Clinical trials: Atrial Fibrillation Catheter Ablation
Atrial Fibrillation
EMOTIon and COgNitive Function After Atrial Fibrillation Catheter Ablation vs. Medical Therapy(EMOTICON Trial)
"Atrial fibrillation (AF) is an arrhythmic disease that increases especially in the elderly, increasing the risk of ischemic stroke by 5 times and is a major cause of dementia and cognitive impairment.
- Trial name
- NCT04942171
- Testing
- Atrial fibrillation catheter ablation group, Medical therapy group
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Radiofrequency Catheter Ablation
Use of Radiofrequency Ablation to Eliminate Continuous Atrial Fibrillation in Patients Undergoing Mitral Valve Surgery
The aim of this prospective randomized clinical trial was to evaluate the early and late outcome following left atrial radiofrequency ablation during MV surgery for the treatment of continuous atrial fibrillation and to assess…
- Trial name
- NCT00238706
- Testing
- Radiofrequency ablation
- Sponsor
- University Hospitals, Leicester
Atrial Fibrillation, Persistent, Blood Pressure
Effect of Blood Pressure on Cardiovascular Outcomes and Recurrence After Catheter Ablation in Patients With Atrial Fibrillation
Effect of blood pressure on cardiovascular outcomes and recurrence after catheter ablation in patients with atrial fibrillation
- Trial name
- AF BP (NCT06433336)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Lanzhou University Second Hospital
Atrial Fibrillation, Catheter Ablation
Inflammatory Response Following " Pulsed Field Ablation " vs. Radiofrequency Ablation-2
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Catheter ablation using pulmonary vein isolation (PVI) in an established treatment strategy for AF.
- Conditions
- Atrial Fibrillation, Catheter Ablation, Inflammation
- Trial name
- RIPAF-2 (NCT06160076)
- Testing
- Radiofrequency, Pulsed electric field
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Bordeaux
Atrial Fibrillation
SMART-SF Radiofrequency Ablation Safety Study
This is a prospective safety assessment of the study device during radiofrequency (RF) ablation treatment of patients with drug refractory symptomatic atrial fibrillation (SMART-SF).
- Trial name
- NCT02359890
- Testing
- THERMOCOOL® SMARTTOUCH® (RF ablation treatment)
- Volunteers
- 165 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
Randomised Comparison of the Octaray and Pentaray Catheters
In this study we aim to compare the mapping performance in the left atrium of the established Pentaray catheter to the newer Octaray catheter.
- Trial name
- COPEC (NCT05988424)
- Testing
- Left atrial mapping
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Atrial Fibrillation
Persistent AF Catheter Ablation: Re-PVI Vs. Re-PVI + Continuous Complex Activity Mapping and Ablation - AF-CAM
Major objective is to compare the efficacy of adding additional ablation step (targeting areas of complex, continuous electrical activity in LA) beyond Re-PVI during catheter ablation of Atrial Fibrillation (AF) in patients…
- Trial name
- AF-CAM (NCT05496088)
- Testing
- Re-PVI only, Re-PVI + substrate ablation
- Where
- 3 sites in Germany
- Volunteers
- 56 people
- Sponsor
- Asklepios proresearch
Persistent Atrial Fibrillation
FIH Study of PFLotus in Persistent Atrial Fibrillation
Single-shot pulsed-field ablation (PFA) catheters maximize pulmonary vein isolation (PVI) efficiency but are limited for focal or linear ablation.
- Trial name
- PFLotus- FIH (NCT07301190)
- Testing
- Pulse field ablation with the PFLotus catheter
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Third People's Hospital of Chengdu
Atrial Fibrillation
Clinical Study for Workflow and Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System for Treating Symptomatic Paroxysmal AF (QDOT-Micro)
The QDOT-Micro study is a prospective, multi-center, non-randomized, interventional clinical study.
- Trial name
- NCT02944968
- Testing
- THERMOCOOL SMARTTOUCH® SF-5D catheter
- Volunteers
- 51 people
- Sponsor
- Biosense Webster, Inc.
Paroxysmal Atrial Fibrillation
Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation
The objective of this study is to demonstrate that the NAVI-STAR THERMO-COOL catheter can be used to safely and effectively reduce symptomatic episodes of paroxysmal atrial fibrillation in patients with frequent (>3…
- Trial name
- NCT00584415
- Testing
- GP ablation + PV isolation
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation and Flutter, Hyperthyroidism
Efficacy and Safety of Catheter Ablation of Atrial Fibrillation in Patients With Thyroid Hormone Stabilization
Patients with hyperthyroidism or hypothyroidism are often combined with atrial fibrillation, but after the stabilization of thyroid hormone levels after treatment, the patients' atrial fibrillation still persists.
