Clinical trials: Atrial Fibrillation Mechanisms
Atrial Fibrillation
Studies of Disorders and Mechanisms Related to Atrial Fibrillation Before and After DC-Conversion.
The purpose of this study is to investigate if breathing disorders are related to atrial fibrillation and if it is possible to predict recurrence of atrial fibrillation after DC-conversion by changes in heart rate variability and…
- Trial name
- NCT00429884
- Where
- Sweden
- Sponsor
- Umeå University
Hypertrophic Cardiomyopathy (HCM), Atrial Fibrillation (AF)
Mechanisms of Atrial Pathoelectrophysiology in HCM
This study aims to learn why atrial fibrillation (AF), a type of irregular heartbeat, happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM).
- Trial name
- MAP HCM (NCT07454135)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Atrial Fibrillation
Evaluating the Effectiveness of Fish Oil Supplements at Reducing the Recurrence of Atrial Fibrillation
Atrial fibrillation (AF) is a heart rhythm disorder that usually involves a rapid heart rate. People who take fish oil supplements may reduce the risk of a recurrence of AF.
- Trial name
- NCT00552084
- Testing
- Fish oil
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Vanderbilt University
Atrial Fibrillation
Atrial Fibrillation Recurrence After Cryoballoon Ablation
The purpose of the study is to evaluate the mechanisms of recurrent atrial fibrillation after cryoballoon ablation using the Arctic Front Ablation System.
- Trial name
- NCT01772030
- Testing
- Use of the Achieve catheter followed by ICE-guided mapping catheter
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Persistent Atrial Fibrillation
The Substrate and Intervention Mechanisms for Persistent Atrial Fibrillation Trial
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with increasing morbidity and mortality. A catheter-based AF ablation technique that isolates pulmonary veins (PV) from the left atrium has been established…
- Trial name
- SIMPle-AF (NCT02918396)
- Testing
- Scar-Based Radio-frequency Ablation, Rotor Anchors Radio-frequency Ablation, Conventional PVI by Radio-frequency Ablation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms
Substrate Remodelling and Targeted Ablation in AF
Atrial fibrillation (AF) is the most common heart rhythm disorder, affecting millions worldwide and causing symptoms such as palpitations, fatigue and breathlessness.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms, Catheter Ablation, Low Voltage Areas
- Trial name
- STRATA-AF (NCT07047235)
- Testing
- Pulmonary vein reisolation, Ganglionic plexi ablation, Substrate ablation
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
High-intensity Interval Training in Patients With Atrial Fibrillation
A key characteristic of the heart is its regular rhythm. When the heart is exposed to irregular electric impulses, such as with atrial fibrillation (AF), detrimental effects can occur affecting the ability of the heart to pump…
- Trial name
- HIIT-AF (NCT05354271)
- Testing
- High-intensity interval training, Moderate-intensity continuous training
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Liverpool John Moores University
Atrial Fibrillation, Stroke
Impact of Steerable Delivery Sheaths on Successful Closure of LA A With AMULET
The novel Amplatzer steerable delivery sheath (Abbott Vascular) is found to be safe and effective in performing LAAO procedure. However, the procedural outcomes have not been compared with the traditional non-steerable fixed…
- Trial name
- NCT05464511
- Testing
- Left atrial appendage occlusion with the dual mechanism closure Amulet device using a novel steerable sheath.
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Atrial Fibrillation, Pulmonary Vein Ablation
Ibutilide Administration During Pulmonary Vein Ablation
To test the hypothesis that localized functional reentry maintains Afib in humans, ibutilide will be administered intravenously in patients undergoing an Afib ablation.
- Trial name
- IBAD-AFIB (NCT00589992)
- Testing
- Ibutilide fumarate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ball Memorial Hospital
Atrial Fibrillation
Non-invasive Characterization of the Mechanisms of Atrial Fibrillation Maintenance
Currently available antiarrhythmic drugs for the treatment of atrial fibrillation (AF) have a limited efficacy and often cause long-term side effects. Pulmonary vein isolation is the therapy of choice in drug-refractory patients.
- Trial name
- PERSONALIZE (NCT02497248)
- Testing
- Pulmonary vein ablation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Heart Valve Incompetence, Atrial Fibrillation, Persistent
In-depth Characterization of Atriogenic Secondary Tricuspid Regurgitation Due to Atrial Fibrillation
1050 patients with persistent/permanent atrial fibrillation (AF) will be studied using conventional and advanced (three-dimensional and deformation imaging) echocardiography.
- Trial name
- ASTRA (NCT05749107)
- Testing
- Echocardiography, Proteomic analyses
- Where
- 2 sites in Italy
- Volunteers
- 1,050 people
- Sponsor
- Istituto Auxologico Italiano
Atrial Fibrillation, Stroke
Occult Paroxysmal Atrial Fibrillation in Patients With Non-cardioembolic Ischemic Stroke of Determined Mechanism
The aim of this study is to determine the yield of 3 weeks outpatient mobile cardiac monitoring for detection of atrial fibrillation in patients with history of stroke of known cause.
- Trial name
- NCT01410396
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Northwestern University
Persistent Atrial Fibrillation
Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
This is a pilot study to assess the usefulness of ECG mapping, and enhanced MRI and PET scan imaging in identifying atrial fibrosis and arrhythmia circuits involved in persistent atrial fibrillation and in guiding an innovative…
- Trial name
- COAST-AF (NCT02184013)
- Testing
- Catheter ablation
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation Recurrent
A Study on the Relationship Between Individualized Low Voltage Regions in Left Atrium and the Mechanism of Atrial Fibrillation in Persistent Atrial Fibrillation Under Ultra-High-Resolution Mapping
The latest OCTARAY multi-electrode mapping catheter and TUREref technology were used to perform ultra-high precision mapping on the left atrial and left atrial auricle of persistent atrial fibrillation in the condition of sinus…
- Trial name
- ILVRA-PAFM-UAH (NCT06694610)
- Testing
- non-pulmonary vein ablation group, only pulmonary vein ablation group
- Volunteers
- 120 people
- Sponsor
- The Third People's Hospital of Chengdu
Atrial Fibrillation
A New Theory of Electrophysiological Mechanism of Atrial Fibrillation
The electrophysiological mechanisms of atrial fibrillation remain disagreements. The goal of this clinical trail is to propose a new electrophysiological mechanism hypothesis of atrial fibrillation（AF）,meanwhile, the…
- Trial name
- ANTEMAF (NCT05845034)
- Testing
- PVI + SPEs ablation, PVI ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Atrial Fibrillation
Release of Acetylcholine From the Ganglionated Plexus During the Thaw Phase of Cryoballon Pulmonary Vein Ablation (GP RESPONSE Study)
Determine whether the presence of acetylcholine in the systemic circulation, correlates with the hypotensive response observed during the thaw phase of cryoballoon ablation.
- Trial name
- NCT03636100
- Testing
- Cryoballoon ablation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Saint Luke's Health System
Atrial Fibrillation
Birkebeiner II Study
Prolonged endurance exercise is associated with an elevated risk of atrial fibrillation (AF). The mechanisms governing this increased risk remains elusive.
- Trial name
- NCT03741491
- Where
- Norway
- Volunteers
- 395 people
- Sponsor
- Diakonhjemmet Hospital
Atrial Fibrillation
Role of Subsequent Atrial Tachycardia in Mechanisms of Persistent AF
In this study, the investigators aim to examine the prognostic role of subsequent Atrial Tachycardias (ATs) in the mechanisms of atrial fibrillation (AF).
- Trial name
- NCT01896570
- Testing
- Catheter ablation of subsequent atrial tachycardia
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Johannes Gutenberg University Mainz
Atrial Fibrillation
Reappraisal of Atrial Fibrillation: Interaction Between HyperCoagulability, Electrical Remodeling, and Vascular Destabilisation in the Progression of Atrial Fibrillation
The purpose of this study is to study clinical factors and (blood) biomarkers related to progression of Atrial Fibrillation (AF) in patients diagnosed with self-terminating AF with special reference to hypercoagulability.
- Trial name
- RACE V (NCT02726698)
- Where
- 9 sites in Netherlands
- Volunteers
- 750 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation, Arrhythmia
Inhibition of Atrial Fibrillation by Elimination of Transitional Mechanisms
There is growing awareness of the importance of electrical rotors to the maintenance of atrial fibrillation (AF). Recent work in our laboratory has found that AF evolves over time, from rapid, focal activation, next to…
- Trial name
- TRANS AF (NCT02758002)
- Testing
- Firm ablation for transitional AF rotors
- Where
- United States
- Sponsor
- University of California, San Diego