Clinical trials: Atheromatosis
Diabetes Mellitus, Coronary Artery Disease
Optical Coherence Tomography Morphologic and Fractional Flow Reserve Assessment in Diabetes Mellitus Patients
Title: Combined Optical Coherence Tomography Morphologic and Fractional Flow Reserve Hemodynamic Assessment of Non-Culprit Lesions to Better Predict Adverse Event Outcomes in Diabetes Mellitus Patients COMBINE (OCT-FFR)…
- Conditions
- Diabetes Mellitus, Coronary Artery Disease, Coronary Atheroscleroses
- Trial name
- COMBINE (NCT02989740)
- Testing
- Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 550 people
- Sponsor
- Diagram B.V.
Atherosclerosis of the Peripheral Artery
Pilot Prospective Study of Two Methods of Revascularization of the Femoral Artery (SFA): Stenting in the SFA, and Stenting of the SFA, Supplemented by Fasciotomy in Hunter Channel.
Comparison of two methods for revascularization of the superficial femoral artery: stenting of the superficial femoral artery vs.
- Trial name
- NCT02590471
- Testing
- Angioplasty with stenting of the femoral artery, Angioplasty with stenting of the femoral artery, supplemented by fasciotomy in Hunter's channel
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Peripheral Arterial Disease
Community-Based Detection and Treatment of Peripheral Arterial Disease in Hispanics.
Peripheral Arterial Disease (PAD) is a highly prevalent public health problem that results from progressive atherosclerosis of arteries in the lower extremities.
- Trial name
- NCT01440634
- Testing
- Supervised exercise Program
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- University of Texas Southwestern Medical Center
Occlusion of the Femoral-popliteal Segment, Femoral Access
Choosing an Access for Endovascular Treatment of Femoral-popliteal Segment Occlusions
The aim of this study is to compare the shoulder and femoral approaches used in the endovascular treatment of occlusive lesions of the femoral-popliteal segment of the lower extremity arteries in terms of the frequency of…
- Conditions
- Occlusion of the Femoral-popliteal Segment, Femoral Access, Brachial Access
- Trial name
- ATFA (NCT07694050)
- Testing
- Brachial artery catheterization, Femoral artery catheterization
- Where
- Russia
- Volunteers
- 304 people
- Sponsor
- Pirogov Russian National Research Medical University
Peripheral Arterial Disease (PAD), Intermittent Claudication
Home-based Exercise Therapy for Patients With PAD
Cardiovascular disease represents a considerable economic burden to society and effective preventive measures are necessary. Patients with peripheral arterial disease (PAD) have a severe impairment of functional ability, namely…
- Trial name
- WalkingPAD (NCT04749732)
- Testing
- WalkingPad plus Psychological Intervention - PsyWPad Group, WalkingPad plus Virtual Assistant - CyberWPad Group, WalkingPad group - Paper WPad Group
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar do Porto
Arteriovenous Malformation, Gastrointestinal Bleed
Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils
The purpose of the Case-Specific Health Care Professional (HCP) Clinical Survey for Concerto Versa™ Detachable Coils, also known as the Concerto Versa HCP Clinical Assessment, is to collect early clinical data from HCPs to assess…
- Conditions
- Arteriovenous Malformation, Gastrointestinal Bleed, Gastric Varices, Hemorrhoid
- Trial name
- NCT07639853
- Testing
- Concerto Versa™ Detachable Coils
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medtronic Endovascular
Peripheral Artery Disease
Clinical Implications of Peripheral Plaque Morphology
Peripheral Artery Disease involves a buildup of fatty deposits (plaque) within blood vessels that can restrict blood flow. Patients who have PAD and claudication (pain in legs during exercise due to poor blood circulation) may be…
- Trial name
- NCT00578422
- Testing
- Ivus (Intravascular Ultrasound) of Amputation Specimens, IVUS (Intravascular Ultrasound)
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- The Cleveland Clinic
Peripheral Arterial Disease
Chronic Total Occlusion Crossing With the Wildcat Catheter
This is a prospective, multi-center, non-randomized study of the Wildcat Catheter to cross a single femoropopliteal chronic total occlusion (CTO).
- Trial name
- CONNECT (NCT01174784)
- Testing
- Chronic TOtAl OcclusioN CrossiNg with thE WildCat CatheTer
- Where
- 15 sites in United States
- Volunteers
- 88 people
- Sponsor
- Avinger, Inc.
Atherosclerotic Cardiovascular Disease
REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification
The Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification (REVEAL) trial aims to determine whether lipid modification with anacetrapib 100mg daily reduces the risk of coronary death, myocardial infarction…
- Trial name
- REVEAL (NCT01252953)
- Testing
- Anacetrapib
- Where
- United Kingdom
- Volunteers
- 30,449 people
- Sponsor
- University of Oxford
Coronary Artery Disease
Cardiac Biomarkers After Marathon Running and Coronary Atherosclerosis
This study evaluates cardiac biomarkers and their association to coronary artery disease in marathon runners.
