Clinical trials: Assisted Reproductive Techniques
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.
The aim of this prospective, non-randomised, open-label, clinical trial is to compare the effects of two pituitary suppression regimens; GnRH Agonist-Long Protocol and GnRH Antagonist-Flexible Protocol on clinical and…
- Conditions
- In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility
- Trial name
- NCT04724343
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Fertilization
Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART
Oocyte activation is an imperative stage in the initiation of embryo development during the fertilization. Indeed, the entrance of sperm into the oocyte causes sequences of calcium oscillations in its cytoplasm, regulating a…
- Trial name
- NCT04519918
- Testing
- AOA
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Infertility, Reproductive Techniques, Assisted
An Alternative Culture Medium to Better Support Preimplantation Embryo Development in Vitro
The purpose of this research study is to evaluate a newly developed embryo culture media system for human clinical use in ART.
- Trial name
- NCT02457481
- Testing
- Embryo Culture medium
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Foundation for Fertility Research
Polycystic Ovary Syndrome
Study to Compare hFSH-HP (Fostipur) and hMG-HP(Meriofert) in Patients With Polycystic Ovary Under a IVF/ICSI Cycle.
Polycystic ovary occurs in 15-20% of the population will be submitted to TRA. Whether it is associated with other signs or symptoms (polycystic ovarian syndrome) as if presented in isolation, its therapeutic management has…
- Trial name
- NCT02785822
- Testing
- hMG-HP, hFSH-HP
- Where
- 2 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Primary Ovarian Insufficiency, Infertility
In Vitro Follicle Activation
The purpose of this study is to evaluate the effectiveness of an experimental treatment, known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women diagnosed with primary ovarian insufficiency (POI).
- Trial name
- IVA (NCT02496598)
- Testing
- In Vitro Follicle Activation (IVA), Follicle Activation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Foundation for Fertility Research
Infertility
Correlating Time-Lapse Parameters Detected by the Eeva™ System With Comprehensive Chromosome Screening Results
The purpose of this research study protocol is to collect imaging data on embryos followed to blastocyst stage (Day 5-6) and correlate Eeva System parameters with comprehensive chromosome screening (CCS) results, implantation and…
- Trial name
- CCS (NCT01635049)
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Progyny, Inc.
Oocyte Retrieval, Pain
Oocyte Retrieval and Virtual Reality (REVPO)
The aim of the study is to ass wether or not the use of virtual reality during oocyte retrieval provides a better pain relief for patients, compared to a standard analgesic procedure.
- Conditions
- Oocyte Retrieval, Pain, Fertilization in Vitro
- Trial name
- REVPO (NCT04935658)
- Testing
- Hypnotic relaxation induced by virtual reality (device), local anesthesia
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Assisted Reproductive Technology, Infertility
Sperm Micro-swim up Technique; Process and Select in the Same Dish: a Sibling-oocyte-split Design
A sibling-Oocyte-split design will be conducted on oocytes before denudation and divided into two groups : control group (MII oocytes will be injected using sperm processed by Density gradient method) and sample group ( MII…
- Trial name
- NCT05113225
- Testing
- Micro-swim up technique
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Royal Fertility Center, Egypt
Infertility
Comparison of IVF and ICSI in Human IVF
In this prospective randomized clinical trial we plan to compare two fertilization method which are widely used during in vitro fertilization (IVF) treatment.
- Trial name
- NCT03513913
- Testing
- ICSI
- Where
- Hungary
- Volunteers
- 600 people
- Sponsor
- Semmelweis University
Male Infertility, Unexplained Infertility
Swim up and Gradient Methods Used in Assisted Reproduction Techniques on DNA Fragmentation of Spermatozoa
Sperms are prepared by sperm washing techniques before used in assisted reproductive technologies. Most commonly used sperm preparation methods are the swim up and the density gradient.
- Trial name
- NCT01859520
- Testing
- swim-up, density gradient sperm preparation techniques
- Volunteers
- 65 people
- Sponsor
- Gazi University
In Vitro Fertilization, Infertility
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI
Selection of developmentally competent oocytes enhances IVF efficiency. Usually, oocyte quality is determined based on its nuclear maturation and the presence of specific cytoplasmic and extracytoplasmic morphologic features.
