Clinical trials: Atherosclerosis, Cerebral
Cardiovascular Diseases, Heart Diseases
Stanford Five-City Multifactor Risk Reduction Study
To conduct a large-scale demonstration and education project designed to evaluate the feasibility and effectiveness of long-term community health education directed toward lowering cardiovascular disease risk, morbidity, and…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- NCT00005143
- Volunteers
- 2,504 people
- Sponsor
- Stanford University
Intracranial Atherosclerosis, Stroke
AcoArt sICAS: DCB in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of the RCT trial is to determine whether DCB is not inferior to stent in treating intracranial stenosis.
- Trial name
- NCT04631055
- Testing
- drug coated balloon, stent system
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Acotec Scientific Co., Ltd
Atherosclerosis, Atherosclerotic Plaque
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. The nine patients will receive an injection of Indocyanine green (ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as…
- Conditions
- Atherosclerosis, Atherosclerotic Plaque, Carotid Stenosis
- Trial name
- BRIGHT-CEA (NCT01873716)
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
ICAS - Intracranial Atherosclerosis, Cerebral Small Vessel Diseases
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing…
- Trial name
- NCT05677607
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Cerebral Atherosclerosis
Study on Prevention and Treatment of Atherosclerotic Cerebral Occlusive Disease With Remote Ischemic Conditioning
The primary objective of the study will be to determine whether remote limb ischemic conditioning (RLIC) together with conventional medication therapy compared with only medication therapy reduces the 3-month risk of composite…
- Trial name
- NCT04470492
- Testing
- Doctormate®+Medical Management, Medical Management
- Volunteers
- 700 people
- Sponsor
- Ji Xunming,MD,PhD
Atherosclerosis, Carotid Atherosclerosis
Visualization of Carotid Atherosclerosis by 68Ga-MSA
Until now, no specific atherosclerosis-targeting agent labeled with positron emitter is not yet available. Investigators developed neomannosyl human serum albumin(MSA) for the terminal mannose residues of MSA binding with the…
- Conditions
- Atherosclerosis, Carotid Atherosclerosis, Noninvasive Imaging of Atherosclerosis
- Trial name
- NCT01893489
- Testing
- 68Gallium-MSA
- Where
- 2 sites in South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Korea University
Cardiovascular Diseases, Carotid Artery Diseases
Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up
This study will evaluate the effects of vitamin E supplementation in retarding the progression of common carotid artery intima-media thickening in African Americans.
- Conditions
- Cardiovascular Diseases, Carotid Artery Diseases, Intracranial Arteriosclerosis, Cerebrovascular Disorders
- Trial name
- NCT00000600
- Testing
- Vitamin E, Vitamin C
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Sleep-disordered Breathing
Apnea, Stroke and Incident Cardiovascular Events
This prospective cohort study aims to compare the proportion of cardiac or cerebrovascular events after a first stroke, a first transient ischemic attack (TIA) or recurrent TIA, between sleep-disordered breathing (SDB) and…
- Conditions
- Stroke, Sleep-disordered Breathing, Sleep Apnea Syndromes, Sleep Apnea, Obstructive
- Trial name
- ASCENT (NCT04399200)
- Testing
- Treatment according to standard care recommandation
- Where
- France
- Volunteers
- 1,620 people
- Sponsor
- University Hospital, Grenoble
Stroke, Carotid Stenosis
PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
Ischaemic stroke is a major cause of death and disability worldwide. In patients with recent stroke, the 18F-fluoride positron emission tomography-computed tomography highlights high-risk culprit carotid plaque and is more…
- Trial name
- NCT03215550
- Testing
- CEA, 18F PET-MRI, Transcranial Doppler
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
Protective Effect of EPA on Cardiovascular Events
The purpose of this study was to test the hypothesis that the long-term use of highly (>98%) purified EPA, in addition to HMG-CoA reductase inhibitor (statin), would be more effective than statin alone in preventing…
- Trial name
- NCT00231738
- Testing
- Eicosapentaenoic acid ethyl ester(EPADEL Capsule 300 TM)
- Where
- Japan
- Volunteers
- 18,000 people
- Sponsor
- Kobe University
Arthritis, Rheumatoid, Arthritis, Psoriatic
Impact of Nurse-led Programme With Carotid Ultrasound on Addressing Cardiovascular Risk in Patients With Arthritis
Elevated CVD risk is a significant public health problem that contributes greatly to the increased morbidity and shortened lifespan of individuals with RA and PsA.