- Trial name
- MaraCat (NCT03738631)
- Where
- Finland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Turku
Peripheral Arterial Disease
The Biomimetic Stent and Vascular Functions Study
The aim of this IIT is to determine the potential improvement and impact of the BioMimics 3D Stent System in the SFA on local vascular function.
- Trial name
- NCT05447052
- Testing
- Bio-MIMICS 3D Stent, Innova Stent
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital, Essen
Atherosclerotic Cardiovascular Disease
Recipe for Heart Health
The overall objectives of this project are to compare clinical parameters in moderate risk Atherosclerotic Cardiovascular Disease (ASCVD) patients following a Whole Food Plant Based (WFPB) diet containing a high (4 TB) compared…
- Trial name
- NCT04828447
- Testing
- Olive Oil
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Solid Malignancy Located in the Head and Neck, Cancer
Study of 68GaNOTA-Anti-MMR-VHH2 in Oncological Lesions, Cardiovascular Atherosclerosis, Syndrome With Abnormal Immune Activation and sarcoïdosis
Phase II study to evaluate the clinical potential of 68GaNOTA-anti-MMR-VHH2 for in vivo imaging of Macrophage Mannose Receptor (MMR)-expressing Macrophages by means of Positron Emission Tomography (PET) in patients with…
- Conditions
- Solid Malignancy Located in the Head and Neck, Cancer, Carotid Stenosis, Atherosclerosis of Artery
- Trial name
- MITRAS (NCT04758650)
- Testing
- 68GaNOTA-Anti-MMR-VHH2
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitair Ziekenhuis Brussel
Peripheral Arterial Disease
Cardiopulmonary Exercise Test in Peripheral Arterial Disease
Aim: To determine whether the lactate threshold during CPET is influenced by the presence of haemodynamically significant PAD. Assumption: Correction of haemodynamically significant PAD results in an increased LT, measured by…
- Trial name
- NCT02657278
- Testing
- Arterial Revascularization surgery or Endovascular procedure
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Hypertension
Simvastatin in Patients With Isolated Arterial Hypertension
The purpose of this study is to determine whether combined therapy with simvastatin and hypotensive drugs (ACEI or ARB) may decrease the blood pressure.
- Trial name
- STIPPARE (NCT01017835)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lodz
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Vascular Disease
Safety/Feasibility Study of HBOC-201 in Amputation at/Below Knee From Critical Lower Limb Ischemia
The purpose of this study is to assess the safety and feasibility of HBOC-201 in increasing adequate wound healing in patients with severe peripheral vascular disease who are undergoing lower limb amputation.
- Trial name
- NCT00300040
- Testing
- Hemoglobin glutamer 250 - bovine, 6% Hydroxyethylstarch
- Where
- 5 sites in South Africa, United Kingdom
- Volunteers
- 16 people
- Sponsor
- Biopure Corporation
Peripheral Arterial Disease
Development and Validation of the Modified Version of VascuQol Scale in Patients With Lower Extremity Peripheral Arterial Disease.
The purpose of this study is to assess the utility of the Modified version of VascuQol Scale as an effective biopsychosocial assessment tool for patients suffering from lower extremity peripheral arterial disease.
- Trial name
- NCT06223217
- Testing
- Surveys and Questionnaires
- Where
- China
- Volunteers
- 480 people
- Sponsor
- RenJi Hospital
Homocysteine, Coronary Artery Disease
The Study of Relationship of Plasma Concentrations of Folic Acid, Vitamin B and Homocysteine With Carotid Atherosclerosis and Endothelium-Dependent Vasodilatation of Geriatric and Young Patients in the Ambulatory Care Department of NTUH
Elevation of plasma homocysteine has been recognized as one of the risk factors of atherosclerotic disease. The objectives of this study are: (1) to investigate the level of plasma homocysteine and the prevalence of…
- Trial name
- NCT00172250
- Sponsor
- National Taiwan University Hospital
Atherosclerosis Cerebral, Carotid Plaque
RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling
Carotid artery stenosis is a major cause of ischemic stroke. However, many strokes occur in patients with only mild-to-moderate stenosis.
- Conditions
- Atherosclerosis Cerebral, Carotid Plaque, Vulnerable Plaque, Carotid Stenosis
- Trial name
- RESCUE (NCT07819643)
- Testing
- Intervention 1, Intervention 3, Intervention 2
- Volunteers
- 120 people
- Sponsor
- Keqiang Zhao
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