Clinical trials: Atherosclerosis Cerebral
Peripheral Artery Disease, Carotid Artery Stenosis
Study on PAD and CAS Based on Omics and Imaging
This study aims to investigate the pathogenesis of Peripheral Artery Disease (PAD) and Carotid Artery Stenosis (CAS) using a comprehensive multi-omics and multi-modal imaging approach.
- Conditions
- Peripheral Artery Disease, Carotid Artery Stenosis, Artery Stenosis
- Trial name
- NCT06917547
- Volunteers
- 100 people
- Sponsor
- Yijie Ning
Diabetes, Peripheral Arterial Occlusive Disease
Evaluate the Correlation of NIRS, ABI, Exercise, baPWV and Albuminuria With Peripheral Artery Occlusion Disease (PAD) and Other Atherosclerosis Outcomes
By utilizing Near infrared spectroscopy (NIRS), the local blood flow, tissue oxygenation (StO2), and recovery time of ischemic leg; can be determined.
- Trial name
- NCT03378024
- Testing
- oscillometric (Omron Colin co)
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Stroke
Stroke - Sleep Disorders, Dysfunction of the Autonomic Nervous System and Depression
The purpose of this study is to investigate sleep disordered breathing, autonomic dysfunction, and post stroke depression in acute and chronic stroke patients.
- Trial name
- NCT02111408
- Where
- Denmark
- Volunteers
- 114 people
- Sponsor
- Helle Klingenberg Iversen, MD, DmSc
Myocardial Infarction, Death
Association of Endothelial Function and Clinical Outcomes in Subjects Admitted to Chest Pain Unit
It is recognized that endothelial dysfunction is a major factor contributing to the atherogenic process. Abnormal function of the endothelium is detectable prior to obvious intimal lesions in patients with risk factors for…
- Conditions
- Myocardial Infarction, Death, Cerebrovascular Accident, Congestive Heart Failure
- Trial name
- NCT01618123
- Where
- 2 sites in United States, Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Asymptomatic, Artery
Stenting Versus Best Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis
Background. Carotid artery stenting (CAS) recently has become an accepted method for treatment of patients with high-grade carotid artery stenosis, who are at an increased risk for surgical carotid endarterectomy (CEA).
- Trial name
- NCT00497094
- Testing
- carotid artery stenting
- Where
- Austria
- Volunteers
- 148 people
- Sponsor
- Vienna General Hospital
ICAD - Intracranial Atherosclerotic Disease, Ischemic Stroke
Stenting for Ischemic Strokes Secondary to Medically Refractory Intracranial Atherosclerotic Disease
The goal of this observational study is to establish a prospective multicenter registry of patients undergoing intracranial stenting for ischemic strokes caused by medically refractory ICAD.
- Trial name
- STRICT-ICAS (NCT06790147)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Nitin Goyal
Carotid Artery Diseases, Stroke
The Role of Maintaining External Carotid Artery Flow in Graft Interposition After Carotid Endarterectomy
Analyzing results of carotid graft interposition with and without flow preservation through external carotid artery after endarterectomy.
- Conditions
- Carotid Artery Diseases, Stroke, Carotid Atherosclerosis
- Trial name
- AGICS (NCT06528717)
- Testing
- Carotid graft interposition
- Where
- Serbia
- Volunteers
- 250 people
- Sponsor
- Institute for Cardiovascular Diseases Dedinje
Stroke, Cerebral Infarction
Platelet Hyperreactivity to Aspirin and Stroke
STUDY QUESTIONS What is the real prevalence of platelet "resistance" to aspirin during the acute phase of stroke and after 3 months, and 1 year, as measured using different platelet function tests? Do all methods measure similar…
- Conditions
- Stroke, Cerebral Infarction, Cardiovascular Diseases, Vascular Diseases
- Trial name
- PLARAS (NCT00766896)
- Testing
- Aspirin (platelet sensitive versus platelet hyperreactivity)
- Where
- Brazil
- Volunteers
- 203 people
- Sponsor
- University of Sao Paulo
Atherosclerosis, Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (SOC) for preventing heart attack and stroke (eg, aspirin, clopidogrel) in participants with a known history of atherosclerosis…
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00526474
- Testing
- Vorapaxar
- Volunteers
- 26,449 people
- Sponsor
- Merck Sharp & Dohme LLC
Hyperlipoproteinemia(a), Progressive Cardiovascular Disease
Randomized Controlled Trial of Lipid Apheresis in Patients With Elevated Lipoprotein(a)
Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease. Non-medical treatment measures (e.g. dietary therapy or weight loss) can hardly influence Lp(a) plasma concentrations.
- Trial name
- ELAILa (NCT01064934)
- Testing
- Lipid apheresis, Standard care
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Stroke, Atherosclerosis
Stroke Prevention in the Wisconsin Native American Population
This project will develop a "Stroke Awareness Team" including training of Oneida Health Service Coaches working in partnership with the UW team for a population-based health awareness program.
- Trial name
- NCT04382963
- Testing
- High Risk - intensive coaching, High Risk - standard care, Low Risk - control
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Ischemic Stroke
Balloon Angioplasty for Minor Unstable Stroke With IntraCranial Atherosclerosis Stenosis (BAMUS-ICAS)
Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, especially in East and South Asia, and is significantly associated with stroke recurrence and early neurological deterioration (END) despite aggressive…
- Trial name
- BAMUS-ICAS (NCT06763458)
- Testing
- Submaximal balloon angioplasty
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Shenyang Military Region
Carotid Artery Stenosis
Evaluation of a Novel Technique to Diagnose Carotid Artery Stenosis
The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared to a carotid ultrasound study.
- Trial name
- NCT03464851
- Testing
- Carotid Stenotic Scan (CSS)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Cleveland Clinic
Carotid Stenosis, Carotid Artery Diseases
Early Warning and Optimization Strategy in Carotid Endarterectomy
Carotid endarterectomy has been proven effective in prevention of cerebral vascular events in patients with severe carotid artery stenosis (symptomatic,>50%;asymptomatic,60%).
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Stroke, Vascular Diseases
- Trial name
- NCT01210937
- Testing
- CEA and TCD monitoring
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Acute Ischemic Cerebral Vascular Disease
Remote Ischemic Conditioning in Acute Ischemic Cerebral Vascular Disease Patients With Coexistence of Cerebral and Coronary Atherosclerosis（RIC-CCCA）
Remote ischemic conditioning(RIC) is a protective systemic strategy by organs brief and sublethal ischemia to confer protection from subsequent severe ischemia in distant organs, especially for heart and brain.
- Trial name
- NCT03721692
- Testing
- RIC
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Capital Medical University
Carotid Artery Occlusion
Effectiveness of Surgical and Diagnostic Methods in Cerebral Vascular Occlusive Disease
This study attempts to improve surgical treatment outcomes among people with chronic carotid artery occlusive disease by conducting a comprehensive review of neuroradiological, clinical, and cognitive data.
- Trial name
- NCT07396025
- Testing
- Revascularization/Conservative management
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- National Centre for Neurosurgery, Republic of Kazakhstan
Atherosclerosis, Cardiovascular Disease
A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease
The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.
- Conditions
- Atherosclerosis, Cardiovascular Disease, Hypercholesterolemia
- Trial name
- HEART-3 (NCT07839936)
- Testing
- VERVE-102
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Verve Therapeutics, Inc.
Cardiovascular Diseases, Heart Diseases
Adipose Distribution and Atherosclerosis
To relate distribution of adipose tissue measured by a then new imaging technique, Magnetic Resonance Imaging (MRI) to extracranial carotid atherosclerosis, cardiovascular disease risk factors, and to more conventional measures…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Carotid Stenosis
- Trial name
- NCT00005348
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Assessment of Coronary Artery Disease in Stroke Patients
This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.
- Trial name
- ACADIS (NCT01850693)
- Where
- South Korea
- Volunteers
- 1,657 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction, Ischemic Stroke
Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease
Autoimmune diseases are diseases in which inappropriate immune responses that have the capability of harming host cells play an important role.
- Conditions
- Myocardial Infarction, Ischemic Stroke, Stroke, Subarachnoid Haemorrhage
- Trial name
- NCT02062021
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University College, London