- Trial name
- NCT03625089
- Testing
- Atorvastatin
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Atherosclerotic Disease, Plaque, Atherosclerotic
Natural History of Carotid Plaque as Determined by 3D Ultrasound
This proposed follow-up study aims to recruit participants from the original BioImage cohort for a one-time follow-up examination.
- Conditions
- Atherosclerotic Disease, Plaque, Atherosclerotic, Heart Diseases, Stroke
- Trial name
- BioImage2 (NCT03314818)
- Testing
- Ultrasound 3D Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Pieter Muntendam
Carotid Artery Diseases, Aortic Diseases
Intervascular Post-Market Clinical Follow-Up (PMCF) Registry
The purpose of this registry is to evaluate the long-term safety and performance of Intervascular Vascular Grafts and Patches (Intergard Standard, Hemashield, Intergard Silver, Intergard Synergy) for bypass, repair or replacement…
- Conditions
- Carotid Artery Diseases, Aortic Diseases, Peripheral Arterial Diseases
- Trial name
- NCT07322913
- Testing
- Intergard Standard - Collagen Coated Vascular Grafts and Patches, Hemashield - Collagen Coated Vascular Grafts and Patches, Intergard Silver - Antimicrobial Collagen Coated Vascular Grafts and Patches
- Where
- 5 sites in United States, Belgium and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Intervascular
Atherosclerosis, Cardiovascular Diseases
Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA)
To foster collaboration between the World Health Organization MONICA Project and the NHLBI Study of Atherosclerosis Risk in Communities (ARIC).
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Cerebrovascular Accident, Coronary Disease
- Trial name
- NCT00005678
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Intracranial Atherosclerosis
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI
Intracranial atherosclerosis (ICAS) accounts for 10 to 40%, depending on ethnicity, of the 700,000 ischemic strokes in the United States every year.
- Trial name
- NCT03084523
- Testing
- Ferumoxytol Injectable Product
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)
Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Coronary Death, Intracerebral Haemorrhage
- Trial name
- NCT01947361
- Where
- United Kingdom
- Volunteers
- 1,961,286 people, healthy volunteers welcome
- Sponsor
- University College, London
Microvascular Angina, Angina Pectoris
Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial
Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected.
- Conditions
- Microvascular Angina, Angina Pectoris, Angina, Stable, Non-Obstructive Coronary Atherosclerosis
- Trial name
- CorCMR (NCT04805814)
- Testing
- CMR results disclosed, CMR performed but results not disclosed
- Where
- 3 sites in United Kingdom
- Volunteers
- 280 people
- Sponsor
- NHS National Waiting Times Centre Board
Atherosclerosis, Coronary Artery Disease
Feasibility of a Multifaceted Program to Reduce Cardiovascular Complications of Air Pollution
The main goal of this clinical trial is to evaluate the feasibility of conducting a large-scale clinical trial testing a program containing several aspects for reducing the effects of air pollution on cardiovascular health (which…
- Conditions
- Atherosclerosis, Coronary Artery Disease, Peripheral Arterial Disease, Ischemic Stroke
- Trial name
- NCT06261606
- Testing
- Hybrid strategy
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Parham Sadeghipour
Dementia, Cardiovascular Risk Factor
Cerebrovascular Correlates of Dementia in Rural Communities - The Three Villages Study
This study aims to assess the prevalence and severity of dementia in an established cohort of community-dwelling older adults living in three neighboring rural Ecuadorian villages (Atahualpa, El Tambo, and Prosperidad), as well…
- Conditions
- Dementia, Cardiovascular Risk Factor, Atherosclerosis, Cerebral Small Vessel Diseases
- Trial name
- NCT04123171
- Testing
- Neuroimaging studies
- Where
- 2 sites in Ecuador
- Volunteers
- 600 people
- Sponsor
- Universidad de Especialidades Espiritu Santo
Atherosclerosis, Cardiovascular Diseases
Postprandial Lipoproteins and Atherosclerosis
To determine whether postprandial lipoproteins were associated with atherosclerosis, and if so, whether the association was statistically independent of that between fasting lipoproteins and atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases
- Trial name
- NCT00005263
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Columbia University