Clinical trials: Atrial Fibrillation Catheter Ablation
Paroxysmal Atrial Fibrillation
Safety-and-effectiveness Clinical Evaluation of Nanosecond-pulse Ablation for Atrial Fibrillation
This study is expected to include 166 subjects and Conducted at 11 research centers；The expected 12 month treatment success rate of using research instruments is 65%. Principle evaluation indexes： 1.
- Trial name
- SCENA-AF (NCT06039722)
- Testing
- Pulse ablation catheter
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Shenzhen Pulsecare Medical Technology Co., Ltd.
Atrial Fibrillation, Obesity & Overweight
Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients
Obese patients with atrial fibrillation (AF) have a high recurrence rate after catheter ablation, even at experienced centers. Weight reduction improves post-ablation outcomes, but lifestyle measures alone are difficult to…
- Conditions
- Atrial Fibrillation, Obesity & Overweight, Catheter Ablation
- Trial name
- TEAR-AF (NCT07715929)
- Testing
- Tirzepatide, Structured Lifestyle Intervention
- Volunteers
- 710 people
- Sponsor
- Yunlong Wang
Atrial Fibrillation (AF), Ablation Treatment
Mazdutide for Reducing Atrial Fibrillation Recurrence After Catheter Ablation in Obese Patients
This is a multicenter, open-label, superiority randomized controlled trial enrolling adult patients aged 18 to 75 years. All participants have abdominal obesity (BMI ≥ 28 kg/m² with specific waist circumference standards) and…
- Conditions
- Atrial Fibrillation (AF), Ablation Treatment, Obesity & Overweight, Mazdutide
- Trial name
- MOTIVE-AF (NCT07897305)
- Testing
- Mazdutide, Conventional treatment
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Catheter Ablation
Low-Level EMF Stimulation for Paroxysmal Atrial Fibrillation
This research has two main specific aims. First, a commercially-available stimulator will be utilized to assess the effect of low-level electromagnetic field (EMF) stimulation on atrial fibrillation (AF) inducibility in patients…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Autonomic Imbalance
- Trial name
- NCT03593486
- Testing
- Low-level Pulsed EMF
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation
Cerebral Embolism (CE) in Catheter Ablation of Atrial Fibrillation (AF)
Radiofrequency catheter ablation of atrial fibrillation (AF) induces a procoagulant state, which leads to an acute risk for symptomatic cerebral embolism (CE) of approximately 1%.
- Trial name
- CE-AF (NCT01361295)
- Testing
- PVI with PVAC gold, PVI with Cooled-RF
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Serge A. Trines
Persistent Atrial Fibrillation
Substrate Guided Ablation Therapy for Atrial Fibrillation
Atrial fibrillation (AF), often referred to as an 'irregular heartbeat', is the most common abnormal heart rhythm worldwide. AF may be intermittent (termed paroxysmal) or sustained (termed persistent).Catheter ablation is…
- Trial name
- HEAT-AF (NCT04657978)
- Testing
- Substrate guided left atrial ablation
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation, Arrhythmias, Cardiac
Telemetric Arrhythmia and Syncope Diagnosis - Evaluation of Arrhythmia Treatment Efficacy
The purpose of this study is to assess efficacy of prolonged Full Disclosure ECG monitoring and signal analysis using advanced GSM telemetric technology to prescribe the most appropriate treatment of arrhythmia.
- Trial name
- TELEMARC 4 (NCT01265303)
- Testing
- Prolonged telemetric Full Disclosure ECG recording.
- Where
- 3 sites in Belgium, Poland
- Volunteers
- 360 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Paroxysmal Atrial Fibrillation
TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation
This clinical investigation is intended to demonstrate the acute safety and effectiveness of ablation with the TactiCath™ Contact Force Ablation Catheter, Sensor Enabled™ (TactiCath SE) for the treatment of drug refractory…
- Trial name
- TactiSense (NCT03354663)
- Testing
- TactiCath SE
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 156 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation, Atrial Arrhythmia
VOLta Medical AI-software in REal-World During AF Ablation
This PMCF study "VOLTAIRE-AF" will allow to observe acute and long-term safety and performance outcomes of the last generation of Volta Medical AI software (Volta AF-Xplorer II) during AF ablation using next-generation mapping…
- Conditions
- Atrial Fibrillation, Atrial Arrhythmia, Arrhythmias, Cardiac
- Trial name
- VOLTAIRE-AF (NCT07621055)
- Testing
- Cardiac mapping
- Where
- 3 sites in France
- Volunteers
- 150 people
- Sponsor
- Volta Medical
Atrial Fibrillation, Catheter Ablation
Electroacupuncture Intervention in Catheter Ablation of Atrial Fibrillation
This is a randomized control trial to determine whether electroacupuncture(EA) intervention with Morphine can reduce the intraoperative pain and early post-operative complications in patients undergoing catheter ablation of…
- Trial name
- NCT05575544
- Testing
- Acupuncture plus morphine
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Dabigatran Versus Warfarin Anticoagulation Before and After Catheter Ablation for the Treatment of Atrial Fibrillation
Both warfarin and dabigatran have been used for stroke prophylaxis at the time of catheter ablation of atrial fibrillation. Although the risks of thromboembolism and bleeding with warfarin are well established, the relative risk…
- Trial name
- NCT01607359
- Where
- United States
- Sponsor
- Corewell Health East
Atrial Fibrillation (AF), Catheter Ablation
PulseSelect Based Pulmonary Vein Isolation and Ablation in Patients With Atrial Fibrillation
Electroanatomical mapping (EAM) based pulmonary vein isolation (PVI) by means of PulseSelect catheter and deep sedation will be compared to fluoroscopy based pulmonary vein isolation in patients with atrial fibrillation in the…
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Pulmonary Vein Isolation
- Trial name
- PVI-PVA (NCT07035288)
- Testing
- EAM based Pulmonary Vein Isolation, Fluoro based pulmonary vein ablation
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Tsiachris Dimitrios
Atrial Fibrillation (AF), Atrial Tachycardia
Conduction Breakthrough in the Coronary Sinus Post Endocardial Mitral Isthmus Ablation
The goal of this observational study is to learn more about how doctors can create a complete electrical block in the heart during catheter ablation procedures used to treat certain abnormal heart rhythms.
- Conditions
- Atrial Fibrillation (AF), Atrial Tachycardia, Paroxysmal AF, Persisent Atrial Fibrillation
- Trial name
- COSMIC (NCT07889440)
- Volunteers
- 50 people
- Sponsor
- Sebastien Knecht
Persistent Atrial Fibrillation
Posterior Mitral Isthmus Line With Vein of Marshall Ethanolisation Compared With Anterior Mitral Lines in Patients With Persistent Atrial Fibrillation
The goal of this clinical study is to find out which treatment works best for people with persistent atrial fibrillation (a type of irregular heartbeat).
- Trial name
- MIVANT (NCT06962176)
- Testing
- Anterior Mitral Line Ablation, Posterior Mitral Isthmus Ablation with Vein of Marshall Ethanol Infusion
- Where
- Belgium
- Volunteers
- 146 people
- Sponsor
- AZ Sint-Jan AV
Atrial Fibrillation
A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation
The purpose of this study is to assess how safe VARIPULSE pulsed field ablation (PFA) catheter is and how well it works compared to food and drug administration (FDA) approved FARAWAVE PFA catheter in participants with…
- Trial name
- PERSIGMA RCT (NCT07523750)
- Testing
- VARIPULSE Catheter, FARAWAVE Catheter
- Where
- 10 sites in United States
- Volunteers
- 566 people
- Sponsor
- Biosense Webster, Inc.
Heart Failure, Atrial Fibrillation
Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
Atrial fibrillation and heart failure are two common heart conditions that are associated with an increase in death and suffering. When both of these two conditions occur in a patient the patient's prognosis is poor.
- Trial name
- RAFT-AF (NCT01420393)
- Testing
- Rhythm control, Rate Control
- Where
- 21 sites in Brazil, Canada and 2 more
- Volunteers
- 411 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation (AF), Atrial Fibrillation Catheter Ablation
The COMBINE-AF Trial
The goal of this clinical trial is to test if a more complete ablation procedure works better than the standard procedure for people with long-lasting persistent atrial fibrillation (AF).
- Trial name
- COMBINE-AF (NCT07633509)
- Testing
- Linear ablation of mitral isthmus and tricuspid isthmus, Ethanol, Radiofrequency Ablation Catheter
- Where
- 3 sites in China
- Volunteers
- 430 people
- Sponsor
- Yunlong Wang
Atrial Fibrillation, Catheter Ablation
Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation
Atrial fibrillation (AF) is a common heart rhythm disorder affecting over a million people in North America and is associated with serious complications including stroke, heart failure, reduced quality of life, and premature…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Radiofrequency Catheter Ablation
- Trial name
- AWARE-2 (NCT04823299)
- Testing
- PVI-ONLY, CONTROL ARM, PVI-PLUS ARM, INTERVENTIONAL ARM
- Where
- 2 sites in Canada
- Volunteers
- 556 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation (AF), Catheter Ablation
Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial
Atrial fibrillation (AF) leads to atrial functional mitral regurgitation (MR) through mechanisms including mitral annular dilatation, systolic leaflet motion distance alteration, and contractility decrease.
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Atrial Functional Mitral Regurgitation
- Trial name
- ELEVATE-AF (NCT06883864)
- Testing
- Catheter ablation plus medication, Medication, (ELEVATE-AF X) experimental group
- Where
- 17 sites in China
- Volunteers
- 146 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Aldosterone
Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study)
Atrial fibrillation (AF) is the most common cardiac arrhythmias with a constantly growing prevalence. Two main techniques are used today to restore sinus rhythm: electrical cardioversion and radiofrequency ablation.
- Trial name
- ALDO-AF (NCT02804321)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Caen