Clinical trials: Atheromatosis
Cardiovascular Diseases, Coronary Arteriosclerosis
Androgens and Subclinical Atherosclerosis in Young Women - Ancillary to CARDIA
To examine whether serum androgens, measured earlier in life, and variation in genes related to androgen synthesis, metabolism, and signaling are associated with early-onset subclinical coronary atherosclerosis in young adult…
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Heart Diseases, Polycystic Ovary Syndrome
- Trial name
- NCT00037245
- Sponsor
- University of Washington
Intermittent Claudication, Peripheral Vascular Disease
Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication
The purpose of this Phase 2 clinical research study is to examine the safety of an experimental gene transfer agent, Ad2/HIF-1α/VP16, and its ability to stimulate the growth of new blood vessels from existing blood vessels (a…
- Conditions
- Intermittent Claudication, Peripheral Vascular Disease, Atherosclerosis
- Trial name
- WALK (NCT00117650)
- Testing
- Ad2/HIF-1α/VP16
- Where
- 47 sites in United States, Germany and 1 more
- Volunteers
- 289 people
- Sponsor
- Genzyme, a Sanofi Company
Peripheral Arterial Disease
PAD Awareness Study
Peripheral arterial disease (PAD) is one of the most common cardiovascular diseases in developed countries [1] and is an emerging problem in developing countries [2, 3].
- Trial name
- NCT05552079
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)
Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Coronary Death, Intracerebral Haemorrhage
- Trial name
- NCT01947361
- Where
- United Kingdom
- Volunteers
- 1,961,286 people, healthy volunteers welcome
- Sponsor
- University College, London
Cardiovascular Diseases
MRI-Guided Balloon Angioplasty to Treat Blood Flow Blockage in the Legs
This study will examine the use of magnetic resonance imaging (MRI) instead of x-rays to guide angioplasty in patients who require these treatments to treat blockages in leg arteries.
- Trial name
- NCT00094783
- Testing
- MRI
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Of Bypass Graft of the Extremities, Peripheral Arterial Disease
Standard Versus PICO Dressings in Lower-Extremity Bypass Patients
The objective of this study is to compare the effectiveness of standard moist dressings and PICO single-use negative pressure dressings in post-operative lower extremity bypass patients.
- Conditions
- Of Bypass Graft of the Extremities, Peripheral Arterial Disease, Vascular Diseases, Cardiovascular Diseases
- Trial name
- PICO-LEB (NCT02492854)
- Testing
- PICO Single-Use Negative Pressure Dressings, Sterile Gauze Dressings
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Boston Medical Center
Atherosclerotic Cardiovascular Disease
Low-Density Lipoprotein Cholesterol Reduction With Alirocumab 150 mg Versus Inclisiran in Individuals Initiating Therapy in Routine Clinical Practice
The objective of this study is to evaluate LDL-C reduction over time among individuals initiating alirocumab 150 mg compared with inclisiran in routine clinical practice.
- Trial name
- NCT07615166
- Testing
- Alirocumab 150 mg, Inclisiran
- Where
- United States
- Volunteers
- 996 people
- Sponsor
- Sanofi
Atherosclerosis, Coronary Artery Disease
National Plaque Registry and Database
The ultimate goal of this project is to develop a risk score to identify patients with vulnerable coronary atherosclerotic plaques, who are prone to suffer acute coronary syndrome.
- Conditions
- Atherosclerosis, Coronary Artery Disease, Cardiovascular Disease
- Trial name
- OPeRA (NCT02578355)
- Where
- 11 sites in Hungary
- Volunteers
- 20,000 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Peripheral Artery Disease
Prevalence of Obstructive Sleep Apnea in Patients With Peripheral Arterial Occlusive Disease
Obstructive sleep apnea syndrome (OSAS) is characterized by partial (hypopnea) or complete (apnea) obstruction of the upper airways, leading to intermittent hypoxemia and sleep fragmentation.
- Trial name
- OSAPAD (NCT07283289)
- Where
- France
- Volunteers
- 295 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Peripheral Artery Disease
Exercise Testing in Peripheral Artery Disease Patients
The aim of this study was to evaluate exercise testing in case of patients suspected of Peripheral Artery Disease (PAD).
- Trial name
- ExercisePAD (NCT03186391)
- Testing
- Data collected
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Rennes University Hospital
Atherosclerosis, Cardiovascular Disease
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
To evaluate the safety, tolerability, PK and immunogenicity of single and multiple ascending doses of MEDI6570 in subjects with Type 2 Diabetes Mellitus
- Trial name
- NCT03654313
- Testing
- MEDI6570
- Where
- 9 sites in United States
- Volunteers
- 88 people
- Sponsor
- MedImmune LLC
Cardiovascular Disease Prevention, Cardiometabolic Diseases
Preventative Screening and Health Coaching in a Food Insecure Population
The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food insecure population.
