Clinical trials: Atherosclerotic Plaque
Atherosclerotic Disease, Plaque, Atherosclerotic
Natural History of Carotid Plaque as Determined by 3D Ultrasound
This proposed follow-up study aims to recruit participants from the original BioImage cohort for a one-time follow-up examination.
- Conditions
- Atherosclerotic Disease, Plaque, Atherosclerotic, Heart Diseases, Stroke
- Trial name
- BioImage2 (NCT03314818)
- Testing
- Ultrasound 3D Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Pieter Muntendam
Coronary Artery Disease
PCSK9 inhibitoRs for Early Passivation of coRonary athEroSclerotic plaqueS in Acute Coronary Syndromes (REPRESS)
In this prospective, multicenter, open-label trial, 212 ACS patients will be randomized 1:1 to either the "PCSK9i early" intensified therapy group (initial addition of PCSK9i to moderate-intensity statin) or the…
- Trial name
- NCT06791031
- Testing
- PCSK9 inhibitor (PCSK9i)
- Volunteers
- 212 people
- Sponsor
- West China Hospital
Myocardial Bridging, Coronary Atherosclerosis
Coronary Myocardial Bridge and Coronary Plaques on MDCT
Myocardial bridging is a condition in which a segment of a coronary artery passes through the heart muscle instead of running on its surface.
- Trial name
- NCT07916272
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Acute Coronary Syndrome, Atherosclerosis
Change in Plaque Characteristics With Atorvastatin
To examine effects of intensive lipid lowering therapy with atorvastatin on stabilization of coronary plaque by using optical coherence tomography (OCT) in patients with acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Atherosclerosis, Dyslipidemia
- Trial name
- EASY-FIT (NCT00700037)
- Testing
- high-dose atorvastatin, low-dose atorvastatin
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Wakayama Medical University
Coronary Heart Disease
A Study of the Effect of RO4607381 on Atherosclerotic Plaque in Patients With Coronary Heart Disease
This study will assess the effect of RO4607381, compared to placebo, on atherosclerotic plaque in patients with coronary heart disease (CHD) including patients with other CHD risk factors.
- Trial name
- NCT00655473
- Testing
- Dalcetrapib (RO4607381)
- Where
- 12 sites in United States, Canada
- Volunteers
- 130 people
- Sponsor
- Hoffmann-La Roche
TIA, Carotid Artery Plaque
The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated with IL-2 compared to control.
- Conditions
- TIA, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- ELLIPSE (NCT05975554)
- Testing
- Interleukin-2 [IL-2], Standard care - Carotid Endarterectomy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Acute Coronary Syndrome (ACS)
Preventive Drug-coated Balloon Angioplasty in Vulnerable Atherosclerotic Plaque (RESTORE Trial)
The objective of this multicenter, prospective, open-label, controlled, randomized trial is to demonstrate the superiority of drug-coated balloon (DCB) treatment on non-flow limited vulnerable plaque as compared to…
- Trial name
- NCT06365502
- Testing
- Drug-coated balloon, Guideline-directed medical treatment
- Where
- 18 sites in China
- Volunteers
- 1,860 people
- Sponsor
- Harbin Medical University
Atrial Fibrillation
Apixaban Versus Warfarin in the Evaluation of Progression of Atherosclerotic Calcification and Vulnerable Plaque
Vitamin K-antagonists (VKA) such as warfarin are the most widely used blood thinners for irregular heart beats like atrial fibrillation.
- Trial name
- NCT02090075
- Testing
- apixaban, warfarin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Prostatic Neoplasms
Evaluation of Atherosclerotic Plaques in Abdominal CT Studies
Background: Fat and calcium can build up as plaque in artery walls. The Agatston score measures plaque using computed tomography (CT) that does not use an injected contrast agent.
- Trial name
- NCT04652973
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Carotid Artery Stenosis, Cerebral Infarction
Bacteria in Atherosclerotic Plaques and Adverse Events
This study is a prospective, multicenter cohort study conducted in western China. The registry study is primarily conducted at the Department of Neurosurgery, Tangdu Hospital, with participation from the Departments of…
- Conditions
- Carotid Artery Stenosis, Cerebral Infarction, Diabetes, Bacteria
- Trial name
- NCT06935279
- Testing
- Carotid Endarterectomy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS
Imaging of Intracranial and Extracranial Arterial Atherosclerotic Plaques Using Different Field Strength MRIs
Atherosclerotic stenosis of the carotid and intracranial arteries is one of the leading causes of ischemic cerebrovascular events worldwide.
- Conditions
- High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS, Arteriosclerosis
- Trial name
- NCT06754956
- Testing
- The patient will receive two intravenous injections of the same gadoterate meglumine contrast agent.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Atheroma; Heart
Assessment of GARP Expression in Acute and Chronic Coronary Syndrome
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions.
- Trial name
- GARP-CS (NCT07384910)
- Testing
- Arterial blood sample
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- Université Catholique de Louvain
Myocardial Infarction, Atheroma
Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European "SCORE 2" Algorithm. (IDEA-CVR)
To prevent myocardial infarction ( MI), coronary atheroma development by LDL-cholesterol deposition in the arterial wall is the basis.
- Conditions
- Myocardial Infarction, Atheroma, Cholesterol, Cardiovascular (CV) Risk
- Trial name
- IDEA-CVR (NCT07252830)
- Testing
- SCORE2
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Elsan
Smoking-related Pathology, Atheroma
Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
Interventional study with minimal risks and constraints, with evaluation of the incidence of lung cancers by low-dose thoracic CT scan without injection of contrast medium, of the immunological, inflammatory and metabolic blood…
- Conditions
- Smoking-related Pathology, Atheroma, Non-progressive Cancer > 5 Years, Lung Cancer
- Trial name
- BIOCEPTION (NCT06387017)
- Testing
- blood sampling, stool collection, low dose CT scan
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Atherosclerosis, Endothelial Dysfunction
Apoptosis Proteins and Endothelial Dysfunction in Patients With Atherosclerosis of Peripheral Arteries
Modern vascular surgery has various options for open and endovascular surgical methods aimed at treating patients with peripheral arterial diseases.
- Trial name
- NCT04502849
- Testing
- Bypass surgery, Endovascular angioplasty/stenting, Hybrid surgery
- Where
- Russia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Stroke, Atheroscleroses
A Cohort Study on Cardiovascular and Cerebrovascular Outcomes
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed.
- Trial name
- NCT07178015
- Testing
- ultrasound scanning
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Sun Yat-sen University
Coronary Artery Disease, Carotid Artery Diseases
Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)
Heart attacks and strokes caused by the unstable atherosclerotic plaques remain the leading cause of death in the United States. Unstable plaques often have more fat than stable plaques.
- Conditions
- Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis
- Trial name
- NCT01178320
- Testing
- Simvastatin, simvastatin plus extended-release niacin
- Where
- 19 sites in United States, Canada
- Volunteers
- 230 people
- Sponsor
- University of Washington
Atherosclerotic Plaque
Digital Secondary Prevention in Cardiovascular Disease
Although advances in knowledge of the prevention, diagnosis and treatment of atherothrombosis are encouraging, cardiovascular diseases (CVD), with acute and chronic ischemic heart disease in particular, remain a major cause of…
- Trial name
- NCT05096637
- Testing
- PreventiPlaque App
- Volunteers
- 240 people
- Sponsor
- University Hospital, Essen
Coronary Artery Disease
A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD
PARAMOUNT is a prospective randomized open-label trial testing the hypothesis that a personalized management strategy in symptomatic patients with suspicion of coronary artery disease (CAD), using a CT-based coronary…
- Trial name
- PARAMOUNT (NCT06713239)
- Testing
- Cleerly Labs and Cleerly ISCHEMIA
- Where
- 21 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Cleerly, Inc.
Carotid Stenosis
Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control
Cerebrovascular accident (CVA) constitutes a major health public problem. This represents the second cardiovascular death cause. CVA is ischemic in 80% of cases.
- Trial name
- ACABII (NCT02748941)
- Testing
- HITS quantification, Ultrasound examinations, High Resolution MRI
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Hospices Civils de Lyon