Clinical trials: Atherosclerotic Plaque
Carotid Artery Stenosis
The Correlation Between the Enzyme Paraoxigenase 1 (PON1) to Carotid Artery Atheromatous Plaque
The objective of the research, is to examine the hypothesis, that the enzyme paraoxygenase 1 ( PON1) can influence carotid artery's atherosclerotic plaque content and stability, and its relation to plasma's enzyme concentration.
- Trial name
- NCT01440036
- Testing
- Carotid endarterectomy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Atherosclerotic Plaque, Diabetes Mellitus, Type 2
Pakistan Study of Premature Coronary Atherosclerosis in Young Adults
Coronary heart disease (CHD) is a major cause of morbidity, disability, mortality, and health expenditures worldwide. A wealth of studies has demonstrated that people of South Asian ancestry have a higher risk of CHD and…
- Conditions
- Atherosclerotic Plaque, Diabetes Mellitus, Type 2, Hypertension, Stroke
- Trial name
- PAKSEHAT (NCT05156736)
- Where
- Pakistan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tabba Heart Institute
Coronary Vessel, Coronary Circulation
Vascular Effects of Alirocumab in Acute MI-Patients
Coronary artery disease (CAD) is the most frequent cause of mortality in the industrialized world. Hypercholesterolemia is a major risk factor for the development and progression of CAD.
- Conditions
- Coronary Vessel, Coronary Circulation, Atheroma; Myocardial
- Trial name
- PACMAN-AMI (NCT03067844)
- Testing
- Alirocumab
- Where
- 9 sites in Austria, Denmark and 2 more
- Volunteers
- 294 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease, Plaque, Atherosclerotic
Identifying Vulnerable CoronAry PLaqUes With Artificial IntElligence-assisted CT Angiography
The goal of this observational study is to develop an automatic whole-process AI model to detect, quantify, and characterize plaques using coronary CT angiography in coronary artery disease patients.
- Trial name
- VALUE (NCT06025305)
- Testing
- Intravascular imaging test, Coronary plaque assessment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Jinling Hospital, China
Carotid Atherosclerotic Plaque
Prospective Management of Plaque Instability With Statins and Extra Folic Acid
This is a prospective, exploratory, cohort clinical study aiming to further investigate the direct impact of folic acid on the stability of carotid atherosclerotic plaques, building upon substantial clinical evidence confirming…
- Trial name
- PROMISE (NCT07680595)
- Testing
- Atorvastatin plus folic acid, Atorvastatin
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruijin Hospital
Aortic Stenosis, Brain Infarction
Neuroprotection in Patients Undergoing Aortic Valve Replacement
To evaluate the efficacy and safety of embolic protection devices to reduce ischemic brain injury in patients undergoing surgical aortic valve replacement (AVR).
- Conditions
- Aortic Stenosis, Brain Infarction, Cerebrovascular Accident, Stroke
- Trial name
- NCT02389894
- Testing
- Embol-X Embolic Protection Device, CardioGard Cannula
- Where
- 18 sites in United States, Canada
- Volunteers
- 383 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atherosclerotic Plaque
Reduced Radiation Dose and IR-impact on Coronary Calcium Quantification
Evaluation of reduced radiation dose iterative reconstruction reconstructions for calcium scoring compared to full dose filtered back projection reconstructions
- Trial name
- NCT04267094
- Testing
- Iterative reconstruction at reduced radiation dose
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Pennsylvania
Atherosclerosis
Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes
The purpose of this study is to test the safety and effectiveness of rosiglitazone against a sulfonylurea in reducing or slowing the development of atherosclerosis in the blood vessels of the heart.
- Trial name
- NCT00116831
- Testing
- Glipizide, rosiglitazone maleate
- Where
- 156 sites in United States, Argentina and 18 more
- Volunteers
- 672 people
- Sponsor
- GlaxoSmithKline
Atherosclerotic Disease, Plaque, Atherosclerotic
Natural History of Carotid Plaque as Determined by 3D Ultrasound
This proposed follow-up study aims to recruit participants from the original BioImage cohort for a one-time follow-up examination.
- Conditions
- Atherosclerotic Disease, Plaque, Atherosclerotic, Heart Diseases, Stroke
- Trial name
- BioImage2 (NCT03314818)
- Testing
- Ultrasound 3D Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Pieter Muntendam
Coronary Artery Disease
Randomized Controlled Trial of Moderate-Intensity Rosuvastatin With Ezetimibe Combination Therapy Versus High-Intensity Rosuvastatin on Progression of Coronary Atherosclerotic Plaque
The aim of this prospective, open-label, randomized, single center study is to compare the effect of usual dose rosuvastatin plus ezetimibe and high-dose rosuvastatin on modifying atherosclerotic plaque.
- Trial name
- Rosuzet-IVUS (NCT03169985)
- Testing
- Rosuvastatin 10 mg plus ezetimibe 10 mg orally once a day, Rosuvastatin 20 mg orally once a day
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Samsung Medical Center
Atherosclerotic Plaque
Efficacy and Safety of Intravascular High-pressure Cutting Balloon Catheters for PCI
The purpose of this study was to evaluate the safety and efficacy of intravascular high-pressure cut balloon catheter compared to cut balloon catheter during PCI, and to support product registration and clinical application.
- Trial name
- NCT06214754
- Testing
- PCI
- Where
- 12 sites in China
- Volunteers
- 168 people
- Sponsor
- BrosMed Medical Co., Ltd
Vascular Disease, Diabetes
A Proposed Study of Atherosclerotic Plaques in Leg Arteries
Biofilm has been identified as the major bacterial phenotype contributing to atherosclerosis. It has become very important to evaluate atherosclerosis and the role of biofilm using advanced technologies.
- Trial name
- NCT01803126
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Southwest Regional Wound Care Center
Smoking-related Pathology, Atheroma
Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
Interventional study with minimal risks and constraints, with evaluation of the incidence of lung cancers by low-dose thoracic CT scan without injection of contrast medium, of the immunological, inflammatory and metabolic blood…
- Conditions
- Smoking-related Pathology, Atheroma, Non-progressive Cancer > 5 Years, Lung Cancer
- Trial name
- BIOCEPTION (NCT06387017)
- Testing
- blood sampling, stool collection, low dose CT scan
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Atherosclerosis
A Clinical Study of IMC-001 for Injection in Improving Atherosclerotic Plaque Stability in Patients With Acute Coronary Syndrome.
A two-center, randomized, double-blind, placebo-controlled, dose-escalation IIT clinical study evaluating the safety and preliminary efficacy of injectable IMC-001 in improving atherosclerotic plaque stability in patients with…
- Trial name
- NCT06788431
- Testing
- IMC-001 and Optimal medical treatment
- Where
- 2 sites in China
- Volunteers
- 18 people
- Sponsor
- ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Carotid Stenosis, Carotid Artery Plaque
CARotid Mri of Atherosclerosis
In the entire world most people die from cardiovascular disease. Death is primarily from myocardial infarction (MI) and stroke which are most often caused by rupture of atherosclerotic plaques. Patients with high-grade, i.e.
- Conditions
- Carotid Stenosis, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- CARMA (NCT04835571)
- Testing
- Optimization of cardiovascular risk management
- Volunteers
- 52 people
- Sponsor
- Linkoeping University
Coronary Heart Disease (CHD)
REsiduAL rISk Under Intensive Lipid-lowering Therapy In Coronary Heart Disease
Intensive lipid-lowering therapy is a cornerstone treatment for coronary heart disease (CHD). However, coronary plaque progression persists in a subset of patients even under intensive lipid-lowering therapy, which may be…
- Trial name
- REALISTIC (NCT06936111)
- Testing
- Assessment of residual cholesterol and inflammatory risk factors
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Shanghai Zhongshan Hospital
Atherosclerosis, Hyperlipidemia
Assessment of Atherosclerotic Plaque Characteristics Change by DCE-MRI With Alirocumab
Aim 1: To determine whether therapy with Alirocumab, compared to pre-treatment, will effectively improve carotid atherosclerotic plaque characteristics by reducing Ktrans and LRNC size.
- Trial name
- NCT02992301
- Testing
- Alirocumab
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Westside Medical Associates of Los Angeles
Dyslipidemias
Effect of Combined Lipid-lowering Therapy on Atherosclerotic Plaque Vulnerability in Patients With ACS
The study is prospective, open-label, randomized, single-center study involving patients admitted on an emergency basis with an acute coronary syndrome (ACS) clinic who underwent PCI of an infarct-related artery (IRA) and had…
- Trial name
- Combi-LLT ACS (NCT05624658)
- Testing
- Combined Lipid-lowering Therapy
- Where
- Russia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Samara Regional Cardiology Dispensary
Asymptomatic Intracranial Atherosclerotic Stenosis Patients
Assessing Vulnerability and Outcomes of Intracranial Atherosclerotic Plaques
This prospective cohort study aims to establish a large-scale cohort for primary stroke prevention in asymptomatic intracranial atherosclerosis (ICAS).
- Trial name
- NCT07156344
- Testing
- Progression and Outcome of Intracranial Atherosclerosis
- Where
- China
- Volunteers
- 3,849 people
- Sponsor
- Xuanwu Hospital, Beijing
Atherosclerotic Plaque
Diagnosis of Macrophage Coronary Plaque by Optical Tomographic Imaging
This study evaluated optimal macrophage diagnosis algorithm through comparative analysis between coronary artery, OCT image, and IVUS, and improve a diagnosis rate of vulnerable coronary plaque accompanied with macrophage…
- Trial name
- OCT pathology (NCT02649881)
- Testing
- The heart subject will undergo OCT
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Young-Hak Kim, MD, PhD