- Conditions
- Cardiovascular Disease Prevention, Cardiometabolic Diseases, Cardiovascular Risk Factor, Cardiovascular Risk Score
- Trial name
- HEALTHCOACH (NCT06907524)
- Testing
- Longitudinal, Individualized Health Coaching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Peripheral Arterial Disease
Ankle Arterial Doppler Waveform Assessment For Surveillance Following Lower Limb Revascularisation
The goal of this observational study is to determine the diagnostic performance of serial ankle arterial Doppler waveform assessments in detecting significant arterial restenosis in patients with Peripheral Arterial Disease (PAD)…
- Trial name
- WAVE (NCT06619223)
- Testing
- Duplex Ultrasound
- Volunteers
- 121 people
- Sponsor
- Imperial College London
Atherosclerosis, Peripheral Arterial Disease
Stella Supera Siberia
Endovascular treatment with stenting is currently used in the treatment of femoro-popliteal lesions. This technique tends to extend to lesions for which the gold standard remains until now the open surgery treatment (lesions TASC…
- Conditions
- Atherosclerosis, Peripheral Arterial Disease, Superficial Femoral Artery Occlusion
- Trial name
- NCT03951727
- Testing
- Endovascular treatment for PAD
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Erectile Dysfunction, Lower Urinary Tract Symptoms
Imaging and Interventional Study for Erectile Dysfunction and Lower Urinary Tract Symptoms
Erectile dysfunction is highly prevalent as men grow older. Among the various causes of erectile dysfunction, it has been shown that pelvic arterial insufficiency plays a very important role.
- Conditions
- Erectile Dysfunction, Lower Urinary Tract Symptoms, Peripheral Arterial Disease
- Trial name
- PERFECT (NCT02178761)
- Testing
- drug-eluting balloon, biodegradable vascular scaffold stent, Apex™ PTCA Dilatation Catheter
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Peripheral Artery Disease
Exercise Therapy for PAD Using Mobile Health
Peripheral artery disease (PAD) is a highly prevalent condition affecting up to 10% of Veterans that leads to loss of walking ability and increased risk of amputation.
- Trial name
- Smart MOVE (NCT04889105)
- Testing
- Smart MOVE!, General walking advice, Performance evaluation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Symptomatic Vascular Disease of the Iliac Arteries
FORMAT Clinical Study
The FORMAT Clinical Study is a clinical trial to evaluate the safety and effectiveness of the Formula™ 535 Iliac Balloon-Expandable Stent in treatment of symptomatic vascular disease of the iliac arteries.
- Trial name
- NCT01804088
- Testing
- Formula™ 535 Iliac Balloon-Expandable Stent
- Where
- 12 sites in United States
- Volunteers
- 80 people
- Sponsor
- Cook Group Incorporated
Atherosclerosis, Heart Failure, Congestive
The Role of Angiotensin Type I Receptor in the Regulation of Human Coronary Vascular Function
The renin angiotensin system (RAS) plays an important physiological and pathophysiological role in the control of blood pressure and plasma volume.
- Conditions
- Atherosclerosis, Heart Failure, Congestive, Hypertension, Myocardial Infarction
- Trial name
- NCT00001629
- Testing
- Angiotensin II type 1 receptor antagonists
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Atherosclerosis
Pathobiological Determinants of Atherosclerosis in Youth (PDAY)
To conduct a multicenter prevalence survey for characterizing pathologically the extent of atherosclerosis in the aortas and coronary arteries of young persons dying from accidental causes, suicide, or homicide.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Heart Diseases, Coronary Disease
- Trial name
- NCT00005679
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atherosclerotic Cardiovascular Disease
Effects of Ezetimibe Combination Therapy for Patients With Atherosclerotic Cardiovascular Disease; Randomized Comparison of LDL-cholesterol Targeting <70 Versus <55mg/dL; Ez-PAVE Trial
Although the clinical efficacy of LDL-cholesterol lowering therapy has been proven with strong evidences and emphasized, there are also growing concerns that intensive lipid-lowering therapy would be related to increased risk of…
- Trial name
- NCT04626973
- Testing
- Ezetimibe/Statin Combination therarpy (ezetimibe plus rosuvastatin), Statin monotherapy (rosuvastatin or atorvastatin)
- Where
- South Korea
- Volunteers
- 3,048 people
- Sponsor
- Yonsei University
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