Clinical trials: Asthenozoospermia
Asthenozoospermia
Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers
Although several studies have considered the relationship between infertility and semen super oxide radical scavengers levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on superoxide…
- Trial name
- NCT02217189
- Testing
- zinc sulfate
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Babylon University
Male Infertility, Oligozoospermia
Probiotics on Sperm Quality in Male Infertility Patients
This randomized, placebo-controlled pilot study aims to evaluate the effects of probiotic supplementation on sperm quality in male patients diagnosed with infertility.
- Conditions
- Male Infertility, Oligozoospermia, Asthenozoospermia, Teratozoospermia
- Trial name
- NCT07345455
- Testing
- Probiotics
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Mackay Memorial Hospital
Mild and Moderate Oligozoospermia Asthenospermia or Oligoasthenospermia and the Syndrome Differentiation Type is Shen (Kidney) Essence Deficiency
Effectiveness and Safety of Guilu Erxian Oral Liquid in the Treatment of Oligozoospermia and Asthenospermia With Syndrome of Shen (Kidney) Essence Deficiency
The main function of Guilu Erxian Oral Liquid is to warm the shen (kindney) and replenish essence. It is used for chronic shen (kindney) deficiency, waist and knee weakness, spermatorrhea and impotence.
- Trial name
- NCT07270146
- Testing
- Guilu Erxian Oral Liquid, Wuzi Yanzong oral liquid
- Where
- China
- Volunteers
- 360 people
- Sponsor
- DongE E Jiao Coporation Limited
Asthenozoospermia
The Effect of Royal Vaginal Gel Compared to IUI Technique on Fertility Rate of Women With Low-fertility Husbands
The present Pocock clinical trial study was conducted In the city of Mashhad in Iran between 2015 and 2016. The study inclusion criteria were men with low fertility of sperm motility<25% and total motility <50%…
- Trial name
- NCT03463005
- Testing
- Royal jelly, IUI
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gonabad University of Medical Sciences
Asthenozoospermia
Effect of Fermented Ginseng (GINST) on Sperm Motility
This randomized, double-blind, placebo-controlled study aimed to evaluate the effect of ginseng(GINST) supplementation for 12 weeks on sperm motility.
- Trial name
- NCT03183999
- Testing
- fermented ginseng (GINST)
- Where
- 3 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jae Hoon Lee
Oligozoospermia, Asthenozoospermia
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy Subjects
This is a Phase 1a, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902.
- Trial name
- NCT06563713
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Infertility Due to Azoospermia
PKB171 Against Placebo in Couples With Mild Male Factor Infertility
The test medication Gel PKB171 is a vaginal gel that has not yet been licensed by the regulatory authorities. However, the active substance pentoxifylline has been available as tablets for decades and is used to increase…
- Trial name
- NCT07669584
- Testing
- Intravaginal gel, Vaginal Gel with Applicator
- Where
- 12 sites in Spain
- Volunteers
- 732 people
- Sponsor
- Prokrea BCN, S.L.
Reproductive Issues, Male Infertility
Efficacy and Safety of a New Sperm Capacitation Method
Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to evaluate the efficacy and safety of HyperSperm, a new sperm capacitation method, in 300 semen samples with various…
- Conditions
- Reproductive Issues, Male Infertility, Asthenozoospermia, Oligozoospermia
- Trial name
- HyperSperm01 (NCT06742437)
- Testing
- Standard sperm preparation, HyperSperm
- Where
- 4 sites in Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fecundis Lab SL
Oligospermia, Teratospermia
Ramipril for the Treatment of Oligospermia
This is a randomized controlled trial to evaluate the effect of ramipril in stimulating and promoting sperm production in men with low sperm count.
- Conditions
- Oligospermia, Teratospermia, Asthenozoospermia, Male Infertility
- Trial name
- NCT01856361
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Men Infertility
The Therapeutic Effect of Co-administration of Pentoxifylline and Zinc in Men With Idiopathic Asthenozoospermia
The aim of this study was to investigate the therapeutic effect of co-administration of pentoxifylline and zinc on sperm apoptosis in men with idiopathic infertility
- Trial name
- PTX-Zn (NCT05178953)
- Testing
- Zinc Sulfate 220 mg Capsules, Pentoxifylline
- Where
- 2 sites in Iran
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Arak University of Medical Sciences
Asthenozoospermia
Alpha Lipoic Acid Plus Coenzyme Q10 Versus Coenzyme Q10 Alone in Asthenozoospermia
The goal of the clinical trial is to learn if Alpha-lipoic acid plus Coenzymeq10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Alpha-lipoic acid plus Coenzymeq10.