- Conditions
- Atrial Fibrillation and Flutter, Hyperthyroidism, Hypothyroidism
- Trial name
- SQUIRREL (NCT06452823)
- Testing
- Catheter Ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Affiliated Hospital of Jiaxing University
Persistent Atrial Fibrillation
Left Atrial Isolation by Catheter Ablation in Persistent Atrial Fibrillation With Severe Atrial Fibrosis
This is a single-arm clinical trial evaluating the efficacy and safety of left atrial isolation achieved by catheter ablation in patients with persistent atrial fibrillation with severe atrial fibrosis.
- Trial name
- NCT05173779
- Testing
- Left atrial isolation by catheter ablation
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Catheter Ablation vs Conservative Care in Elderly Patients With Atrial Fibrillation
ACE-AF is a multicenter randomized study in people aged 78 years and older with symptomatic atrial fibrillation (AF). AF is a common heart rhythm disorder in older adults and can cause reduced quality of life and lead to serious…
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Elderly
- Trial name
- ACE-AF (NCT07424690)
- Testing
- Catheter Ablation for Atrial Fibrillation, Optimized Medical Therapy for Atrial Fibrillation, Implantable Loop Recorder (ILR)
- Where
- 2 sites in Sweden
- Volunteers
- 282 people
- Sponsor
- Karolinska University Hospital
Atrial Fibrillation
A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy
The purpose of this exploratory study is to evaluate the safety of rivaroxaban and uninterrupted vitamin K antagonist (VKA) in adult participants with non-valvular atrial fibrillation (NVAF) who undergo catheter ablation as…
- Trial name
- VENTURE-AF (NCT01729871)
- Testing
- rivaroxaban, uninterrupted vitamin K antagonist (VKA)
- Where
- 44 sites in United States, Belgium and 3 more
- Volunteers
- 253 people
- Sponsor
- Janssen Scientific Affairs, LLC
Atrial Fibrillation Paroxysmal, Cardiac Ablation
NS-PFA Catheter Ablation of Paroxysmal Atrial Fibrillation With the Pulse Biosciences CellFX System
The objective of this study is to demonstrate the safety and effectiveness of the CellFX nano-second Pulsed Field Ablation (nsPFA) Cardiac Catheter Ablation System in treating recurrent, drug-resistant, symptomatic paroxysmal…
- Conditions
- Atrial Fibrillation Paroxysmal, Cardiac Ablation, Cardiac Arrhythmia
- Trial name
- NANOPULSE-AF (NCT07018596)
- Testing
- CellFX nsPFA Cardiac Catheter System
- Where
- Czechia
- Volunteers
- 215 people
- Sponsor
- Pulse Biosciences, Inc.
Atrial Fibrillation
Comparison of Contact-force Monitoring Irrigated Tip Catheter and Mesh-like Irrigated Tip Catheter in Atrial Fibrillation Ablation: Prospective Randomized Trial (COMMIC Trial)
Mesh-type flexible tip (MFT) catheter is developed to generate bigger radiofrequency (RF) lesion, and contract force (CF) catheter improves the maintenance of catheter-tissue contact during atrial fibrillation catheter ablation…
- Trial name
- NCT04264117
- Testing
- FlexAbility (Mesh-like irrigated tip catheter) group, TactiCath (Contract force monitoring catheter) group
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Yonsei University
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Impact of Catheter Stability on the Outcomes With Very High Power Short Duration Ablation
Background: Atrial fibrillation (AF), the most common cardiac rhythm disorder can be treated with pulmonary vein isolation (PVI). One technique for PVI is point-by-point radiofrequency ablation.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Pulmonary Vein Isolation
- Trial name
- SVtag (NCT06721221)
- Testing
- Point-by-point PVI with the QDot Micro catheter in QMODE+ setting with the Svtag software
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University
Atrial Fibrillation
A New Approach for Catheter Ablation of Atrial Fibrillation
This is a retrospective cohort study of radiofrequency ablation for the treatment atrial fibrillation(AF). Based on the electrophysiological phenomena found in these cases, the investigators propose a hypothesis regarding the…
- Trial name
- NCT05989321
- Testing
- PVI alone, PVI + SPs ablation
- Where
- China
- Volunteers
- 116 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Atrial Fibrillation, Catheter Ablation
Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation
Atrial fibrillation (AF) is a common heart rhythm disorder affecting over a million people in North America and is associated with serious complications including stroke, heart failure, reduced quality of life, and premature…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Radiofrequency Catheter Ablation
- Trial name
- AWARE-2 (NCT04823299)
- Testing
- PVI-ONLY, CONTROL ARM, PVI-PLUS ARM, INTERVENTIONAL ARM
- Where
- 2 sites in Canada
- Volunteers
- 556 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation
Renal Function and Hemolysis After Pulsed-field Ablation for Atrial Fibrillation
The aim of the project is to assess hemolysis and renal function after catheter ablation for atrial fibrillation using pulsed-field energy.
- Trial name
- NCT06198933
- Testing
- Pulsed-field ablation
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Charles University, Czech Republic