central Venous Pressure (CVP) Variation to Predict Fluid Responsiveness in Spontaneously Breathing Patients
Volume expansion (VE) is often administered in intensive care (ICU)-patient to improve arterial oxygen delivery. Such effect is secondary to an increase in stroke volume and cardiac output.
- Trial name
- VPVC (NCT03780660)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Lille
Cardiovascular Disease
Accuracy of Non-invasive Effective Pulmonary Perfusion Measurement by CO2
Cardiac output monitoring is mandatory in most surgical and critical care patients. Many techniques to assess cardiac output are invasive and/or have many limitations, contraindications and drawbacks.
- Trial name
- NCT02382120
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata