Clinical trials: Atherosclerosis Cardiovascular Disease
Peripheral Arterial Disease
Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent
The objective of this clinical investigation is to evaluate the clinical outcome (up to 12 months) of treatment by means of stenting with the RoadSaver (Terumo) in subjects at high risk for carotid endarterectomy requiring…
- Trial name
- NCT02529345
- Testing
- RoadSaver stent
- Where
- 4 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Flanders Medical Research Program
Anesthesia, Peripheral Arterial Diseases
The Effect of Blood Pressure on Cerebral Perfusion During Vascular Surgery
Anesthesia reduces blood pressure and cerebral blood flow is normally considered to be maintained despite marked changes in blood pressure.
- Trial name
- NCT02531139
- Testing
- MAP maintained at 80 mmHg, MAP maintained at 60 mmHg
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Peripheral Arterial Disease
Hypoxic Exercise in Lower Extremity Artery Disease
The aim of this randomized controlled trial is to: Phase I: To explore, in a first pilot phase, the adequate combination of hypoxia severity and exercise intensity in patients with symptomatic lower extremity artery disease…
- Trial name
- NCT03506607
- Testing
- Exercise in hypoxia 1500m, Exercise in hypoxia 2500m, Exercise in normoxia
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Systemic Lupus Erythematosus
Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)
Background: Lupus causes a person s immune system to attack the body. It can cause blood vessel problems, heart attack, or stroke. Researchers want to see if the drug pioglitazone may help.
- Trial name
- NCT02338999
- Testing
- PET/CT, Pioglitazone
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Peripheral Arterial Disease, Peripheral Vascular Disease
Safety Study of MultiGeneAngio in Patients With Chronic Critical Limb Ischemia
The purpose of this study is to evaluate the safety and activity of two doses of MultiGeneAngio, a cell therapy product produced from the patient's own cells, as potential treatment for patients with chronic critical limb…
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Disease, Critical Limb Ischemia
- Trial name
- NCT00956332
- Testing
- MultiGeneAngio
- Where
- 7 sites in Israel
- Volunteers
- 28 people
- Sponsor
- MultiGene Vascular Systems Ltd.
Peripheral Arterial Disease, Claudication
THE OMEGA-SPM-DOSE and OMEGA-SPM-PAD: Specialized Pro-Resolving Mediators in Patients With Peripheral Artery Disease
The purpose of this study is to understand the effects of fish oil supplement (containing parts of omega-3 fatty acids) on inflammation.
- Conditions
- Peripheral Arterial Disease, Claudication, Claudication, Intermittent, Vascular Occlusion
- Trial name
- NCT02719665
- Testing
- SPM Emulsion, Dose-modality, SPM Softgel, Dose-Modality
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Adverse Effect, Atherosclerosis, Coronary
Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease
Pioglitazone, a medication of thiazolidinedione group, is capable of triggering the peroxisome proliferator-activated receptors (PPAR-γ).
- Conditions
- Adverse Effect, Atherosclerosis, Coronary, Insulin Resistance Syndrome
- Trial name
- EFFORT (NCT03011775)
- Testing
- Pioglitazone 15 mg Tablet, Isosorbide Dinitrate 10Mg Tablet, Acetylsalicylic Acid 75Mg Tablet
- Where
- Ukraine
- Volunteers
- 43 people
- Sponsor
- Ukrainian Medical Stomatological Academy
Critical Limb Ischemia
Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia
This study will compare the effectiveness of best available surgical treatment with best available endovascular treatment in adults with critical limb ischemia (CLI) who are eligible for both treatment options.
- Trial name
- BEST-CLI (NCT02060630)
- Testing
- Open surgical revascularization, Endovascular revascularization
- Where
- 161 sites in United States, Canada and 3 more
- Volunteers
- 1,843 people
- Sponsor
- Carelon Research
Peripheral Arterial Disease (PAD), Claudication, Intermittent
Expression of GLP1 Receptor on Peripheral Blood Mononuclear Cells in Advanced Peripheral Artery Disease: Paving the Way for GLP1R Agonists Treatment in Chronic Limb Threatening Ischemia
The goal of this observational study is to learn whether activation of the GLP-1 receptor could represent a therapeutic target by characterizing its expression and associated inflammatory mechanisms in patients with peripheral…
- Conditions
- Peripheral Arterial Disease (PAD), Claudication, Intermittent, Chronic Limb-Threatening Ischemia
- Trial name
- EXCEL-CLTI (NCT07340112)
- Testing
- Analysis of GLP-1 receptor expression
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Peripheral Artery Disease
Hepatocyte Growth Factor to Improve Functioning in PAD
HI-PAD is a placebo controlled double-blind randomized pilot clinical trial to determine whether VM202 may improve walking ability in people with lower extremity peripheral artery disease (PAD).
- Trial name
- HI-PAD (NCT03363165)
- Testing
- VM202
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Northwestern University
Atherosclerosis, Cardiovascular Diseases
Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions
This study will compare medical therapy plus stenting of hemodynamically significant renal artery stenoses versus medical therapy alone in patients with systolic hypertension and renal artery stenosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Hypertension, Renovascular, Renal Artery Obstruction
- Trial name
- CORAL (NCT00081731)
- Testing
- Atacand/HCT, Caduet, GENESISTM Embolic Protection Stent and Angioguard Device (Angioplasty plus stenting)
- Where
- United States
- Volunteers
- 947 people
- Sponsor
- Baim Institute for Clinical Research
Atherosclerosis
Oxford Niaspan Study: Effects of Niaspan on Atherosclerosis and Endothelial Function
AIM 1 will test the hypothesis that elevation of high-density lipoprotein (HDL) through treatment with Niaspan will accelerate the regression of atherosclerotic plaque in patients with established atherosclerosis.
- Trial name
- NCT00232531
- Testing
- Niaspan
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Oxford
Acute Coronary Syndrome, Atherosclerosis
Protocol for The Lipid Registry of Africa
The Lipid Registry of Africa (LIPRA) aims to understand why some individuals in Africa experience heart issues at a younger age than others.
- Trial name
- NCT06238375
- Volunteers
- 4,000 people
- Sponsor
- European Atherosclerosis Society
Death, Carotid Artery Disease
NOR-SYS: The Norwegian Stroke in the Young Study
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to…
- Conditions
- Death, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery Disease
- Trial name
- NOR-SYS (NCT01597453)
- Testing
- Lifestyle counseling
- Where
- Norway
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Atherosclerosis, Diabetes
Strategies for Inflammation and Cardiovascular Disease (CVD) Prevention
The long-term goal of the proposed research is to identify and develop effective interventions to decrease persistent, low-level inflammation and risk of CVD.
- Trial name
- SICVDP (NCT02165228)
- Testing
- Mindfulness-based stress reduction, Nutrition Enhancement
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Montana State University
Critical Limb Ischemia (CLI)
Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Non-diabetic Patients With Critical Limb Ischemia (CLI).
Phase II Clinical Trial, a prospective, multicenter, open, randomized, parallel-group controlled with three levels of dose. The hypothesis of the test we propose is that the mononuclear cells of bone marrow provide progenitor…
- Trial name
- NCT01408381
- Testing
- Intraarterial Infusion of Autologous Bone Marrow Mononuclear Cells
- Where
- 5 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Atherosclerosis, Cardiovascular Diseases
Genetic Mapping of Atherogenic Lipoprotein Phenotypes
To map the major gene influencing low-density lipoprotein subclass phenotypes, denoted atherogenic lipoprotein (ALP) phenotypes, with a long term goal of cloning the ALP gene and understanding its role in genetic susceptibility…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00005465
- Sponsor
- University of Washington
Venous Thromboembolism, Deep Venous Thrombosis
Aspirin for the Prevention of Recurrent Venous Thromboembolism
To determine whether aspirin is more effective than placebo for the prevention of recurrent symptomatic venous thromboembolism when given for at least two years after the initial 6-12 month of oral anticoagulant therapy in…
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism, Atherosclerosis
- Trial name
- NCT00222677
- Testing
- aspirin
- Where
- 15 sites in Austria, Italy
- Volunteers
- 70 people
- Sponsor
- University Of Perugia
Diabetes Mellitus, Type 2, Diabetic Foot
Non-invasive Imaging for In-vivo Quantification of Skin Composition and Structure
The goal of this clinical investigation is to explore a non-invasive technology for measuring the microcirculatory structure, composition and function in patients from a primary care population. The main aims are: 1.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Foot, Peripheral Arterial Disease, Skin Cancer
- Trial name
- Spectrum1 (NCT06976073)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Peripheral Arterial Disease, Peripheral Vascular Disease
Clinical Pilot-Study of ProEndoTecc Vascular Grafts as Superficial Femoral Artery Bypass / Interponate
This is a multi-center, clinical pilot-study of ProEndoTecc Vascular Grafts (6, 7 or 8 mm Diameter) as superficial femoral artery bypass/interponate.
- Trial name
- NCT01095237
- Testing
- ProEndoTecc Vascular Graft
- Where
- 12 sites in Germany
- Volunteers
- 33 people
- Sponsor
- NonWoTecc Medical GmbH
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