- Trial name
- CoQ10 ALA (NCT07455890)
- Testing
- ALA 500mg once daily for 3 month, CoenzymeQ10
- Where
- Bangladesh
- Volunteers
- 40 people
- Sponsor
- Mst.Sumyara Khatun
Male Subfertility, Oligospermia
7 NUTS Study. Diet Modification and Male Fertility.
Setting. Outpatient fertility clinic. Aim. Investigate if a modification in nutritional habits may improve in the short term the qualities of human sperm, testing two hypothesis: i) that adding to the diet a natural whole food…
- Conditions
- Male Subfertility, Oligospermia, Asthenospermia, Teratospermia
- Trial name
- NCT02063256
- Testing
- 7 nuts a day, Diet modification
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Pentoxifylline Allergy
Beneficial Effect of Adding Pentoxifylline to Processed Semen Samples on ICSI Outcome in Infertile Males
To evaluate the effect of pentoxifylline used in preparation of semen samples that will be used for ICSI in infertile men complaining of mild and moderate asthenozoospermia (i.e.
- Trial name
- NCT01793272
- Testing
- effect of pentoxifylline on ICSI outcome
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Adam International Hospital
Infertility
Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI.
- Trial name
- PXN (NCT02051075)
- Testing
- PXN sperm treatment, Sperm activation with PXN and oocyte activation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
in Vitro Fertilization
ICSI Using Pentoxifylline to Identify Viable Spermatozoa in Absolute Asthenozoospermia Patients
Absolute asthenozoospermia is a rare condition in men with an occurrence frequency of 1/5000 and greatly affects fertility product. Previous studies have shown that the ovum can be fertilized with live but immotile sperm.
- Trial name
- NCT05943353
- Testing
- Pentoxifylline
- Where
- Vietnam
- Volunteers
- 10 people
- Sponsor
- Mỹ Đức Hospital
Oligozoospermia, Asthenozoospermia
Effect of Walnuts on Sperm Parameters and Male Fertility
The investigators are testing the hypothesis that two ounces of whole-shelled walnuts/day added to the diet of men seeking care for infertility will beneficially affect sperm parameters and fertility.
- Conditions
- Oligozoospermia, Asthenozoospermia, Teratozoospermia, Fertility
- Trial name
- NCT01954498
- Testing
- Walnuts, OTC multivitamin
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Asthenozoospermia
The Effects of Administration of Combined Docosahexaenoic Acid and Vitamin E Supplements on Spermatogram and Seminal Plasma Oxidative Stress in Infertile Men With Asthenozoospermia
Since docosahexaenoic acid (DHA) level in sperm membrane has been shown to be decreased in asthenozoospermic men, the investigators hypothesized that DHA supplementation may improve it.
- Trial name
- NCT01846325
- Testing
- vitamin E, DHA
- Volunteers
- 180 people
- Sponsor
- National Nutrition and Food Technology Institute
Oligospermia
A Preliminary Study on Effect of Omega-3 on Human Sperm
The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids.
- Trial name
- NCT00479960
- Testing
- commercially available omega-3 fatty acids supplementation
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Male Infertility, Oxidative Stress
Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress
The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality.
- Conditions
- Male Infertility, Oxidative Stress, Subfertility, Oligozoospermia
- Trial name
- G-OXSEM (NCT07375238)
- Testing
- Standardized Mediterranean Diet, Gazpacho
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Ginefiv
Infertility, Male
PKB171 Against Placebo in Couples With Asthenozoospermia Who Wish to Conceive
The test medication Gel PKB171 is a vaginal gel that has not yet been licensed by the regulatory authorities. However, the active substance pentoxifylline has been available as tablets for decades and is used to increase…
- Trial name
- PKB171 (NCT06986031)
- Testing
- Vaginal product
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Prokrea BCN, S.L.