Clinical trials: Assisted Reproduction
Pain Intensity Assessment
Pain Relief in Women Undergoing Oocyte Retrieval (OR) With Electro-acupuncture (EA) or Conscious Sedation (CS) in a Single Assisted Reproduction Centre.
This study aims to determine whether one can replace pain relief in women undergoing oocyte retrieval (OR) using electro-acupuncture (EA) instead of conscious sedation (CS).
- Trial name
- EA (NCT07041632)
- Testing
- electro-acupuncture, Conscious sedation
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Pain, Estradiol
Estrogen and Propofol Injection Pain
This prospective observational study investigates the relationship between serum estrogen concentration and the incidence and severity of propofol injection pain (PIP) in female patients undergoing general anesthesia.
- Conditions
- Pain, Estradiol, Assisted Reproductive Techniques
- Trial name
- NCT06929416
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Infertility
Comparative Study of Two Embryo Culture Systems
The centre for Medically-Assisted Procreation (MAP) of Dijon CHU has two high-technology embryo culture systems, with incubation characteristics that are potentially superior to those provided by classical culture systems.
- Trial name
- INCUBATE (NCT02722252)
- Testing
- Embryoscope, Embryo culture system without incorporated camera
- Where
- France
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Fertility
Effect of GnRH Antagonist vs Agonist Long on IVF Outcome, Peak Estradiol Level,and Duration of Stimulation
The purpose of this study is to determine if utilizing GnRH antagonists versus agonist long protocol during controlled ovarian stimulation (COH) with human-derived gonadotropins for assisted reproduction affects IVF outcome, peak…
- Trial name
- NCT01669291
- Testing
- Bravelle and Menopur, Agonist, Antagonist
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
HIV
HIV Physician's Survey
This is a survey study to assess the variability in the current management of pregnancy, reproductive care and assisted reproductive technologies for HIV-positive individuals in Canada to estimate interest for further projects.
- Trial name
- NCT01104974
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
IVF Cycle, Ovarian Stimulation
Efficacy and Safety of Medication Used to Stimulate Ovulation
Individuals undergoing In Vitro Fertilization must undergo controlled ovarian hyperstimulation (COH) to produce enough quality eggs for fertility treatment.
- Conditions
- IVF Cycle, Ovarian Stimulation, Egg Retrieval, Pregnancy
- Trial name
- NCT02715336
- Testing
- Ovulation induction with hCG and Lupron (GnRH agonist)
- Where
- Canada
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Create Fertility Center
Infertility, Assisted Reproductive Technology
Prognostic Value of Progesterone on Oocyte Retrieval Day for In Vitro Fertilization Outcome
This observational study aims the potential role of serum progesterone levels on the day of oocyte pick-up on the probability of pregnancy, in patients undergoing antagonist IVF cycles.
- Trial name
- NCT02109900
- Testing
- Serum Progesterone Levels
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Endometriosis, Uterine Fibroids, Male Hormone-sensitive Prostate Cancer, Assisted Reproduction
A Clinical Study Evaluating the Relative Bioavailability of SHR7280 Dry Suspension and Tablets
To assess the relative bioavailability of SHR7280 dry suspension and tablets in healthy subjects. To assess the safety and tolerability of a single dose of SHR7280 dry suspension and tablets.
- Trial name
- NCT05868057
- Testing
- SHR7280 tablets, SHR7280 dry suspension
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
No Condition
Comparison of Clinical Outcomes Between IVM and Minimal Stimulation IVF in Patients With PCOS
Polycystic ovarian syndrome (PCOS) is most common endocrinologic disease in women of reproductive age with incidence of 6.6 ~ 8%.
- Trial name
- NCT03134482
- Testing
- IVM, Minimal stimulation IVF
- Where
- 2 sites in South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHA University
Endometriosis, Uterine Fibroids
A Phase 1 Clinical Study to Evaluate the Effects of SHR7280 on the Pharmacokinetics of Midazolam, S-warfarin, Omeprazole, Digoxin, and Rosuvastatin in Healthy Subjects
The purpose of this study is to evaluate the effects of SHR7280 on the pharmacokinetics of midazolam, S-warfarin, omeprazole, digoxin and rosuvastatin in healthy subjects.
- Conditions
- Endometriosis, Uterine Fibroids, Assisted Reproduction
- Trial name
- NCT06949124
- Testing
- SHR7280 Tablets
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Infertility
Evaluation of SiD's System for Improving Assisted Reproduction Treatments
According to the WHO, infertility affects 15% of reproductive age couples worldwide. Among the assisted reproductive technologies available for patients with infertility, intracytoplasmic sperm injection (ICSI) has become one of…
- Trial name
- NCT05611164
- Testing
- Software assisted selection of individual spermatozoa for intracytoplasmic sperm injection
- Where
- 2 sites in Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IVF 2.0 Limited
Infertility
Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes
The purpose of this study is to determine if cryopreservation at the blastocyst stage followed by embryo thaw and transfer is as effective as cryopreservation of bipronuclear oocytes followed by post-thaw extended culture (PTEC)…
- Trial name
- NCT01247987
- Testing
- Blastocyst cryopreservation, Bipronuclear oocyte cryopreservation
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Chronic Endometritis
Diagnosis of Chronic Endometritis in Endometrial Fluid Using Molecular Techniques to Improve the Outcomes of Assisted Reproductive Treatments
Chronic endometritis (CE) is a persistent inflammation of the endometrial lining caused by the infection of the uterine cavity mainly by bacterial pathogens.
- Trial name
- ChEndometritis (NCT03169621)
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Assisted Reproduction
A Study to Evaluate the Mass Balance of [14C]SHR7280 in Healthy Adult Volunteers
Evaluate the Mass Balance of [14C]SHR7280 in Healthy Adult Volunteers.
- Trial name
- NCT06408948
- Testing
- [14C]SHR7280
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Ovarian Hyperstimulation Syndrome
Cabergoline Reduces OHSS
The present study was designed to provide clinical confirmation of Cb2's value as a new approach in the prevention of increased vascular permeability and hemoconcentration, both signs of OHSS in humans, and in order to explore…
- Trial name
- NCT00440258
- Testing
- Cabergoline, MR, Ultrasound
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility Assisted Reproductive Technology
The Impact of Uterine Immunity and Its Alterations on the Embryo Implantation Process
Evaluation of uterine immunity, histological picture, and endometrial microbiome for embryo implantation
- Trial name
- UTIMEE (NCT07120958)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Momo Fertilife
Ovarian Failure
MAR With Artificial Gametes: Treatment Characteristics and Their Trade-offs Determining Treatment Preference
To gain insight by means of a discrete choice experiment questionnaire into characteristics of medically assisted reproduction (MAR) with artificial gametes (AGs) valued by couples confronted with ovarian failure and their…
- Trial name
- NCT02280681
- Testing
- No intervention, only questionnaire
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Quantifying Uterine Elastography in Menstruating Women
This study is aiming to characterize the elasticity of the female reproductive tract including the uterus, cervix and ovary using shear wave elastography at different times during the menstrual cycle and define the standard…
- Trial name
- QUEST (NCT06816381)
- Testing
- Shear wave elastography measurements
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Female Infertility Due to Advanced Maternal Age
Mitochondrial Energy Production in ART (Assisted Reproductive Technology )
Oocyte maturation requires a lot of energy, which is provided by the mitochondria via the synthesis of ATP. The majority of patients with advanced maternal age (AMA) have poor egg quality.
- Trial name
- Mitenergy (NCT02727400)
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Assisted Reproduction
Predictive Value of Th1, Th2 and Th17 Cytokines on the Success of Embryo Implantation (ImmuNoFertilité)
Infertility affects approximately 10-15% of the population. The number of assisted reproduction procedures has increased by a factor of 3 to 5.3 worldwide over the last 20 years.
- Trial name
- NCT05783349
- Testing
- Unique blod sample
- Where
- France
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice