Clinical trials: Atheromatosis
Atherosclerosis, Cardiovascular Diseases
The Role of Stem Cells on Immune Cells in the Development of Cardiovascular Diseases
An observational pilot proof-of-principle study. 15 patients with significant coronary artery disease and 15 matched controls. To investigate whether long-term activation of the innate immune system, named 'trained innate…
- Trial name
- ATHEROSTEM (NCT03172507)
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Peripheral Arterial Disease
Safety and Effectiveness of Jetstream Atherectomy System (J-SUPREME II)
The purpose of this study is to evaluate the safety and effectiveness of the Jetstream Atherectomy System for the treatment of Japanese patients with symptomatic occlusive atherosclerotic lesions in native superficial femoral…
- Trial name
- NCT03847233
- Testing
- Jetstream Atherectomy System
- Where
- 5 sites in Japan
- Volunteers
- 31 people
- Sponsor
- Boston Scientific Corporation
Peripheral Arterial Disease, Aortoiliac Occlusive Disease
Predictors of Major Adverse Limb Events After Endovascular Iliac Stenting: a Real-world Cohort Study
Peripheral arterial disease involving the iliac arteries is a common manifestation of systemic atherosclerosis and a major cause of lifestyle-limiting claudication and chronic limb-threatening ischemia.
- Conditions
- Peripheral Arterial Disease, Aortoiliac Occlusive Disease, Chronic Limb-Threatening Ischemia, Intermittent Claudication
- Trial name
- PREMISE-ILIAC (NCT07672249)
- Testing
- Iliac stenting
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Hypertension, Hypercholesterolemia
Effects of Purple Vegetables on Cardiovascular Disease (CVD) Risk Factors
The hypothesis is that richly coloured purple vegetables, rich in polyphenolic compounds including anthocyanins will have higher antioxidant and other biological activities, than more lightly coloured versions of these foods.
- Conditions
- Hypertension, Hypercholesterolemia, Type II Diabetes, Obesity
- Trial name
- NCT01564498
- Testing
- vegetable
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Guelph
Carotid Atherosclerosis, Carotid Intimal Medial Thickness 1
Effects of Lutein Supplementation on Subclinical Atherosclerosis
This study is to investigate the possible positive effects of lutein and lycopene supplementation on early atherosclerosis in Beijing.
- Trial name
- NCT01534533
- Testing
- Lutein group, Combination group, Normal lutein control group
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Peking University
Peripheral Artery Disease
FlowMet-R Blood Flow Measurement for the Diagnosis of Peripheral Artery Disease and Critical Limb Ischemia
Non-randomized, multi-center, longitudinal study of healthy subjects and subjects with PAD who are scheduled for ABI, TBI, and either Duplex Ultrasound or Angiographic assessments in a vascular clinic.
- Trial name
- NCT04120610
- Testing
- FlowMet-R, ABI, TBI
- Where
- 5 sites in United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Medtronic Endovascular
Atheroscleroses, Coronary
Dotatate to Locate Coronary Plaques at High-risk of Myocardial Infarction
To assess whether vulnerable coronary plaques have more uptake of 68Ga-Dotatate than non-vulnerable plaques.
- Trial name
- DOLPHIN (NCT05536960)
- Testing
- 68Ga-Dotatate PET/CT
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atherosclerotic Carotid Disease, Atheroma
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
A new way of scanning narrowing in the arteries (main blood vessels) caused by fatty deposits known as plaques has been developed. Heart attacks and strokes occur when plaques become inflamed, depending on the artery affected.
- Conditions
- Atherosclerotic Carotid Disease, Atheroma, Atherosclerosis
- Trial name
- NCT00368589
- Testing
- atorvastatin
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Peripheral Arterial Disease
Effects of Dietary Flaxseed on Symptoms of Cardiovascular Disease in Patients With Peripheral Arterial Disease
This Clinical Trial is being conducted to study how patients with peripheral arterial disease (a condition in which the blood vessels of the extremities are affected) respond to a dietary regimen of flaxseed.
- Trial name
- FLAXPAD (NCT00781950)
- Testing
- Flaxseed
- Volunteers
- 110 people
- Sponsor
- Dr. Grant Pierce
Peripheral Artery Disease
Predicting Outcomes of PAD Patients Undergoing Endovascular Intervention With CTA
Lower extremity peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular morbidity following coronary artery disease and stroke, affect 200 million people worldwide and is associated with high…
- Trial name
- NCT03974880
- Where
- China
- Volunteers
- 480 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Peripheral Arterial Disease
Investigating Efficacy and Safety of JETi® in Arterial Occlusions in FEM-POP and Prox BTK-Lesions (JETART)
To demonstrate the efficacy and safety of the mechanical thrombectomy device (JETi 6F and 8F) for treatment of patients with symptomatic peripheral artery disease (PAD) due to acute or acute on chronic occlusions of the femoral…
- Trial name
- JETART (NCT06434779)
- Testing
- JETi 6F and 8F Thrombectomy system
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vascular Science LP GmbH
Coronary Artery Bypass, Atherosclerosis
Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions
The specific aim of the SOS-Xience V study is to examine the 12-month incidence of binary angiographic in-stent restenosis after implantation of the Xience V stent in aortocoronary saphenous vein bypass graft lesions.
- Trial name
- SOS-Xience V (NCT00911976)
- Testing
- Xience V coronary stent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- North Texas Veterans Healthcare System
Coronary Disease, Coronary Arteriosclerosis
Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease
Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear.
- Conditions
- Coronary Disease, Coronary Arteriosclerosis, Myocardial Infarction, Chronic Coronary Syndrome
- Trial name
- NORDHEART (NCT06701968)
- Testing
- Healthy Nordic Diet, Usual Care
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Peripheral Arterial Disease, Type II Diabetes Mellitus
Dietary Nitrate and Exercise to Augment Exercise Training Benefits in Subjects With DM+PAD
The hypothesis of this proposal is that in subjects with Type II diabetes mellitus (T2D) and peripheral arterial disease (PAD) with intermittent claudication (IC), regular consumption of a high nitrate supplement which raises…
- Trial name
- DM+PAD (NCT01785524)
- Testing
- Beetroot Juice (Beet-It Stamina Shot) and Exercise Training
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Atherosclerosis, Carotid Artery Disease
Magnetic Resonance Imaging (MRI) Characterization of Carotid Plaque and Prediction of End-organ and Clinical Outcomes
The Canadian Atherosclerosis Imaging Network (CAIN) is a pan-canadian imaging network funded through grants from the Canadian Foundation for Innovation (CFI) and the Canadian Institutes of Health Research (CIHR).
- Trial name
- NCT01440296
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Peripheral Artery Disease, PAD
Unacylated Ghrelin to Improve FuncTioning in PAD: The GIFT Trial
The GIFT pilot study will investigate the optimal subcutaneous dose and safety of subcutaneously administered unacylated ghrelin in older people with peripheral artery disease (PAD).
- Conditions
- Peripheral Artery Disease, PAD, Peripheral Arterial Disease
- Trial name
- GIFT (NCT03358355)
- Testing
- unacelyated ghrelin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwestern University
Intermittent Claudication, Peripheral Arterial Disease
SUPER Study; SUPERvised Exercise or Angioplasty for Intermittent Claudication Due to an Iliac Artery Obstruction.
The purpose of our study is to compare the clinical effectiveness and cost-effectiveness of two treatment strategies of Intermittent Claudication (IC) due to an iliac artery obstruction: to start with SUPERvised Exercise Therapy…
- Trial name
- SUPER (NCT01385774)
- Testing
- Percutaneous Transluminal Angioplasty, Supervised Exercise Therapy
- Where
- 15 sites in Netherlands
- Volunteers
- 240 people
- Sponsor
- M.J.W. Koelemaij
Familial Hypercholesterolemia
EAS Familial Hypercholesterolaemia Studies Collaboration
Familial hypercholesterolaemia (FH) is a common genetic disorder resulting in marked elevations in low-density lipoprotein cholesterol (LDL-C).
- Trial name
- FHSC (NCT04272697)
- Where
- United Kingdom
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Peripheral Arterial Disease
Revascularization of Total or Sub-total Occluded Peripheral Arteries With ByCross® Device. Post Market Clinical Followup
Post market clinical follow up of Bycross® device.
- Trial name
- NCT05110079
- Testing
- ByCross Atherectomy and Thrombectomy
- Where
- 3 sites in Germany
- Volunteers
- 75 people
- Sponsor
- Taryag Medical Ltd.
Peripheral Arterial Disease
Ultrasonic Perfusion Estimation in Calf Muscle
The purpose of this study is to evaluate the potential of ultrasound perfusion imaging technique for assessing the progression of peripheral arterial disease (PAD) and monitoring its response to therapy by measuring changes in…
- Trial name
- NCT04755335
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Mayo Clinic
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