Clinical trials: Assisted Reproduction, open to volunteers
Infertility, Infertility (IVF Patients)
Language Matters: Exploring the Impact of Language Concordance on Fertility Treatment Progression
Currently, patients presenting to the Fertility and Reproductive Medicine Center meet with an English-speaking provider and communicate through an interpreter, as none of the physicians speak Spanish.
- Conditions
- Infertility, Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Ovulation Ind
- Trial name
- ImpaLa (NCT06636838)
- Testing
- Spanish-Speaking Provider
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Anxiety, Assisted Reproductive Treatments
Virtual Reality for Anxiety Relief in Infertile Women
This study examines the impact of virtual reality (VR) applications on anxiety levels before and after embryo transfer procedures.
- Conditions
- Anxiety, Assisted Reproductive Treatments, Women, VR
- Trial name
- NCT07020975
- Testing
- VR Glasses
- Where
- Cyprus
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cyprus Aydin University
ICSI, IVF
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders
To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.
- Conditions
- ICSI, IVF, Normal Responders, Infertility Assisted Reproductive Technology
- Trial name
- DT-HCG-IVF (NCT07861399)
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), hCG trigger
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Repeated IVF Failure, Microbiota
The Role of the Physiological Endometrial Microbiota in Assisted Reproduction Outcomes
The goal of this observational study is to investigate the influence and contribution of the normal composition and balance of the endometrial microbiota on the achievement of embryo implantation and the maintenance of pregnancy…
- Trial name
- no exist (NCT07606053)
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Assisting Nature
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility Assisted Reproductive Technology, Infertility (IVF Patients)
Blastocyst AI Assisted Morphokinetics in ART
The goal of this observational study is to learn if embryo characteristics obtained via the recording of real-time embryo activity via 30-seconds video capture (e.g.: Embryo Morphokinetics) can correlate with known embryo outcome…
- Trial name
- AIM (NCT07611448)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Viable Biosciences
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Infertility Assisted Reproductive Technology
Prospective International Multi-center Clinical Trial of PGT-A Upgrade
The goals of this international multicenter cross-sectional study are: 1. To provide patients with a comprehensive PGT solution capable of simultaneously detecting embryonic chromosomal aneuploidy, mosaicism, microdeletions/…
- Trial name
- NCT07533630
- Testing
- PGT-A upgrade
- Where
- 7 sites in Argentina, China and 3 more
- Volunteers
- 1,700 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Overweight or Obesity
Effectiveness of a Digital Behavioral Intervention Program for Overweight and Obese Patients
This study applied digital technology to a comprehensive lifestyle intervention strategy to design a digital behavioural intervention programme suitable for weight reduction in overweight obese infertile patients in China, and…
- Trial name
- NCT07045272
- Testing
- Experimental
- Volunteers
- 90 people
- Sponsor
- Anhui Medical University
Male Infertility
Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
Men enrolled in the study are assigned to each APHRODITE group. Group 2,3,4 are treated with either gonadotropin preparations or clompihene-citrate (except group 4).
- Trial name
- GONACLO (NCT07523022)
- Testing
- recFSH, HCG injection, Clomiphene Citrate 50 mg
- Where
- Hungary
- Volunteers
- 500 people
- Sponsor
- Szeged University
Infertility Assisted Reproductive Technology
A Prospective Study to Evaluate the Outcome of the Aurora Test Used With Blastocyst Transfer in an ICSI Cycle (Aurora-Blasto)
In current treatments for In Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI), the creation of multiple embryos is a common practice.
- Trial name
- Aurora-Blasto (NCT07359703)
- Testing
- Aurora-Blasto
- Where
- Belgium
- Volunteers
- 1,028 people
- Sponsor
- University Hospital, Ghent
Infertility (IVF Patients)
Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.
The goal of this multicenter, randomized, placebo-controlled, double-blind clinical trial is toto evaluate the efficacy and safety of a human menopausal gonadotropin (hMG) in the development of multiple follicles, pregnancy, and…
- Trial name
- GRACE (NCT07216742)
- Testing
- hMG subcutaneous injection
- Where
- 16 sites in United States
- Volunteers
- 659 people
- Sponsor
- Granata Bio Corporation
Infertility, Assisted Reproductive Technology
Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes
This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization.
- Conditions
- Infertility, Assisted Reproductive Technology, Pregnancy Complications, Pregnancy Loss, Early
- Trial name
- Mi IVF (NCT07532629)
- Where
- 3 sites in Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Infertility
Discarded Materials Study
Use of discarded embryos to advance laboratory expertise and technology in the area of human embryo development and assisted reproductive technologies
- Trial name
- NCT01219335
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Endometriosis, Infertility Assisted Reproductive Technology
First Line Surgery or First Line Fertility Treatment Using Assisted Reproductive Technologies in Patients With Advanced Endometriosis
Endometriosis is a chronic disease affecting approximately 10% of women of reproductive age. It is strongly associated with pelvic pain and infertility.
- Trial name
- EndoSOFT (NCT07240363)
- Testing
- Endometriosis surgery
- Where
- 4 sites in Sweden
- Volunteers
- 350 people
- Sponsor
- Karolinska Institutet
Infertility (IVF Patients), Infertility
Intra-ovarian CAPA-IVM vs Standard IVM
This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a…
- Conditions
- Infertility (IVF Patients), Infertility, Infertility Female
- Trial name
- IO-CAPA (NCT07858435)
- Testing
- CAPA-IVM, In-House CAPA-IVM Pre-Maturation Medium, Minimal-Stimulation OS-IVF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New Hope Fertility Center
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Infertility, Infertility, Female
Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo Ploidy
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Unexplained
- Trial name
- SMARTAI (NCT06539104)
- Testing
- arteficial inteligence evaluation of oocyte and embryo development
- Where
- 4 sites in Czechia
- Volunteers
- 1,000 people
- Sponsor
- Charles University, Czech Republic
Infertility
Outcomes of Couples After Failed PGD Management: A Single-Center Study at the Paris PGD Center (Antoine Béclère - Necker)
Preimplantation genetic testing (PGT) is a reproductive genetic technique aimed at preventing the transmission of severe genetic disorders.
- Trial name
- DECOPI (NCT07371312)
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage
This study evaluates a more affordable medication protocol for ovarian stimulation during in vitro fertilization (IVF). Standard IVF protocols use medications called gonadotropins to stimulate the ovaries to produce multiple…
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Infertile Patients, Infertility Drugs
- Trial name
- NCT07771283
- Testing
- Human Chorionic Gonadotropin (hCG), GnRH antagonist, Dual trigger (human chorionic gonadotropin plus GnRH-agonist)
- Where
- 3 sites in Uganda, Ukraine
- Volunteers
- 360 people
- Sponsor
- LTD "EKODNIPRO", Medical centre Medical Plaza Dnipro