- Conditions
- In Vitro Fertilization, Infertility, Intracytoplasmic Sperm Injection, Polycystic Ovary Syndrome
- Trial name
- NCT04727684
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Reproductive Techniques, Assisted
Study to Evaluate if the Addition of r-hLH (Luveris®) to FSH From Day 8 of Ovarian Stimulation is Able to Decrease Total FSH Dose and to Improve Cycle Outcome in Infertile Women Undergoing ART, Who Required High FSH Dose in a Previous Cycle
The present study was designed to investigate, in hyporesponder subjects, that required in a previous assisted reproductive technologies (ART) cycle follicle stimulating hormone (FSH) >3500 International Unit (IU), the…
- Trial name
- Luveris in ART (NCT01071200)
- Testing
- Recombinant human Follicle Stimulating Hormone (r-hFSH) and Recombinant human Luteinizing Hormone (r-hLH), r-hFSH
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
An Observational Study of Cetrotide® Gonadotropin-releasing Hormone Antagonist (GnRH Antagonist) With GONAL-f® in Assisted Reproductive Technologies (ART)
This is a multicentric, prospective, observational study on the use of Cetrotide to control the endogenous gonadotrophin levels in Gonal-f stimulated ART treatment cycles in the Asia-Pacific region.
- Trial name
- NCT01109654
- Testing
- Cetrorelix acetate and Follitropin alfa
- Where
- Singapore
- Volunteers
- 2,175 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Assisted Reproductive Technology, Freezing/Thawing Procedure
Study of the Impact of Freezing-thawing Procedures and the Prolonged Culture of Embryos on Epigenetic Regulation in Humans
For this project, 4 groups of 38 infants have been created so as to evaluate the impact of Assisted-Reproduction Technology (ART) and more particularly the two procedures classically used in ART: the freezing/thawing of embryos…
- Conditions
- Assisted Reproductive Technology, Freezing/Thawing Procedure, Prolonged Culture Procedure
- Trial name
- NCT02171884
- Testing
- Sample of cord blood, Sample of placenta
- Where
- 2 sites in France
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Infertility Assisted Reproductive Technology
The Feasibility of taVNS on Pregnancy Outcomes of Infertility Patients Undergoing IVF
To assess the feasibility of taVNS on pregnancy outcomes of infertility subjects undergoing IVF, the primary aim of this trial will focus on encompassing recruitment, compliance, and preliminary engagement outcomes.
- Trial name
- NCT06742788
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Progesterone Supplementation in Women Undergoing ART
Clinical Safety Study of the Progesterone Vaginal Ring in Women Undergoing Assisted Reproductive Technology Procedures
The purpose of the study is to assess the safety of Progesterone Vaginal Ring (PVR) in women undergoing fresh embryo transfer (ART).
- Trial name
- SARA (NCT03565211)
- Testing
- Progesterone vaginal ring
- Where
- 15 sites in United States
- Volunteers
- 352 people
- Sponsor
- Ferring Pharmaceuticals
Infertility, Obesity
Physical Activity and ARTs
Obese women experience increased infertility rate and longer time to conception showing lower pregnancy and live-birth rates both in natural and assisted conceptions.
- Conditions
- Infertility, Obesity, Stable BMI
- Trial name
- SETART (NCT01892111)
- Testing
- Structured exercise program.
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Modena and Reggio Emilia
Birth Rate, Embryo Implantation
EFFects of Thrombophilia on the Outcomes of Assisted Reproduction Technologies
Both hereditary and acquired thrombophilia have been associated with recurrent miscarriage and pregnancy complications. Thrombophilia could favor the development of thrombosis of the maternal vasculature and obstacle…
- Conditions
- Birth Rate, Embryo Implantation, Reproductive Techniques, Thrombophilia
- Trial name
- NCT02407730
- Where
- Italy
- Volunteers
- 687 people
- Sponsor
- G. d'Annunzio University
Infertility
Food Intake Among Women and Men in Fertility Treatment
Worldwide infertility is highly prevalent and lifestyle factors, such as food intake, could have an essential role in the success of a fertility treatment.
- Trial name
- Food&Fertility (NCT05454046)
- Testing
- Food intake among women and men in fertility treatment
- Where
- 8 sites in Denmark
- Volunteers
- 4,000 people
- Sponsor
- Aalborg University Hospital
Benign Female Reproductive System Neoplasm
Does Less Trendelenburg Make a Difference in Robotic Assisted Gynecological Procedures?
Patient/Population: Women over the age of 18, who are not pregnant and are undergoing benign, robotic-assisted gynecologic procedures at Lutheran General Hospital.
- Trial name
- NCT02728999
- Testing
- Steep Trendelenburg, Decreased Trendelenburg
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences